Identification of RELMgamma, a novel resistin-like molecule with a distinct expression patternB Gerstmayer
MEMOREC Stoffel GmbH, Nattermannallee 1, D 50829 Cologne, Germany
Genomics 81:588-95. 2003
..Finally we could demonstrate that white adipose tissue of mice shows strong RELMalpha expression but only low levels of RELMgamma, indicating a species-specific gene regulation...
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexesHartmut Scheel
Bioinformatics Group, Memorec Biotec GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
BMC Bioinformatics 6:71. 2005
..Initially, the PCI domain was defined as the region of detectable sequence similarity between the components mentioned above...
- MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
Vered Maytal-Kivity
Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
BMC Biochem 3:28. 2002
..In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function...
- The modular nature of apoptotic signaling proteins
K Hofmann
MEMOREC Stoffel GmbH, Koln, Germany
Cell Mol Life Sci 55:1113-28. 1999
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- A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain
K Hofmann
Bioinformatics Group, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges, CH 1066, Switzerland
J Mol Biol 282:195-208. 1998
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- A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
K Hofmann
Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
Trends Biochem Sci 26:347-50. 2001
..The presence of this motif in Eps15, Epsin and HRS, proteins involved in ligand-activated receptor endocytosis and degradation, suggest a more general role in ubiquitin recognition...
- Ceramide in apoptosis--does it really matter?
K Hofmann
MEMOREC Stoffel GmbH, Koln, Germany
Trends Biochem Sci 23:374-7. 1998
..Recently, several observations have challenged the notion that ceramide is an important cell-death mediator and have prompted a re-evaluation of previously published results...
- The CARD domain: a new apoptotic signalling motif
K Hofmann
Swiss Institute for Experimental Cancer Research, University of Lausanne, Switzerland
Trends Biochem Sci 22:155-6. 1997
- Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension
T Kataoka
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
J Biol Chem 276:19548-54. 2001
..Thus, Bcl-rambo constitutes a novel type of pro-apoptotic Bcl-2 member that triggers cell death independently of its BH motifs...
- Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
M Thome
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Nature 386:517-21. 1997
..Protection of virus-infected cells against death-receptor-induced apoptosis may lead to higher virus production and contribute to the persistence and oncogenicity of several FLIP-encoding viruses...
- Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
M Thome
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Curr Biol 8:885-8. 1998
..Together, these data suggest that CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1...
- Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway
K Becker
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
FEBS Lett 412:102-6. 1997
..1996) Proc. Natl. Acad. Sci. USA 92, 11894-11898), was found to contain sequences similar to ubiquitin. These results suggest that proteins related to the ubiquitination pathway may modulate the Fas signaling pathway...
- Characterization of two receptors for TRAIL
P Schneider
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
FEBS Lett 416:329-34. 1997
..All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals...
- Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
K Hofmann
Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, D 50829 Cologne, Germany
Proc Natl Acad Sci U S A 97:5895-900. 2000
..Both mammalian nSMases are members of a superfamily of Mg(2+)-dependent phosphohydrolases, which also contains nucleases, inositol phosphatases, and bacterial toxins...
- Apoptosis: Silencing the death receptors
J Tschopp
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
Curr Biol 9:R381-4. 1999
..An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling...
- APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
M Hahne
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
J Exp Med 188:1185-90. 1998
..Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth...
- Sensitive protein comparisons with profiles and hidden Markov models
K Hofmann
Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Koln, Germany
Brief Bioinform 1:167-78. 2000
..This review discusses the concept of profiles, generalised profiles and profile-HMMs, the methods how they are constructed and the scope of possible applications in gene discovery and gene functional assignment...
- A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
K Hofmann
Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, , , Germany
Trends Biochem Sci 25:111-2. 2000
- Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein
S Schmidt
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nucleic Acids Res 25:3433-9. 1997
..Immunolocalisation indicates that Sce3p is located predominantly in the cytoplasm. Elevated expression of sce3 increases the steady-state level of cdc14 mRNA. Possible mechanisms of its action are discussed...
- The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway
K Hofmann
Swiss Institute for Experimental Cancer Research, Epalinges s/Lausanne, Switzerland
Trends Biochem Sci 21:172-3. 1996
- The protease-associated domain: a homology domain associated with multiple classes of proteases
X Luo
Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, , Weg 1, , Germany
Trends Biochem Sci 26:147-8. 2001
..In addition to proteases, the domain is also found in two different families of plant vacuolar sorting receptors...
- Microarray probe selection strategies
S Tomiuk
Bioinformatics Group, MEMOREC Stoffel GmbH, Koln, Germany
Brief Bioinform 2:329-40. 2001
..This paper discusses the full scope of probe selection strategies, highlighting the problems that may be encountered in the various systems...
- Apoptosis. Searching for FLASH domains
E V Koonin
NCBI, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Nature 401:662; discussion 662-3. 1999
- Quoderat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences
L M Iyer
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Genome Biol 2:RESEARCH0051. 2001
..Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by experiment...
- Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9
T Caspari
MRC Cell Mutation Unit, University of Sussex, Brighton BN1 9RR, United Kingdom
Mol Cell Biol 20:1254-62. 2000
..However, two-hybrid interaction, in vitro association and in vivo overexpression experiments suggest a transient interaction between Rad1 and Rad17...
- Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
H Koch
Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Germany
Biochem J 349:247-53. 2000
..The MHD profiles described in the present study are useful tools for the identification of Munc13-like proteins, that would otherwise have remained undetected...
- The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation
F Martinon
Curr Biol 11:R118-20. 2001
- Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase
M Thome
Institute of Biochemistry, University of Lausanne, Switzerland
J Biol Chem 274:9962-8. 1999
..Through activation of NF-kappaB, v-CARMEN may regulate the expression of the cellular and viral genes important for viral replication...
- The frizzled motif: in how many different protein families does it occur?
M Rehn
Collagen Research Unit, University of Oulu, Finland
Trends Biochem Sci 23:415-7. 1998
- TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)
J L Bodmer
Institute of Biochemistry, University of Lausanne, Switzerland
Immunity 6:79-88. 1997
..TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family...
- A conserved domain is present in different families of vesicular fusion proteins: a new superfamily
T Weimbs
Department of Anatomy, University of California, San Francisco 94143 0452, USA
Proc Natl Acad Sci U S A 94:3046-51. 1997
..The evolutionary conservation of the SNARE coiled-coil homology domain suggests that this domain has a similar function in different membrane fusion proteins...
- The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
S Schmidt
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Epalinges
Genes Dev 11:1519-34. 1997
..These data indicate that Spg1p is a key element in controlling the onset of septum formation in Schizosaccharomyces pombe, and that it acts through the Cdc7p kinase...
- Inhibition of death receptor signals by cellular FLIP
M Irmler
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
Nature 388:190-5. 1997
..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
- SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
C Bai
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 86:263-74. 1996
..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
- SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles
R Janz
Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas, Texas 75235, USA
J Neurosci 18:9269-81. 1998
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- TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
P Schneider
Institute of Biochemistry, University of Lausanne, Switzerland
Immunity 7:831-6. 1997
..Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family...
- Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle
N Lauper
Swiss Institute for Experimental Cancer Research ISREC, Epalinges
Oncogene 17:2637-43. 1998
..We speculate that cyclin E2 is not simply redundant with cyclin E, but may regulate distinct rate-limiting pathway(s) in G1-S control...
- Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15
K Hofmann
Institut fur Biochemie, Universitat Koln, Germany
Genomics 24:20-6. 1994
..The DNA region immediately upstream of the transcription start lacks any TATA or CAAT boxes but contains several binding sites for the transcription factors Sp1 and Egr-1.(ABSTRACT TRUNCATED AT 250 WORDS)..
- The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
B Schumacher
Max Planck Institut fur Biochemie, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany
Curr Biol 11:1722-7. 2001
..elegans as a genetically tractable model organism for studying the p53 apoptotic pathway...
- The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis
C Fankhauser
Swiss Institute for Experimental Cancer Research
Cell 82:435-44. 1995
..Expression of cdc15 in G2-arrested cells induces actin rearrangement to the center of the cell. These data implicate cdc15p as a key element in mediating the cytoskeletal rearrangements required for cytokinesis...
- Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12
W Stoffel
Institut fur Biochemie, Universitat zu Koln, Germany
FEBS Lett 386:189-93. 1996
..The L-glutamate transporter gene structures might help to understand the correlation of L-glutamate reuptake in neurodegenerative disorders...
- Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins
N Brose
Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
J Biol Chem 270:25273-80. 1995
..The presence of C1- and C2-domains in these proteins and the phenotype of the C. elegans mutants raise the possibility that Munc13s may have an essential signaling role during neurotransmitter release...
- Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase
W Stoffel
Institut fur Biochemie, Medizinische Fakultat, Universitat zu Koln, Germany
FEBS Lett 333:119-22. 1993
..Knowledge of the gene organization and availability of genomic clones for mouse mECI will facilitate the study of unsaturated fatty acid metabolism in normal and pathological states...
- SAM as a protein interaction domain involved in developmental regulation
J Schultz
EMBL, Heidelberg, Germany
Protein Sci 6:249-53. 1997
..A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine...
- Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
T Storck
Institute for Biochemistry, Medical Faculty, University of Cologne, Federal Republic of Germany
Proc Natl Acad Sci U S A 89:10955-9. 1992
..These data suggest that GLAST may be involved in the regulation of neurotransmitter concentration in central nervous system...
- Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development
X W Deng
Trends Genet 16:202-3. 2000
- Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
Y Wang
Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
Nature 388:593-8. 1997
..We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles...
- Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
S Tomiuk
Laboratory of Molecular Neurosciences, Institute of Biochemistry, Faculty of Medicine, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
Proc Natl Acad Sci U S A 95:3638-43. 1998
..Tumor necrosis factor alpha triggers the ERK1 pathway in none of the cell lines. The cloned nSMase will facilitate further controlled experiments aiming at the definition of a possible role of ceramide as signal transduction molecule...
- Clathrin self-assembly is mediated by a tandemly repeated superhelix
J A Ybe
The G W Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
Nature 399:371-5. 1999
..The resulting model provides a three-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding and trimerization...
- BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
P Schneider
Institute of Biochemistry, University of Lausanne, Switzerland
J Exp Med 189:1747-56. 1999
..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
- PCI complexes: pretty complex interactions in diverse signaling pathways
T Kim
Dept Botany, The University of Tennessee, Knoxville TN 37996-1100, USA
Trends Plant Sci 6:379-86. 2001
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