Christian Holscher

Summary

Publications

  1. doi request reprint New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    Neurobiol Aging 31:1495-502. 2010
  2. doi request reprint Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Biochem Soc Trans 39:891-7. 2011
  3. ncbi request reprint Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
    Christian Holscher
    School of Biomed Sci, Ulster University, Coleraine, UK
    Eur J Pharmacol 561:85-90. 2007
  4. doi request reprint D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    J Alzheimers Dis 35:267-83. 2013
  5. doi request reprint Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice
    David Porter
    The SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Peptides 35:1-8. 2012
  6. doi request reprint Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    Talib Abbas
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Behav Brain Res 205:265-71. 2009
  7. doi request reprint GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
    Eur J Pharmacol 587:112-7. 2008
  8. doi request reprint The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    Alison Hamilton
    School of Biomedical Science, University of Ulster, Coleraine, Northern Ireland, UK
    Brain Res 1449:83-93. 2012
  9. doi request reprint Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    Simon Gengler
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    Neurobiol Aging 33:265-76. 2012
  10. doi request reprint Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    Eur J Pharmacol 674:294-306. 2012

Collaborators

Detail Information

Publications29

  1. doi request reprint New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    Neurobiol Aging 31:1495-502. 2010
    ..Therefore, incretins show great promise as a novel treatment for reducing degenerative processes in AD...
  2. doi request reprint Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Biochem Soc Trans 39:891-7. 2011
    ....
  3. ncbi request reprint Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
    Christian Holscher
    School of Biomed Sci, Ulster University, Coleraine, UK
    Eur J Pharmacol 561:85-90. 2007
    ..These results suggest that treatment at very early stages of Alzheimer's disease could prevent later irreversible neuronal degeneration...
  4. doi request reprint D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    J Alzheimers Dis 35:267-83. 2013
    ..This suggests that novel GIP analogues may have beneficial effects in non-demented aged people and perhaps even in AD patients even when the disease is further progressed...
  5. doi request reprint Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice
    David Porter
    The SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Peptides 35:1-8. 2012
    ..These data indicate that incretin metabolites do not influence locomotor activity, cognitive function and hippocampal synaptic plasticity when administered at pharmacological doses to mice fed a high-fat diet...
  6. doi request reprint Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    Talib Abbas
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Behav Brain Res 205:265-71. 2009
    ..The results shed light on the molecular processes that underlie the neuroprotective properties of GLP-1 analogues in animal models of Alzheimer's disease...
  7. doi request reprint GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
    Eur J Pharmacol 587:112-7. 2008
    ..Therefore, longer-acting GLP-1 agonists show great potential as a novel treatment for preventing neurodegenerative processes in neurodegenerative disorders...
  8. doi request reprint The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    Alison Hamilton
    School of Biomedical Science, University of Ulster, Coleraine, Northern Ireland, UK
    Brain Res 1449:83-93. 2012
    ..Therefore, therapies would have the best effects if started early, but promoting neurogenesis may act in a protective and reconstructive way even in later stages of AD...
  9. doi request reprint Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    Simon Gengler
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    Neurobiol Aging 33:265-76. 2012
    ..In 18-month-old mice, however, the number of Congo red positive dense-core amyloid plaques was reduced. Treatment with Val(8)GLP-1 might prevent or delay neurodegenerative processes...
  10. doi request reprint Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    Eur J Pharmacol 674:294-306. 2012
    ....
  11. pmc Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice
    Simon Gengler
    School of Biomed Sciences, Ulster University, Coleraine, United Kingdom
    PLoS ONE 5:e9764. 2010
    ..This model shows initial plaque formation at 2 months in the neocortex and 4 months in the hippocampus and displays beta-amyloid-associated pathologies and learning impairments...
  12. doi request reprint Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    Victor A Gault
    School of Biomedical Schiences, University of Ulster, Coleraine, Northern Ireland
    J Neurophysiol 99:1590-5. 2008
    ..The use of enzyme-resistant analogues of GIP show great promise as a potential novel treatment for preventing neurodegenerative processes in AD and other related disorders...
  13. doi request reprint Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Eur J Pharmacol 630:158-62. 2010
