K Hofmann

Summary

Publications

  1. ncbi request reprint Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern
    B Gerstmayer
    MEMOREC Stoffel GmbH, Nattermannallee 1, D 50829 Cologne, Germany
    Genomics 81:588-95. 2003
  2. pmc Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
    Hartmut Scheel
    Bioinformatics Group, Memorec Biotec GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    BMC Bioinformatics 6:71. 2005
  3. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
  4. ncbi request reprint The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
  5. ncbi request reprint A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain
    K Hofmann
    Bioinformatics Group, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges, CH 1066, Switzerland
    J Mol Biol 282:195-208. 1998
  6. ncbi request reprint A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Trends Biochem Sci 26:347-50. 2001
  7. ncbi request reprint Ceramide in apoptosis--does it really matter?
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Trends Biochem Sci 23:374-7. 1998
  8. ncbi request reprint The CARD domain: a new apoptotic signalling motif
    K Hofmann
    Swiss Institute for Experimental Cancer Research, University of Lausanne, Switzerland
    Trends Biochem Sci 22:155-6. 1997
  9. ncbi request reprint Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension
    T Kataoka
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    J Biol Chem 276:19548-54. 2001
  10. ncbi request reprint Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
    M Thome
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nature 386:517-21. 1997

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern
    B Gerstmayer
    MEMOREC Stoffel GmbH, Nattermannallee 1, D 50829 Cologne, Germany
    Genomics 81:588-95. 2003
    ..Finally we could demonstrate that white adipose tissue of mice shows strong RELMalpha expression but only low levels of RELMgamma, indicating a species-specific gene regulation...
  2. pmc Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
    Hartmut Scheel
    Bioinformatics Group, Memorec Biotec GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    BMC Bioinformatics 6:71. 2005
    ..Initially, the PCI domain was defined as the region of detectable sequence similarity between the components mentioned above...
  3. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
    ..In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function...
  4. ncbi request reprint The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
    ....
  5. ncbi request reprint A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain
    K Hofmann
    Bioinformatics Group, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges, CH 1066, Switzerland
    J Mol Biol 282:195-208. 1998
    ....
  6. ncbi request reprint A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Trends Biochem Sci 26:347-50. 2001
    ..The presence of this motif in Eps15, Epsin and HRS, proteins involved in ligand-activated receptor endocytosis and degradation, suggest a more general role in ubiquitin recognition...
  7. ncbi request reprint Ceramide in apoptosis--does it really matter?
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Trends Biochem Sci 23:374-7. 1998
    ..Recently, several observations have challenged the notion that ceramide is an important cell-death mediator and have prompted a re-evaluation of previously published results...
  8. ncbi request reprint The CARD domain: a new apoptotic signalling motif
    K Hofmann
    Swiss Institute for Experimental Cancer Research, University of Lausanne, Switzerland
    Trends Biochem Sci 22:155-6. 1997
  9. ncbi request reprint Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension
    T Kataoka
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    J Biol Chem 276:19548-54. 2001
    ..Thus, Bcl-rambo constitutes a novel type of pro-apoptotic Bcl-2 member that triggers cell death independently of its BH motifs...
  10. ncbi request reprint Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
    M Thome
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nature 386:517-21. 1997
    ..Protection of virus-infected cells against death-receptor-induced apoptosis may lead to higher virus production and contribute to the persistence and oncogenicity of several FLIP-encoding viruses...
  11. ncbi request reprint Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
    M Thome
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Curr Biol 8:885-8. 1998
    ..Together, these data suggest that CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1...
  12. ncbi request reprint Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway
    K Becker
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    FEBS Lett 412:102-6. 1997
    ..1996) Proc. Natl. Acad. Sci. USA 92, 11894-11898), was found to contain sequences similar to ubiquitin. These results suggest that proteins related to the ubiquitination pathway may modulate the Fas signaling pathway...
  13. ncbi request reprint Characterization of two receptors for TRAIL
    P Schneider
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    FEBS Lett 416:329-34. 1997
    ..All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals...
