Alina Maria Holban



  1. Visan A, Popescu Pelin G, Gherasim O, Grumezescu V, Socol M, Zgura I, et al. Laser Processed Antimicrobial Nanocomposite Based on Polyaniline Grafted Lignin Loaded with Gentamicin-Functionalized Magnetite. Polymers (Basel). 2019;11: pubmed publisher
    ..These results encourage further assessment of this type of biomaterial for their application in controlled drug release at implantation sites by external activation. ..
  2. Grumezescu A, Gestal M, Holban A, Grumezescu V, Vasile B, Mogoanta L, et al. Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria. Molecules. 2014;19:5013-27 pubmed publisher
    ..Fe3O4@AMO represents also a suitable approach for the development of new alternative strategies for improving the activity of therapeutic agents by targeted delivery and controlled release. ..
  3. Liakos I, Grumezescu A, Holban A. Magnetite nanostructures as novel strategies for anti-infectious therapy. Molecules. 2014;19:12710-26 pubmed publisher
    ..Recent promising applications of MNPs, as the development of delivery nanocarriers and improved nanovehicles for the therapy of different diseases are discussed, together with the mechanisms of microbial inhibition. ..
  4. Ficai D, Grumezescu V, Fufă O, Popescu R, Holban A, Ficai A, et al. Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..The PLGA/Fe?O?@CEF materials proved significant and sustained anti-biofilm activity against staphylococcal and Escherichia coli colonisation. ..
  5. request reprint
    Holban A. Magnetite Nanoshuttles for Fighting Staphylococcus aureus Infections: A Recent Review. Curr Top Med Chem. 2015;15:1589-95 pubmed
  6. Mihai M, Preda M, Lungu I, Gestal M, Popa M, Holban A. Nanocoatings for Chronic Wound Repair-Modulation of Microbial Colonization and Biofilm Formation. Int J Mol Sci. 2018;19: pubmed publisher
  7. Ion A, Andronescu E, Rădulescu D, Radulescu M, Iordache F, Vasile B, et al. Biocompatible 3D Matrix with Antimicrobial Properties. Molecules. 2016;21:E115 pubmed publisher
    ..Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering. ..
  8. Radulescu M, Holban A, Mogoanta L, Bălşeanu T, Mogoşanu G, Savu D, et al. Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications. Molecules. 2016;21: pubmed publisher
    ..The evaluation of antimicrobial potential was evaluated by the viable cell count assay on strains belonging to two clinically relevant bacterial species (i.e., Escherichia coli and Staphylococcus aureus). ..
  9. Liakos I, Grumezescu A, Holban A, Florin I, D Autilia F, Carzino R, et al. Polylactic Acid-Lemongrass Essential Oil Nanocapsules with Antimicrobial Properties. Pharmaceuticals (Basel). 2016;9: pubmed publisher

More Information


  1. Karavolos M, Holban A. Nanosized Drug Delivery Systems in Gastrointestinal Targeting: Interactions with Microbiota. Pharmaceuticals (Basel). 2016;9: pubmed
    ..These coordinated studies will provide novel techniques to replace or act synergistically with current technologies and help develop new treatments for major diseases via the discovery of unique antimicrobial molecules. ..
  2. Oprea A, Pandel L, Dumitrescu A, Andronescu E, Grumezescu V, Chifiriuc M, et al. Bioactive ZnO Coatings Deposited by MAPLE-An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules. 2016;21: pubmed publisher
  3. Torres Sangiao E, Holban A, Gestal M. Advanced Nanobiomaterials: Vaccines, Diagnosis and Treatment of Infectious Diseases. Molecules. 2016;21: pubmed publisher
  4. Radulescu M, Andronescu E, Dolete G, Popescu R, Fufă O, Chifiriuc M, et al. Silver Nanocoatings for Reducing the Exogenous Microbial Colonization of Wound Dressings. Materials (Basel). 2016;9: pubmed publisher
    ..The reported data recommend this type of coatings to obtain modified WDs with antibacterial properties, able to prevent the exogenous microbial contamination of the wound tissue, colonization and further biofilm development. ..
  5. Anghel A, Grumezescu A, Chirea M, Grumezescu V, Socol G, Iordache F, et al. MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes. Molecules. 2014;19:8981-94 pubmed publisher
    ..Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization. ..
  6. Grigore M, Biscu E, Holban A, Gestal M, Grumezescu A. Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles. Pharmaceuticals (Basel). 2016;9: pubmed
    ..It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections. ..
  7. Liakos I, Holban A, Carzino R, Lauciello S, Grumezescu A. Electrospun Fiber Pads of Cellulose Acetate and Essential Oils with Antimicrobial Activity. Nanomaterials (Basel). 2017;7: pubmed publisher
    ..This work describes an effective and simple method to prepare CA/EOs ESFs and opens up many new applications of micro/nanofibers such as improved antimicrobial wound dressings, anti-biofilm surfaces, sensors and packaging alternatives. ..