Unbiased comparison of sample size estimates from longitudinal structural measures in ADNIDominic Holland
Department of Neurosciences, University of California, San Diego, La Jolla, California 92037, USA
Hum Brain Mapp 33:2586-602. 2012
..Of all the measures publicly available in ADNI, thinning of the entorhinal cortex quantified with the Quarc methodology provides the most powerful change biomarker...
Enrichment and stratification for predementia Alzheimer disease clinical trialsDominic Holland
Department of Neurosciences, University of California San Diego, La Jolla, California, USA
PLoS ONE 7:e47739. 2012
..Longer natural history studies are needed to inform design of trials aimed at the presymptomatic stage...
- Rates of decline in Alzheimer disease decrease with age
Dominic Holland
Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 7:e42325. 2012
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- Nonlinear registration of longitudinal images and measurement of change in regions of interest
Dominic Holland
Multimodal Imaging Laboratory, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
Med Image Anal 15:489-97. 2011
..Quarc produced a slightly improved, though not significantly different, whole brain effect size compared with the standard KN-BSI method, but in all other cases it produced significantly larger effect sizes...
- Subregional neuroanatomical change as a biomarker for Alzheimer's disease
Dominic Holland
Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:20954-9. 2009
..The findings indicate that regional temporal lobe cortical changes would have great utility as outcome measures in clinical trials and may also have utility in clinical practice for aiding early diagnosis of neurodegenerative disease...
- Efficient correction of inhomogeneous static magnetic field-induced distortion in Echo Planar Imaging
Dominic Holland
Multimodal Imaging Laboratory, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
Neuroimage 50:175-83. 2010
..We further demonstrate that the proposed method can be used to recover dropouts in gradient echo (BOLD and DSC-MRI) EPI images...
- Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment
Linda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
Radiology 251:195-205. 2009
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- Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
Linda K McEvoy
Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
Alzheimer Dis Assoc Disord 24:269-77. 2010
..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...
- Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau
Rahul S Desikan
Department of Radiology, University of California San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037 0841, USA
Arch Neurol 69:709-13. 2012
..To elucidate the relationship between the 2 hallmark proteins of Alzheimer disease (AD), amyloid-(Aβ) and tau, and clinical decline over time among cognitively normal older individuals...
- Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment
Carrie R McDonald
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Neurobiol Aging 33:242-53. 2012
..MRI measures of regional atrophy can provide valuable information for understanding the neural basis of cognitive impairment in MCI...
- Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
Linda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Radiology 259:834-43. 2011
..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
- Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairment
Jagan A Pillai
Department of Neurology, VA San Diego Medical Center, San Diego, CA, USA
J Clin Exp Neuropsychol 34:925-35. 2012
..Connectivity and synaptic efficiency or other lifestyle factors may more directly reflect cognitive reserve...
- CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner
Elizabeth A Murphy
Department of Neurosciences, University of California, San Diego, CA, USA
Brain Imaging Behav 6:16-26. 2012
..These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner...
- Basal ganglia atrophy in prodromal Huntington's disease is detectable over one year using automated segmentation
D S Adnan Majid
Department of Psychology, University of California, San Diego, San Diego, California 92093 0841, USA
Mov Disord 26:2544-51. 2011
..This underscores the utility of this automatic image segmentation and longitudinal nonlinear registration method for upcoming studies of preHD and other neurodegenerative disorders...
- Automated white-matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy
Donald J Hagler
Multimodal Imaging Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Hum Brain Mapp 30:1535-47. 2009
..However, the between-group effect sizes using the atlas-derived fibers were generally as large or larger than those obtained with manually selected fiber tracks...
- Bias in tensor based morphometry Stat-ROI measures may result in unrealistic power estimates
Wesley K Thompson
Department of Psychiatry, The University of California, San Diego, La Jolla, CA 92037, USA
Neuroimage 57:1-4. 2011
..The resulting bias seriously impacts the validity of conclusions reached using these measures; for example, sample size estimates reported by Hua et al. (2010) may be underestimated by a factor of five to sixteen...
- Brain changes in older adults at very low risk for Alzheimer's disease
Anders M Fjell
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway, Multimodal Imaging Laboratory and Department of Neurosciences, University of California, San Diego, California 92093, and Department of Radiology, University of California, San Diego, California 92103
J Neurosci 33:8237-42. 2013
..In conclusion, reductions in regional brain volumes can be detected over the course of 1 year even in older adults who are unlikely to be in a presymptomatic stage of AD...
