Henry H Q Heng

Summary

Publications

  1. doi request reprint The evolutionary mechanism of cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
    J Cell Biochem 109:1072-84. 2010
  2. doi request reprint Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 220:538-47. 2009
  3. doi request reprint The genome-centric concept: resynthesis of evolutionary theory
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Bioessays 31:512-25. 2009
  4. doi request reprint Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Syst Biol Reprod Med 59:124-30. 2013
  5. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
  6. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
  7. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
  8. doi request reprint Why imatinib remains an exception of cancer research
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Cell Physiol 228:665-70. 2013
  9. doi request reprint Decoding the genome beyond sequencing: the new phase of genomic research
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genomics 98:242-52. 2011
  10. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint The evolutionary mechanism of cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
    J Cell Biochem 109:1072-84. 2010
    ..Recognizing the fundamental importance of the underlying basis of the evolutionary mechanism of cancer mandates the development of new strategies in cancer research...
  2. doi request reprint Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 220:538-47. 2009
    ..Compared to the degree of heterogeneity, individual molecular pathways will have limited predictability during stochastic cancer evolution where genome dynamics (reflected by karyotypic heterogeneity) will dominate...
  3. doi request reprint The genome-centric concept: resynthesis of evolutionary theory
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Bioessays 31:512-25. 2009
    ....
  4. doi request reprint Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Syst Biol Reprod Med 59:124-30. 2013
    ..Importantly, this approach will be useful in studying the potential for diseases to arise as a result of bypassing the filter of sexual reproduction...
  5. ncbi request reprint Stochastic cancer progression driven by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Cell Physiol 208:461-72. 2006
    ..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
  6. pmc Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer
    Christine J Ye
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 219:288-300. 2009
    ..This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression...
  7. ncbi request reprint Mitotic cell death by chromosome fragmentation
    Joshua B Stevens
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:7686-94. 2007
    ..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization...
  8. doi request reprint Why imatinib remains an exception of cancer research
    Steven D Horne
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Cell Physiol 228:665-70. 2013
    ..Changing the focus of cancer research from a gene-based view to a genome-based theory will provide insight into solid tumor evolutionary dynamics...
  9. doi request reprint Decoding the genome beyond sequencing: the new phase of genomic research
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Genomics 98:242-52. 2011
    ..To make this transition for the next phase of genomic research, it is essential to acknowledge the importance of new genome-based biological concepts and to establish new technology platforms to decode the genome beyond sequencing...
  10. ncbi request reprint Cancer progression by non-clonal chromosome aberrations
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Biochem 98:1424-35. 2006
    ..To further illustrate the involvement of NCCA/CCA cycles in the pattern of cancer evolution, four cancer evolutionary models have been proposed based on the comparative analysis of karyotype patterns of various types of cancer...
  11. ncbi request reprint Clonal and non-clonal chromosome aberrations and genome variation and aberration
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Genome 49:195-204. 2006
    ..This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes...
  12. doi request reprint Evolutionary mechanisms and diversity in cancer
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, MI, USA
    Adv Cancer Res 112:217-53. 2011
    ..Finally, the potential clinical implications of the evolutionary mechanism of cancer are briefly reviewed...
  13. ncbi request reprint A mathematical model relating chromosome aberrations to cancer progression
    Julia DiPierdomenico
    Coll of Electr and Comput Eng, Wayne State Univ, Detroit, MI 48202, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2028-31. 2006
    ..Lastly, this novel approach to quantifying and predicting the dynamics of cancer in an in vitro model may be extended to other forms of malignancies...
  14. ncbi request reprint Cancer genome sequencing: the challenges ahead
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Bioessays 29:783-94. 2007
    ..This analysis suggests that cancer is a disease of probability and the most-challenging issue to the TCGA project, as well as the development of general strategies for fighting cancer, lie at the conceptual level...
  15. ncbi request reprint Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    J Cell Sci 117:999-1008. 2004
    ..Consequently, S/MAR anchors were necessary but not sufficient for chromatin loops to form. These observations reconcile many seemingly contradictory attributes previously associated with S/MARs...
  16. ncbi request reprint Elimination of altered karyotypes by sexual reproduction preserves species identity
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Karmanos Cancer Institute, Department of Pathology, 3226 Scott Hall, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Genome 50:517-24. 2007
    ..Genetic recombination does contribute to genetic diversity, but it does so secondarily and within the framework of the chromosomally defined genome...
  17. pmc Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model
    Paul C Roberts
    Department of Immunology Microbiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Neoplasia 7:944-56. 2005
    ....
  18. doi request reprint High-resolution FISH analysis
    Henry H Q Heng
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Curr Protoc Hum Genet . 2005
    ..The Basic Protocol 2, high-resolution FISH mapping with free chromatin, is a modification of the method used for FISH mapping of interphase nuclei...