Kenneth G Holden

Summary

Publications

  1. ncbi Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate
    Kenneth G Holden
    Holden Laboratories, 179 Mal Paso Road, Carmel, California 93923, and Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Org Chem 67:5913-8. 2002
  2. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position
    Kenneth G Holden
    Holden Laboratories, Carmel, CA 93923, USA
    Bioorg Med Chem Lett 17:6111-5. 2007
  3. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 69:107-12. 2006
  4. ncbi Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 16:3170-4. 2006

Collaborators

  • Richard B Rothman
  • Wayne W Harding
  • Pavitra Kannan
  • Kevin Tidgewell
  • Matthew Schmidt
  • Thomas E Prisinzano
  • Hernan Navarro
  • Brian Gilmour
  • Christina M Dersch

Detail Information

Publications4

  1. ncbi Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate
    Kenneth G Holden
    Holden Laboratories, 179 Mal Paso Road, Carmel, California 93923, and Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Org Chem 67:5913-8. 2002
    ..The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide...
  2. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position
    Kenneth G Holden
    Holden Laboratories, Carmel, CA 93923, USA
    Bioorg Med Chem Lett 17:6111-5. 2007
    ..These observations suggest that the ketone of 2b is a key structural feature responsible for mu agonist activity...
  3. pmc Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 69:107-12. 2006
    ..divinorum. In particular, this work provides a semisynthesis of salvinicins A (2) and B (3) and has identified 10a as the first neoclerodane diterpene with delta opioid antagonist activity...
  4. ncbi Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 16:3170-4. 2006
    ..In addition, a procedure has been found to remove the furan skeleton completely. Biological results indicate that replacement of the furan ring with an N-sulfonylpyrrole leads to reduced affinity and efficacy at kappa opioid receptors...