Ian B Hickie

Summary

Publications

  1. doi request reprint Evaluating differential developmental trajectories to adolescent-onset mood and psychotic disorders
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 13:303. 2013
  2. pmc More age-care staff report helping care recipients following a brief depression awareness raising intervention
    Joanna Atkins
    Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia
    BMC Nurs 12:10. 2013
  3. doi request reprint Applying clinical staging to young people who present for mental health care
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales
    Early Interv Psychiatry 7:31-43. 2013
  4. pmc Clinical classification in mental health at the cross-roads: which direction next?
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown 2050, Australia
    BMC Med 11:125. 2013
  5. pmc Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
    BMC Med 11:79. 2013
  6. ncbi request reprint The 2010 Rudd plan: will it actually deliver better health services?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 192:511-2. 2010
  7. doi request reprint Novel melatonin-based therapies: potential advances in the treatment of major depression
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Lancet 378:621-31. 2011
  8. doi request reprint Youth mental health: we know where we are and we can now say where we need to go next
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    Early Interv Psychiatry 5:63-9. 2011
  9. doi request reprint Social cognitive performance as a marker of positive psychotic symptoms in young people seeking help for mental health problems
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Schizophr Res 149:77-82. 2013
  10. pmc Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    J Psychiatry Neurosci 37:313-21. 2012

Detail Information

Publications91

  1. doi request reprint Evaluating differential developmental trajectories to adolescent-onset mood and psychotic disorders
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 13:303. 2013
    ....
  2. pmc More age-care staff report helping care recipients following a brief depression awareness raising intervention
    Joanna Atkins
    Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia
    BMC Nurs 12:10. 2013
    ....
  3. doi request reprint Applying clinical staging to young people who present for mental health care
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales
    Early Interv Psychiatry 7:31-43. 2013
    ....
  4. pmc Clinical classification in mental health at the cross-roads: which direction next?
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown 2050, Australia
    BMC Med 11:125. 2013
    ..Although this enhanced epidemiology and health services planning, it failed to link broad diagnostic groupings to underlying pathophysiology or specific treatment response...
  5. pmc Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression
    Ian B Hickie
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
    BMC Med 11:79. 2013
    ..Due to very considerable progress in the basic and clinical neurosciences of sleep-wake cycles and underlying circadian systems this situation is now rapidly changing...
  6. ncbi request reprint The 2010 Rudd plan: will it actually deliver better health services?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 192:511-2. 2010
  7. doi request reprint Novel melatonin-based therapies: potential advances in the treatment of major depression
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Lancet 378:621-31. 2011
    ..As agomelatine does not raise serotonin levels, it has less potential for the common gastrointestinal, sexual, or metabolic side-effects that characterise many other antidepressant compounds...
  8. doi request reprint Youth mental health: we know where we are and we can now say where we need to go next
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    Early Interv Psychiatry 5:63-9. 2011
    ..To provide an overview of the state of knowledge relevant to the development of youth-specific mental health initiatives...
  9. doi request reprint Social cognitive performance as a marker of positive psychotic symptoms in young people seeking help for mental health problems
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Schizophr Res 149:77-82. 2013
    ..Research is also needed to investigate whether targeted social cognition treatments reduce risk for the development of positive psychotic symptoms. ..
  10. pmc Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    J Psychiatry Neurosci 37:313-21. 2012
    ..Further research is warranted to determine whether patients with bipolar-spectrum disorders show similar impairments in these biomarkers...
  11. pmc Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation
    Rico S C Lee
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    PLoS ONE 8:e58176. 2013
    ..The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning...
  12. ncbi request reprint Psychomotor slowing in older patients with major depression: Relationships with blood flow in the caudate nucleus and white matter lesions
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Psychiatry Res 155:211-20. 2007
    ..Reduced %rCBF is associated with demonstrable psychomotor slowing and presence of WMLs. While psychomotor slowing is determined in part by subcortical changes, other cortical and illness-dependent factors are likely to be relevant...
  13. pmc Mismatch negativity/P3a complex in young people with psychiatric disorders: a cluster analysis
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    PLoS ONE 7:e51871. 2012
    ..A data driven approach may help to further elucidate novel patterns of MMN/P3a amplitudes that characterise distinct subgroups in patients with emerging psychiatric disorders...
