Henner Hollert

Summary

Publications

  1. ncbi request reprint Application of a sediment quality triad and different statistical approaches (Hasse diagrams and fuzzy logic) for the comparative evaluation of small streams
    Henner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Ecotoxicology 11:311-21. 2002
  2. doi request reprint Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test
    Melanie Boettcher
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Mutat Res 700:11-7. 2010
  3. doi request reprint Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies
    Paula Suares Rocha
    Aquatic Ecology and Toxicology Section, Heidelberg Institute of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Ecotoxicol Environ Saf 72:1842-8. 2009
  4. doi request reprint A novel statistical approach for the evaluation of comet assay data
    Nadja Seitz
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Mutat Res 652:38-45. 2008
  5. doi request reprint Assessment of fish health status in the Upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus
    Stefanie Grund
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Dis Aquat Organ 88:235-48. 2010
  6. ncbi request reprint Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river
    Steffen Keiter
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany
    Anal Bioanal Chem 390:2009-19. 2008
  7. doi request reprint Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites--DDA, DDMU, DDMS, and DDCN
    Bernhard Wetterauer
    Aquatic Ecology and Toxicology, COS Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 19:403-15. 2012
  8. ncbi request reprint Ecotoxicological assessment of sediment, suspended matter and water samples in the upper Danube River. A pilot study in search for the causes for the decline of fish catches
    Steffen Keiter
    Department of Zoology, Aquatic Ecology and Toxicology Section, University of Heidelberg, Germany
    Environ Sci Pollut Res Int 13:308-19. 2006
  9. doi request reprint A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments
    Thomas Kosmehl
    Aquatic Ecology and Toxicology Group, COS Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Reprod Toxicol 33:245-53. 2012
  10. ncbi request reprint DNA damage induced by genotoxicants in zebrafish (Danio rerio) embryos after contact exposure to freeze-dried sediment and sediment extracts from Laguna Lake (The Philippines) as measured by the comet assay
    Thomas Kosmehl
    Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 61920 Heidelberg, Germany
    Mutat Res 650:1-14. 2008

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Application of a sediment quality triad and different statistical approaches (Hasse diagrams and fuzzy logic) for the comparative evaluation of small streams
    Henner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Ecotoxicology 11:311-21. 2002
    ..In contrast, fuzzy logic allows both to develop site-specific expert systems in order to assess the ecotoxicological burden and to give insight into the pattern of the contamination...
  2. doi request reprint Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test
    Melanie Boettcher
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Mutat Res 700:11-7. 2010
    ..With respect to the ecological status of the Danube River, the results overall indicate a moderate to severe genotoxic potential with a highly differential localization...
  3. doi request reprint Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies
    Paula Suares Rocha
    Aquatic Ecology and Toxicology Section, Heidelberg Institute of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Ecotoxicol Environ Saf 72:1842-8. 2009
    ..The high genotoxic burden of the Tietê River warrants measures to reduce the input of toxic effluents...
  4. doi request reprint A novel statistical approach for the evaluation of comet assay data
    Nadja Seitz
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Mutat Res 652:38-45. 2008
    ..The so-called "concentration-dependent induction factor" (CDI) introduces an index for a straightforward, precise and realistic assessment of the genotoxic potential of any kind of field sample or genotoxic agent...
  5. doi request reprint Assessment of fish health status in the Upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus
    Stefanie Grund
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Dis Aquat Organ 88:235-48. 2010
    ..A relationship between impaired fish health status and the decline of fish catches along the Upper Danube River cannot be excluded...
  6. ncbi request reprint Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river
    Steffen Keiter
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany
    Anal Bioanal Chem 390:2009-19. 2008
    ..Nevertheless, owing to the effects of PAHs towards fish and the connection between dioxin-like activity and carcinogenicity, the link between contamination and the fish population decline cannot be ruled out...
  7. doi request reprint Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites--DDA, DDMU, DDMS, and DDCN
    Bernhard Wetterauer
    Aquatic Ecology and Toxicology, COS Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 19:403-15. 2012
    ..The objective of this communication is to evaluate, for the first time, the cytotoxicity, dioxin-like activity, and estrogenicity of the least-studied DDT metabolites...
  8. ncbi request reprint Ecotoxicological assessment of sediment, suspended matter and water samples in the upper Danube River. A pilot study in search for the causes for the decline of fish catches
    Steffen Keiter
    Department of Zoology, Aquatic Ecology and Toxicology Section, University of Heidelberg, Germany
    Environ Sci Pollut Res Int 13:308-19. 2006
    ..The results of this pilot study will be used to decide if a comprehensive weight-of-evidence study is needed...
  9. doi request reprint A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments
    Thomas Kosmehl
    Aquatic Ecology and Toxicology Group, COS Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Reprod Toxicol 33:245-53. 2012
    ..However, it is difficult to distinguish between specific responses and more universal detoxification of the organism...
