Markus Herrmann

Summary

Publications

  1. ncbi Stimulation of osteoclast activity by low B-vitamin concentrations
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Bone 41:584-91. 2007
  2. ncbi The challenge of continuous exogenous glucocorticoid administration in mice
    Markus Herrmann
    ANZAC Research Institute, The University of Sydney, and Department of Endocrinology and Metabolism, Concord Hospital, Hospital Road, Gate 3, Concord, NSW 2139, Australia
    Steroids 74:245-9. 2009
  3. ncbi Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    Bone 44:467-75. 2009
  4. ncbi Experimental folate and vitamin B12 deficiency does not alter bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    J Bone Miner Res 24:589-96. 2009
  5. ncbi Folate supplementation does not affect biochemical markers of bone turnover
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Clin Lab 52:131-6. 2006
  6. ncbi Hyperhomocysteinemia--the biochemical link between a weak heart and brittle bones?
    Markus Herrmann
    Institut für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Lab 52:137-47. 2006
  7. ncbi Stimulation of osteoblast activity by homocysteine
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    J Cell Mol Med 12:1205-10. 2008
  8. ncbi Accumulation of homocysteine by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, D 66421 Homburg Saar, Germany
    Clin Chim Acta 384:129-34. 2007
  9. ncbi The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Chem Lab Med 45:1621-32. 2007
  10. ncbi The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Chem Lab Med 45:1785-92. 2007

Detail Information

Publications59

  1. ncbi Stimulation of osteoclast activity by low B-vitamin concentrations
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Bone 41:584-91. 2007
    ..Moreover, HCY activates osteoclasts (OC). Elevated HCY concentrations are mainly caused by folate, vitamin B12 (B12) and B6 (B6) deficiencies. We hypothesized that folate, B12 and B6 deficiencies stimulate OC activity...
  2. ncbi The challenge of continuous exogenous glucocorticoid administration in mice
    Markus Herrmann
    ANZAC Research Institute, The University of Sydney, and Department of Endocrinology and Metabolism, Concord Hospital, Hospital Road, Gate 3, Concord, NSW 2139, Australia
    Steroids 74:245-9. 2009
    ..Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice...
  3. ncbi Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    Bone 44:467-75. 2009
    ..This study investigated if an experimental HHCY in rats induces an accumulation of homocysteine (HCY) in bone tissue that is accompanied by bone loss and reduced bone strength...
  4. ncbi Experimental folate and vitamin B12 deficiency does not alter bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    J Bone Miner Res 24:589-96. 2009
    ..The unchanged HCY metabolism in bone is the most probable explanation for the missing effect of the vitamin-free diet on bone...
  5. ncbi Folate supplementation does not affect biochemical markers of bone turnover
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Clin Lab 52:131-6. 2006
    ..This study aimed to analyze the effect of a HCY lowering therapy by folic acid (FA) supplementation on biochemical bone markers in healthy subjects...
  6. ncbi Hyperhomocysteinemia--the biochemical link between a weak heart and brittle bones?
    Markus Herrmann
    Institut für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Lab 52:137-47. 2006
    ..Existing data suggest that HHCY could be a useful paradigm with most interesting therapeutic implications, because HCY lowering therapy could favourably influence the course in CHF and osteoporotic patients...
  7. ncbi Stimulation of osteoblast activity by homocysteine
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    J Cell Mol Med 12:1205-10. 2008
    ..However, the magnitude of this effect seems to be less pronounced than recent observations on primary human osteoclasts, suggesting a dysbalance between OBs and osteoclasts in favour of osteoclasts...
  8. ncbi Accumulation of homocysteine by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, D 66421 Homburg Saar, Germany
    Clin Chim Acta 384:129-34. 2007
    ..However, little is known about the effect of these vitamins on the activity of osteoblasts. We hypothesized that decreasing concentrations of folate, vitamin B12 and B6 decrease osteoblasts activity by accumulation of HCY...
  9. ncbi The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Chem Lab Med 45:1621-32. 2007
    ..In conclusion, existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking...
  10. ncbi The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Chem Lab Med 45:1785-92. 2007
    ..Hyperhomocysteinemia is a new risk factor for osteoporosis. This study analyzed the effect of a homocysteine (HCY)-lowering treatment in osteoporotic individuals...
  11. ncbi The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1381-9. 2007
    ..In vitro, decreases in pH stimulate osteoclasts and inhibit osteoblasts. We hypothesized that exercise-induced lactacidosis stimulates osteoclasts and reduces osteoblast activity in vivo...