  14. doi request reprint Reduced mismatch negativity in mild cognitive impairment: associations with neuropsychological performance
    Loren Mowszowski
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
    J Alzheimers Dis 30:209-19. 2012
    ..These findings overall suggest that MMN may be a viable neurophysiological biomarker of underlying disease in this 'at risk' group...
  15. doi request reprint Emotion recognition in mild cognitive impairment: relationship to psychosocial disability and caregiver burden
    Donna McCade
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
    J Geriatr Psychiatry Neurol 26:165-73. 2013
    ..Emerging evidence supports the presence of very early emotion recognition difficulties in mild cognitive impairment (MCI); however, the relationship between these impairments and psychosocial measures is not yet explored...
  16. doi request reprint Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia
    J Affect Disord 138:71-8. 2012
    ..This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability...
  17. pmc Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 12:234. 2012
    ..This study determines the socio-demographic, psychopathological and illness-stage correlates of suicidal ideation in young persons attending headspace services...
  18. doi request reprint Distinguishing young people with emerging bipolar disorders from those with unipolar depression
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    J Affect Disord 144:208-15. 2013
    ..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
  19. doi request reprint Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Sydney, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 34:822-9. 2010
    ..Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning...
  20. ncbi request reprint Targeted primary care-based mental health services for young Australians
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
    Med J Aust 196:136-40. 2012
    ....
  21. doi request reprint Sleep disturbance relates to neuropsychological functioning in late-life depression
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, Australia
    J Affect Disord 132:139-45. 2011
    ..Sleep-wake disturbance in older people is a risk factor for depression onset and recurrence. The aim of this study was to determine if objective sleep-wake disturbance in late-life depression relates to neuropsychological functioning...
  22. ncbi request reprint Australian mental health reform: time for real outcomes
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, PO Box M160, Camperdown, NSW 2050, Australia
    Med J Aust 182:401-6. 2005
    ..New independent and national reporting systems on the progress of mental health reform are urgently required...
  23. doi request reprint Does sleep disturbance mediate neuropsychological functioning in older people with depression?
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 94 Mallet Street, Camperdown NSW 2050, Australia
    J Affect Disord 116:139-43. 2009
    ..However, the association between sleep disturbance and neuropsychological functioning in depression has not been well evaluated. The current study therefore aimed to investigate these relationships...
  24. pmc Social cognition deficits and psychopathic traits in young people seeking mental health treatment
    Anita van Zwieten
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    PLoS ONE 8:e67753. 2013
    ..Research is needed to establish the directionality of this relationship and to determine whether social cognition training is an effective treatment amongst young people with psychopathic tendencies. ..
  25. doi request reprint Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
    Gail A Alvares
    Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
    Psychoneuroendocrinology 37:2022-31. 2012
    ..It adds to a growing body of evidence that oxytocin seems to attenuate negative cognitive responses to stress in anxious individuals...
  26. doi request reprint MMN/P3a deficits in first episode psychosis: comparing schizophrenia-spectrum and affective-spectrum subgroups
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Schizophr Res 130:203-9. 2011
    ..First-episode psychosis (FEP) patients show reduced amplitudes of the 'MMN/P3a complex', but it is unclear whether this occurs across the FEP spectrum...
  27. doi request reprint Fronto-striatal correlates of impaired implicit sequence learning in major depression: an fMRI study
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    J Affect Disord 125:256-61. 2010
    ..This study sought to probe the integrity of fronto-striatal circuits using functional magnetic resonance imaging (fMRI) in conjunction with a theoretically-driven motor sequencing implicit learning (IL) task...
  28. ncbi request reprint Mental health expenditure in Australia: time for affirmative action
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, New South Wales
    Aust N Z J Public Health 30:119-22. 2006
    ..Urgent investments in cost-effective modes of care are required and these should prioritise increased access among those subpopulations disadvantaged by other social, economic or geographic factors...
  29. pmc Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trial
    Nicole L Cockayne
    Brain and Mind Research Institute, The University of Sydney, Camperdown NSW, Australia
    BMC Psychiatry 11:10. 2011
    ....
  30. ncbi request reprint Increased access to evidence-based primary mental health care: will the implementation match the rhetoric?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 187:100-3. 2007
    ..The responsibility for achieving the best outcome does not lie only with governments. To date, the professions have not placed enough emphasis on systematically adopting evidence-based forms of collaborative care...
  31. pmc Young men's attitudes and behaviour in relation to mental health and technology: implications for the development of online mental health services
    Louise A Ellis
    Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
    BMC Psychiatry 13:119. 2013
    ..This mixed-methods study was designed to explore young Australian men's attitudes and behaviour in relation to mental health and technology use to inform the development of online mental health services for young men...
