Leif Hertz

Summary

Publications

  1. pmc The Glutamate-Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation
    Leif Hertz
    Clinical Pharmacology, Medical University of China Shenyang, China
    Front Endocrinol (Lausanne) 4:59. 2013
  2. pmc Brain glutamine synthesis requires neuronal aspartate: a commentary
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    J Cereb Blood Flow Metab 31:384-7. 2011
  3. pmc Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Neurochem Int 57:411-20. 2010
  4. doi request reprint Astrocytic energy metabolism and glutamate formation--relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, No 92 Beier Road, Heping District, Shenyang, PR China
    Magn Reson Imaging 29:1319-29. 2011
  5. doi request reprint Isotope-based quantitation of uptake, release, and metabolism of glutamate and glucose in cultured astrocytes
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    Methods Mol Biol 814:305-23. 2012
  6. doi request reprint Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, People s Republic of China
    Psychopharmacology (Berl) 201:443-58. 2008
  7. doi request reprint Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Heping District, Shenyang, PR China
    Neurochem Int 57:432-9. 2010
  8. doi request reprint Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Neurochem Int 61:1325-32. 2012
  9. doi request reprint ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors
    Ting Du
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Neurochem Int 55:593-600. 2009
  10. ncbi request reprint Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    J Cereb Blood Flow Metab 27:219-49. 2007