  12. ncbi Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem Lab Med 43:1118-23. 2005
    ..Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD)...
  13. ncbi Homocysteine--a newly recognised risk factor for osteoporosis
    Markus Herrmann
    Institut für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem Lab Med 43:1111-7. 2005
    ..However, more studies are needed to clarify the mechanistic role of Hcy, folate, vitamin B6 and vitamin B12 in bone metabolism...
  14. ncbi A new quantitative LC tandem mass spectrometry assay for serum 25-hydroxy vitamin D
    Markus Herrmann
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia
    Steroids 75:1106-12. 2010
    ..The new method was compared with two widely used commercially available immunoassays...
  15. ncbi Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
    ..This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA)...
  16. ncbi The cardiac effects of prolonged vitamin B12 and folate deficiency in rats
    Omid Taban-Shomal
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Cardiovasc Toxicol 9:95-102. 2009
    ..05), and tissue HCY (Co vs VitDef: 0.13 +/- 0.07 vs 0.07 +/- 0.04 micromol/g protein, P < 0.05) were lower in VitDef animals. Folate and vitamin B12 deficiency do not affect cardiac function and morphology...
  17. ncbi Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers
    Markus Herrmann
    Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany
    Clin Chem Lab Med 41:1525-31. 2003
    ..CONCLUSION: Three weeks of strenuous swimming caused a prolonged Hcy increase, which was accompanied by changes in vitamin B12 and folate. The magnitude of these effects was not influenced by the training intensity...
  18. ncbi Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism
    Holger Henneicke
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia
    Bone 49:733-42. 2011
    ..3-11βHSD2 transgenic mouse model of osteoblast-targeted disruption of glucocorticoid signalling...
  19. ncbi Altered vitamin B12 status in recreational endurance athletes
    Markus Herrmann
    University Hospital of Saarland, Dept. of Clinical Chemistry and Laboratory Medicine, Homburg/Saar, Germany
    Int J Sport Nutr Exerc Metab 15:433-41. 2005
    ..51), MMA and holoTC (r = -0.36). In athletes, MMA did not correlate with vitamin B(12)and holoTC. Our data suggests an altered vitamin B(12)metabolism in recreational athletes that needs further investigation...
  20. ncbi Homocysteine increases during endurance exercise
    Markus Herrmann
    Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany
    Clin Chem Lab Med 41:1518-24. 2003
    ..Furthermore, about 25% of recreational endurance athletes exhibited hyperhomocysteinemia in association with low vitamin B12 and folate levels...
  21. ncbi Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 90:1440-5. 2009
    ..Several clinical trials have reported B vitamins to be associated with osteoporosis...
  22. ncbi Experimental hyperhomocysteinemia reduces bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:1455-61. 2007
    ..Recently, hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. This study investigated if HHCY is a causal osteoporotic factor in vivo...
  23. ncbi Enhanced bone metabolism in vegetarians--the role of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 47:1381-7. 2009
    ..Vitamin B12 deficiency and bone fractures are common in vegetarians. However, a direct relationship between vitamin B12 status and bone metabolism in vegetarians has not been tested sufficiently...
  24. ncbi Plasma B vitamins and their relation to the severity of chronic heart failure
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 85:117-23. 2007
    ..Total homocysteine (tHcy) has been linked to the severity of chronic heart failure (CHF). Elevated tHcy concentrations are mainly caused by folate and vitamin B-12 deficiencies...
  25. ncbi Hyperhomocysteinemia and myocardial expression of brain natriuretic peptide in rats
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:773-80. 2007
    ..We hypothesized that HHcy stimulates myocardial brain natriuretic peptide (BNP) expression and induces adverse left ventricular remodeling...
  26. ncbi Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg, Germany
    J Neurochem 117:1047-54. 2011
    ..The effect of the diet on P-tau and pNF-H seemed not to be explained by a lower activity or protein level of PP2A. Folate might prove protective against multiple steps in the process of neurodegeneration...
  27. ncbi [Hyperhomocysteinemia and B-vitamin deficiency. Current clinical aspects]
    Wolfgang Herrmann
    Klinische Chemie Zentrallabor, Universitatsklinikum des Saarlandes, Homburg
    Med Monatsschr Pharm 29:291-302. 2006
    ..Current recommendations stress the importance of measurement of plasma concentrations of homocysteine in patients with multiple risk factors. This allow early intervention with B-vitamins...
