Alexander Hermani

Summary

Publications

  1. doi Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-α activation in breast cancer cells in an IGF-independent manner
    Alexander Hermani
    Hormones and Signal Transduction Group, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Cell Signal 25:1395-402. 2013
  2. ncbi Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor
    Jean Grisouard
    Hormones and Signal Transduction Group, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Endocrinol 21:2427-39. 2007
  3. doi Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines
    Ashish Shukla
    Hormones and Signal Transduction Group, German Cancer Research Center, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Endocr Relat Cancer 16:429-41. 2009
  4. ncbi Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity
    Senad Medunjanin
    Hormones and Signal Transduction Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 280:33006-14. 2005
  5. ncbi Up-regulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor grade
    Yongde Liao
    Hormones and Signal Transduction Group, German Cancer Research Centre, D 69120 Heidelberg, Germany
    Hum Pathol 36:1186-96. 2005
  6. ncbi Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005

Collaborators

Detail Information

Publications6

  1. doi Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-α activation in breast cancer cells in an IGF-independent manner
    Alexander Hermani
    Hormones and Signal Transduction Group, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Cell Signal 25:1395-402. 2013
    ..Our data suggest that IGFBPs interfere with the E2-induced activation of the Akt/PKB-pathway and prevent full hormone-dependent activation of ERα and breast cancer cell growth in an IGF- and IGF-IR-independent manner...
  2. ncbi Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor
    Jean Grisouard
    Hormones and Signal Transduction Group, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Endocrinol 21:2427-39. 2007
    ..These findings demonstrated that GSK-3 is required for E2-induced ERalpha phosphorylation at Ser-118 and full transcriptional activity of the receptor upon E2 stimulation...
  3. doi Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines
    Ashish Shukla
    Hormones and Signal Transduction Group, German Cancer Research Center, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Endocr Relat Cancer 16:429-41. 2009
    ..We conclude that unlike regular insulin and other insulin analogs, Lantus strongly activates the IGF-IR and the MAP kinase pathway in MCF7 cells and is a strong mitogen for cells characterized by a high-IGF-IR/IR ratio...
  4. ncbi Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity
    Senad Medunjanin
    Hormones and Signal Transduction Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 280:33006-14. 2005
    ..These findings uncover a novel mechanism for the regulation of ERalpha-mediated estrogen signaling controlled by a dual action of GSK-3...
  5. ncbi Up-regulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor grade
    Yongde Liao
    Hormones and Signal Transduction Group, German Cancer Research Centre, D 69120 Heidelberg, Germany
    Hum Pathol 36:1186-96. 2005
    ..Expression of IGFs, especially IGF-II, may be predictors of the outcome of prostate cancer...
  6. ncbi Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005
    ....