A tropical diabetic footL Henckaerts
Department of General Internal Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Acta Clin Belg 67:362-4. 2012
..Eumycetoma caused by Madurella mycetomatis is an uncommon cause of osteomyelitis in patients with diabetes in Europe, but should be considered in patients from endemic regions when (antibacterial) therapy fails...
Genetic variation in the autophagy gene ULK1 and risk of Crohn's diseaseLiesbet Henckaerts
Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
Inflamm Bowel Dis 17:1392-7. 2011
..Our aim was to investigate polymorphisms in selected autophagy genes for their association with susceptibility to CD...
Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel diseaseLiesbet Henckaerts
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Gut 56:1536-42. 2007
..Materials and..
- Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis
Liesbet Henckaerts
Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
J Hepatol 50:150-7. 2009
..The histological features in the liver of PSC patients are similar to those observed in cystic fibrosis (CF). Our aim was to study whether variants in the CFTR gene are associated with the occurrence and/or evolution of PSC...
- Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients
Marko Brinar
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
J Crohns Colitis 6:43-50. 2012
..Genetic variants in autophagy genes IRGM and ATG16L1 have been associated with susceptibility to Crohn's disease. We therefore investigated whether variants in autophagy genes contribute to granuloma formation...
- Genetic risk profiling and prediction of disease course in Crohn's disease patients
Liesbet Henckaerts
Department of Medicine, Gastroenterology Section, Catholic University of Leuven, Leuven, Belgium
Clin Gastroenterol Hepatol 7:972-980.e2. 2009
..We examined the influence of recently discovered CD-associated susceptibility loci on changes in disease behavior and evaluated whether a genetic risk model for disease progression could be generated...
- New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
Marc Ferrante
Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Gut 56:1394-403. 2007
....
- Molecular reclassification of Crohn's disease by cluster analysis of genetic variants
Isabelle Cleynen
Department of Gastroenterology, KU Leuven, Leuven, Belgium
PLoS ONE 5:e12952. 2010
..We hypothesized that the large number of confirmed genetic variants enables (better) classification of CD patients...
- The role of vascular endothelial growth factor (VEGF) in inflammatory bowel disease
Marc Ferrante
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 12:870-8. 2006
..Moreover, serum VEGF (sVEGF) levels are increased in IBD and correlate with disease activity. Both VEGF expression and sVEGF levels may be influenced by VEGF gene polymorphisms...
- Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit
Liesbet Henckaerts
Department of Medicine, Catholic University of Leuven, Leuven, Belgium
Crit Care Med 37:192-201, e1-3. 2009
..Our aim was to study the influence of single nucleotide polymorphisms in selected genes involved in innate immunity on the development of bacteremia or risk of death in patients admitted to a medical intensive care unit...
- Predictive model for the outcome of infliximab therapy in Crohn's disease based on apoptotic pharmacogenetic index and clinical predictors
Tibor Hlavaty
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 13:372-9. 2007
..Predictors of response could improve selection of patients with a higher probability of favorable outcomes and could improve the safety profile. We aimed to develop a predictive model for the response to infliximab in CD...
- The role of genetics in inflammatory bowel disease
Liesbet Henckaerts
Department of Gastroenterology University Hospital Gasthuisberg, Leuven, Belgium
Curr Drug Targets 9:361-8. 2008
..The optimal prediction of both disease behaviour and response to therapy might result from complex combinations of clinical, biochemical, serological and genetic factors...
- Malignancies and mortality in 200 patients with primary sclerosering cholangitis: a long-term single-centre study
Johan Fevery
Department of Hepatology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Liver Int 32:214-22. 2012
..The outcome of primary sclerosing cholangitis (PSC) has improved by liver transplantation (LT), but patients often develop malignancies. We analysed morbidity and mortality patterns to define strategies to prevent complications...
- CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis
Liesbet Henckaerts
Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 12:272-7. 2006
..We therefore investigated the role of the functional 32-bp deletion in this gene (CCR5-Delta32) with regard to susceptibility to PSC...
- NOD2/CARD15 disease associations other than Crohn's disease
Liesbet Henckaerts
Department of Gastroenterology, U Z Gasthuisberg, Leuven, Belgium
Inflamm Bowel Dis 13:235-41. 2007
..Whether NOD2 variants are also associated with an increased risk for infections and sepsis in patients receiving immunosuppressive therapies is unclear...
- Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD
Severine Vermeire
Department of Gastroenterology, UZ Gasthuisberg, Leuven, Belgium
Gastroenterology 129:1845-53. 2005
..We studied mutation prevalence, assessed phenotypic expression, and performed conditional analysis to examine evidence for gene-gene interactions...
- Intravenous iron therapy restores functional iron deficiency induced by infliximab
Konstantinos Katsanos
Department of Gastroenterology, University of Leuven Hospitals, Leuven, Belgium
J Crohns Colitis 1:97-105. 2007
..Infliximab (IFX) and iron sucrose (FeS) are of high value in inflammatory bowel disease (IBD). We aimed to assess the relative role of both therapies in IBD related anaemia and their safety when used in combination...