  28. ncbi Long-distance mountain biking does not disturb the measurement of total, free or complexed prostate-specific antigen in healthy men
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg/Saar, Germany
    Clin Chem Lab Med 42:347-9. 2004
    ..Based on the present data, there is no evidence for a recommendation to limit bicycle riding or physical activity before the measurement of tPSA, fPSA or cPSA...
  29. ncbi Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
    ..As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair...
  30. ncbi Sustained telomere erosion due to increased stem cell turnover during triple autologous hematopoietic stem cell transplantation
    Thomas Widmann
    Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Homburg, Homburg, Germany
    Exp Hematol 36:104-10. 2008
    ..We observed sustained telomere shortening in hematopoietic cells after triple stem cell transplantation with prolonged stem cell replication during the first year after stem cell transplantation...
  31. ncbi Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  32. ncbi The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 42:1051-7. 2004
    ..Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes...
  33. ncbi The assessment of bone metabolism in female elite endurance athletes by biochemical bone markers
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, 66421 Hamburg/Saar, Germany
    Clin Chem Lab Med 42:1384-9. 2004
    ..Since increased bone resorption was not detectable in A-OCC(+) athletes, it can be suggested that OCC use might protect bone health in female athletes...
  34. ncbi Long-term corticosterone treatment induced lobe-specific pathology in mouse prostate
    Ulla Simanainen
    Department of Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Prostate 71:289-97. 2011
    ..Glucocorticoids influence prostate development and pathology, yet the underlying mechanisms including possible direct glucocorticoid effect on the prostate are not well characterized...
  35. ncbi Increased osteoclast activity in the presence of increased homocysteine concentrations
    Markus Herrmann
    , , Homburg/Saar, Germany
    Clin Chem 51:2348-53. 2005
    ..Future studies clarifying the mechanistic role of increased HCY concentrations in osteoporosis could have interesting therapeutic implications...
  36. ncbi 25-Hydroxyvitamin D testing: challenging the performance of current automated immunoassays
    Chris Farrell
    Laverty Pathology, Sydney, NSW, Australia
    Clin Chem Lab Med 50:1953-63. 2012
    ..This study assessed the performance of four recently released automated 25-OHD immunoassays against a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay...
  37. ncbi Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 45:1633-44. 2007
    ..Future studies need to explore the pathomechanisms of HHCY in CHF. Moreover, larger intervention trials are needed to clarify whether modification of plasma HCY by B-vitamin supplementation improves the clinical outcome in CHF patients...
  38. ncbi The amino- and carboxyterminal cross-linked telopeptides of collagen type I, NTX-I and CTX-I: a comparative review
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney NSW, Australia
    Clin Chim Acta 393:57-75. 2008
    ..We here review the biochemistry, analytical background and clinical performance of NTX-I and CTX-I, as documented in the accessible literature until March 2008...
  39. ncbi Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status
    Wolfgang Herrmann
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 43:1139-46. 2005
    ..Asymmetric dimethylarginine (ADMA) is an inhibitor of NO-synthase that may adversely affect the endothelium...
  40. ncbi The effects of hormonal contraceptives on bone turnover markers and bone health
    Markus Herrmann
    ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 72:571-83. 2010
    ....
  41. ncbi Weight loss on stimulant medication: how does it affect body composition and bone metabolism? - A prospective longitudinal study
    Alison Poulton
    Department of Paediatrics, Sydney Medical School Nepean, The University of Sydney, Penrith, NSW, Australia
    Int J Pediatr Endocrinol 2012:30. 2012
    ..abstract:..
  42. ncbi Decreased bone formation and osteopenia in lamin a/c-deficient mice
    Wei Li
    Ageing Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    PLoS ONE 6:e19313. 2011
    ....
  43. ncbi Post-race kinetics of cardiac troponin T and I and N-terminal pro-brain natriuretic peptide in marathon runners
    Markus Herrmann
    Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, D-66421 Homburg/Saar, Germany
    Clin Chem 49:831-4. 2003
  44. ncbi A review of homocysteine and heart failure
    Markus Herrmann
    , , D-66421 Homburg/Saar, Germany
    Eur J Heart Fail 8:571-6. 2006
    ..Future studies need to clarify the mechanistic role of HHCY in CHF as a useful paradigm with most interesting therapeutic implications, because HCY lowering therapy could favourably influence the prognosis in CHF patients...
  45. ncbi An old friend in a new light: the role of osteocalcin in energy metabolism
    Tim R Sullivan
    Hornsby Kuring gai Hospital, Northern Sydney Health Service, Hornsby, Australia
    Cardiovasc Ther 31:65-75. 2013
    ....
