Thiravat Hemachudha

Summary

Publications

  1. doi request reprint Human rabies: neuropathogenesis, diagnosis, and management
    Thiravat Hemachudha
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Lancet Neurol 12:498-513. 2013
  2. pmc Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level
    Shanop Shuangshoti
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    BMC Vet Res 9:31. 2013
  3. doi request reprint Detection of rabies viral RNA by TaqMan real-time RT-PCR using non-neural specimens from dogs infected with rabies virus
    Supaporn Wacharapluesadee
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
    J Virol Methods 184:109-12. 2012
  4. doi request reprint Comprehensive proteome analysis of hippocampus, brainstem, and spinal cord from paralytic and furious dogs naturally infected with rabies
    Natthapaninee Thanomsridetchai
    Inter Department Program of BioMedical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Proteome Res 10:4911-24. 2011
  5. ncbi request reprint Rabies control in South and Southeast Asia
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, WHO Collaborating Center and Department of Medicine, King Chulalongkorn University Hospital, 1871 Rama IV Road, Bangkok 10330, Thailand
    Vaccine 23:2284-9. 2005
  6. ncbi request reprint [Bat lyssavirus in Thailand]
    Boonlert Lumlertdacha
    Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama 4 Rd, Bangkok 10330, Thailand
    J Med Assoc Thai 88:1011-4. 2005
  7. doi request reprint Comparative detection of rabies RNA by NASBA, real-time PCR and conventional PCR
    Supaporn Wacharapluesadee
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
    J Virol Methods 175:278-82. 2011
  8. doi request reprint Development of a TaqMan real-time RT-PCR assay for the detection of rabies virus
    Supaporn Wacharapluesadee
    Molecular Biology Laboratory for Neurological Diseases, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    J Virol Methods 151:317-20. 2008
  9. ncbi request reprint Difference in neuropathogenetic mechanisms in human furious and paralytic rabies
    Erawady Mitrabhakdi
    Neurology Division, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    J Neurol Sci 238:3-10. 2005
  10. pmc Transmission dynamics of rabies virus in Thailand: implications for disease control
    Jessada Denduangboripant
    Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    BMC Infect Dis 5:52. 2005

