Pathways to alcohol-induced brain impairment in young people: a reviewDaniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
Cortex 49:3-17. 2013
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Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disordersD F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Transl Psychiatry 2:e110. 2012
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- Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, The University of Sydney, Sydney, Australia
Prog Neuropsychopharmacol Biol Psychiatry 34:822-9. 2010
..Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning...
- Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptoms
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
J Int Neuropsychol Soc 17:267-76. 2011
..Distinct neuropsychological profiling may help to predict later psychiatric outcomes and enhance individually-tailored early intervention strategies...
- Impaired verbal memory in young adults with unipolar and bipolar depression
Daniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Early Interv Psychiatry 4:227-33. 2010
..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
- Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster
Manreena Kaur
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
J Psychiatry Neurosci 37:313-21. 2012
..Further research is warranted to determine whether patients with bipolar-spectrum disorders show similar impairments in these biomarkers...
- Misinterpreting emotional expressions in attention-deficit/hyperactivity disorder: evidence for a neural marker and stimulant effects
Leanne M Williams
Brain Dynamics Centre and Clinics, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, New South Wales, Australia
Biol Psychiatry 63:917-26. 2008
..We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment with stimulant medication...
- Using brain-based cognitive measures to support clinical decisions in ADHD
Leanne M Williams
Brain Dynamics Center, Westmead Millennium Institute and University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
Pediatr Neurol 42:118-26. 2010
..quot; These markers offer a frame of reference to support diagnostic and treatment decisions, and an objective benchmark for monitoring outcomes of interventions...
- Reduced mismatch negativity in mild cognitive impairment: associations with neuropsychological performance
Loren Mowszowski
Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia
J Alzheimers Dis 30:209-19. 2012
..These findings overall suggest that MMN may be a viable neurophysiological biomarker of underlying disease in this 'at risk' group...
Event-related wave activity in the EEG provides new marker of ADHDDavid M Alexander
The Brain Resource International Database, Brain Resource Company, Sydney, Australia
Clin Neurophysiol 119:163-79. 2008
..This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample...
- A randomized controlled trial investigation of a non-stimulant in attention deficit hyperactivity disorder (ACTION): rationale and design
Tracey W Tsang
Brain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, Sydney, New South Wales, Australia
Trials 12:77. 2011
..This manuscript will describe the methodology and rationale for the ACTION study...
- MMN/P3a deficits in first episode psychosis: comparing schizophrenia-spectrum and affective-spectrum subgroups
Manreena Kaur
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Schizophr Res 130:203-9. 2011
..First-episode psychosis (FEP) patients show reduced amplitudes of the 'MMN/P3a complex', but it is unclear whether this occurs across the FEP spectrum...
- Reduced temporal mismatch negativity in late-life depression: an event-related potential index of cognitive deficit and functional disability?
Sharon L Naismith
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Australia
J Affect Disord 138:71-8. 2012
..This study examined MMN elicited by duration deviant stimuli in older people with lifetime depression, and explored its relationship with neuropsychological functioning and disability...
- Distinguishing symptom profiles in adolescent ADHD using an objective cognitive test battery
Simon D Clarke
Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital and Western Clinical School, University of Sydney, Westmead, NSW, 2145, Australia
Int J Adolesc Med Health 19:355-67. 2007
..Currently diagnosis and assessment of ADHD relies on clinical interview and subjective ratings. Standardized objective cognitive tests can provide additional information about ADHD and help distinguish symptom profiles...
- Predicting stimulant medication response in ADHD: evidence from an integrated profile of neuropsychological, psychophysiological and clinical factors
Daniel F Hermens
The Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW, Australia
J Integr Neurosci 4:107-21. 2005
..0% of non-responders, with a broadly similar profile of psychophysiological predictors. These finding indicate the value of integrating neuropsychological and psychophysiological data in predicting medication response in ADHD...
- Alcohol use and mismatch negativity in young patients with psychotic disorder
Kate M Chitty
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
Neuroreport 22:918-22. 2011
..This may reflect an additive effect of N-methyl-D-aspartate receptor hypofunction and high-alcohol consumption...
- How does social functioning in the early stages of psychosis relate to depression and social anxiety?
