Kristof Hirschberg

Summary

Publications

  1. doi request reprint Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation
    K Hirschberg
    Experimental Laboratory of Cardiac Surgery, University of Heidelberg, Germany
    Int J Cardiol 167:470-7. 2013
  2. doi request reprint Combined superoxide dismutase mimetic and peroxynitrite scavenger protects against neointima formation after endarterectomy in association with decreased proliferation and nitro-oxidative stress
    K Hirschberg
    Experimental Laboratory of Cardiac Surgery, University of Heidelberg, Germany
    Eur J Vasc Endovasc Surg 40:168-75. 2010
  3. doi request reprint [Restenosis following endovascular interventions: clinical and experimental studies]
    Kristof Hirschberg
    Semmelweis Egyetem, Általános Orvostudományi Kar, Kardiológiai Központ, Budapest Gaál József u 9 1122
    Orv Hetil 150:1307-12. 2009
  4. doi request reprint Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy
    Kristof Hirschberg
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 137:1508-14. 2009
  5. ncbi request reprint Early restenosis after eversion carotid endarterectomy versus carotid stenting: a single-centre retrospective study
    K Hirschberg
    Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University Budapest, Hungary
    J Cardiovasc Surg (Torino) 50:655-63. 2009
  6. doi request reprint Association between estrogen receptor alpha gene polymorphisms and early restenosis after eversion carotid endarterectomy and carotid stenting
    Kristof Hirschberg
    Department of Cardiovascular Surgery, Semmelweis University, Varosmajor utca 68, Budapest, Hungary
    Atherosclerosis 206:186-92. 2009
  7. ncbi request reprint Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, 2 OG INF 326, 69120 Heidelberg, Germany
    Eur J Pharmacol 615:155-62. 2009
  8. doi request reprint Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, Heidelberg, Germany
    Thorac Cardiovasc Surg 60:247-54. 2012
  9. doi request reprint Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, Laboratory of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Cardiovasc Pharmacol Ther 18:70-7. 2013
  10. doi request reprint Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:1414-8. 2008

