Individualising the risks of statins in men and women in England and Wales: population-based cohort studyJulia Hippisley-Cox
Division of Primary Care, University Park, Nottingham, UK
Heart 96:939-47. 2010
..To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients...
Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresJulia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
BMJ 339:b4229. 2009
..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
- Identifying patients with suspected lung cancer in primary care: derivation and validation of an algorithm
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, UK
Br J Gen Pract 61:e715-23. 2011
..The challenge is to help earlier diagnosis of lung cancer and hence improve prognosis...
- Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2
Julia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
BMJ 336:1475-82. 2008
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Accidental injury: a neglected area within Primary Care Groups and Trusts?Denise Kendrick
Division of General Practice, Floor 13, Tower Building, University Park, Nottingham NG7 2RD, UK
Health Educ Res 18:380-8. 2003
..Gaps in knowledge about accidents and their prevention are apparent. PCG/Ts will need help and support to fully develop their potential in preventing accidental injuries...
- Association of deprivation, ethnicity, and sex with quality indicators for diabetes: population based survey of 53,000 patients in primary care
Julia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
BMJ 329:1267-9. 2004
..To determine the effect of deprivation and ethnicity on the achievement of quality indicators for patients with diabetes and the extent of any inequalities between the sexes...
- Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data
Yana Vinogradova
Division of Primary Care, University Park, Nottingham NG2 7RD, UK
BMJ 346:f114. 2013
..To investigate the association between use of bisphosphonates estimated from prescription information and risk of gastrointestinal cancers...
- Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study
Julia Hippisley-Cox
Division of Primary Care, University Park, Nottingham, UK
BMJ 344:e3427. 2012
..To develop and validate an updated version of the QFracture algorithm for estimating the risk of a patient sustaining an osteoporotic fracture or hip fracture in a primary care population...
- Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database
Julia Hippisley-Cox
Division of Primary Care, University Park, Nottingham NG2 7RD, UK
BMJ 341:c6624. 2010
..To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease...
- Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
Julia Hippisley-Cox
Tower Building, University Park, Nottingham NG2 7RD
BMJ 335:136. 2007
..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
- Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, Nottingham NG2 7RD, UK
BMJ 344:d8009. 2012
..To derive and validate an algorithm to estimate the absolute risk of having ovarian cancer in women with and without symptoms...
- Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database
Julia Hippisley-Cox
Division of Primary Care, University Park, Nottingham NG2 7RD
BMJ 340:c2197. 2010
..To quantify the unintended effects of statins according to type, dose, and duration of use...
- Effects of severe mental illness on survival of people with diabetes
Yana Vinogradova
Department of Primary Care, Tower Building 13th Floor, University Park, University of Nottingham, Nottingham NG7 2RD, UK
Br J Psychiatry 197:272-7. 2010
..People with mental health problems are more likely to die prematurely than the general population but no study has examined this in individuals with diabetes...
- Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore
Julia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
BMJ 338:b880. 2009
..To develop and validate a new diabetes risk algorithm (the QDScore) for estimating 10 year risk of acquiring diagnosed type 2 diabetes over a 10 year time period in an ethnically and socioeconomically diverse population...
- A randomized controlled trial of the effect of providing information on accidental injury admissions and their costs to Primary Care Groups and Trusts
Carol A C Coupland
Division of Primary Care, University of Nottingham, Tower Building, University Park, Nottingham, NG7 2RD, UK
Fam Pract 22:249-52. 2005
..Primary Care Groups and Trusts (PCG/Ts) are responsible for improving the health of local populations, but there is little evidence of their strategic involvement in accident prevention...
- Identifying patients with suspected gastro-oesophageal cancer in primary care: derivation and validation of an algorithm
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, UK
Br J Gen Pract 61:e707-14. 2011
..Gastro-oesphageal is one of the most common cancers worldwide. Evidence suggested that increased awareness of symptoms and earlier diagnosis could help improve treatment options and improve survival...
- Risk of pneumonia in patients taking statins: population-based nested case-control study
Yana Vinogradova
Division of Primary Care, University Park, Nottingham, UK
Br J Gen Pract 61:e742-8. 2011
..Recent research suggests that statins might improve the outcome of infectious diseases because of their anti-oxidative and anti-inflammatory properties...
- Assisted delivery in the teenage population: the effect of inter-hospital variation, deprivation, and age
Jane Allen
Division of Primary Care, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom
Int J Adolesc Med Health 15:341-7. 2003
..The objective was to determine the relationship between the risk of assisted delivery in women aged under 20 years and place of treatment, deprivation and age...
- Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study
Yana Vinogradova
Division of Primary Care, University of Nottingham, Nottingham, United Kingdom
Gastroenterology 133:393-402. 2007
..Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use...
- General practice characteristics associated with rates of testing and detection of hepatitis C: cross-sectional study in Nottingham and Derbyshire
Carol Coupland
School of Community Health Sciences, Division of Primary Care, University of Nottingham, UK
Br J Gen Pract 56:620-3. 2006
..Practices where at least half of the GPs were female had higher testing rates but lower positivity rates. The variation observed was not explained by deprivation or rurality of the practice...