  32. pmc Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study
    Jim Lagopoulos
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    PLoS ONE 8:e59108. 2013
    ..Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons...
  33. doi request reprint Delayed sleep phase in young people with unipolar or bipolar affective disorders
    Rébecca Robillard
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
    J Affect Disord 145:260-3. 2013
    ..Despite marked changes in circadian rhythms during the normal course of adolescence and young adulthood, less is known about changes in the 24-h sleep-wake cycle in young persons with mood disorders...
  34. pmc Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
    Sean N Hatton
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    BMC Psychiatry 12:45. 2012
    ..This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care...
  35. doi request reprint Impaired verbal memory in young adults with unipolar and bipolar depression
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Early Interv Psychiatry 4:227-33. 2010
    ..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
  36. doi request reprint The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features
    Sharon L Naismith
    Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Prog Neurobiol 98:99-143. 2012
    ..Ultimately, future research must aim to evaluate whether basic biomedical knowledge can be successfully translated into enhanced health outcomes via the implementation of early intervention paradigms...
  37. doi request reprint Sleep well, think well: sleep-wake disturbance in mild cognitive impairment
    Sharon L Naismith
    Ageing Brain Centre, Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    J Geriatr Psychiatry Neurol 23:123-30. 2010
    ..This preliminary data suggests that sleep-wake disturbance in nonamnestic forms of MCI is related to cognitive functioning and may be indicative of shared neurobiological underpinnings...
  38. doi request reprint Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptoms
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    J Int Neuropsychol Soc 17:267-76. 2011
    ..Distinct neuropsychological profiling may help to predict later psychiatric outcomes and enhance individually-tailored early intervention strategies...
  39. doi request reprint Can older "at risk" adults benefit from psychoeducation targeting healthy brain aging?
    Louisa M Norrie
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Int Psychogeriatr 23:413-24. 2011
    ..The current study sought to investigate whether older adults "at risk" of cognitive decline benefit from psychoeducation targeting healthy brain aging...
  40. doi request reprint Heart rate variability predicts alcohol craving in alcohol dependent outpatients: further evidence for HRV as a psychophysiological marker of self-regulation
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia
    Drug Alcohol Depend 132:395-8. 2013
    ..Thus, the aim of the present study was to determine whether HRV predicts alcohol craving in dependent individuals in the community...
  41. doi request reprint Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service
    Blake A Hamilton
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2050 Australia
    J Affect Disord 131:84-91. 2011
    ..This study examined patient self-reported disability in young people attending a designated early intervention service...
  42. doi request reprint Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach
    Sharon L Naismith
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    J Affect Disord 121:258-62. 2010
    ..Some of these changes persist despite antidepressant treatment. While research in other areas of psychiatry has shown cognitive training techniques to be effective, only one study has evaluated this approach in depression...
  43. doi request reprint Sleep-wake cycle in young and older persons with a lifetime history of mood disorders
    Rébecca Robillard
    Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia
    PLoS ONE 9:e87763. 2014
    ..Conversely, disruptions in sleep consolidation seem more stable across age. ..
  44. doi request reprint Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions?
    Sharon L Naismith
    Brain and Mind Research Institute, The George Institute for International Health, University of Sydney, Sydney, New South Wales, Australia
    Early Interv Psychiatry 3:19-27. 2009
    ..Evidence for the beneficial effects of providing relevant interventions is assessed...
  45. ncbi request reprint Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    J Affect Disord 98:137-42. 2007
    ....
  46. doi request reprint Heart rate variability is associated with emotion recognition: direct evidence for a relationship between the autonomic nervous system and social cognition
    Daniel S Quintana
    SCAN Research and Teaching Unit, School of Psychology, University of Sydney, Australia
    Int J Psychophysiol 86:168-72. 2012
    ..Our data suggests that increased HRV may provide a novel marker of one's ability to recognize emotions in humans. Implications for understanding the biological basis of emotion recognition, and social impairment in humans are discussed...
  47. doi request reprint Recognition and treatment of depression: a comparison of Australian and Chinese medical students
    Ye Rong
    Brain and Mind Research Institute, The University of Sydney, Camperdown NSW 2050, Australia
    Soc Psychiatry Psychiatr Epidemiol 44:636-42. 2009
    ..To improve services, we need to ensure health professionals have an appropriate understanding of depression and its treatments. This study compares the level of awareness of depression between Chinese and Australian medical students...
