Bosco K Ho

Summary

Publications

  1. pmc Inmembrane, a bioinformatic workflow for annotation of bacterial cell-surface proteomes
    Andrew J Perry
    Department of Biochemistry, Monash University, Melbourne, Australia
    Source Code Biol Med 8:9. 2013
  2. pmc Probing the flexibility of large conformational changes in protein structures through local perturbations
    Bosco K Ho
    Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 5:e1000343. 2009
  3. pmc Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility
    Bosco K Ho
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, California 94158 2517, USA
    Protein Sci 19:398-411. 2010
  4. pmc HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures
    Bosco K Ho
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    BMC Struct Biol 8:49. 2008
  5. pmc Folding very short peptides using molecular dynamics
    Bosco K Ho
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    PLoS Comput Biol 2:e27. 2006
  6. pmc Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms
    Bosco K Ho
    Department of Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco CA 94158 2517, USA
    BMC Struct Biol 8:41. 2008
  7. doi request reprint Hybrid approaches to molecular simulation
    Bosco K Ho
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Curr Opin Struct Biol 22:386-93. 2012
  8. pmc The Ramachandran plots of glycine and pre-proline
    Bosco K Ho
    Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th St, San Francisco, CA 94107, USA
    BMC Struct Biol 5:14. 2005

Collaborators

Detail Information

Publications9

  1. pmc Inmembrane, a bioinformatic workflow for annotation of bacterial cell-surface proteomes
    Andrew J Perry
    Department of Biochemistry, Monash University, Melbourne, Australia
    Source Code Biol Med 8:9. 2013
    ..In particular, proteins detected by cell surface protease shaving experiments can indicate exposed regions of membrane proteins that may contain antigenic determinants or constitute vaccine targets in pathogenic bacteria...
  2. pmc Probing the flexibility of large conformational changes in protein structures through local perturbations
    Bosco K Ho
    Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 5:e1000343. 2009
    ..RIP analysis has the potential to discover sites of functional conformational changes and the linchpin residues critical in determining these conformational states...
  3. pmc Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility
    Bosco K Ho
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, California 94158 2517, USA
    Protein Sci 19:398-411. 2010
    ..As these dynamic modules are exploited by various allosteric mechanisms, these tertiary contacts have been conserved by evolution...
  4. pmc HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures
    Bosco K Ho
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    BMC Struct Biol 8:49. 2008
    ..Neither method is entirely satisfactory, as unwanted additional pieces of surfaces are always generated...
  5. pmc Folding very short peptides using molecular dynamics
    Bosco K Ho
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    PLoS Comput Biol 2:e27. 2006
    ..Such physics-based modeling may be useful for identifying early nuclei in folding kinetics and for assisting in protein-structure prediction methods that utilize the assembly of peptide fragments...
  6. pmc Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms
    Bosco K Ho
    Department of Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco CA 94158 2517, USA
    BMC Struct Biol 8:41. 2008
    ..Despite the many libraries of sidechain rotamers that have been developed, a number of rotamers have been overlooked, due to the fact that they involve hydrogen atoms...
  7. doi request reprint Hybrid approaches to molecular simulation
    Bosco K Ho
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Curr Opin Struct Biol 22:386-93. 2012
    ..Here, we review some recent hybrid approaches to the simulation of proteins...
  8. pmc The Ramachandran plots of glycine and pre-proline
    Bosco K Ho
    Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th St, San Francisco, CA 94107, USA
    BMC Struct Biol 5:14. 2005
    ..Of the 4 basic types of Ramachandran plots, the interactions that determine the generic and proline Ramachandran plots are well understood. The interactions of the glycine and pre-proline Ramachandran plots are not...