  14. pmc Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, D 50829 Cologne, Germany
    Proc Natl Acad Sci U S A 97:5895-900. 2000
    ..Both mammalian nSMases are members of a superfamily of Mg(2+)-dependent phosphohydrolases, which also contains nucleases, inositol phosphatases, and bacterial toxins...
  15. ncbi request reprint Apoptosis: Silencing the death receptors
    J Tschopp
    Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
    Curr Biol 9:R381-4. 1999
    ..An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling...
  16. pmc APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
    M Hahne
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 188:1185-90. 1998
    ..Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth...
  17. ncbi request reprint Sensitive protein comparisons with profiles and hidden Markov models
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Koln, Germany
    Brief Bioinform 1:167-78. 2000
    ..This review discusses the concept of profiles, generalised profiles and profile-HMMs, the methods how they are constructed and the scope of possible applications in gene discovery and gene functional assignment...
  18. ncbi request reprint A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Trends Biochem Sci 25:111-2. 2000
  19. pmc Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein
    S Schmidt
    Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nucleic Acids Res 25:3433-9. 1997
    ..Immunolocalisation indicates that Sce3p is located predominantly in the cytoplasm. Elevated expression of sce3 increases the steady-state level of cdc14 mRNA. Possible mechanisms of its action are discussed...
  20. ncbi request reprint The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway
    K Hofmann
    Swiss Institute for Experimental Cancer Research, Epalinges s Lausanne, Switzerland
    Trends Biochem Sci 21:172-3. 1996
  21. ncbi request reprint The protease-associated domain: a homology domain associated with multiple classes of proteases
    X Luo
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, , Weg 1, , Germany
    Trends Biochem Sci 26:147-8. 2001
    ..In addition to proteases, the domain is also found in two different families of plant vacuolar sorting receptors...
  22. ncbi request reprint Microarray probe selection strategies
    S Tomiuk
    Bioinformatics Group, MEMOREC Stoffel GmbH, Koln, Germany
    Brief Bioinform 2:329-40. 2001
    ..This paper discusses the full scope of probe selection strategies, highlighting the problems that may be encountered in the various systems...
  23. ncbi request reprint Apoptosis. Searching for FLASH domains
    E V Koonin
    NCBI, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Nature 401:662; discussion 662-3. 1999
  24. pmc Quoderat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences
    L M Iyer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Genome Biol 2:RESEARCH0051. 2001
    ..Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by experiment...
  25. pmc Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9
    T Caspari
    MRC Cell Mutation Unit, University of Sussex, Brighton BN1 9RR, United Kingdom
    Mol Cell Biol 20:1254-62. 2000
    ..However, two-hybrid interaction, in vitro association and in vivo overexpression experiments suggest a transient interaction between Rad1 and Rad17...
  26. pmc Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
    H Koch
    Max Planck Institut fur experimentelle Medizin, AG Molekulare Neurobiologie, Hermann Rein Str 3, D 37075 Gottingen, Germany
    Biochem J 349:247-53. 2000
    ..The MHD profiles described in the present study are useful tools for the identification of Munc13-like proteins, that would otherwise have remained undetected...
  27. ncbi request reprint The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation
    F Martinon
    Curr Biol 11:R118-20. 2001
  28. ncbi request reprint Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase
    M Thome
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Biol Chem 274:9962-8. 1999
    ..Through activation of NF-kappaB, v-CARMEN may regulate the expression of the cellular and viral genes important for viral replication...
  29. ncbi request reprint The frizzled motif: in how many different protein families does it occur?
    M Rehn
    Collagen Research Unit, University of Oulu, Finland
    Trends Biochem Sci 23:415-7. 1998
  30. ncbi request reprint TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)
    J L Bodmer
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 6:79-88. 1997
    ..TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family...
  31. pmc A conserved domain is present in different families of vesicular fusion proteins: a new superfamily
    T Weimbs
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Proc Natl Acad Sci U S A 94:3046-51. 1997
    ..The evolutionary conservation of the SNARE coiled-coil homology domain suggests that this domain has a similar function in different membrane fusion proteins...
  32. ncbi request reprint The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
    S Schmidt
    Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    Genes Dev 11:1519-34. 1997
    ..These data indicate that Spg1p is a key element in controlling the onset of septum formation in Schizosaccharomyces pombe, and that it acts through the Cdc7p kinase...
