Lars Holm

Summary

Publications

  1. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
  2. pmc Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans
    Lars Holm
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 304:E895-907. 2013
  3. pmc Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders
    Lars Holm
    Department of Orthopaedic Surgery M and Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, Center of Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e15606. 2010
  4. doi request reprint Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:274-81. 2008
  5. doi request reprint Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity
    L Holm
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:1454-61. 2008
  6. pmc Measuring protein breakdown rate in individual proteins in vivo
    Lars Holm
    Institute of Sports Medicine and Department of Orthopedic Surgery, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Clin Nutr Metab Care 13:526-31. 2010
  7. doi request reprint GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients
    Simon Doessing
    Department of Orthopaedic Surgery M, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Aging, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    Eur J Endocrinol 163:853-62. 2010
  8. pmc Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
    Simon Doessing
    Institute of Sports Medicine, Bispebjerg Hospital, Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen NV, Denmark
    J Physiol 588:341-51. 2010
  9. doi request reprint Assessment of satellite cell number and activity status in human skeletal muscle biopsies
    Abigail L Mackey
    Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Muscle Nerve 40:455-65. 2009
  10. doi request reprint The anabolic potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
    Rasmus Bechshoeft
    Institute of Sports Medicine, Dept of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Nutr 32:236-44. 2013

Detail Information

Publications26

  1. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
    ..Furthermore, although functionally linked, the contractile and the supportive matrix structures upregulate their protein synthesis rate quite differently in response to feeding and contractile activity and intensity...
  2. pmc Determination of steady-state protein breakdown rate in vivo by the disappearance of protein-bound tracer-labeled amino acids: a method applicable in humans
    Lars Holm
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 304:E895-907. 2013
    ..The applicability of this protein-specific FBR approach is suitable for human in vivo experimentation. The labeling period of deuterium oxide administration is dependent on the turnover rate of the protein of interest...
  3. pmc Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders
    Lars Holm
    Department of Orthopaedic Surgery M and Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, Center of Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e15606. 2010
    ..These changed responses may lead to divergent adaptation over the course of prolonged exposure...
  4. doi request reprint Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital, Copenhagen, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:274-81. 2008
    ..The observed differences following such a short intervention emphasize the significance of postexercise nutrient supply on musculoskeletal maintenance...
  5. doi request reprint Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity
    L Holm
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 105:1454-61. 2008
    ..However, LL resistance training was inferior to HL training in evoking adaptive changes in muscle size and contractile strength and was insufficient to induce changes in MHC composition...
  6. pmc Measuring protein breakdown rate in individual proteins in vivo
    Lars Holm
    Institute of Sports Medicine and Department of Orthopedic Surgery, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Clin Nutr Metab Care 13:526-31. 2010
    ..To outline different approaches of how protein breakdown can be quantified and to present a new approach to determine the fractional breakdown rate of individual slow turnover proteins in vivo...
  7. doi request reprint GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients
    Simon Doessing
    Department of Orthopaedic Surgery M, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Aging, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    Eur J Endocrinol 163:853-62. 2010
    ..GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1...
  8. pmc Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
    Simon Doessing
    Institute of Sports Medicine, Bispebjerg Hospital, Center of Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen NV, Denmark
    J Physiol 588:341-51. 2010
    ..The results suggest that GH is more important in strengthening the matrix tissue than for muscle cell hypertrophy in adult human musculotendinous tissue...
  9. doi request reprint Assessment of satellite cell number and activity status in human skeletal muscle biopsies
    Abigail L Mackey
    Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Muscle Nerve 40:455-65. 2009
    ..This study provides valuable tools to assess the behavior of satellite cells, both in pathological conditions and in response to physiological stimuli...
  10. doi request reprint The anabolic potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
    Rasmus Bechshoeft
    Institute of Sports Medicine, Dept of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Nutr 32:236-44. 2013
    ..Hyperaminoacidemia stimulates myofibrillar fractional synthesis rate (myoFSR) transiently in resting skeletal muscle. We investigated whether light-load resistance exercise can extent this responsiveness...