Collaborators

Detail Information

Publications45

  1. pmc The Glutamate-Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation
    Leif Hertz
    Clinical Pharmacology, Medical University of China Shenyang, China
    Front Endocrinol (Lausanne) 4:59. 2013
    ..The possibility is suggested that analogous maturational changes may contribute to differences in the way learning is accomplished in the newborn human brain and during later development...
  2. pmc Brain glutamine synthesis requires neuronal aspartate: a commentary
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    J Cereb Blood Flow Metab 31:384-7. 2011
    ..The model is consistent with experimental observations made by Pardo et al...
  3. pmc Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Neurochem Int 57:411-20. 2010
    ..The Ca(2+)- and cAMP-mediated association between energy-consuming and energy-yielding processes is emphasized...
  4. doi request reprint Astrocytic energy metabolism and glutamate formation--relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking
    Leif Hertz
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, No 92 Beier Road, Heping District, Shenyang, PR China
    Magn Reson Imaging 29:1319-29. 2011
    ....
  5. doi request reprint Isotope-based quantitation of uptake, release, and metabolism of glutamate and glucose in cultured astrocytes
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    Methods Mol Biol 814:305-23. 2012
    ..References are made to the in vivo situation, and the importance of using metabolically competent cultures is emphasized...
  6. doi request reprint Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, People s Republic of China
    Psychopharmacology (Berl) 201:443-58. 2008
    ..Part of these receptors in brain are on astrocytes, where fluoxetine causes an increase in free cytosolic calcium concentration ([Ca(2+)](i)) and phosphorylation of extracellular regulated kinase 1 and 2 (ERK(1/2))...
  7. doi request reprint Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Heping District, Shenyang, PR China
    Neurochem Int 57:432-9. 2010
    ..In contrast the relevance of the observed 5-HT(2C) receptors on astrocytes is questioned...
  8. doi request reprint Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Neurochem Int 61:1325-32. 2012
    ..The same level of aralar expression was reached in well-differentiated astrocyte cultures, but not until late development, coinciding with the late-maturing brain capability for glutamate formation and degradation...
  9. doi request reprint ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors
    Ting Du
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Neurochem Int 55:593-600. 2009
    ....
  10. ncbi request reprint Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    J Cereb Blood Flow Metab 27:219-49. 2007
    ....
  11. doi request reprint Astrocytic alkalinization by therapeutically relevant lithium concentrations: implications for myo-inositol depletion
    Dan Song
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    Psychopharmacology (Berl) 200:187-95. 2008
    ..In this study, we therefore investigated Li+ effects on intracellular pH in astrocytes, measured by 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) fluorescence...
  12. doi request reprint Astrocyte ERK phosphorylation precedes K(+)-induced swelling but follows hypotonicity-induced swelling
    Liping Cai
    Department of Clinical Pharmacology, China Medical University, Shenyang, China
    Neuropathology 31:250-64. 2011
    ..In the former, inhibition of the MAP kinase pathway, but not of EGF receptor activation, abolishes ERK phosphorylation, but has no effect on swelling, indicating that activation of ERK is a result, not a cause, of the swelling...
  13. doi request reprint 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'
    Shiquen Zhang
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    Neuron Glia Biol 6:113-25. 2010
    ..One micromolar of paroxetine, fluvoxamine or sertraline increased cPLA2a expression during chronic treatment; citalopram had a similar effect at 0.1-0.5 μM; these are therapeutically relevant concentrations...
  14. doi request reprint Mechanisms for L-channel-mediated increase in [Ca(2+)]i and its reduction by anti-bipolar drugs in cultured astrocytes combined with its mRNA expression in freshly isolated cells support the importance of astrocytic L-channels
    Enzhi Yan
    Department of Clinical Pharmacology and Institute of Pathology and Pathophysiology, China Medical University, Shenyang, PR China
    Cell Calcium 54:335-42. 2013
    ..Finally, expression of mRNA for Cav1.3 is demonstrated in freshly separated astrocytes from normal brain. ..
  15. doi request reprint Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH
    Hui Fu
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Neurochem Int 61:187-94. 2012
    ..At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification, consistent with the transporter's pH sensitivity reported in the literature...
  16. ncbi request reprint Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation
    Baoman Li
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Psychopharmacology (Berl) 207:1-12. 2009
    ..0 microM) upregulates Ca(2+)-dependent phospholipase A(2) (cPLA(2)), which releases arachidonic acid from the sn-2 position of membrane-bound phospholipid, without effect on secretory PLA(2) (sPLA(2)) and intracellular PLA(2) (iPLA(2))...
  17. doi request reprint What learning in day-old chickens can teach a neurochemist: focus on astrocyte metabolism
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, China
    J Neurochem 109:10-6. 2009
    ..The importance of glycogen reflects that it selectively supports de novo synthesis of transmitter glutamate by combined pyruvate dehydrogenation and carboxylation in astrocytes...
  18. doi request reprint Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent
    Ting Du
    Department of Clinical Pharmacology, China Medical University, Shenyang, China
    J Neurochem 115:1007-23. 2010
    ....
  19. ncbi request reprint Requirement of glycogenolysis for uptake of increased extracellular K+ in astrocytes: potential implications for K+ homeostasis and glycogen usage in brain
    Junnan Xu
    Department of Clinical Pharmacology, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Neurochem Res 38:472-85. 2013
    ..This will allow Kir1.4-mediated release and reuptake by the less powerful neuronal Na(+),K(+)-ATPase...
  20. ncbi request reprint Energy metabolism in brain cells: effects of elevated ammonia concentrations
    Leif Hertz
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Metab Brain Dis 22:199-218. 2007
    ..This effect occurs in both neurons and astrocytes, is unrelated to MAS activity and seen after chronic treatment with ammonia even in the absence of elevated ammonia concentrations...
  21. doi request reprint Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Neuropharmacology 57:375-85. 2009
    ..Possible relationships between these and previously demonstrated effects are discussed...
  22. pmc Fluoxetine affects GluK2 editing, glutamate-evoked Ca(2+) influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes
    Baoman Li
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, China
    J Psychiatry Neurosci 36:322-38. 2011
    ....
  23. ncbi request reprint Comparison between drug-induced and K⁺-induced changes in molar acid extrusion fluxes (JH⁺) and in energy consumption rates in astrocytes
