Julia U Holle

Summary

Publications

  1. ncbi request reprint Expansion of CD28-CD27-NKG2D+ effector memory T cells and predominant Th1-type response during febrile attacks in tumor necrosis factor-associated periodic syndrome
    Julia U Holle
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, and Rheumaklinik Bad Bramstedt, Lubeck, Germany
    Isr Med Assoc J 8:142-4. 2006
  2. doi request reprint Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis
    Julia U Holle
    Department of Rheumatology and Immunology, University Hospital Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Oskar Alexander Straße 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:1183-9. 2013
  3. doi request reprint Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage
    Julia U Holle
    Vasculitis Center, Oskar Alexander Str 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:875-82. 2013
  4. ncbi request reprint Comparative analysis of different commercial ELISA systems for the detection of anti-neutrophil cytoplasm antibodies in ANCA-associated vasculitides
    Julia U Holle
    University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Dept of Rheumatology and Immunology, Germany
    Clin Exp Rheumatol 30:S66-9. 2012
  5. doi request reprint Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Ann Rheum Dis 71:327-33. 2012
  6. pmc Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides
    Julia U Holle
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Germany
    Arthritis Res Ther 13:224. 2011
  7. doi request reprint Prospective long-term follow-up of patients with localised Wegener's granulomatosis: does it occur as persistent disease stage?
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Germany
    Ann Rheum Dis 69:1934-9. 2010
  8. ncbi request reprint The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC
    Bo Jiang
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:56-61. 2010
  9. ncbi request reprint Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS)
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein and Klinikum Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:46-50. 2010
  10. doi request reprint Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades
    Julia U Holle
    University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Arthritis Rheum 63:257-66. 2011

Detail Information

Publications17

  1. ncbi request reprint Expansion of CD28-CD27-NKG2D+ effector memory T cells and predominant Th1-type response during febrile attacks in tumor necrosis factor-associated periodic syndrome
    Julia U Holle
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, and Rheumaklinik Bad Bramstedt, Lubeck, Germany
    Isr Med Assoc J 8:142-4. 2006
  2. doi request reprint Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis
    Julia U Holle
    Department of Rheumatology and Immunology, University Hospital Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Oskar Alexander Straße 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:1183-9. 2013
    ..The aim of the study was to characterize the expression of TLR2, TLR4 and TLR9 in PMNs of patients with granulomatosis with polyangiitis (GPA) and to elucidate the role of these receptors in GPA with respect to neutrophil activation...
  3. doi request reprint Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage
    Julia U Holle
    Vasculitis Center, Oskar Alexander Str 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:875-82. 2013
    ....
  4. ncbi request reprint Comparative analysis of different commercial ELISA systems for the detection of anti-neutrophil cytoplasm antibodies in ANCA-associated vasculitides
    Julia U Holle
    University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Dept of Rheumatology and Immunology, Germany
    Clin Exp Rheumatol 30:S66-9. 2012
    ..To assess the diagnostic performance of 11 commercial PR3- and MPO-ANCA ELISA systems (direct, capture and high sensitive [hs] ELISA)...
  5. doi request reprint Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Ann Rheum Dis 71:327-33. 2012
    ..Second, to compare the efficacy of RTX in granulomatous and vasculitic manifestations in GPA...
  6. pmc Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides
    Julia U Holle
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Germany
    Arthritis Res Ther 13:224. 2011
    ..Furthermore, it provides the diagnostic procedures required to asses a patient with vasculitic lung involvement and gives an overview of current treatment strategies...
  7. doi request reprint Prospective long-term follow-up of patients with localised Wegener's granulomatosis: does it occur as persistent disease stage?
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Germany
    Ann Rheum Dis 69:1934-9. 2010
    ..To identify patients with localised Wegener's granulomatosis (locWG) to assess whether it occurs as a long-term disease stage or phenotype and to characterise its outcome...
  8. ncbi request reprint The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC
    Bo Jiang
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:56-61. 2010
    ....
  9. ncbi request reprint Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS)
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein and Klinikum Bad Bramstedt, Germany
    Clin Exp Rheumatol 28:46-50. 2010
    ..generalised)...
  10. doi request reprint Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades
    Julia U Holle
    University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Arthritis Rheum 63:257-66. 2011
    ..To determine the long-term outcome in patients with Wegener's granulomatosis (WG) over 4 decades in an academic hospital unit specializing in rheumatology...
  11. doi request reprint The future of ANCA-associated vasculitis
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Bad Bramstedt, 24576 Bad Bramstedt, Germany
    Rheum Dis Clin North Am 36:609-21. 2010
    ..The elucidation of the genetic background in patients with AAV and the role of granulomatous lesions found in Wegener's granulomatosis are required to fully understand the pathophysiology of AAV...
  12. doi request reprint Treatment of ANCA-associated vasculitides (AAV)
    Julia U Holle
    Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Germany
    Autoimmun Rev 12:483-6. 2013
    ..Besides conventional treatment, biologics have emerged as a new treatment option. The paper summarizes the current evidence for the use of conventional therapy and biologics in AAV...
  13. doi request reprint Clinical manifestations and treatment of Wegener's granulomatosis
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Bad Bramstedt, 24576 Bad Bramstedt, Germany
    Rheum Dis Clin North Am 36:507-26. 2010
    ..Treatment regimens for WG, adapted to disease stage and activity, are reviewed and discussed in this article...
  14. doi request reprint Neurological involvement in Wegener's granulomatosis
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Luebeck, Germany
    Curr Opin Rheumatol 23:7-11. 2011
    ..The purpose of this review is to give a systematic overview on Wegener's granulomatosis manifestations of the PNS and CNS and to highlight new findings regarding manifestations, diagnosis and therapy...
  15. ncbi request reprint Diagnostic and therapeutic management of Churg-Strauss syndrome
    Julia U Holle
    University Hospital Schleswig Holstein, Campus Luebeck, Dept of Rheumatology and Klinikum Bad Bramstedt, Dept of Rheumatology and Immunology, Oskar Alexander Strasse 26, 24576 Bad, Bramstedt, Germany
    Expert Rev Clin Immunol 5:813-23. 2009
    ..g., cyclophosphamide for life-threatening disease) are usually required. Future promising therapy options target cytokines involved in the disease process, such as IL-5...
  16. pmc Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?
    Frank Moosig
    Department of Rheumatology, University Hospital of Schleswig Holstein and Klinikum Bad Bramstedt, Oskar Alexander Str, 26, 24576 Bad Bramstedt, Germany
    Arthritis Res Ther 11:253. 2009
    ..The only prophylactic measure that is widely accepted is trimethoprim/sulfamethoxazole to avoid Pneumocystis jiroveci pneumonia in small vessel vasculitis patients with generalised disease receiving therapy for induction of remission...
  17. ncbi request reprint Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway
    Elena Csernok
    Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Lubeck, Germany
    Blood 107:4440-8. 2006
    ..Wegener autoantigen interacts with a "gateway" receptor (PAR-2) on iDCs in vitro triggering their maturation and licenses them for a T helper 1 (Th1)-type response potentially favoring granuloma formation in WG...