Naoyuki Hirata

Summary

Publications

  1. doi request reprint Heart rate variability during abdominal surgical manipulation under general and epidural anesthesia
    Naoyuki Hirata
    Department of Anesthesiology, Obihiro Kyokai Hospital, Obihiro, Japan
    J Anesth 26:900-4. 2012
  2. pmc Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning
    Naoyuki Hirata
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 115:531-40. 2011
  3. doi request reprint Low-dose continuous infusion of landiolol can reduce adrenergic response during tracheal intubation in elderly patients with cardiovascular disease
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Anesth 24:786-8. 2010
  4. ncbi request reprint Pulmonary embolism caused by a carbon dioxide blower during off-pump coronary artery bypass grafting
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Anesth 24:114-6. 2010
  5. doi request reprint Cardioprotective effects of propofol in isolated ischemia-reperfused guinea pig hearts: role of KATP channels and GSK-3beta
    Noriko Kamada
    Department of Anesthesiology, Sapporo Medical University School of Medicine, S 1, W 6, Chuo Ku, Sapporo 060 8543, Japan
    Can J Anaesth 55:595-605. 2008
  6. pmc Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1797:1749-58. 2010
  7. doi request reprint Differential effects of propofol and sevoflurane on ischemia-induced ventricular arrhythmias and phosphorylated connexin 43 protein in rats
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesthesiology 110:50-7. 2009
  8. pmc Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Eur J Pharmacol 690:149-57. 2012
  9. ncbi request reprint Cardioprotective effect and mechanism of action of landiolol on the ischemic reperfused heart
    Saori Kimura-Kurosawa
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Anesth 21:480-9. 2007
  10. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011

Collaborators

Detail Information

Publications12

  1. doi request reprint Heart rate variability during abdominal surgical manipulation under general and epidural anesthesia
    Naoyuki Hirata
    Department of Anesthesiology, Obihiro Kyokai Hospital, Obihiro, Japan
    J Anesth 26:900-4. 2012
    ..04-0.15 Hz) calculated from the power spectral density of heart rate variability. Our results suggest that both vagal tone and sympathetic tone could be activated during the vagal reflex caused by abdominal surgical manipulation...
  2. pmc Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning
    Naoyuki Hirata
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 115:531-40. 2011
    ..Further, the authors investigated the mechanism by which isoflurane alters ROS generation in isolated mitochondria and submitochondrial particles...
  3. doi request reprint Low-dose continuous infusion of landiolol can reduce adrenergic response during tracheal intubation in elderly patients with cardiovascular disease
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Anesth 24:786-8. 2010
    ..Results showed that low-dose continuous infusion of landiolol is an effective and relatively safe method of preventing an intubation-induced adrenergic response in elderly patients with cardiovascular disease...
  4. ncbi request reprint Pulmonary embolism caused by a carbon dioxide blower during off-pump coronary artery bypass grafting
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Anesth 24:114-6. 2010
    ..Although a CO2 blower is useful to enhance visualization of the anastomosis during OPCAB, it should not be used for the venous system because it may cause CO2 embolism...
  5. doi request reprint Cardioprotective effects of propofol in isolated ischemia-reperfused guinea pig hearts: role of KATP channels and GSK-3beta
    Noriko Kamada
    Department of Anesthesiology, Sapporo Medical University School of Medicine, S 1, W 6, Chuo Ku, Sapporo 060 8543, Japan
    Can J Anaesth 55:595-605. 2008
    ..The present study examines the cardioprotective effects of propofol and its role in cardiac function, including its effect on K(ATP) channel opening and the inhibition of GSK-3beta activity in ischemia-reperfused hearts...
  6. pmc Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes
    Filip Sedlic
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1797:1749-58. 2010
    ..The NAD(P)H-FP fluorometry is a useful method for exploring the effect of drugs on mitochondria and identifying their specific sites of action within the ETC of intact cardiomyocytes...
  7. doi request reprint Differential effects of propofol and sevoflurane on ischemia-induced ventricular arrhythmias and phosphorylated connexin 43 protein in rats
    Naoyuki Hirata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesthesiology 110:50-7. 2009
    ....
  8. pmc Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria
    Danijel Pravdic
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Eur J Pharmacol 690:149-57. 2012
    ..K(+) channels and uncoupling proteins appear not to be involved in the direct effects of isoflurane on mitochondria...
  9. ncbi request reprint Cardioprotective effect and mechanism of action of landiolol on the ischemic reperfused heart
    Saori Kimura-Kurosawa
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Anesth 21:480-9. 2007
    ....
  10. pmc Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia
    Zhi Dong Ge
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cardiovasc Res 91:340-9. 2011
    ....
  11. pmc Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia
    Martin Bienengraeber
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 45:163-70. 2013
    ..Thus, a proteomic mass spectral approach does not only assess quantitative changes without prior knowledge of proteins, but also allows insight into the mechanisms of ischemia and reperfusion injury and APC...
  12. ncbi request reprint Differential effects of propofol and sevoflurane on heart rate variability
    Noriaki Kanaya
    Department of fAnesthesioloty, Sapporto Medical University School of Medicine, Sapporo, Japan
    Anesthesiology 98:34-40. 2003
    ..The purposes of the present study were (1) to evaluate the changes in heart rate variability at different depths of hypnosis and (2) to compare the effects of propofol on heart rate variability with that of sevoflurane...