Collaborators

Detail Information

Publications22

  1. doi request reprint Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation
    K Hirschberg
    Experimental Laboratory of Cardiac Surgery, University of Heidelberg, Germany
    Int J Cardiol 167:470-7. 2013
    ..In this study we investigated the effects of cinaciguat on post-injury arterial stenosis...
  2. doi request reprint Combined superoxide dismutase mimetic and peroxynitrite scavenger protects against neointima formation after endarterectomy in association with decreased proliferation and nitro-oxidative stress
    K Hirschberg
    Experimental Laboratory of Cardiac Surgery, University of Heidelberg, Germany
    Eur J Vasc Endovasc Surg 40:168-75. 2010
    ..In a rat carotid endarterectomy (CEA) model, we investigated the effects of the manganese(III)tetrakis(4-benzoic acid)porphyrin (MnTBAP), a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger on neointima formation...
  3. doi request reprint [Restenosis following endovascular interventions: clinical and experimental studies]
    Kristof Hirschberg
    Semmelweis Egyetem, Általános Orvostudományi Kar, Kardiológiai Központ, Budapest Gaál József u 9 1122
    Orv Hetil 150:1307-12. 2009
    ..Polymorphisms in the estrogen receptor alpha gene could contribute to the restenosis formation, especially in women. Neointimal hyperplasia can be attenuated by increased cyclic guanosine monophosphate signaling...
  4. doi request reprint Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy
    Kristof Hirschberg
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 137:1508-14. 2009
    ..In a rat model of endarterectomy, we investigated the effect of pharmacologic inhibition of cyclic guanosine monophosphate degradation on neointima formation by using the selective phosphodiesterase-5 inhibitor vardenafil...
  5. ncbi request reprint Early restenosis after eversion carotid endarterectomy versus carotid stenting: a single-centre retrospective study
    K Hirschberg
    Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University Budapest, Hungary
    J Cardiovasc Surg (Torino) 50:655-63. 2009
    ..The aim of our study was to compare the early restenosis rate between patients undergoing carotid artery stenting (CAS) and carotid endarterectomy (CEA) at a single cardiovascular institution...
  6. doi request reprint Association between estrogen receptor alpha gene polymorphisms and early restenosis after eversion carotid endarterectomy and carotid stenting
    Kristof Hirschberg
    Department of Cardiovascular Surgery, Semmelweis University, Varosmajor utca 68, Budapest, Hungary
    Atherosclerosis 206:186-92. 2009
    ..Our aim was to identify the role of PvuII and XbaI polymorphisms of the ESR1 (estrogen receptor alpha) gene in the occurrence of early restenosis after carotid endarterectomy and carotid artery stenting...
  7. ncbi request reprint Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, 2 OG INF 326, 69120 Heidelberg, Germany
    Eur J Pharmacol 615:155-62. 2009
    ..This work supports the view that acute PDE5-inhibition might be advantageous in the treatment of endothelial dysfunction induced by disturbed NO-cGMP pathway due to nitro-oxidative stress...
  8. doi request reprint Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, Heidelberg, Germany
    Thorac Cardiovasc Surg 60:247-54. 2012
    ..In the present study, we investigated the effects of vardenafil on myocardial contractility and vascular function in a dose-response study...
  9. doi request reprint Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta
    Sevil Korkmaz
    Department of Cardiac Surgery, Laboratory of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Cardiovasc Pharmacol Ther 18:70-7. 2013
    ....
  10. doi request reprint Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:1414-8. 2008
    ..We could show that up-regulating this pathway has a preconditioning-like effect and can effectively reduce ischemia/reperfusion injury...
  11. pmc Acute ethanol exposure increases the susceptibility of the donor hearts to ischemia/reperfusion injury after transplantation in rats
    Shiliang Li
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e49237. 2012
    ..The aims of this work were 1) to evaluate in rats the time-course cardiac effects of acute ethanol-exposure and 2) to explore how its abuse by donors might affect recipients in cardiac pump function after transplantation...
  12. doi request reprint Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury
    Sivakkanan Loganathan
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326 2 OG, 69120 Heidelberg, Germany
    J Thorac Cardiovasc Surg 139:1048-56. 2010
    ..On the basis of this solution, the novel Custodiol-N was developed. The present study investigated the effects of Custodiol-N in a rat model of heart transplantation...
  13. doi request reprint Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes
    Gábor Széplaki
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Atherosclerosis 204:315-20. 2009
    ..According to data from animal models, complement activation plays a major role in the brain injury after acute ischemic stroke. Scarce findings are, however, available on the detection of complement activation products in stroke patients...
  14. ncbi request reprint Q50, an iron-chelating and zinc-complexing agent, improves cardiac function in rat models of ischemia/reperfusion-induced myocardial injury
    Sevil Korkmaz
    Laboratory of Cardiac Surgery, Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Circ J 77:1817-26. 2013
    ....
  15. doi request reprint Echolucent or predominantly echolucent femoral plaques predict early restenosis after eversion carotid endarterectomy
    Edit Dosa
    Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Vasc Surg 51:345-50. 2010
    ....
  16. doi request reprint Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Circulation 120:677-86. 2009
    ..We investigated the effects of cinaciguat on myocardial infarction induced by isoproterenol in rats...
  17. pmc Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
    George Fust
    3rd Department of Internal Medicine, Semmelwies University, Budapest, Hungary
    J Neuroinflammation 8:185. 2011
    ..Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined...
  18. doi request reprint Coronary vasoconstrictor effect of ghrelin is not mediated by growth hormone secretagogue receptor 1a type in dogs
    Balazs Sax
    Heart Center, Semmelweis University, Budapest, Hungary
    Peptides 32:362-7. 2011
    ..The results suggest that GHR induces tone-dependent constriction of canine coronary arterioles which is mediated by a receptor other than GHS-R1a...
  19. doi request reprint Early complement activation follows eversion carotid endarterectomy and correlates with the time of clamping of the carotid artery
    Gábor Széplaki
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125Budapest, Hungary
    Mol Immunol 45:3289-94. 2008
    ..Complement activation plays an important role in ischemia/reperfusion (I/R) injury. The objective of the present study was to detect the presence and mechanism of complement activation in patients who underwent carotid endarterectomy (CEA)...
  20. ncbi request reprint Development and evaluation of a perfusion decellularization porcine heart model--generation of 3-dimensional myocardial neoscaffolds
    Alexander Weymann
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326 OG 2, 69120 Heidelberg, Germany
    Circ J 75:852-60. 2011
    ..The aim of this study was to evaluate the potential of a perfusion decellularization model for whole heart tissue engineering...
  21. doi request reprint Percutaneous endovascular treatment of innominate artery lesions: a single-centre experience on 77 lesions
    T M Paukovits
    Heart Center, Faculty of Medicine, Semmelweis University, 1122 Gaal Jozsef Street 9, Budapest, Hungary
    Eur J Vasc Endovasc Surg 40:35-43. 2010
    ..To assess primary success and safety of percutaneous transluminal angioplasty and/or stenting of innominate artery lesions and to compare its 30-day stroke/mortality level with the literature data...
  22. doi request reprint Efficacy of the non-adenosine analogue A1 adenosine receptor agonist (BR-4935) on cardiovascular function after cardiopulmonary bypass
    G Veres
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Thorac Cardiovasc Surg 58:86-92. 2010
    ..We tested the hypothesis that pharmacological preconditioning with a newly developed, potent non-adenosine analogue A1AdoR agonist (BR-4935) improves biventricular cardiac and endothelial function after cardiopulmonary bypass...