Patrick Herr

Summary

Publications

  1. doi Porcupine-mediated lipidation is required for Wnt recognition by Wls
    Patrick Herr
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 361:392-402. 2012
  2. doi Wingless secretion promotes and requires retromer-dependent cycling of Wntless
    Fillip Port
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Nat Cell Biol 10:178-85. 2008
  3. doi WNT secretion and signalling in human disease
    Patrick Herr
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Mol Med 18:483-93. 2012

Collaborators

  • Konrad Basler
  • Fillip Port
  • Edy Furger
  • Marco Kuster
  • Carla Bänziger
  • George Hausmann

Detail Information

Publications3

  1. doi Porcupine-mediated lipidation is required for Wnt recognition by Wls
    Patrick Herr
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 361:392-402. 2012
    ..Together, these findings indicate that Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls...
  2. doi Wingless secretion promotes and requires retromer-dependent cycling of Wntless
    Fillip Port
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Nat Cell Biol 10:178-85. 2008
    ..Our results indicate that Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt secretion...
  3. doi WNT secretion and signalling in human disease
    Patrick Herr
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Mol Med 18:483-93. 2012
    ..Here we review the proteins required for Wnt secretion and signalling at the plasma membrane, ending with a discussion on potential therapeutic approaches to treat Wnt-induced diseases...