Thomas J Hoffmann

Summary

Publications

  1. pmc Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco 94143 0794, CA, USA
    Genomics 98:79-89. 2011
  2. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
  3. pmc Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco, CA 94143 0794, USA
    Genomics 98:422-30. 2011
  4. pmc Combining disease models to test for gene-environment interaction in nuclear families
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 67:1260-70. 2011
  5. pmc Gene-environment interaction tests for dichotomous traits in trios and sibships
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:691-9. 2009
  6. ncbi request reprint The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies
    Karla J Lindquist
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158 9001, USA
    Genet Epidemiol 37:383-92. 2013
  7. pmc Estimating kinship in admixed populations
    Timothy Thornton
    Department of Biostatistics, University of Washington, Seattle, 98195, USA
    Am J Hum Genet 91:122-38. 2012
  8. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
  9. pmc Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer
    John S Witte
    Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    OMICS 15:393-8. 2011
  10. ncbi request reprint Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco2Department of Epidemiology and Biostatistics, University of California, San Francisco
    JAMA Psychiatry 71:943-51. 2014

Detail Information

Publications10

  1. pmc Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco 94143 0794, CA, USA
    Genomics 98:79-89. 2011
    ..At steady state, we have produced 462 million genotypes per week for each Axiom system. The new array provides a valuable addition to the repertoire of tools for large scale genome-wide association studies...
  2. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  3. pmc Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco, CA 94143 0794, USA
    Genomics 98:422-30. 2011
    ..The arrays provide excellent genome-wide coverage and are valuable additions for large-scale GWA studies...
  4. pmc Combining disease models to test for gene-environment interaction in nuclear families
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 67:1260-70. 2011
    ..We utilize this hybrid approach to analyze a chronic obstructive pulmonary disorder dataset to test for gene-environment interaction in the Serpine2 gene with smoking. The methods are freely available in the R package fbati...
  5. pmc Gene-environment interaction tests for dichotomous traits in trios and sibships
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:691-9. 2009
    ..Lastly, we apply these three tests to a group of nuclear families ascertained according to affection with Bipolar Disorder...
  6. ncbi request reprint The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies
    Karla J Lindquist
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158 9001, USA
    Genet Epidemiol 37:383-92. 2013
    ..Furthermore, increasing sample size has a much larger impact than increasing coverage on the potential of future GWAS to detect additional SNP-disease associations and heritability...
  7. pmc Estimating kinship in admixed populations
    Timothy Thornton
    Department of Biostatistics, University of Washington, Seattle, 98195, USA
    Am J Hum Genet 91:122-38. 2012
    ..We also apply REAP to the African American and Hispanic samples from the Women's Health Initiative SNP Health Association Resource (WHI-SHARe) study, in which hundreds of pairs of cryptically related individuals have been identified...
  8. pmc Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  9. pmc Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer
    John S Witte
    Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    OMICS 15:393-8. 2011
    ..This supports the further development and application of polygenic models to genomic data...
  10. ncbi request reprint Evidence of reproductive stoppage in families with autism spectrum disorder: a large, population-based cohort study
    Thomas J Hoffmann
    Institute for Human Genetics, University of California, San Francisco2Department of Epidemiology and Biostatistics, University of California, San Francisco
    JAMA Psychiatry 71:943-51. 2014
    ..Few studies have examined the curtailment of reproduction (ie, stoppage) after the diagnosis of a child with autism spectrum disorder (ASD)...