  46. ncbi Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study
    Markus Herrmann
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Clin Chem Lab Med 50:2213-9. 2012
    ..This study investigated the relationship between HCY and the risk of VTE in patients treated with fenofibrate...
  47. ncbi Supplementation with vitamin D and calcium in long-term care residents
    Oddom Demontiero
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, NSW, Australia
    J Am Med Dir Assoc 12:190-4. 2011
    ..The addition of calcium depends on tolerance, history of kidney stones, and emerging data regarding its cardiovascular safety...
  48. ncbi Short telomeres in aggressive non-Hodgkin's lymphoma as a risk factor in lymphomagenesis
    Thomas A Widmann
    Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Homburg, Homburg, Germany
    Exp Hematol 35:939-46. 2007
    ..It has not been systematically studied whether patients with malignancy have shortened telomeres in their normal, nontransformed cells, which might point to a preexisting disposition for chromosomal instability...
  49. ncbi Synergism between AT1 receptor and hyperhomocysteinemia during vascular remodeling
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Clin Chem Lab Med 45:1771-6. 2007
    ..Therefore, we hypothesized that Hcy activates AT1 receptor that potentiates STAT3 via ERK-1/2 phosphorylation. STAT3 modulates target MMP-9 and collagen, resulting in vascular remodeling...
  50. ncbi Effect of folate supplementation on N-terminal pro-brain natriuretic peptide
    Markus Herrmann
    Int J Cardiol 118:267-9. 2007
    ..CONCLUSION: FA supplementation with doses between 0.4 and 5 mg does not affect NT-proBNP in healthy subjects with an NT-proBNP concentration <40 ng/L, but possibly lowers NT-proBNP in individuals with NT-proBNP levels >40 ng/L...
  51. ncbi Re: "Elevated serum homocysteine and McKusick's hypothesis of a disturbed collagen cross-linking: What do we really know?"
    Markus Herrmann
    Bone 39:1385-6; author reply 1386-7. 2006
  52. ncbi Hyperhomocysteinaemia: a critical review of old and new aspects
    Wolfgang Herrmann
    Clinical Chemistry and Laboratory Medicine Central Laboratory, Saarland University Medical School, 66421 Homburg, Germany
    Curr Drug Metab 8:17-31. 2007
    ..HHCY and low folate are causal factors for pregnancy complications. In addition to the recommended folate supplementation, vitamin B12 supplementation may also decrease pregnancy complications...
  53. ncbi Measurement of serum beta-crosslaps is influenced by proteolytic conditions
    Markus Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Homburg/Saar, Germany
    Clin Chem Lab Med 40:790-4. 2002
    ..Therefore, serum should be separated from the whole blood immediately after coagulation and stored until analysis in a deep freezer...
  54. ncbi N-terminal B-type natriuretic peptide concentrations are similarly increased by 30 minutes of moderate and brisk walking in patients with coronary artery disease
    Jurgen Scharhag
    Institut für Sport und Präventivmedizin, Fachbereich Klinische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Res Cardiol 96:218-26. 2007
    ..Derived from the exercise- induced increase in NTproBNP, the myocardial strain in BW is not elevated in comparison to MW...
  55. ncbi Clinical significance of increased cardiac troponins T and I in participants of ultra-endurance events
    Axel Urhausen
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrucken, Germany
    Am J Cardiol 94:696-8. 2004
    ..Within 3 months after the events, 21 troponin-positive participants underwent an extensive cardiac examination, which in all but 1 (critical coronary heart disease) revealed no signs of persistent cardiac damage...
  56. ncbi Reproducibility and clinical significance of exercise-induced increases in cardiac troponins and N-terminal pro brain natriuretic peptide in endurance athletes
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrucken, Germany
    Eur J Cardiovasc Prev Rehabil 13:388-97. 2006
    ..In addition, they allow risk stratification in cardiovascular patients. The clinical significance of increases in cardiac markers after strenuous endurance exercise in obviously healthy athletes is unclear...
  57. ncbi Relationship of plasma homocysteine with the severity of chronic heart failure
    Markus Herrmann
    , , , Epidemiologie und Medizinische Informatik, , Homburg/Saar, Germany
    Clin Chem 51:1512-5. 2005
  58. ncbi Different kinetics of bone markers in normal and delayed fracture healing of long bones
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of the Saarland, D-66421 Homburg/Saar, Germany
    Clin Chem 48:2263-6. 2002
  59. ncbi Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken Homburg, Germany
    Am Heart J 150:1128-34. 2005
    ....