Stephen L Hoffman

Summary

Publications

  1. pmc Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria
    Walter R J Taylor
    The US Navy Medical Research Unit no 2 NAMRU 2, Jakarta, Indonesia
    Malar J 12:209. 2013
  2. pmc Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria
    Walter R J Taylor
    The US Navy Medical Research Unit no 2, Jakarta, Indonesia
    Malar J 7:259. 2008
  3. pmc Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor
    Jonathan A Chappel
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Malar J 3:28. 2004
  4. ncbi request reprint Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
    Stephen L Hoffman
    Sanaria Inc, Rockville, MD, USA
    Hum Vaccin 6:97-106. 2010
  5. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
  6. doi request reprint The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine
    Rana Chattopadhyay
    Sanaria Inc, 9800 Medical Center Drive, Rockville, MD 20850, United States
    Vaccine 27:3675-80. 2009
  7. ncbi request reprint Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
  8. pmc Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA
    Thomas L Richie
    Naval Medical Research Center Silver Spring, MD, USA
    Hum Vaccin Immunother 8:1564-84. 2012
  9. ncbi request reprint Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:512-9. 2002
  10. ncbi request reprint Parasitology. Malaria--from infants to genomics to vaccines
    Carole A Long
    Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA
    Science 297:345-7. 2002

Research Grants

Detail Information

Publications21

  1. pmc Haemoglobin dynamics in Papuan and non-Papuan adults in northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria
    Walter R J Taylor
    The US Navy Medical Research Unit no 2 NAMRU 2, Jakarta, Indonesia
    Malar J 12:209. 2013
    ..Haemoglobin (Hb) recovers slowly in malaria and may be influenced by naturally acquired immunity. Hb recovery was compared in malaria immune, indigenous Papuan and non-Papuan adults with limited malaria exposure...
  2. pmc Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria
    Walter R J Taylor
    The US Navy Medical Research Unit no 2, Jakarta, Indonesia
    Malar J 7:259. 2008
    ..There are limited data on the evolution of the leukocyte and platelet counts in malaria patients...
  3. pmc Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor
    Jonathan A Chappel
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Malar J 3:28. 2004
    ..In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the anti-repeat response dominates and is thought by many to play a role in protective immunity...
  4. ncbi request reprint Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
    Stephen L Hoffman
    Sanaria Inc, Rockville, MD, USA
    Hum Vaccin 6:97-106. 2010
    ..A medium term goal is to design and build a facility for manufacturing highly potent and stable vaccine for pivotal Phase 3 studies and commercial launch...
  5. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  6. doi request reprint The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine
    Rana Chattopadhyay
    Sanaria Inc, 9800 Medical Center Drive, Rockville, MD 20850, United States
    Vaccine 27:3675-80. 2009
    ..These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses...
  7. ncbi request reprint Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
    ..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
  8. pmc Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA
    Thomas L Richie
    Naval Medical Research Center Silver Spring, MD, USA
    Hum Vaccin Immunother 8:1564-84. 2012
    ..It also laid the foundation for priming with DNA plasmids and boosting with recombinant viruses, an approach known for nearly 15 y to enhance the immunogenicity and protective efficacy of DNA vaccines...
  9. ncbi request reprint Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:512-9. 2002
    ..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
  10. ncbi request reprint Parasitology. Malaria--from infants to genomics to vaccines
    Carole A Long
    Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA
    Science 297:345-7. 2002
  11. ncbi request reprint Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
    ..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
  12. pmc Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route
    Solomon Conteh
    Sanaria Inc, Rockville, Maryland, United States of America
    PLoS ONE 5:e8947. 2010
    ....
  13. ncbi request reprint Immunological responses of neonates and infants to DNA vaccines
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Methods Mol Med 127:239-51. 2006
    ..These data support assessment of this immunization strategy in neonates/young infants in areas where malaria exacts the greatest toll...
  14. pmc Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites
    Ruobing Wang
    Sanaria, Inc, 12115 Parklawn Drive, Suite L, Rockville, MD 20852, USA
    Infect Immun 73:2863-72. 2005
    ....
  15. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  16. pmc Establishment of an in vitro assay for assessing the effects of drugs on the liver stages of Plasmodium vivax malaria
    Rana Chattopadhyay
    Sanaria Inc, Rockville, Maryland, United States of America
    PLoS ONE 5:e14275. 2010
    ..We have also identified small parasite forms that may be hypnozoites. These data provide the foundation for finalizing a medium throughput, high content assay to identify new drugs for the elimination of all Pv liver stages...
  17. ncbi request reprint The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  18. ncbi request reprint Nucleic acid vaccines against malaria
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Chem Immunol 80:308-21. 2002
  19. pmc Comparative immunopeptidomics of humans and their pathogens
    Sorin Istrail
    Celera Genomics, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:13268-72. 2004
    ....
  20. ncbi request reprint Plasmodium, human and Anopheles genomics and malaria
    Stephen L Hoffman
    Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
    Nature 415:702-9. 2002
    ....
  21. pmc Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
    Meta Roestenberg
    Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
    Am J Trop Med Hyg 88:5-13. 2013
    ..After further optimization, the use of such PfSPZ may facilitate and accelerate clinical development of novel malaria drugs and vaccines...

Research Grants8

  1. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    ..The project will also provide a method for cryopreserving unirradiated sporozoites that could be used to challenge volunteers by injection with P. falciparum in vaccine studies worldwide. ..
  2. Genetically Attenuated Malaria Sporozote Vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..Success in this project has the potential to lead to development of a safe, effective, attenuated malaria vaccine. ..
  3. Attenuated Malaria Sporozoite Vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..Success in these first clinical trials will lead to a massive development effort leading to licensure and deployment of the vaccine. ..
  4. Lyophilization of Plasmodium falciparum sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..Additionally, a dried vaccine may accelerate a concerted world-wide effort to eradicate this devastating disease. ..
  5. Universal Attenuated Malaria Sporozoite Vaccine and Challenge System
    Stephen Hoffman; Fiscal Year: 2007
    ..Success in this project will significantly decrease the cost of development and time to market for this malaria vaccine. ..