  11. doi request reprint Myogenic, matrix, and growth factor mRNA expression in human skeletal muscle: effect of contraction intensity and feeding
    Jakob Agergaard
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, Denmark
    Muscle Nerve 47:748-59. 2013
    ..We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise...
  12. ncbi request reprint Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Gerontol A Biol Sci Med Sci 67:1005-13. 2012
    ..Nevertheless, resistance exercise in combination with ERT seems to have a counteracting effect on myofibrillar FSR in hysterectomized/oophorectomized women...
  13. doi request reprint GH receptor blocker administration and muscle-tendon collagen synthesis in humans
    Rie Harboe Nielsen
    Institute of Sports Medicine, Dept of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Denmark
    Growth Horm IGF Res 21:140-5. 2011
    ..The growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis stimulates collagen synthesis in tendon and skeletal muscle, but no studies have investigated the effect of reducing IGF-I on collagen synthesis in healthy humans...
  14. ncbi request reprint Postexercise nutrient intake enhances leg protein balance in early postmenopausal women
    Lars Holm
    Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, Bld 8 1st Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Gerontol A Biol Sci Med Sci 60:1212-8. 2005
    ....
  15. doi request reprint Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion
    Søren Reitelseder
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Copenhagen NV, Denmark
    Am J Physiol Endocrinol Metab 300:E231-42. 2011
    ..05). In conclusion, whey and casein intake immediately after resistance exercise results in an overall equal MPS response despite temporal differences in insulin and amino acid concentrations and 4E-BP1...
  16. doi request reprint Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation
    Søren Reitelseder
    Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 8, 1st Floor, 2400, Copenhagen NV, Denmark
    Eur J Nutr 53:321-33. 2014
    ..30 g/kg lean body mass), or a non-caloric control after heavy resistance exercise on protein turnover and mRNA expressions of forkhead homeobox type O (FOXO) isoforms, muscle RING finger 1 (MuRF1), and Atrogin1 in young healthy males...
  17. doi request reprint Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients
    Susanne G Petersen
    Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Centre for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arch Phys Med Rehabil 92:1185-93. 2011
    ....
  18. ncbi request reprint The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans
    Abigail L Mackey
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bldg 8, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    J Appl Physiol (1985) 103:425-31. 2007
    ..05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity...
  19. ncbi request reprint The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracers
    Lars Holm
    Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 306:E1330-9. 2014
    ....
  20. doi request reprint Local administration of growth hormone stimulates tendon collagen synthesis in elderly men
    Poul Vestergaard
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Medical Research Laboratories, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark
    J Appl Physiol (1985) 113:1432-8. 2012
    ..control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I...
  21. doi request reprint Exercise and NSAIDs: effect on muscle protein synthesis in patients with knee osteoarthritis
    Susanne Germann Petersen
    Department of Orthopaedic Surgery, Faculty of Health Sciences, Institute of Sports Medicine, Bispebjerg Hospital and Centre for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 43:425-31. 2011
    ....
  22. doi request reprint Increase in tendon protein synthesis in response to insulin-like growth factor-I is preserved in elderly men
    Rie Harboe Nielsen
    Department of Orthopedic Surgery, Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health and Medical Sciences, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 116:42-6. 2014
    ..This could indicate that the changed phenotype in aging tendon is not caused by decreased fibroblast function. ..
  23. pmc Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans
    Kasper Dideriksen
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital, Copenhagen NV, Denmark
    Nutrients 5:852-76. 2013
    ..However, to improve coherence between these types of data and to further improve our knowledge of the effects of protein ingestion, other investigative approaches than those presently used are requested...
  24. doi request reprint Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women
    Mette Hansen
    Institute of Sports Medicine, Bispebjerg Hospital, and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1385-93. 2009
    ..These results indicate a pivotal role for estradiol in maintaining homeostasis of female connective tissue...
  25. doi request reprint Aquaporins 6-12 in the human eye
    Thuy Linh Tran
    Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Acta Ophthalmol 91:557-63. 2013
    ..AQPs 0-5 have been localized at the cellular level in human eyes. We investigated the presence of the more recently discovered AQPs 6-12 in the human eye...
  26. ncbi request reprint The effects of regular strength training on telomere length in human skeletal muscle
    Fawzi Kadi
    Department of Health Sciences, Orebro University, Orebro, Sweden
    Med Sci Sports Exerc 40:82-7. 2008
    ..Therefore, we aimed to compare telomere length of a group of power lifters (PL; N = 7) who trained for 8 +/- 3 yr against that of a group of healthy, active subjects (C; N = 7) with no history of strength training...