  10. ncbi request reprint DNA damage induced by genotoxicants in zebrafish (Danio rerio) embryos after contact exposure to freeze-dried sediment and sediment extracts from Laguna Lake (The Philippines) as measured by the comet assay
    Thomas Kosmehl
    Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 61920 Heidelberg, Germany
    Mutat Res 650:1-14. 2008
    ..In conclusion, the present study demonstrates that the bioavailable fraction of the genotoxic pollutants may pose a threat for both benthic organisms and human health via drinking-water and fish consumption...
  11. doi request reprint Sediment-contact fish embryo toxicity assay with Danio rerio to assess particle-bound pollutants in the Tietê River Basin (São Paulo, Brazil)
    Paula Suares Rocha
    Aquatic Ecology and Toxicology Section, Center for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Ecotoxicol Environ Saf 74:1951-9. 2011
    ..This test provides an ecological highly realistic and relevant exposure scenario, and should therefore be added in ecotoxicological sediment quality assessments...
  12. doi request reprint The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis
    Stefanie Grund
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany
    Environ Sci Pollut Res Int 18:446-60. 2011
    ..The present study was part of a comprehensive weight-of-evidence approach with the goal of identifying potential causes for the declines in fish populations, which have been observed during the past decades in the Upper Danube River...
  13. doi request reprint Changes in toxicity and dioxin-like activity of sediments from the Tietê River (São Paulo, Brazil)
    Paula Suares Rocha
    Aquatic Ecology and Toxicology Section, Institute for Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Ecotoxicol Environ Saf 73:550-8. 2010
    ..Moreover, they indicate additional sources of pollutants along the river course, which contribute to the degradation of each reservoir...
  14. ncbi request reprint Some heterocyclic aromatic compounds are Ah receptor agonists in the DR-CALUX assay and the EROD assay with RTL-W1 cells
    Gunnar Hinger
    Aquatic Toxicology and Ecology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 18:1297-304. 2011
    ..However, only few publications are available investigating NSO-HET using in vitro bioassays. To support better characterization of environmental samples, selected NSO-HET were screened for dioxin-like activity in two bioassays...
  15. ncbi request reprint Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAse protection-assay using isolated hepatocytes of rainbow trout
    Henner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Environ Sci Pollut Res Int 12:347-60. 2005
    ....
  16. ncbi request reprint A novel contact assay for testing genotoxicity of chemicals and whole sediments in zebrafish embryos
    Thomas Kosmehl
    Department of Zoology, Aquatic Ecology and Toxicology Section, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Environ Toxicol Chem 25:2097-106. 2006
    ..In conclusion, the newly developed sediment contact assay can be recommended for the detection of both single substances but also the bioavailable fraction of the total hazard potential of sediments...
  17. doi request reprint Oxygen requirements of zebrafish (Danio rerio) embryos in embryo toxicity tests with environmental samples
    Ruben Strecker
    Aquatic Ecology and Toxicology Section, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230 D 69120 Heidelberg, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 153:318-27. 2011
    ..In the sediment contact tests with zebrafish embryos, native sediments rich in organic materials rapidly developed strongly hypoxic conditions, particularly at the sediment-water interface (0 to 500μm distance to the sediment)...
  18. doi request reprint Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)
    Jens C Otte
    Aquatic Ecology and Toxicology, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Aquat Toxicol 100:38-50. 2010
    ..The differentiation between constitutive and induced spatio-temporal patterns of CYP1 activity even as early as the gastrula stage provide further insights into the endogenous role of CYP1 activity...
  19. ncbi request reprint Changes in toxicity and genotoxicity of industrial sewage sludge samples containing nitro- and amino-aromatic compounds following treatment in bioreactors with different oxygen regimes
    Nina Klee
    Department of Zoology, Aquatic Ecology and Toxicology Group, Morphology and Ecology Section, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 11:313-20. 2004
    ....
  20. ncbi request reprint Perfluorooctane sulfonate increases the genotoxicity of cyclophosphamide in the micronucleus assay with V79 cells. Further proof of alterations in cell membrane properties caused by PFOS
    Susanne Jernbro
    Dept of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 14:85-7. 2007
    ..5 microg/ml, but that further investigations are needed to assess the potential interaction between PFOS and other substances, in particular regarding the impact of membrane alterations on the uptake of toxic substances...
  21. ncbi request reprint Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species -- an update
    Thomas Braunbeck
    Aquatic Ecology and Toxicology Group, Department of Zoology, University of Heidelberg, D Heidelberg
    ALTEX 22:87-102. 2005
    ..Finally, examples are given as to how additional endpoints can be incorporated into the fish embryo test protocol to extend its scope, e.g. to sediment toxicity assessment or genotoxicity and mutagenicity testing...