  48. doi request reprint The role of mild depression in sleep disturbance and quality of life in Parkinson's disease
    Sharon L Naismith
    Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    J Neuropsychiatry Clin Neurosci 22:384-9. 2010
    ..Overall, these data highlight the need to screen patients for even mild levels of depression because its relationship with sleep and quality of life are evident early in the disease course...
  49. doi request reprint The impact of gender on early ill-health retirement in people with heart disease and depression
    Matt B Paradise
    Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    Aust N Z J Psychiatry 46:249-56. 2012
    ..Given the deleterious effects of ill-health retirement, identifying at-risk groups is important for guiding targeted interventions...
  50. pmc Frontal lobe changes occur early in the course of affective disorders in young people
    Jim Lagopoulos
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    BMC Psychiatry 12:4. 2012
    ..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately...
  51. doi request reprint Alcohol use and mismatch negativity in young patients with psychotic disorder
    Kate M Chitty
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Neuroreport 22:918-22. 2011
    ..This may reflect an additive effect of N-methyl-D-aspartate receptor hypofunction and high-alcohol consumption...
  52. doi request reprint Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program
    Sharon L Naismith
    Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Am J Geriatr Psychiatry 19:240-8. 2011
    ..To evaluate the efficacy of a multifactorial cognitive training (CT) program for older people with a lifetime history of depressive disorder...
  53. pmc Disability in major depression related to self-rated and objectively-measured cognitive deficits: a preliminary study
    Sharon L Naismith
    Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    BMC Psychiatry 7:32. 2007
    ..This study examined the relationships between self-rated disability in persons with MD and both self-rated and objectively-measured cognitive functioning...
  54. doi request reprint Recent advances in sleep-wake cycle and biological rhythms in bipolar disorder
    Rébecca Robillard
    Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia
    Curr Psychiatry Rep 15:402. 2013
    ..Increasing evidence now supports the integration of behavioural or pharmacological therapeutic strategies that target the sleep-wake and circadian systems in the ongoing treatment of various phases of bipolar disorder. ..
  55. pmc A preliminary study of aged care facility staff indicates limitations in awareness of the link between depression and physical morbidity
    Joanna Atkins
    Brain and Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW, 2050, Australia
    BMC Geriatr 13:30. 2013
    ..This study assessed the awareness and knowledge of age-care staff of the link between physical morbidity and depression...
  56. doi request reprint Neuropsychological functioning is compromised in binge drinking young adults with depression
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia Electronic address
    Psychiatry Res 210:256-62. 2013
    ..The findings suggest that when treating young people with a depressive disorder, strategies targeting binge drinking may contribute to preventing potential neurobiological changes underlying poorer long-term clinical outcomes. ..
  57. pmc Rethinking the dose-response relationship between usage and outcome in an online intervention for depression: randomized controlled trial
    Liesje Donkin
    Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia
    J Med Internet Res 15:e231. 2013
    ..Analysis of alternative measures of usage and their relationship to outcome may help to understand how much of the intervention users may need to obtain a clinically significant benefit from the program...
  58. pmc Reduced heart rate variability in social anxiety disorder: associations with gender and symptom severity
    Gail A Alvares
    Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e70468. 2013
    ..The purpose of this study was to examine whether heart rate variability was reduced in treatment-seeking patients diagnosed with social anxiety disorder, a disorder characterized by social fear and avoidance...
  59. doi request reprint Identification and management of depression in Australian primary care and access to specialist mental health care
    Nicholas Glozier
    Brain and Mind Research Institute, Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, New South Wales 2050, Australia
    Psychiatr Serv 63:1247-51. 2012
    ..The authors evaluated management of illness, including access to specialist mental health care, among people identified by general practitioners as clinically depressed...
  60. doi request reprint Arginine Vasopressin selectively enhances recognition of sexual cues in male humans
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Camperdown, Sydney, NSW, Australia
    Psychoneuroendocrinology 36:294-7. 2011
    ..They further extend animal and human genetic studies linking Arginine Vasopressin to sexual behavior in males. Findings suggest an important cognitive mechanism that could enhance sexual behaviors in humans...
  61. doi request reprint The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in Parkinson's Disease
    Sharon L Naismith
    Parkinson s Disease Research Clinic, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, 94 Mallett St, Camperdown, NSW 2050, Australia
    Clin Neurol Neurosurg 112:420-3. 2010
    ..In this study, we sought to evaluate the utility of actigraphy for examining symptoms of rapid eye movement sleep behaviour disorder (RSBD)...
