Daniel Hesselson

Summary

Publications

  1. pmc Suppression of Ptf1a activity induces acinar-to-endocrine conversion
    Daniel Hesselson
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics, and Human Genetics, Institute for Regeneration Medicine, Liver Center, and Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA
    Curr Biol 21:712-7. 2011
  2. doi request reprint Metabolic regulation of cellular plasticity in the pancreas
    Nikolay Ninov
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, The Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4 th Street, San Francisco, CA 94158, USA
    Curr Biol 23:1242-50. 2013
  3. pmc Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Liver Center and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003650. 2013
  4. pmc Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Dev Biol 334:213-23. 2009
  5. pmc Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
    Philipp Gut
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 9:97-104. 2013
  6. pmc Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling
    Daniel Hesselson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Liver Center and Diabetes Center, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 106:14896-901. 2009

Collaborators

Detail Information

Publications6

  1. pmc Suppression of Ptf1a activity induces acinar-to-endocrine conversion
    Daniel Hesselson
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics, and Human Genetics, Institute for Regeneration Medicine, Liver Center, and Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA
    Curr Biol 21:712-7. 2011
    ..These data indicate that targeted postembryonic disruption of the acinar cell fate can restore the developmental plasticity that is lost during development...
  2. doi request reprint Metabolic regulation of cellular plasticity in the pancreas
    Nikolay Ninov
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, The Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4 th Street, San Francisco, CA 94158, USA
    Curr Biol 23:1242-50. 2013
    ..Thus, this study reveals critical insights into how cells modulate their plasticity in response to metabolic cues and identifies nutrient-sensitive progenitors in the mature pancreas. ..
  3. pmc Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Liver Center and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003650. 2013
    ..Altogether, these results reveal a novel and essential role for HGF signaling in the intrapancreatic ducts during exocrine morphogenesis...
  4. pmc Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration
    Ryan M Anderson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Dev Biol 334:213-23. 2009
    ..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate...
  5. pmc Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
    Philipp Gut
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    Nat Chem Biol 9:97-104. 2013
    ..Thus, using a whole-organism screening strategy, this study has identified new small-molecule activators of fasting metabolism...
  6. pmc Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling
    Daniel Hesselson
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Liver Center and Diabetes Center, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 106:14896-901. 2009
    ..g., diabetes mellitus). Our data reveal the existence of distinct populations of beta-cells in vivo and should help develop better strategies to regulate beta-cell differentiation and proliferation...