- A case-control study on the effect of hormone replacement therapy on ischaemic heart disease
Julia Hippisley-Cox
Division of General Practice, University of Nottingham, 13th Floor, Tower Building, University Park, Nottingham NG2 7RD
Br J Gen Pract 53:191-6. 2003
..Since CHD is common in women--about half of all postmenopausal women will get it and about a third of these will die from it--the effect of HRT on CHD is of great public health importance...
- Exposure to statins and risk of common cancers: a series of nested case-control studies
Yana Vinogradova
Division of Primary Care, 13th Floor, Tower Building, University Park, Nottingham, NG2 7RD, UK
BMC Cancer 11:409. 2011
..Many studies and meta-analyses have investigated the effects of statins on cancer incidence but without showing consistent effects...
- Risk of malignancy in patients with schizophrenia or bipolar disorder: nested case-control study
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, 13th Floor Tower Bldg, University Park, Nottingham NG7 2RD, England
Arch Gen Psychiatry 64:1368-76. 2007
..There is conflicting evidence on whether people with schizophrenia have a different risk of cancer from that of the general population...
- Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
Julia Hippisley-Cox
Institution 13th floor, Tower Building, University Park, Nottingham NG2 7RD
BMJ 330:1366. 2005
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- Predicting the risk of chronic Kidney Disease in men and women in England and Wales: prospective derivation and external validation of the QKidney Scores
Julia Hippisley-Cox
Division of Primary Care, 13th Floor, Tower Building, University Park, Nottingham NG2 7RD, UK
BMC Fam Pract 11:49. 2010
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- Sex inequalities in access to care for patients with diabetes in primary care: questionnaire survey
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, Nottingham
Br J Gen Pract 56:342-8. 2006
..Given the increased prevalence of diabetes, the healthcare needs and experiences of women with diabetes are increasing...
- Identifying patients with suspected renal tract cancer in primary care: derivation and validation of an algorithm
Julia Hippisley-Cox
Division of Primary Care, University Park, Nottingham
Br J Gen Pract 62:e251-60. 2012
..Earlier diagnosis of renal tract cancer could help improve survival so better tools are needed to help this...
- Antidepressant use and risk of adverse outcomes in older people: population based cohort study
Carol Coupland
Division of Primary Care, University of Nottingham, Nottingham NG7 2RD, UK
BMJ 343:d4551. 2011
..To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose...
- Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis
Julia Hippisley-Cox
Division of Primary Care, School of Community Health Sciences, University Park, Nottingham NG2 7RD
BMJ 330:1059-63. 2005
..To determine the effect of combinations of statins, aspirin, beta blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease...
- Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, Nottingham NG2 7RD
BMJ 331:1310-6. 2005
..To determine the risk of an adverse upper gastrointestinal event in patients taking different cyclo-oxygenase-2 inhibitors compared with non-selective non-steroidal anti-inflammatory drugs...
- Identification of new risk factors for pneumonia: population-based case-control study
Yana Vinogradova
Division of Primary Care, University of Nottingham, Nottingham
Br J Gen Pract 59:e329-38. 2009
..Certain conditions are established as risk factors for community-acquired pneumonia. There are a number of other conditions that may also be risk factors, but information on these is limited...
- Inequalities in the primary care of patients with coronary heart disease and serious mental health problems: a cross-sectional study
Julia Hippisley-Cox
Division of Primary Care, University of Nottingham, Nottingham, UK
Heart 93:1256-62. 2007
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- Exposure to bisphosphonates and risk of cancer: a protocol for nested case-control studies using the QResearch primary care database
Yana Vinogradova
Division of Primary Care, University of Nottingham, School of Community Health Sciences, Division of Primary Care, University Park, Nottingham, UK
BMJ Open 2:e000548. 2012
..Conditional logistic regression will be applied to produce ORs adjusted for smoking status, socioeconomic status, ethnicity, cancer-specific co-morbidities and use of other medications...
- Inequalities in uptake of influenza vaccine by deprivation and risk group: time trends analysis
Carol Coupland
Division of Primary Care, Tower Building, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
Vaccine 25:7363-71. 2007
..This general practice based study suggests that substantial increases in influenza vaccination rates have occurred across all risk groups, but that increased focus should be given to immunising high-risk patients below the age of 65...
- Symptoms and risk factors to identify men with suspected cancer in primary care: derivation and validation of an algorithm
Julia Hippisley-Cox
Division of Primary Care, Tower Building, University Park, Nottingham, NG2 7RD, UK
Br J Gen Pract 63:1-10. 2013
..Early diagnosis of cancer could improve survival so better tools are needed...
- Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study
Julia Hippisley-Cox
Division of Primary Care, University Park, Nottingham NG2 7RD, UK
BMJ 343:d4656. 2011
..To derive and validate a new clinical risk prediction algorithm (QThrombosis, www.qthrombosis.org) to estimate individual patients' risk of venous thromboembolism...
- Severe traffic injuries to children, Trent, 1992-7: time trend analysis
Carol Coupland
Division of Primary Care, University of Nottingham, Nottingham NG7 2RD, UK
BMJ 327:593-4. 2003