  33. ncbi request reprint Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
  34. ncbi request reprint SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    C Bai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 86:263-74. 1996
    ..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
  35. ncbi request reprint SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles
    R Janz
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas, Texas 75235, USA
    J Neurosci 18:9269-81. 1998
    ....
  36. ncbi request reprint TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    Immunity 7:831-6. 1997
    ..Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family...
  37. ncbi request reprint Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle
    N Lauper
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    Oncogene 17:2637-43. 1998
    ..We speculate that cyclin E2 is not simply redundant with cyclin E, but may regulate distinct rate-limiting pathway(s) in G1-S control...
  38. ncbi request reprint Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15
    K Hofmann
    Institut fur Biochemie, Universitat Koln, Germany
    Genomics 24:20-6. 1994
    ..The DNA region immediately upstream of the transcription start lacks any TATA or CAAT boxes but contains several binding sites for the transcription factors Sp1 and Egr-1.(ABSTRACT TRUNCATED AT 250 WORDS)..
  39. ncbi request reprint The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
    B Schumacher
    Max Planck Institut fur Biochemie, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Curr Biol 11:1722-7. 2001
    ..elegans as a genetically tractable model organism for studying the p53 apoptotic pathway...
  40. ncbi request reprint The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis
    C Fankhauser
    Swiss Institute for Experimental Cancer Research
    Cell 82:435-44. 1995
    ..Expression of cdc15 in G2-arrested cells induces actin rearrangement to the center of the cell. These data implicate cdc15p as a key element in mediating the cytoskeletal rearrangements required for cytokinesis...
  41. ncbi request reprint Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12
    W Stoffel
    Institut fur Biochemie, Universitat zu Koln, Germany
    FEBS Lett 386:189-93. 1996
    ..The L-glutamate transporter gene structures might help to understand the correlation of L-glutamate reuptake in neurodegenerative disorders...
  42. ncbi request reprint Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins
    N Brose
    Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA
    J Biol Chem 270:25273-80. 1995
    ..The presence of C1- and C2-domains in these proteins and the phenotype of the C. elegans mutants raise the possibility that Munc13s may have an essential signaling role during neurotransmitter release...
  43. ncbi request reprint Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase
    W Stoffel
    Institut fur Biochemie, Medizinische Fakultat, Universitat zu Koln, Germany
    FEBS Lett 333:119-22. 1993
    ..Knowledge of the gene organization and availability of genomic clones for mouse mECI will facilitate the study of unsaturated fatty acid metabolism in normal and pathological states...
  44. pmc SAM as a protein interaction domain involved in developmental regulation
    J Schultz
    EMBL, Heidelberg, Germany
    Protein Sci 6:249-53. 1997
    ..A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine...
  45. pmc Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain
    T Storck
    Institute for Biochemistry, Medical Faculty, University of Cologne, Federal Republic of Germany
    Proc Natl Acad Sci U S A 89:10955-9. 1992
    ..These data suggest that GLAST may be involved in the regulation of neurotransmitter concentration in central nervous system...
  46. ncbi request reprint Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development
    X W Deng
    Trends Genet 16:202-3. 2000
  47. ncbi request reprint Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
    ..We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles...
  48. pmc Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
    S Tomiuk
    Laboratory of Molecular Neurosciences, Institute of Biochemistry, Faculty of Medicine, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 95:3638-43. 1998
    ..Tumor necrosis factor alpha triggers the ERK1 pathway in none of the cell lines. The cloned nSMase will facilitate further controlled experiments aiming at the definition of a possible role of ceramide as signal transduction molecule...
  49. ncbi request reprint Clathrin self-assembly is mediated by a tandemly repeated superhelix
    J A Ybe
    The G W Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 399:371-5. 1999
    ..The resulting model provides a three-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding and trimerization...
  50. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  51. ncbi request reprint PCI complexes: pretty complex interactions in diverse signaling pathways
    T Kim
    Dept Botany, The University of Tennessee, Knoxville TN 37996-1100, USA
    Trends Plant Sci 6:379-86. 2001
    ....