  22. ncbi request reprint The identification of readily bioavailable pollutants in Lake Shkodra/Skadar using semipermeable membrane devices (SPMDs), bioassays and chemical analysis
    Andrew C Rastall
    Institute of Hygiene and Medical Microbiology, University of Heidelberg, INF 324, D 69120 Heidelberg, Germany
    Environ Sci Pollut Res Int 11:240-53. 2004
    ..The aim of the current study was to use SPMD-based sampling in conjunction with appropriate bioassays and chemical analysis to identify readily bioavailable HOPs in the lake...
  23. ncbi request reprint Bacterial community structure analyses to assess pollution of water and sediments in the Lake Shkodra/Skadar, Balkan Peninsula
    Rok Kostanjsek
    University of Ljubljana, Biotechnical Faculty, Department of Biology, Slovenia
    Environ Sci Pollut Res Int 12:361-8. 2005
    ..In the present study, bacterial community structure among differently polluted sites of the lake was compared using a genetic fingerprinting technique...
  24. ncbi request reprint Effect-directed analysis of mutagens and ethoxyresorufin-o-deethylase inducers in aquatic sediments
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2445-58. 2005
    ..This suggests that hazard and risk assessment of complex environmental mixtures should make increasing attempts to identify and consider hazardous key pollutants rather than focusing on a priori-selected key pollutants alone...
  25. ncbi request reprint Fate of Ah receptor agonists during biological treatment of an industrial sludge containing explosives and pharmaceutical residues
    Lillemor K Gustavsson
    Man Technology Environment Research Centre MTM, Department of Natural Science, University of Orebro, S 70182 Orebro, Sweden
    Environ Sci Pollut Res Int 11:379-87. 2004
    ..Therefore, we studied the sludge before and after the treatments in order to detect any changes in levels of Ah receptor (AhR) agonists using two bioassays for dioxin-like compounds...
  26. doi request reprint Dioxin- and POP-contaminated sites--contemporary and future relevance and challenges: overview on background, aims and scope of the series
    Roland Weber
    POPs Environmental Consulting, Ulmenstrasse 3, 73035 Göppingen, Germany
    Environ Sci Pollut Res Int 15:363-93. 2008
    ..It also details the various strategies used to assess these historical legacies of contamination and the concepts developed, or which are under development, to effect their remediation...
  27. doi request reprint The risk of altering soil and sediment samples upon extract preparation for analytical and bio-analytical investigations--a review
    Thomas Benjamin Seiler
    Department of Ecosystem Analysis, Institute for Environmental Research Biology 5, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany
    Anal Bioanal Chem 390:1975-85. 2008
    ..New or optimized extraction procedures should circumvent the issues mentioned here while being suitable for routine application...
  28. ncbi request reprint Phytoplankton community and chlorophyll a as trophic state indices of Lake Skadar (Montenegro, Balkan)
    Jelena Rakocevic-Nedovic
    University of Montenegro, Faculty of Sciences, Biology Department, Cetinjski put bb, 81000 Podgorica, Serbia and Montenegro
    Environ Sci Pollut Res Int 12:146-52. 2005
    ..In this study, we tried to assess and predict the trophic state of Lake Skadar according to phytoplankton data...
  29. ncbi request reprint The SeKT joint research project: definition of reference conditions, control sediments and toxicity thresholds for limnic sediment contact tests
    Ute Feiler
    German Federal Institute for Hydrology, Am Mainzer Tor 1, 56068 Koblenz, Germany
    Environ Sci Pollut Res Int 12:257-8. 2005
  30. ncbi request reprint Reed beds receiving industrial sludge containing nitroaromatic compounds. Effects of outgoing water and bed material extracts in the umu-c genotoxicity assay, DR-CALUX assay and on early life stage development in zebrafish (Danio rerio)
    Lillemor Gustavsson
    Man Technology Environment Research Centre MTM, Department of Natural Science, Orebro University, 70182 Orebro, Sweden
    Environ Sci Pollut Res Int 14:202-11. 2007
    ..We also compared unplanted and planted systems in order to examine the impact of the root system on the fate of the toxicants...
  31. ncbi request reprint Measurement of genotoxicity in wastewater samples with the in vitro micronucleus test: results of a round-robin study in the context of standardisation according to ISO
    Georg Reifferscheid
    German Federal Institute of Hydrology BfG, Department of Biochemistry Ecotoxicology, Am Mainzer Tor 1, 56068, Koblenz, Germany
    Mutat Res 649:15-27. 2008
    ..e. the umu-test and the Ames plate-incorporation assay. The data provide evidence that the robust and practicable in vitro micronucleus test is suitable as a routine method for wastewater testing...