- EGFR associated expression profiles vary with breast tumor subtype
Katherine A Hoadley
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Genomics 8:258. 2007
..An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors...
- Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell lines
Melissa A Troester
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Environ Health Perspect 112:1607-13. 2004
..These analyses also showed that toxicant-specific gene expression patterns, similar to general stress responses, vary according to cell type...
- Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
Jeffrey S Damrauer
Department of Genetics, Department of Medicine, Division of Hematology Oncology, Department of Surgery, Department of Pathology and Laboratory Medicine, and Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
Proc Natl Acad Sci U S A 111:3110-5. 2014
..Future studies exploring the predictive value of the BASE47 subtypes for standard of care bladder cancer therapies, as well as novel subtype-specific therapies, will be of interest. ..
- Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
Heather Ann Brauer
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Cancer Res 19:571-85. 2013
..This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabolism...
- Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 8:e56823. 2013
..Model systems representative of each of the four subtypes are also presented...
- RNA expression analysis of formalin-fixed paraffin-embedded tumors
Shannon K Penland
Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
Lab Invest 87:383-91. 2007
..Although only a minority of FFPE blocks could be analyzed, we show that informative RNA expression analysis can be derived from selected FFPE samples...
- TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
Lisa A Carey
Hematology Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, 170 Manning Dr, Chapel Hill, NC 27599 7305, USA
J Clin Oncol 30:2615-23. 2012
..Epidermal growth factor receptor (EGFR) is a targetable receptor frequently overexpressed in basal-like breast cancer, which comprises most triple-negative breast cancers (TNBCs), the only subtype without established targeted therapy...
- Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer
Aaron R Thorner
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e13073. 2010
..However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly understood, despite its high expression in the majority of breast cancer cases (60-80%)...
- Cell-type-specific responses to chemotherapeutics in breast cancer
Melissa A Troester
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
Cancer Res 64:4218-26. 2004
..Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics...
- Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis
Curriculum in Applied and Materials Sciences, UNC CH, Chapel Hill, NC, USA
Proteomics Clin Appl 1:1651-9. 2007
..The addition of stable-labeled versions of the target peptide (synthesized from stable-isotope coded amino acids) as internal standards allows absolute quantitation of the target protein...
- Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types
Matthew D Wilkerson
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
Clin Cancer Res 16:4864-75. 2010
..We sought to determine if SCC mRNA expression subtypes exist, are reproducible across multiple patient cohorts, and are clinically relevant...