    Dan Song
    Department of Clinical Pharmacology and Institute of Pathology and Pathophysiology, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Neurochem Res 38:2364-74. 2013
    ..Drug-induced up-regulation of acid extrusion flux was slow and less than physiologically seen after increase in K(+) concentration. Energetically, K(+) uptake is much costlier than NBCe1 activity...
  24. doi request reprint Cell-specific mRNA alterations in Na+, K+-ATPase α and β isoforms and FXYD in mice treated chronically with carbamazepine, an anti-bipolar drug
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, No 92 Beier Road, Heping District, Shenyang, People s Republic of China
    Neurochem Res 38:834-41. 2013
    ..This process seems to be important for K(+) homeostasis of the cellular level of the brain (Xu et al. Neurochem Res E-pub Dec. 12, 2012)...
  25. doi request reprint Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-)
    Li Gu
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Toxicol Appl Pharmacol 242:209-23. 2010
    ....
  26. doi request reprint Ouabain binding kinetics and FXYD7 expression in astrocytes and neurons in primary cultures: implications for cellular contributions to extracellular K+ homeostasis?
    Liang Peng
    Department of Clinical Pharmacology, China Medical University, Shenyang, P R China
    Neuron Glia Biol 6:127-35. 2010
    ..The role of these characteristics for K+ homeostasis are discussed...
  27. ncbi request reprint Glutamine as an energy substrate in cultured neurons during glucose deprivation
    Liang Peng
    Department of Clinical Pharmacology, China Medical University, Shenyang, China
    J Neurosci Res 85:3480-6. 2007
    ....
  28. doi request reprint Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?
    Liang Peng
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Pharmacol Biochem Behav 100:712-25. 2012
    ..A resultant strengthening of neuronal afterhyperpolarization may cause reduced NMDA-mediated activity...
  29. doi request reprint Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity
    Baoman Li
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Cell Calcium 50:42-53. 2011
    ..Neuron Glia Biol. 16 (2010) 1-13)...
  30. pmc Role of glycogenolysis in stimulation of ATP release from cultured mouse astrocytes by transmitters and high K+ concentrations
    Junnan Xu
    Department of Clinical Pharmacology, China Medical University, Shenyang, P R China
    ASN Neuro 6:e00132. 2014
    ..It has also shown that this release is virtually abolished by an inhibitor of glycogenolysis as well as by inhibitors of transmitter-mediated signaling or of L-channel opening by elevated K+ concentrations. ..
  31. ncbi request reprint The astrocyte-neuron lactate shuttle: a challenge of a challenge
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, China
    J Cereb Blood Flow Metab 24:1241-8. 2004
  32. ncbi request reprint Astrocytic control of glutamatergic activity: astrocytes as stars of the show
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    Trends Neurosci 27:735-43. 2004
    ....
  33. ncbi request reprint Glutamate, a neurotransmitter--and so much more. A synopsis of Wierzba III
    Leif Hertz
    Department of Clinical Pharmacology, China Medical University, Shenyang, China
    Neurochem Int 48:416-25. 2006
    ..e., astrocytic de novo synthesis exceeds astrocytic metabolic degradation of glutamate...
  34. doi request reprint Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent
    Ting Du
    Department of Clinical Pharmacology, China Medical University, PR China
    Eur J Pharmacol 587:73-7. 2008
    ..The effect of vasopressin was abolished in the presence of AG1478, indicating its dependence upon transactivation, and by U0126 an inhibitor of the MAP kinase/ERK kinase (MEK), and thus of ERK 1/2 phosphorylation...
  35. doi request reprint Basic mechanism leading to stimulation of glycogenolysis by isoproterenol, EGF, elevated extracellular K+ concentrations, or GABA
    Junnan Xu
    Department of Clinical Pharmacology, China Medical University, No 92 Beier Road, Heping District, Shenyang, 110001, People s Republic of China
    Neurochem Res 39:661-7. 2014
    ..The same pathway could be activated by GABA (also in brain slices) due to its depolarizing effect in astrocytes. ..
  36. ncbi request reprint Ammonia-induced Na,K-ATPase/Ouabain-mediated EGF Receptor Transactivation, MAPK/ERK and PI3K/AKT Signaling and ROS Formation Cause Astrocyte Swelling
    Hongliang Dai
    Department of Clinical Pharmacology, China Medical University, Shenyang, P R China
    Neurochem Int . 2013
    ..This information may provide new therapeutic targets for treatment of hyperammonic brain disorders...
  37. pmc Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na(+),K(+)-ATPase and Marie E. Gibbs' pioneering learning studies
    Leif Hertz
    Department of Clinical Pharmacology, China Medical University Shenyang, People s Republic of China
    Front Integr Neurosci 7:20. 2013
    ....
  38. ncbi request reprint The astrocytic GABA(A)/benzodiazepine-like receptor: the Joker receptor for benzodiazepine-mimetic drugs?
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang 110001, PR China
    Recent Pat CNS Drug Discov 1:93-103. 2006
    ..This receptor should be kept in mind when developing and testing new drugs; in turn these drugs may help elucidating its functional role...
  39. ncbi request reprint Bioenergetics of cerebral ischemia: a cellular perspective
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Neuropharmacology 55:289-309. 2008
    ..Hyperglycemia can be beneficial for neurons but increases astrocytic death due to enhanced acidosis...
  40. ncbi request reprint Chronic fluoxetine administration increases expression of the L-channel gene Cav1.2 in astrocytes from the brain of treated mice and in culture and augments K(+)-induced increase in [Ca(2+)]i
    Ting Du
    Department of Clinical Pharmacology, China Medical University, Shenyang, PR China
    Cell Calcium 55:166-74. 2014
    ..We have previously shown a similar effect after fluoxetine treatment, but it becomes overridden by the Cav1.2 up-regulation. ..
  41. ncbi request reprint Intercellular metabolic compartmentation in the brain: past, present and future
    Leif Hertz
    College of Medical Sciences, China Medical University, Shenyang, PR China
    Neurochem Int 45:285-96. 2004
    ..The energy yield in astrocytes from glutamate formation is strongly dependent upon the fate of the generated glutamate...
  42. ncbi request reprint Complexity of depolarization-mediated ERK phosphorylation in cerebellar granule cells in primary cultures
    Liang Peng
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, PR China
    Neurochem Res 33:328-35. 2008
    ..The response at 20 min was insensitive to PKC inhibition. The potential importance of these complex responses for synaptic plasticity is discussed...
  43. ncbi request reprint Up-regulation of cPLA(2) gene expression in astrocytes by all three conventional anti-bipolar drugs is drug-specific and enzyme-specific
    Baoman Li
    Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, People s Republic of China
    Psychopharmacology (Berl) 194:333-45. 2007
    ....
  44. ncbi request reprint Lactate transport and transporters: general principles and functional roles in brain cells
    Leif Hertz
    College of Basic Medical Sciences, China Medical University, Shenyang, P R China
    J Neurosci Res 79:11-8. 2005
    ....