Suzana Herculano-Houzel

Summary

Publications

  1. doi request reprint Decreasing sleep requirement with increasing numbers of neurons as a driver for bigger brains and bodies in mammalian evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Instituto Nacional de Neurociência Translacional, INCT MCT, Sao Paulo, Brazil
    Proc Biol Sci 282:20151853. 2015
  2. pmc How to count cells: the advantages and disadvantages of the isotropic fractionator compared with stereology
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Cell Tissue Res 360:29-42. 2015
  3. pmc Different scaling of white matter volume, cortical connectivity, and gyrification across rodent and primate brains
    Lissa Ventura-Antunes
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Ilha do Fundão, Brazil Instituto Nacional de Neurociência Translacional, Ministério de Ciência de Tecnologia CNPq Rio de Janeiro, Brazil
    Front Neuroanat 7:3. 2013
  4. pmc How the cortex gets its folds: an inside-out, connectivity-driven model for the scaling of Mammalian cortical folding
    Bruno Mota
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil
    Front Neuroanat 6:3. 2012
  5. pmc Coordinated scaling of cortical and cerebellar numbers of neurons
    Suzana Herculano-Houzel
    Laboratorio de Neuroanatomia Comparada, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro RJ, Brazil
    Front Neuroanat 4:12. 2010
  6. pmc Age-related neuronal loss in the rat brain starts at the end of adolescence
    Priscilla Morterá
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil Instituto Nacional de Neurociência Translacional São Paulo, Brazil
    Front Neuroanat 6:45. 2012
  7. pmc The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 902, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 109:10661-8. 2012
  8. pmc Updated neuronal scaling rules for the brains of Glires (rodents/lagomorphs)
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Brain Behav Evol 78:302-14. 2011
  9. doi request reprint Neuronal scaling rules for primate brains: the primate advantage
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brasil and Instituto Nacional de Neurociência Translacional, Rio de Janeiro, Brazil
    Prog Brain Res 195:325-40. 2012
  10. doi request reprint Brains matter, bodies maybe not: the case for examining neuron numbers irrespective of body size
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Ann N Y Acad Sci 1225:191-9. 2011

Collaborators

  • Jon H Kaas
  • Roberto Lent
  • Christine E Collins
  • Paul R Manger
  • Bruno Mota
  • Lissa Ventura-Antunes
  • Karina Fonseca-Azevedo
  • Priscilla Morterá
  • Mariana Gabi
  • Frederico A C Azevedo
  • Fabiana Bandeira
  • Laila B Torres
  • Peiyan Wong
  • Renata E L Ferretti
  • Ludmila R B Carvalho
  • Renata E P Leite
  • Lea T Grinberg
  • Jose Marcelo Farfel
  • Wilson Jacob Filho

