Michael V Holmes

Summary

Publications

  1. pmc Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study
    Michael V Holmes
    Faculty of Population Health Sciences, University College London, London, United Kingdom Electronic address
    J Am Coll Cardiol 62:1966-76. 2013
  2. doi The role of dietary vitamin K in the management of oral vitamin K antagonists
    Michael V Holmes
    Department of Clinical Pharmacology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Blood Rev 26:1-14. 2012
  3. doi CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis
    Michael V Holmes
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Pl, London, WC1E 6BT, United Kingdom
    JAMA 306:2704-14. 2011
  4. doi Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers
    Tina Shah
    Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London WC1E 6BT, United Kingdom
    Circ Cardiovasc Genet 6:163-70. 2013
  5. doi The genetics of coronary heart disease
    Daniel I Swerdlow
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK
    Br Med Bull 102:59-77. 2012
  6. doi Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis
    Michael V Holmes
    Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1 19 Torrington Place, London WC1E 6BT, UK Electronic address
    Am J Hum Genet 94:198-208. 2014
  7. pmc CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis
    Danny W K Lum
    Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom
    PLoS ONE 8:e76648. 2013
  8. pmc Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
  9. pmc Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
    Tina Shah
    Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, United Kingdom
    PLoS ONE 8:e71345. 2013
  10. pmc Complex disease genetics: present and future translational applications
    Michael V Holmes
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Genome Med 1:104. 2009

Detail Information

Publications14

  1. pmc Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study
    Michael V Holmes
    Faculty of Population Health Sciences, University College London, London, United Kingdom Electronic address
    J Am Coll Cardiol 62:1966-76. 2013
    ..This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease...
  2. doi The role of dietary vitamin K in the management of oral vitamin K antagonists
    Michael V Holmes
    Department of Clinical Pharmacology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Blood Rev 26:1-14. 2012
    ....
  3. doi CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis
    Michael V Holmes
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Pl, London, WC1E 6BT, United Kingdom
    JAMA 306:2704-14. 2011
    ....
  4. doi Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers
    Tina Shah
    Genetic Epidemiology Group, Research Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, London WC1E 6BT, United Kingdom
    Circ Cardiovasc Genet 6:163-70. 2013
    ..Genetic variants associated with IL-6 provide important tools for probing the causal relevance of IL-6 signaling in a range of cardiometabolic diseases...
  5. doi The genetics of coronary heart disease
    Daniel I Swerdlow
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK
    Br Med Bull 102:59-77. 2012
    ..Recent major advances in genomic science and technology have opened new avenues of investigation in the pathogenesis of CHD, some of which are leading to clinical translation...
  6. doi Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis
    Michael V Holmes
    Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1 19 Torrington Place, London WC1E 6BT, UK Electronic address
    Am J Hum Genet 94:198-208. 2014
    ..04 (95% CI = 0.97-1.12) per 1 kg/m(2) increase in BMI. In conclusion, we identified causal effects of BMI on several cardiometabolic traits; however, whether BMI causally impacts CHD risk requires further evidence...
  7. pmc CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis
    Danny W K Lum
    Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom
    PLoS ONE 8:e76648. 2013
    ..To evaluate evidence on the association between CYP2D6 genotype and tamoxifen response through...
  8. pmc Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
    ..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
  9. pmc Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
    Tina Shah
    Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, United Kingdom
    PLoS ONE 8:e71345. 2013
    ....
  10. pmc Complex disease genetics: present and future translational applications
    Michael V Holmes
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Genome Med 1:104. 2009
    ..ABSTRACT: A report on the British Atherosclerosis Society autumn meeting 'Genetics of Complex Diseases', Cambridge, UK, 17-18 September 2009...
  11. pmc Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies
    Michael V Holmes
    Centre for Clinical Pharmacology, University College London, London, United Kingdom
    PLoS ONE 4:e7960. 2009
    ..Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics)...
  12. pmc Interleukin-6 receptor pathways in abdominal aortic aneurysm
    Seamus C Harrison
    Department of Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, Rayne Building, University Street, London WC1E 6JJ, UK
    Eur Heart J 34:3707-16. 2013
    ..Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach...
  13. doi Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis
    Sonia Shah
    University College London Genetics Institute, University College London, London, United Kingdom
    Circ Cardiovasc Genet 6:63-72. 2013
    ..We aimed to determine the causal association among the 3 major blood lipid fractions and common CIMT using mendelian randomization analysis...
  14. doi Utility of genetic determinants of lipids and cardiovascular events in assessing risk
    Michael V Holmes
    Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Nat Rev Cardiol 8:207-21. 2011
    ..Many of the issues we discuss hold true for any late-onset common disease with modifiable risk factors and proven preventative strategies...