Kevin P High

Summary

Publications

  1. doi request reprint Translational research in immune senescence: assessing the relevance of current models
    Kevin P High
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Semin Immunol 24:373-82. 2012
  2. pmc HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group
    Kevin P High
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1042, USA
    J Acquir Immune Defic Syndr 60:S1-18. 2012
  3. pmc JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Kidney Int 84:1207-13. 2013
  4. doi request reprint Workshop on immunizations in older adults: identifying future research agendas
    Kevin P High
    Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 58:765-76. 2010
  5. pmc Prostaglandin E2-dependent IL-23 production in aged murine dendritic cells
    Rebecca G Myer
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, 100 Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Gerontol 45:834-41. 2010
  6. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
  7. doi request reprint Acute kidney injury in older adults
    Sharon Anderson
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, 100 Medical Center Boulevard, Winston Salem, NC 27157 1042, USA
    J Am Soc Nephrol 22:28-38. 2011
  8. pmc Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates
    Johannes F Plate
    Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Shoulder Elbow Surg 22:1019-29. 2013
  9. ncbi request reprint Outcome and immune responses after Brucella abortus infection in young adult and aged mice
    Kevin P High
    Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biogerontology 8:583-93. 2007
  10. pmc Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases
    Ana Paula Oppenheimer
    Section of Infectious Diseases, Department of Medicine, Wake Forest School of Medicine, Winston Salem, NC 27109 7205, USA
    World J Gastroenterol 19:115-21. 2013

Collaborators

Detail Information

Publications13

  1. doi request reprint Translational research in immune senescence: assessing the relevance of current models
    Kevin P High
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Semin Immunol 24:373-82. 2012
    ..In this review, we outline the major advantages and limitations of current models and offer suggestions for how to move forward...
  2. pmc HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group
    Kevin P High
    Department of Internal Medicine, Section on Infectious Diseases, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1042, USA
    J Acquir Immune Defic Syndr 60:S1-18. 2012
    ....
  3. pmc JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Kidney Int 84:1207-13. 2013
    ....
  4. doi request reprint Workshop on immunizations in older adults: identifying future research agendas
    Kevin P High
    Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 58:765-76. 2010
    ....
  5. pmc Prostaglandin E2-dependent IL-23 production in aged murine dendritic cells
    Rebecca G Myer
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, 100 Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Gerontol 45:834-41. 2010
    ..These data indicate that age-related changes in DC PGE2 production are necessary, but not sufficient to induce DC IL-23 production. Such changes may play a role in the expansion of Th17 cells in the aged immune system...
  6. pmc Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults
    John R Stehle
    Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 67:1212-8. 2012
    ..We hypothesized that markers of MT, soluble CD14 (sCD14) and lipopolysaccharide (LPS) binding protein (LBP), may be a source of chronic inflammation in older persons and be associated with poorer physical function...
  7. doi request reprint Acute kidney injury in older adults
    Sharon Anderson
    Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, 100 Medical Center Boulevard, Winston Salem, NC 27157 1042, USA
    J Am Soc Nephrol 22:28-38. 2011
    ..Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury...
  8. pmc Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates
    Johannes F Plate
    Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Shoulder Elbow Surg 22:1019-29. 2013
    ..We hypothesized that age-related degenerative changes in the shoulders of nonhuman primates would resemble those observed in aging humans...
  9. ncbi request reprint Outcome and immune responses after Brucella abortus infection in young adult and aged mice
    Kevin P High
    Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biogerontology 8:583-93. 2007
    ..Brucella in aged mice...
  10. pmc Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases
    Ana Paula Oppenheimer
    Section of Infectious Diseases, Department of Medicine, Wake Forest School of Medicine, Winston Salem, NC 27109 7205, USA
    World J Gastroenterol 19:115-21. 2013
    ..In HIV-positive patients with progressive cholestasis, early identification of VBDS and referral for transplantation may improve outcomes...
  11. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
  12. pmc Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications
    Rabab El Mezayen
    Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Aging Cell 8:553-65. 2009
    ..This suggests epigenetic and transcriptional mechanisms contribute to dysregulated inflammatory and autoimmune responses associated with aging...
  13. ncbi request reprint Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysis
    Abbie C Connoy
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, 100 Medical Center Blvd, Winston Salem, NC 27157 1042, USA
    Exp Gerontol 41:225-9. 2006
    ..The senescence marker p16INK4a increases in B cells and CD8+T cells within the spleen and can be measured by flow cytometry...