James C Hogg

Summary

Publications

  1. pmc Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging
    James C Hogg
    James Hogg Research Centre, The University of British Columbia, Vancouver, BC, Canada
    Chest 143:1436-43. 2013
  2. pmc A brief review of chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia Research Laboratories, St Paul s Hospital, Vancouver, British Columbia
    Can Respir J 19:381-4. 2012
  3. doi request reprint Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression
    Sean H Ling
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 140:1540-9. 2011
  4. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
  5. ncbi request reprint Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
  6. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
  7. ncbi request reprint Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques
    Kazuhiro Yatera
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Saint Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 294:H944-53. 2008
  8. pmc Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits
    Erin M Tranfield
    St Paul s Hospital, University of British Columbia, Vancouver
    Can J Cardiol 26:e258-69. 2010
  9. pmc The lung tissue microbiome in chronic obstructive pulmonary disease
    Marc A Sze
    The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:1073-80. 2012
  10. doi request reprint Localization of DNA and RNA in eosinophil secretory granules
    Ali R Behzad
    The James Hogg iCAPTURE Centre, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, B C, Canada
    Int Arch Allergy Immunol 152:12-27. 2010

Collaborators

Detail Information

Publications38

  1. pmc Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging
    James C Hogg
    James Hogg Research Centre, The University of British Columbia, Vancouver, BC, Canada
    Chest 143:1436-43. 2013
    ..Moreover, the observation that terminal bronchiolar loss precedes the onset of emphysematous destruction suggests this destruction begins in the very early stages of COPD...
  2. pmc A brief review of chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia Research Laboratories, St Paul s Hospital, Vancouver, British Columbia
    Can Respir J 19:381-4. 2012
    ....
  3. doi request reprint Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression
    Sean H Ling
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 140:1540-9. 2011
    ..Particulate matter (PM) is present in lung tissues of smokers and urban dwellers. This study was designed to quantify the burden of PM in different lung tissues of subjects with COPD and determine its relationship to disease severity...
  4. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
  5. ncbi request reprint Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
    ..The aim of the present study was to determine the nature and mechanism of calcium responses induced by PM(10) in HBECs and its relationship to cytokine synthesis...
  6. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
    ..The airflow limitation that defines severity of chronic obstructive pulmonary disease (COPD) is caused by a combination of small airway obstruction and emphysematous lung destruction...
  7. ncbi request reprint Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques
    Kazuhiro Yatera
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Saint Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 294:H944-53. 2008
    ....
  8. pmc Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits
    Erin M Tranfield
    St Paul s Hospital, University of British Columbia, Vancouver
    Can J Cardiol 26:e258-69. 2010
    ..Epidemiological studies have established that cardiovascular events account for the greatest number of air pollution-related deaths. However, the underlying structural changes are still unknown...
  9. pmc The lung tissue microbiome in chronic obstructive pulmonary disease
    Marc A Sze
    The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:1073-80. 2012
    ..Based on surface brushings and bronchoalveolar lavage fluid, Hilty and coworkers demonstrated microbiomes in the human lung characteristic of asthma and chronic obstructive pulmonary disease (COPD), which have now been confirmed by others...
  10. doi request reprint Localization of DNA and RNA in eosinophil secretory granules
    Ali R Behzad
    The James Hogg iCAPTURE Centre, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, B C, Canada
    Int Arch Allergy Immunol 152:12-27. 2010
    ....
  11. ncbi request reprint Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease
    Stephan F van Eeden
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Proc Am Thorac Soc 2:61-7. 2005
    ..We speculate that this mechanism may contribute to the cardiovascular morbidity and mortality associated with COPD...
  12. doi request reprint Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells
    Noriho Sakamoto
    University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Toxicol 28:17-23. 2009
    ..It is concluded that statins can modulate the PM(10)-induced inflammatory response in the lung by reducing mediator production by AMs...
  13. doi request reprint The disruption of the epithelial mesenchymal trophic unit in COPD
    Ali R Behzad
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Depts of Medicine and Pathology, University of British Columbia, Canada
    COPD 6:421-31. 2009
    ..Development of COPD is associated with significant disruption of the EMTU due to a reduction of contacts between fibroblasts and the epithelium...
  14. doi request reprint Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter
    Kiyoshi Morimoto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L361-71. 2009
    ..E1A regulation of the LPS response may play a role in acute exacerbations as a consequence of bacterial infections in COPD...
  15. ncbi request reprint CCL23/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrow
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Exp Hematol 33:1101-8. 2005
    ..This study concerns in vivo inhibitory effect of CCL23 on production of polymorphonuclear leukocytes (PMNs) and monocytes in the bone marrow and their release into the circulation...
  16. ncbi request reprint Respiratory viral detection and small airway inflammation in lung tissue of patients with stable, mild COPD
    Soraya Utokaparch
    1UBC James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    COPD 11:197-203. 2014
    ....
