The evolutionary mechanism of cancerHenry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201
J Cell Biochem 109:1072-84. 2010
..Recognizing the fundamental importance of the underlying basis of the evolutionary mechanism of cancer mandates the development of new strategies in cancer research...
- The genome-centric concept: resynthesis of evolutionary theory
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
Bioessays 31:512-25. 2009
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- Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Cell Physiol 220:538-47. 2009
..Compared to the degree of heterogeneity, individual molecular pathways will have limited predictability during stochastic cancer evolution where genome dynamics (reflected by karyotypic heterogeneity) will dominate...
Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancerChristine J Ye
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Cell Physiol 219:288-300. 2009
..This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression...
Stochastic cancer progression driven by non-clonal chromosome aberrationsHenry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Cell Physiol 208:461-72. 2006
..The dynamic relationship between NCCAs and CCAs provides a mechanism underlying chromosomal based cancer evolution and could have broad clinical applications...
- Mitotic cell death by chromosome fragmentation
Joshua B Stevens
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 67:7686-94. 2007
..Paradoxically, this process could result in genome aberrations common in cancer. The characterization of chromosome fragmentation may also shine light on the mechanism of chromosomal pulverization...
- Decoding the genome beyond sequencing: the new phase of genomic research
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Genomics 98:242-52. 2011
..To make this transition for the next phase of genomic research, it is essential to acknowledge the importance of new genome-based biological concepts and to establish new technology platforms to decode the genome beyond sequencing...
- Cancer progression by non-clonal chromosome aberrations
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Cell Biochem 98:1424-35. 2006
..To further illustrate the involvement of NCCA/CCA cycles in the pattern of cancer evolution, four cancer evolutionary models have been proposed based on the comparative analysis of karyotype patterns of various types of cancer...
- Clonal and non-clonal chromosome aberrations and genome variation and aberration
Henry H Q Heng
Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Genome 49:195-204. 2006
..This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes...
- Why imatinib remains an exception of cancer research
Steven D Horne
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
J Cell Physiol 228:665-70. 2013
..Changing the focus of cancer research from a gene-based view to a genome-based theory will provide insight into solid tumor evolutionary dynamics...
- Evolutionary mechanisms and diversity in cancer
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, MI, USA
Adv Cancer Res 112:217-53. 2011
..Finally, the potential clinical implications of the evolutionary mechanism of cancer are briefly reviewed...
- A mathematical model relating chromosome aberrations to cancer progression
Julia DiPierdomenico
Coll of Electr and Comput Eng, Wayne State Univ, Detroit, MI 48202, USA
Conf Proc IEEE Eng Med Biol Soc 1:2028-31. 2006
..Lastly, this novel approach to quantifying and predicting the dynamics of cancer in an in vitro model may be extended to other forms of malignancies...
- Cancer genome sequencing: the challenges ahead
Henry H Q Heng
Center for Molecular Medicine and Genetics, Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
Bioessays 29:783-94. 2007
..This analysis suggests that cancer is a disease of probability and the most-challenging issue to the TCGA project, as well as the development of general strategies for fighting cancer, lie at the conceptual level...
- Elimination of altered karyotypes by sexual reproduction preserves species identity
Henry H Q Heng
Center for Molecular Medicine and Genetics, Karmanos Cancer Institute, Department of Pathology, 3226 Scott Hall, Wayne State University School of Medicine, Detroit, MI 48201, USA
Genome 50:517-24. 2007
..Genetic recombination does contribute to genetic diversity, but it does so secondarily and within the framework of the chromosomally defined genome...
- Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model
Paul C Roberts
Department of Immunology Microbiology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Neoplasia 7:944-56. 2005
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- Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48202, USA
J Cell Sci 117:999-1008. 2004
..Consequently, S/MAR anchors were necessary but not sufficient for chromatin loops to form. These observations reconcile many seemingly contradictory attributes previously associated with S/MARs...
- High-resolution FISH analysis
Henry H Q Heng
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
Curr Protoc Hum Genet . 2005
..The Basic Protocol 2, high-resolution FISH mapping with free chromatin, is a modification of the method used for FISH mapping of interphase nuclei...