Catherine Chudleigh
Clinical Research Unit, Brain and Mind Research Institute, New South Wales, Australia
Early Interv Psychiatry 5:224-32. 2011
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- Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
BMC Psychiatry 12:234. 2012
..This study determines the socio-demographic, psychopathological and illness-stage correlates of suicidal ideation in young persons attending headspace services...
- Applying clinical staging to young people who present for mental health care
Ian B Hickie
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales
Early Interv Psychiatry 7:31-43. 2013
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- Distinguishing young people with emerging bipolar disorders from those with unipolar depression
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
J Affect Disord 144:208-15. 2013
..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
- Delayed preattentional functioning in early psychosis patients with cannabis use
Nicole Pesa
School of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia
Psychopharmacology (Berl) 222:507-18. 2012
..The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-D-aspartate receptors which are involved in MMN generation...
- Frontal lobe changes occur early in the course of affective disorders in young people
Jim Lagopoulos
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
BMC Psychiatry 12:4. 2012
..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately...
- Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation
Rico S C Lee
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 8:e58176. 2013
..The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning...
- Mismatch negativity/P3a complex in young people with psychiatric disorders: a cluster analysis
Manreena Kaur
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 7:e51871. 2012
..A data driven approach may help to further elucidate novel patterns of MMN/P3a amplitudes that characterise distinct subgroups in patients with emerging psychiatric disorders...
- Targeted primary care-based mental health services for young Australians
Elizabeth M Scott
Clinical Research Unit, Brain and Mind Research Institute, Sydney, NSW
Med J Aust 196:136-40. 2012
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- Integrative neuroscience approach to predict ADHD stimulant response
Daniel F Hermens
The Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School, University of Sydney, Westmead Hospital, NSW, Australia
Expert Rev Neurother 6:753-63. 2006
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- Sex differences in adolescent ADHD: findings from concurrent EEG and EDA
Daniel F Hermens
The Brain Dynamics Centre, University of Sydney, Westmead Hospital, NSW, Australia
Clin Neurophysiol 116:1455-63. 2005
..We determined whether psychophysiological differences are associated with the expression of ADHD in males and females, using simultaneously recorded electroencephalography (EEG) and electrodermal activity (EDA)...
- Amphetamine psychosis: a model for studying the onset and course of psychosis
Daniel F Hermens
Brain and Mind Research Institute, University of Sydney, Sydney, NSW
Med J Aust 190:S22-5. 2009
..It is possible that the same approach may be used in young people known to be at risk of schizophrenia and related disorders, by informing models that involve other environmental or genetic risks...
- Chronic use of cannabis and poor neural efficiency in verbal memory ability
Robert A Battisti
School of Psychology, University of Wollongong, Wollongong, Australia
Psychopharmacology (Berl) 209:319-30. 2010
..We sought to examine the impact of chronic cannabis use upon memory-related brain function via examination of the subsequent memory effect (SME) of the event-related potential (ERP)...
- Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution
Robert A Battisti
School of Psychology, University of Wollongong, Wollongong, Australia
Psychopharmacology (Berl) 212:613-24. 2010
..There is increasing evidence that conflict monitoring and resolution processes (i.e. the ability to detect and respond to change) may be affected...
- Delayed sleep phase in young people with unipolar or bipolar affective disorders
Rébecca Robillard
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, New South Wales, Australia
J Affect Disord 145:260-3. 2013
..Despite marked changes in circadian rhythms during the normal course of adolescence and young adulthood, less is known about changes in the 24-h sleep-wake cycle in young persons with mood disorders...
- Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
Sean N Hatton
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
BMC Psychiatry 12:45. 2012
..This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care...
- Attention-deficit/hyperactivity disorder: neurophysiology, information processing, arousal and drug development
Donald L Rowe
The Brain Dynamics Centre and Department of Psychological Medicine, Westmead Hospital and University of Sydney, NSW, Australia
Expert Rev Neurother 6:1721-34. 2006
..The clinical implications for a cholinergic hypothesis of ADHD are considered, along with its possible implications for treatment and pharmacological development...
- Resting EEG theta activity predicts cognitive performance in attention-deficit hyperactivity disorder
Daniel F Hermens
The Brain Dynamics Centre, Westmead Hospital, NSW, Australia; School of Psychology, University of Sydney, NSW, Australia
Pediatr Neurol 32:248-56. 2005
..This observation has important implications for the role of trait-like biologic deficits in attention-deficit hyperactivity disorder predicting performance in information processing...