  17. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
    ..Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function...
  18. pmc Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
    Hisashi Suzuki
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Room 166, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 9:25. 2008
    ..Here we report the behavior of BM-derived lineage negative progenitor cells (Lin- PCs) during pneumococcal pneumonia using quantum dots (QDs), nanocrystal fluorescent probes as a cell-tracking technique...
  19. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  20. pmc Micro-computed tomography measurements of peripheral lung pathology in chronic obstructive pulmonary disease
    James C Hogg
    Emeritus Lab Medicine, iCAPTURE Center, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Proc Am Thorac Soc 6:546-9. 2009
    ..Conclusions: The centrilobular emphysematous phenotype of COPD is associated with narrowing and obliteration of the terminal bronchioles that begins prior to the onset of emphysematous destruction...
  21. pmc What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease?
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 6:668-72. 2009
    ....
  22. ncbi request reprint Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    James C Hogg
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Lancet 364:709-21. 2004
    ....
  23. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
    ....
  24. doi request reprint Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses
    Christoph J Blohmke
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, The University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Immunol 189:5467-75. 2012
    ..Strategies to restore ER homeostasis and normalize the UPR activation profile may represent a novel therapeutic approach to minimize lung-damaging inflammation in CF...
  25. doi request reprint The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department
    Soraya Utokaparch
    James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 30:e18-23. 2011
    ..The relationship between viral load and specific viruses to clinical diagnosis made by physicians in this setting is poorly understood...
  26. doi request reprint The pathology of chronic obstructive pulmonary disease
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia and iCapture Center, St Paul s Hospital, Vancouver, BC, Canada
    Annu Rev Pathol 4:435-59. 2009
    ..The mechanism(s) that allow small airways to thicken in such close proximity to lung tissue undergoing emphysematous destruction remains a puzzle that needs to be solved...
  27. pmc Quantification of lung surface area using computed tomography
    Ren Yuan
    University of British Columbia James Hogg Research Centre and the Heart and Lung Institute, St Paul s Hospital, Burrard Street, Vancouver, Canada
    Respir Res 11:153. 2010
    ..To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume...
  28. ncbi request reprint The effects of radiation dose and CT manufacturer on measurements of lung densitometry
    Ren Yuan
    Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
    Chest 132:617-23. 2007
    ..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
  29. ncbi request reprint A lung tissue bank for gene expression studies in chronic obstructive pulmonary disease
    Lily Ding
    Department of Pathology, University of British Columbia iCAPTURE Centre McDonald Research Laboratories, Vancouver, British Columbia, Canada
    COPD 1:191-204. 2004
    ..Storage time had no detectable effect on RNA quality. We conclude that both frozen and paraffin-embedded tissues as well as laser-captured cells are suitable for gene expression studies but frozen tissue offered greater sensitivity...
  30. ncbi request reprint Pulmonary and systemic response to atmospheric pollution
    James C Hogg
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, The University of British Columbia, Vancouver, British Columbia, Canada
    Respirology 14:336-46. 2009
    ....
  31. doi request reprint Bacterial microbiome of lungs in COPD
    Marc A Sze
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 9:229-38. 2014
    ..This review summarizes the current knowledge concerning the lung microbiota in COPD and its potential implications for pathogenesis of the disease. ..
  32. pmc Canadian contributions to pulmonary anatomy and pathology
    James C Hogg
    University of British Columbia, Vancouver, Canada
    Can Respir J 14:393-7. 2007
  33. ncbi request reprint Evaluation of small sample cDNA amplification for microdissected airway expression profiling in COPD
    John V Gosselink
    St Paul s Hospital, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, Vancouver, British Columbia
    COPD 4:91-105. 2007
    ..We conclude that SMART amplification provides cDNA sufficient for studying large numbers of genes even in laser-captured small airways and this cDNA maintains the relative expression found in corresponding unamplified RNAs...
  34. pmc State of the art. Bronchiolitis in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia iCAPTURE Centre, St Pauls Hospital, Vancouver, BC, Canada V6Z 1Y6
    Proc Am Thorac Soc 3:489-93. 2006
  35. ncbi request reprint Flow cytometric method for enumeration and characterization of newly released polymorphonuclear leukocytes from the bone marrow using 5'-bromo-2'-deoxyuridine
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Cell Physiol 289:C757-65. 2005
    ..We conclude that a flow cytometric approach for identifying BrdU-labeled leukocytes provides an objective and accurate method for studying leukocyte kinetics and behavior...
  36. ncbi request reprint Adenovirus infections and lung disease
    Shizu Hayashi
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC V6Z 1Y6, Canada
    Curr Opin Pharmacol 7:237-43. 2007
    ..These results support its additional role in the airway remodeling process reported in COPD...
  37. ncbi request reprint The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  38. ncbi request reprint Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD
    Emiko Ogawa
    McDonald Research Laboratories iCAPTURE Centre, Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 286:L189-97. 2004
    ..We conclude that latent infection of epithelial cells by adenovirus E1A could contribute to airway remodeling in COPD by the viral E1A gene, inducing TGF-beta 1 and CTGF expression and shifting cells to a more mesenchymal phenotype...