Thrombocytosis and venous thromboembolism in cancer patients with chemotherapy induced anemia may be related to ESA induced iron restricted erythropoiesis and reversed by administration of IV ironDavid H Henry
Department of Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
Am J Hematol 87:308-10. 2012
..Our study suggests that ESA associated VTE in CIA patients may be, in part, related to the thrombocytosis of ESA induced iron restricted erythropoiesis and may be countered by IV iron...
- Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
David H Henry
Joan Karnell Cancer Center, Philadelphia, PA 19106, USA
J Clin Oncol 29:1125-32. 2011
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- Parenteral iron therapy in cancer-associated anemia
David H Henry
Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, PA 19106, USA
Hematology Am Soc Hematol Educ Program 2010:351-6. 2010
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Guidelines and recommendations for the management of anaemia in patients with lymphoid malignanciesDavid H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, Pennsylvania 19106, USA
Drugs 67:175-94. 2007
..Clearly, an update on the definition, identification and optimal management of anaemia in patients with lymphoid malignancies is warranted...
- Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, 230 West Washington Square, Philadelphia, PA 19106, USA
Oncologist 12:231-42. 2007
..To evaluate the safety and efficacy of intravenous (IV) sodium ferric gluconate complex (FG), oral ferrous sulfate, or no iron to increase hemoglobin (Hb) in anemic cancer patients receiving chemotherapy and epoetin alfa...
- Epoetin alfa. Clinical evolution of a pleiotropic cytokine
David H Henry
Pennsylvania Hospital, Joan Karnell Cancer Center, Philadelphia, PA 19106, USA
Arch Intern Med 164:262-76. 2004
..The therapeutic potential of epoetin alfa appears yet to be fully realized...
- Natural history of anemia associated with interferon/ribavirin therapy for patients with HIV/HCV coinfection
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, PA 19106, USA
AIDS Res Hum Retroviruses 23:1-9. 2007
..sEPO and reticulocyte increases were blunted in response to anemia; Hb levels did not return to baseline values and anemia was a frequent reason for discontinuing the study...
- Epoetin alfa for the treatment of cancer- and chemotherapy-related anaemia: product review and update
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, 230 West Washington Square, 2nd Floor, Philadelphia, PA 19106, USA
Expert Opin Pharmacother 6:295-310. 2005
..Areas of recent and ongoing investigation with epoetin alfa are also covered in this review...
- The role of intravenous iron in cancer-related anemia
David H Henry
Department of Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania 19106, USA
Oncology (Williston Park) 20:21-4. 2006
..v. iron supplementation in improving the hematopoietic responses in these patients...
- Hematologic outcomes and blood utilization in cancer patients with chemotherapy-induced anemia (CIA) pre- and post-national coverage determination (NCD): results from a multicenter chart review
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, PA 19106, USA
Support Care Cancer 20:2089-96. 2012
..The primary objective of this study was to compare transfusion rates in patients with CIA with lung, breast, or colorectal cancer before and after the NCD...
- Epoetin alfa for treatment of anemia in HIV-infected patients: past, present, and future
David H Henry
Department of Oncology, Hematology, Pennsylvania Hospital, Philadelphia, PA 19106, USA
J Acquir Immune Defic Syndr 37:1221-7. 2004
..Current and future research will further clarify the role of epoetin alfa in the clinical management of the HIV-infected population...
- The evolving role of epoetin alfa in cancer therapy
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, Pennsylvania 19106, USA
Oncologist 9:97-107. 2004
..Thus, the role of epoetin alfa is likely to expand in the cancer setting in the coming years...
- Randomized, open-label comparison of epoetin alfa extended dosing (80 000 U Q2W) vs weekly dosing (40 000 U QW) in patients with chemotherapy-induced anemia
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia, PA, USA
Curr Med Res Opin 22:1403-13. 2006
..CONCLUSIONS: Extended dosing (80 000 U Q2W) and once-weekly dosing (40 000 U QW) of EPO provided comparable safety and efficacy for chemotherapy-induced anemia...
- Optimizing the treatment of anemia in cancer patients. The role of a new erythropoietic agent
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, Philadelphia 19106, USA
Oncology (Williston Park) 16:9-12. 2002
..The articles in this supplement describe the basic scientific research and clinical development of darbepoetin alfa--another safe, effective, and approved treatment for chemotherapy-induced anemia...
- Blood management in total joint arthroplasty
Hari R Bezwada
Balderston Orthopaedics, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
Am J Orthop (Belle Mead NJ) 35:458-64. 2006
..This article reviews these techniques as well as the consequences of perioperative anemia. Problems associated with blood transfusions are also outlined...
- Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S
David H Henry
Joan Karnell Cancer Center, Pennsylvania Hospital, 230 W Washington Square, Philadelphia, PA, 19106, USA
Support Care Cancer 16:791-801. 2008
..To examine the prevalence of chemotherapy-or radiotherapy-associated side effects and related treatment burden, and correlates of fatigue and missed work days among cancer patients...
- Preoperative use of recombinant human erythropoietin before total joint arthroplasty
Hari P Bezwada
Pennsylvania Hospital, Philadelphia, 19107, USA
J Bone Joint Surg Am 85:1795-800. 2003
..The purpose of this study was to evaluate the efficacy of erythropoietin in combination with, and compared with, preoperative autologous donation for reducing allogeneic blood requirements for total joint arthroplasty...
- Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium
Brett T Brinker
Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University and the Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA
Cancer 112:1083-8. 2008
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