  62. doi request reprint Delayed preattentional functioning in early psychosis patients with cannabis use
    Nicole Pesa
    School of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia
    Psychopharmacology (Berl) 222:507-18. 2012
    ..The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-D-aspartate receptors which are involved in MMN generation...
  63. pmc Improving knowledge and attitudes towards depression: a controlled trial among Chinese medical students
    Ye Rong
    Brain and Mind Research Institute, The University of Sydney, Sydney, Australia
    BMC Psychiatry 11:36. 2011
    ..The purpose of this study was to determine whether a self-directed learning strategy as a part of student-centred education improved knowledge of and attitudes towards depression among Chinese medical students...
  64. doi request reprint How does social functioning in the early stages of psychosis relate to depression and social anxiety?
    Catherine Chudleigh
    Clinical Research Unit, Brain and Mind Research Institute, New South Wales, Australia
    Early Interv Psychiatry 5:224-32. 2011
    ....
  65. pmc A systematic review of the impact of adherence on the effectiveness of e-therapies
    Liesje Donkin
    Brain and Mind Research Institute, The University of Sydney, Camperdown, Australia
    J Med Internet Res 13:e52. 2011
    ..Understanding the role of adherence may be crucial to understanding how program usage influences the effectiveness of e-therapy interventions...
  66. doi request reprint Longitudinal associations between mismatch negativity and disability in early schizophrenia- and affective-spectrum disorders
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Sydney, Australia Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:161-9. 2013
    ....
  67. doi request reprint Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biol Psychiatry 67:692-4. 2010
    ..Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems...
  68. ncbi request reprint Practitioner-supported delivery of internet-based cognitive behaviour therapy: evaluation of the feasibility of conducting a cluster randomised trial
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 192:S31-5. 2010
    ..To determine the feasibility of conducting a cluster randomised trial in Australia of the effectiveness of general practitioner-supported delivery of internet-based cognitive behaviour therapy (CBT) and enhanced psychological care...
  69. doi request reprint Clinical staging model applied to young people presenting with social anxiety
    Patrick J F Clarke
    Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Early Interv Psychiatry 6:256-64. 2012
    ..The goal was to provide a detailed description of common clinical stage of those presenting for treatment of social anxiety, and to delineate the associations between symptom type, severity and clinical stage...
  70. ncbi request reprint Responding to experiences of young people with common mental health problems attending Australian general practice
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 187:S47-52. 2007
    ..Improved access to specific psychological treatments should remain a priority...
  71. doi request reprint Perspectives of young people on depression: awareness, experiences, attitudes and treatment preferences
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, Sydney, New South Wales, Australia
    Early Interv Psychiatry 1:333-9. 2007
    ..Ascertaining current knowledge and attitudes towards depression among young people is vital for developing campaigns promoting community awareness and early intervention...
  72. ncbi request reprint Can we track the impact of Australian mental health research?
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
    Aust N Z J Psychiatry 39:591-9. 2005
    ..Specifically, we describe the research output of nations, Australian states, Australian and New Zealand institutions and Australian and New Zealand researchers using citation rates...
  73. pmc Young men, mental health, and technology: implications for service design and delivery in the digital age
    Louise A Ellis
    Brain and Mind Research Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    J Med Internet Res 14:e160. 2012
    ....
  74. doi request reprint Intranasal arginine vasopressin enhances the encoding of happy and angry faces in humans
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Biol Psychiatry 67:1220-2. 2010
    ..There has been little research in humans exploring its effect on social cognition, including the encoding of social memories...
  75. pmc Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e44014. 2012
    ..Furthermore, no studies have examined the impact of OT on HRV under resting conditions, which provides an index of maximal capacity for social engagement...
  76. ncbi request reprint What can alert the general practitioner to people whose common mental health problems are unrecognised?
    Kay A Wilhelm
    Consultation Liaison Psychiatry, St Vincent s Hospital, Sydney, NSW, Australia
    Med J Aust 188:S114-8. 2008
    ..To assess the characteristics of people with common mental health problems who are recognised by their general practitioner, and those who are not...
  77. doi request reprint Pathways to alcohol-induced brain impairment in young people: a review
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Cortex 49:3-17. 2013
    ....
