Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malariaWalter R J Taylor
The US Navy Medical Research Unit no 2, Jakarta, Indonesia
Malar J 7:259. 2008
..There are limited data on the evolution of the leukocyte and platelet counts in malaria patients...
- Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor
Jonathan A Chappel
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Malar J 3:28. 2004
..In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the anti-repeat response dominates and is thought by many to play a role in protective immunity...
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malariaStephen L Hoffman
Sanaria Inc, Rockville, MD, USA
Hum Vaccin 6:97-106. 2010
..A medium term goal is to design and build a facility for manufacturing highly potent and stable vaccine for pivotal Phase 3 studies and commercial launch...
- Comparative genomics of the neglected human malaria parasite Plasmodium vivax
Jane M Carlton
The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Nature 455:757-63. 2008
..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccineRana Chattopadhyay
Sanaria Inc, 9800 Medical Center Drive, Rockville, MD 20850, United States
Vaccine 27:3675-80. 2009
..These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses...
- Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
Judith E Epstein
Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
J Infect Dis 196:145-54. 2007
..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
- Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:531-4. 2002
..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
- Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Jane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:512-9. 2002
..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
- Parasitology. Malaria--from infants to genomics to vaccines
Carole A Long
Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA
Science 297:345-7. 2002
- Immunological responses of neonates and infants to DNA vaccines
Martha Sedegah
Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
Methods Mol Med 127:239-51. 2006
..These data support assessment of this immunization strategy in neonates/young infants in areas where malaria exacts the greatest toll...
- Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route
Solomon Conteh
Sanaria Inc, Rockville, Maryland, United States of America
PLoS ONE 5:e8947. 2010
....
- Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites
Ruobing Wang
Sanaria, Inc, 12115 Parklawn Drive, Suite L, Rockville, MD 20852, USA
Infect Immun 73:2863-72. 2005
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- Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002
..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
- Establishment of an in vitro assay for assessing the effects of drugs on the liver stages of Plasmodium vivax malaria
Rana Chattopadhyay
Sanaria Inc, Rockville, Maryland, United States of America
PLoS ONE 5:e14275. 2010
..We have also identified small parasite forms that may be hypnozoites. These data provide the foundation for finalizing a medium throughput, high content assay to identify new drugs for the elimination of all Pv liver stages...
- The genome sequence of the malaria mosquito Anopheles gambiae
Robert A Holt
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 298:129-49. 2002
..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
- Nucleic acid vaccines against malaria
Denise L Doolan
Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
Chem Immunol 80:308-21. 2002
- Plasmodium, human and Anopheles genomics and malaria
Stephen L Hoffman
Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
Nature 415:702-9. 2002
....
- Comparative immunopeptidomics of humans and their pathogens
Sorin Istrail
Celera Genomics, Rockville, MD 20850, USA
Proc Natl Acad Sci U S A 101:13268-72. 2004
....
- Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
Meta Roestenberg
Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
Am J Trop Med Hyg 88:5-13. 2013
..After further optimization, the use of such PfSPZ may facilitate and accelerate clinical development of novel malaria drugs and vaccines...