Detail Information

Publications30

  1. doi request reprint Decreasing sleep requirement with increasing numbers of neurons as a driver for bigger brains and bodies in mammalian evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Instituto Nacional de Neurociência Translacional, INCT MCT, Sao Paulo, Brazil
    Proc Biol Sci 282:20151853. 2015
    ..Coupling of increasing numbers of neurons to decreasing sleep requirement and increasing hours of feeding thus may have not only allowed but also driven the trend of increasing brain and body mass in mammalian evolution. ..
  2. pmc How to count cells: the advantages and disadvantages of the isotropic fractionator compared with stereology
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Cell Tissue Res 360:29-42. 2015
    ..The main disadvantage of IF, however, is that it necessarily destroys the tissue analyzed and thus provides no spatial information on the cellular composition of biological regions of interest. ..
  3. pmc Different scaling of white matter volume, cortical connectivity, and gyrification across rodent and primate brains
    Lissa Ventura-Antunes
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Ilha do Fundão, Brazil Instituto Nacional de Neurociência Translacional, Ministério de Ciência de Tecnologia CNPq Rio de Janeiro, Brazil
    Front Neuroanat 7:3. 2013
    ..The different scaling of the white matter has implications for the scaling of propagation time and computational capacity in evolution, and calls for a reappraisal of developmental models of cortical expansion in evolution...
  4. pmc How the cortex gets its folds: an inside-out, connectivity-driven model for the scaling of Mammalian cortical folding
    Bruno Mota
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil
    Front Neuroanat 6:3. 2012
    ....
  5. pmc Coordinated scaling of cortical and cerebellar numbers of neurons
    Suzana Herculano-Houzel
    Laboratorio de Neuroanatomia Comparada, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro RJ, Brazil
    Front Neuroanat 4:12. 2010
    ....
  6. pmc Age-related neuronal loss in the rat brain starts at the end of adolescence
    Priscilla Morterá
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil Instituto Nacional de Neurociência Translacional São Paulo, Brazil
    Front Neuroanat 6:45. 2012
    ..Our findings indicate that age-related decline in the brain begins as soon as the end of adolescence, a novel finding has important clinical and social implications for public health and welfare...
  7. pmc The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 902, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 109:10661-8. 2012
    ....
  8. pmc Updated neuronal scaling rules for the brains of Glires (rodents/lagomorphs)
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Brain Behav Evol 78:302-14. 2011
    ....
  9. doi request reprint Neuronal scaling rules for primate brains: the primate advantage
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brasil and Instituto Nacional de Neurociência Translacional, Rio de Janeiro, Brazil
    Prog Brain Res 195:325-40. 2012
    ....
  10. doi request reprint Brains matter, bodies maybe not: the case for examining neuron numbers irrespective of body size
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Ann N Y Acad Sci 1225:191-9. 2011
    ....
  11. pmc Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil
    PLoS ONE 6:e17514. 2011
    ....
  12. pmc Connectivity-driven white matter scaling and folding in primate cerebral cortex
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 902 Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 107:19008-13. 2010
    ..We offer a white matter-based mechanism to account for increased cortical folding across species, which we propose to be driven by connectivity-related tension in the white matter, pulling down on the gray matter...
  13. doi request reprint Not all brains are made the same: new views on brain scaling in evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, e Instituto Nacional de Neurociência Translacional, Rio de Janeiro, Brasil
    Brain Behav Evol 78:22-36. 2011
    ....
  14. pmc Cellular scaling rules for the brains of an extended number of primate species
    Mariana Gabi
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil
    Brain Behav Evol 76:32-44. 2010
    ....
  15. pmc The basic nonuniformity of the cerebral cortex
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 105:12593-8. 2008
    ....
  16. pmc Cellular scaling rules for rodent brains
    Suzana Herculano-Houzel
    Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 590, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 103:12138-43. 2006
    ....
  17. pmc Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution
    Karina Fonseca-Azevedo
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 590, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 109:18571-6. 2012
    ....
  18. pmc Gorilla and orangutan brains conform to the primate cellular scaling rules: implications for human evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, and Instituto Nacional de Neurociência Translacional, Rio de Janeiro, Brazil
    Brain Behav Evol 77:33-44. 2011
    ....
  19. ncbi request reprint Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain
    Suzana Herculano-Houzel
    Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941 590
    J Neurosci 25:2518-21. 2005
    ..Moreover, contrary to what is commonly assumed in the literature, we show that glial cells are not the majority in the rat brain...
  20. doi request reprint Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain
    Frederico A C Azevedo
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, Brazil
    J Comp Neurol 513:532-41. 2009
    ....
  21. ncbi request reprint Encephalization, neuronal excess, and neuronal index in rodents
    Suzana Herculano-Houzel
    Departamento de Anatomia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Anat Rec (Hoboken) 290:1280-7. 2007
    ....
  22. pmc Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat
    Fabiana Bandeira
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941 590, Brazil
    Proc Natl Acad Sci U S A 106:14108-13. 2009
    ....
  23. doi request reprint Response to Comments on "Cortical folding scales universally with surface area and thickness, not number of neurons"
    Bruno Mota
    Instituto de F sica, Universidade Federal do Rio de Janeiro, Brasil
    Science 351:826. 2016
    ..Here, we show that both claims are inappropriate...
  24. doi request reprint Corticalization of motor control in humans is a consequence of brain scaling in primate evolution
    Suzana Herculano-Houzel
    Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro CEP 21941 902, Brazil
    J Comp Neurol 524:448-55. 2016
    ..J. Comp. Neurol. 524:448-455, 2016. © 2015 Wiley Periodicals, Inc. ..
  25. doi request reprint Mammalian Brains Are Made of These: A Dataset of the Numbers and Densities of Neuronal and Nonneuronal Cells in the Brain of Glires, Primates, Scandentia, Eulipotyphlans, Afrotherians and Artiodactyls, and Their Relationship with Body Mass
    Suzana Herculano-Houzel
    Instituto de Cix00EA ncias Biomx00E9 dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Brain Behav Evol 86:145-63. 2015
    ..Thus, larger bodies do not uniformly come with more neurons - but they do fairly uniformly come with larger neurons in the rest of brain, which contains a number of structures directly connected to sources or targets in the body. ..
  26. doi request reprint BRAIN STRUCTURE. Cortical folding scales universally with surface area and thickness, not number of neurons
    Bruno Mota
    Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Science 349:74-7. 2015
    ..We discuss the implications of this finding for the evolutionary and developmental origin of folding, including the newfound continuum between lissencephaly and gyrencephaly, and for pathologies such as human lissencephaly. ..