  78. pmc Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study
    Matt B Paradise
    Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW 2050, Australia
    BMC Psychiatry 11:108. 2011
    ..We therefore aimed to test the hypothesis that vascular risk factors were associated with SMC, independent of psychological distress, in a middle-aged community-dwelling population...
  79. ncbi request reprint Amphetamine psychosis: a model for studying the onset and course of psychosis
    Daniel F Hermens
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW
    Med J Aust 190:S22-5. 2009
    ..It is possible that the same approach may be used in young people known to be at risk of schizophrenia and related disorders, by informing models that involve other environmental or genetic risks...
  80. ncbi request reprint Were the budgetary reforms to the Better Access to Mental Health Care initiative appropriate?--no
    Sebastian Rosenberg
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW sebastian rosenbergATsydney edu au
    Med J Aust 194:595. 2011
    ..Mental health policy expert Sebastian Rosenberg and psychiatrist Ian Hickie want more change...
  81. ncbi request reprint Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors
    Sharon L Naismith
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Clin Exp Neuropsychol 25:866-77. 2003
    ..These findings underscore the need to consider subtypes when investigating neuropsychological deficits in patients with depression...
  82. ncbi request reprint Therapeutic signposts: using biomarkers to guide better treatment of schizophrenia and other psychotic disorders
    Richard Banati
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW
    Med J Aust 190:S26-32. 2009
    ..A specific example of the use of a novel positron emission tomography marker of progressive brain disease in patients with schizophrenia is described...
  83. ncbi request reprint Effect of oral appliance therapy on neurobehavioral functioning in obstructive sleep apnea: a randomized controlled trial
    Sharon L Naismith
    Department of Respiratory and Sleep Medicine, St George Hospital, The University of New South Wales, Sydney, Australia
    J Clin Sleep Med 1:374-80. 2005
    ..This study aimed to assess the efficacy of a custom-made mandibular advancement splint for the treatment of obstructive sleep apnea with respect to neuropsychological functioning and mood state...
  84. doi request reprint Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection
    Gail A Alvares
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Exp Clin Psychopharmacol 18:316-21. 2010
    ..The results suggest that in an explicitly aversive context, oxytocin does not buffer against the immediate impact of blunt social rejection...
  85. ncbi request reprint Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction?
    Sharon L Naismith
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Psychol Med 36:313-23. 2006
    ..Consequently, it is ideally suited for testing elements of the frontostriatal model of major depression and performance can be related to key clinical, neuropsychological, vascular and biochemical data...
  86. doi request reprint Electroconvulsive therapy-induced persistent retrograde amnesia: could it be minimised by ketamine or other pharmacological approaches?
    Emily M Gregory-Roberts
    Brain and Mind Research Institute, University of Sydney, Australia
    J Affect Disord 126:39-45. 2010
    ..This review examines mechanisms for electroconvulsive therapy-induced retrograde amnesia, and evaluates the suitability of the anaesthetic ketamine for preventing this amnestic outcome...
  87. ncbi request reprint Effect of sertraline on symptoms and survival in patients with advanced cancer, but without major depression: a placebo-controlled double-blind randomised trial
    Martin R Stockler
    NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
    Lancet Oncol 8:603-12. 2007
    ..We aimed to identify the effects of an established antidepressant on these symptoms and survival in patients with advanced cancer who did not have major depression as assessed by clinicians...
  88. ncbi request reprint Making new choices about antidepressants in Australia: the long view 1975-2002
    Andrea Mant
    Quality Use of Medicines, South East Health, Sydney Hospital, PO Box 1614, Sydney, NSW 2001, Australia
    Med J Aust 181:S21-4. 2004
    ..To examine trends in types of antidepressant medications prescribed in Australia between 1975 and 2002...
  89. ncbi request reprint Reducing the burden of depression: are we making progress in Australia?
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, PO Box M160, Camperdown, NSW 1450, Australia
    Med J Aust 181:S4-5. 2004
  90. ncbi request reprint Measuring outcomes in patients with depression or anxiety: an essential part of clinical practice
    Ian B Hickie
    School of Psychiatry, University of New South Wales at St George Hospital, Sydney, NSW
    Med J Aust 177:205-7. 2002
    ..As depression and anxiety are relapsing or chronic conditions and are often comorbid with other medical conditions, standard outcome measures should be incorporated into the management plans for all such patients...
  91. ncbi request reprint General practitioners' response to depression and anxiety in the Australian community: a preliminary analysis
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, NSW 2039, Australia
    Med J Aust 181:S15-20. 2004
    ....