Andrew J Hirsh

Summary

Publications

  1. ncbi request reprint Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Parkway, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 311:929-38. 2004
  2. ncbi request reprint Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill NC 27599, USA
    Adv Drug Deliv Rev 54:1445-62. 2002
  3. ncbi request reprint Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Parkway, Suite 260, Durham, North Carolina 27713, USA
    J Med Chem 49:4098-115. 2006
  4. doi request reprint Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung d
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Pkwy, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 325:77-88. 2008
  5. ncbi request reprint Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 46:10373-83. 2007
  6. pmc A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
    Brett M Rollins
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Respir Cell Mol Biol 39:190-7. 2008
  7. pmc Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency
    William R Thelin
    Parion Sciences, Durham, North Carolina, USA
    J Ocul Pharmacol Ther 28:433-8. 2012
  8. ncbi request reprint Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways
    Maryse Picher
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:13468-79. 2003
  9. ncbi request reprint Cytokine secretion by cystic fibrosis airway epithelial cells
    Marie N Becker
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Medicine, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Crit Care Med 169:645-53. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Parkway, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 311:929-38. 2004
    ..More potent, less absorbable, third generation ENaC blockers will be required for an effective aerosol CF pharmacotherapy...
  2. ncbi request reprint Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill NC 27599, USA
    Adv Drug Deliv Rev 54:1445-62. 2002
    ..The advantages and disadvantages of each therapy are discussed, as well as future directions for improving airway surface liquid volume by inhalation pharmacotherapy...
  3. ncbi request reprint Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Parkway, Suite 260, Durham, North Carolina 27713, USA
    J Med Chem 49:4098-115. 2006
    ..Lead compound 32 was 102-fold more potent and 5-fold less reversible than amiloride and displayed the lowest IC(50) value ever reported for an ENaC blocker...
  4. doi request reprint Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung d
    Andrew J Hirsh
    Parion Sciences Inc, 2525 Meridian Pkwy, Suite 260, Durham, NC 27713, USA
    J Pharmacol Exp Ther 325:77-88. 2008
    ..In summary, the preclinical data support the clinical use of 552-02 +/- hypertonic saline for CF lung disease...
  5. ncbi request reprint Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 46:10373-83. 2007
    ..This study shows that adenosine elimination on human airway epithelia is mediated by ADA1, CNT2, and CNT3, which constitute important regulators of adenosine-mediated inflammation...
  6. pmc A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
    Brett M Rollins
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Respir Cell Mol Biol 39:190-7. 2008
    ..A(2B)-R are required for ASL volume homeostasis in human airways, and therapies directed at inhibiting A(2B)-R may lead to a cystic fibrosis-like phenotype with depleted ASL volume and mucus stasis...
  7. pmc Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency
    William R Thelin
    Parion Sciences, Durham, North Carolina, USA
    J Ocul Pharmacol Ther 28:433-8. 2012
    ....
  8. ncbi request reprint Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways
    Maryse Picher
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:13468-79. 2003
    ..Collectively, these experiments support a major role for extracellular nucleotide catalysis and for ecto 5'-NT and NS AP in the regulation of adenosine concentrations on airway surfaces...
  9. ncbi request reprint Cytokine secretion by cystic fibrosis airway epithelial cells
    Marie N Becker
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Medicine, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Crit Care Med 169:645-53. 2004
    ..Thus, although exaggerated responses may develop under certain conditions, our results do not support an overall intrinsically hyperinflammatory phenotype in CF cells...