    ..Therefore, the drug effects seen here could potentially ameliorate the impairments in neuronal communication and cognitive processes observed in Alzheimer's disease...
  14. doi request reprint The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    J Neurosci 31:6587-94. 2011
    ..Our results show that liraglutide prevents key neurodegenerative developments found in Alzheimer's disease, suggesting that GLP-1 analogs represent a novel treatment strategy for Alzheimer's disease...
  15. pmc A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease
    Vadivel Parthsarathy
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Londonderry, United Kingdom
    PLoS ONE 8:e54769. 2013
    ....
  16. doi request reprint Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    J Neurophysiol 105:1574-80. 2011
    ..Together the results suggest that GIP receptors play an important role in cognition, neurotransmission, and cell proliferation...
  17. pmc Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model
    Vadivel Parthsarathy
    School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom
    PLoS ONE 8:e58784. 2013
    ..These results demonstrate that liraglutide, which is currently on the market as a treatment for type 2 diabetes (Victoza(TM)), increases neurogenesis, which may have beneficial effects in neurodegenerative disorders like AD...
  18. doi request reprint Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain
    Stephen F J McGovern
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Brain Res 1473:204-13. 2012
    ..The results demonstrate that (Val8)GLP-1 is safe in a range of doses, crosses the BBB and has potentially beneficial effects in the CNS by enhancing neurogenesis...
  19. doi request reprint Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
    David W Porter
    SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Eur J Pharmacol 650:688-93. 2011
    ....
  20. ncbi request reprint Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine BT52 1SA, UK
    Recent Pat CNS Drug Discov 5:109-17. 2010
    ..Currently, there are three patents covering native GLP-1 and different GLP-1 analogues and one patent for the use of GIP and different GIP analogues for the treatment of neurodegenerative diseases...
  21. doi request reprint The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain
    Vadivel Parthsarathy
    School of Biomedical Sciences, Ulster University, Cromore Road, BT52 1SA Coleraine, Northern Ireland
    Eur J Pharmacol 700:42-50. 2013
    ..Liraglutide or similar GLP-1 analogues may be a suitable treatment for reducing the chronic inflammatory response in the brain found in several neurodegenerative conditions...
  22. pmc Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    Kerry Hunter
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    BMC Neurosci 13:33. 2012
    ..Therefore, if GLP-1 analogues can cross the blood brain barrier, diffuse through the brain to reach the receptors and most importantly activate them, their neuroprotective effects may be realized...
  23. ncbi request reprint Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background
    Simon Gengler
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland
    Exp Brain Res 179:621-30. 2007
    ....
  24. doi request reprint The role of GLP-1 in neuronal activity and neurodegeneration
    Christian Holscher
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Vitam Horm 84:331-54. 2010
    ..Therefore, GLP-1 analogues show great promise as a novel treatment for AD or other neurodegenerative conditions...
  25. doi request reprint Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    Paula L McClean
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA Northern Ireland, UK
    Neuropharmacology 76:57-67. 2014
    ..Liraglutide is now being tested in clinical trials in AD patients. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'. ..
  26. pmc Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
    Emilie Faivre
    School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK
    Alzheimers Res Ther 5:20. 2013
    ..CONCLUSION: The results demonstrate that D-Ala2GIP has neuroprotective properties on key hallmarks found in AD. This finding shows that novel GIP analogues have the potential as a novel therapeutic for AD...
  27. doi request reprint Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection
    Christian Holscher
    School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK
    CNS Drugs 26:871-82. 2012
    ..Therefore, GLP-1 analogues show great promise as a novel treatment for AD or other neurodegenerative conditions...
  28. doi request reprint Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
    Alison Hamilton
    School of Biomedical Sciences, Ulster University, Coleraine, UK
    Neuroreport 20:1161-6. 2009
    ..The fact that the receptor is located on neurons and dendrites suggests that the neuroprotective action is caused by the modulation of neuronal excitation...
  29. ncbi request reprint Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
    Christian Holscher
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Rev Neurosci 16:181-212. 2005
    ..They could help to prolong the time of unimpaired cognitive abilities of people who develop AD, allowing them to lead an independent life...