Collaborators

Detail Information

Publications29

  1. doi request reprint Human rabies: neuropathogenesis, diagnosis, and management
    Thiravat Hemachudha
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Lancet Neurol 12:498-513. 2013
    ..However, to develop a pragmatic treatment strategy, a thorough understanding of the neuropathogenetic mechanisms is needed...
  2. pmc Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level
    Shanop Shuangshoti
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    BMC Vet Res 9:31. 2013
    ..The distribution and degree of inflammation were also studied...
  3. doi request reprint Detection of rabies viral RNA by TaqMan real-time RT-PCR using non-neural specimens from dogs infected with rabies virus
    Supaporn Wacharapluesadee
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
    J Virol Methods 184:109-12. 2012
    ..However, these oral swab and whisker specimens may serve to enhance epidemiological surveillance; such data will contribute in the planning of rabies control programs...
  4. doi request reprint Comprehensive proteome analysis of hippocampus, brainstem, and spinal cord from paralytic and furious dogs naturally infected with rabies
    Natthapaninee Thanomsridetchai
    Inter Department Program of BioMedical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Proteome Res 10:4911-24. 2011
    ..These data will be useful for better understanding of molecular mechanisms of rabies and for differentiation of its paralytic and furious forms...
  5. ncbi request reprint Rabies control in South and Southeast Asia
    Henry Wilde
    Queen Saovabha Memorial Institute, Thai Red Cross Society, WHO Collaborating Center and Department of Medicine, King Chulalongkorn University Hospital, 1871 Rama IV Road, Bangkok 10330, Thailand
    Vaccine 23:2284-9. 2005
    ..There have been many new developments since publication of the last WHO rabies expert committee report in 1992 (new version in print)] and we will address those that have practical applicability...
  6. ncbi request reprint [Bat lyssavirus in Thailand]
    Boonlert Lumlertdacha
    Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama 4 Rd, Bangkok 10330, Thailand
    J Med Assoc Thai 88:1011-4. 2005
    ..The present study and preparation of this article was supported by grants from the Thailand Research Fund and the National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand...
  7. doi request reprint Comparative detection of rabies RNA by NASBA, real-time PCR and conventional PCR
    Supaporn Wacharapluesadee
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
    J Virol Methods 175:278-82. 2011
    ..Due to the unavailability of the NASBA-ECL assay, the results show that TaqMan real-time RT-PCR and RT-hnPCR can be useful for ante- and post-mortem diagnosis of rabies...
  8. doi request reprint Development of a TaqMan real-time RT-PCR assay for the detection of rabies virus
    Supaporn Wacharapluesadee
    Molecular Biology Laboratory for Neurological Diseases, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    J Virol Methods 151:317-20. 2008
    ..Challenge Virus Standard, a fixed virus strain with 4 mismatches at probe binding site, could not be detected but remained amplified. This assay could be used as an adjunct to FAT and may serve as a rabies surveillance tool...
  9. ncbi request reprint Difference in neuropathogenetic mechanisms in human furious and paralytic rabies
    Erawady Mitrabhakdi
    Neurology Division, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    J Neurol Sci 238:3-10. 2005
    ..We conclude that differential sites of neural involvement and possibly different neuropathogenetic mechanisms may explain the clinical diversity in human rabies...
  10. pmc Transmission dynamics of rabies virus in Thailand: implications for disease control
    Jessada Denduangboripant
    Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    BMC Infect Dis 5:52. 2005
    ..We have used molecular epidemiology to define geographic localization of rabies virus phylogroups and their pattern of spread in Thailand...
  11. doi request reprint Molecular analysis of the mutational effects of Thai street rabies virus with increased virulence in mice after passages in the BHK cell line
    Phatthamon Virojanapirom
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
    Arch Virol 157:2201-5. 2012
    ..None of the mutations in the G gene occurred in previously reported pathogenic determinants. The roles of mutations in particular non-coding regions remain to be elucidated...
  12. pmc Autoimmune causes of encephalitis syndrome in Thailand: prospective study of 103 patients
    Abhinbhen Saraya
    Neuroscience Centre for Research and Development, Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    BMC Neurol 13:150. 2013
    ..We prospectively analyzed 103 Thai patients from 27 provinces for the causes of encephalitis using clinical, microbiological and neuroimaging indices; caseswithout a diagnosis were evaluated for autoimmune causes of encephalitis...
  13. ncbi request reprint Computer based program for rapid canine rabies diagnosis
    Boonlert Lumlertdacha
    Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama 4 Rd, Bangkok 10330, Thailand
    J Med Assoc Thai 88:1144-6. 2005
    ..It is easily accessed from the website: www.soonak.com/rabies...
  14. doi request reprint Rabies virus infection and microRNAs
    Nipan Israsena
    Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Adv Virus Res 79:329-44. 2011
    ....
  15. doi request reprint Neuroimaging in rabies
    Jiraporn Laothamatas
    Advanced Diagnostic Imaging and Image Guided Minimal Invasive Therapy Center AIMC and Department of Radiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand
    Adv Virus Res 79:309-27. 2011
    ..Neuroimaging is one of the most useful tools for the in vivo study of central nervous system infections...
  16. doi request reprint Rabies in Asia: the classical zoonosis
    Henry Wilde
    Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand
    Curr Top Microbiol Immunol 365:185-203. 2013
    ..Rabies is one of the first recognized zoonoses and a model for a true "One Health" management goal where human; veterinary, and government officials must work together in harmony to defeat this disease. ..
  17. ncbi request reprint Pathophysiology of human paralytic rabies
    Thiravat Hemachudha
    Department of Medicine and the Molecular Biology Laboratory for Neurological Diseases, Chulalongkorn University Hospital, Bangkok 10330, Thailand
    J Neurovirol 11:93-100. 2005
    ..Longer survival period in paralytic rabies may possibly be related to currently unidentified mechanism(s) on neuronal gene expression, required for virus transcription/replication and for maintaining neuronal survival...
  18. ncbi request reprint Rabies
    Thiravat Hemachudha
    Neurology Division, Department of Medicine, Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    Curr Neurol Neurosci Rep 6:460-8. 2006
    ..Neuroprotective treatment, using a coma-induction regimen, proves not to be beneficial. Survival of patients with excellent recovery relies on early innate and adaptive immunity plus adequate intensive care support...
  19. ncbi request reprint Rabies and dog population control in Thailand: success or failure?
    Thiravat Hemachudha
    Molecular Biology Laboratory for Neurological Diseases, Neurology Division, Department of Medicine, Chulalongkorn University Hospital, Bangkok 10330, Thailand
    J Med Assoc Thai 88:120-3. 2005
    ..When the dog population statistics collected in 1999 are compared to an earlier survey conducted in 1992, the stray dog population appears to have almost tripled in size in Bangkok over the eight year..
  20. ncbi request reprint [Rabies diagnosis in human]
    Supaporn Wacharapluesadee
    Molecular Biology Laboratory for Neurological Diseases, Thai Red Cross Society, 1871 Rama IV Rd, Bangkok 10330, Thailand
    J Med Assoc Thai 88:859-66. 2005
    ..Accurate data on rabies statistics contribute to the success in control and prevention of rabies...
  21. ncbi request reprint Duplex nested RT-PCR for detection of Nipah virus RNA from urine specimens of bats
    Supaporn Wacharapluesadee
    Molecular Biology Laboratory for Neurological Diseases, Department of Medicine Chulalongkorn University Hospital, Rama 4 Road, Bangkok 10330, Thailand
    J Virol Methods 141:97-101. 2007
    ..PCR inhibitors were present in a significant number of bat urine samples. The technique described in this study should improve reliability of surveillance statistics...
  22. doi request reprint Inhibition of rabies virus replication by multiple artificial microRNAs
    Nipan Israsena
    Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Antiviral Res 84:76-83. 2009
    ..Our results suggest the benefit of using multiple targeting amiRNAs when confronting with wild type rabies virus, the sequence of which is not completely known...
  23. doi request reprint Viewpoint: Management of human rabies
    Henry Wilde
    Faculty of Medicine, Division of Research and Department of Medicine, Chulalongkorn University Hospital, Bangkok 10330, Thailand
    Trans R Soc Trop Med Hyg 102:979-82. 2008
    ..Curative efforts for human rabies using critical care resources should especially target patients who show early neutralizing antibody. More basic research is needed to develop effective therapies for human rabies...
  24. doi request reprint A preliminary study of chemo- and cytokine responses in rabies vaccine recipients of intradermal and intramuscular regimens
    Abhinbhen Saraya
    Faculty of Medicine, Chulalongkorn University and WHO Collaborating Centre for Research and Training on Viral Zoonoses, Rama 4 Road, Bangkok 10330, Thailand
    Vaccine 28:4553-7. 2010
    ....
  25. doi request reprint Ante- and post-mortem diagnosis of rabies using nucleic acid-amplification tests
    Supaporn Wacharapluesadee
    WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand, 10330
    Expert Rev Mol Diagn 10:207-18. 2010
    ..This review the details obstacles in making a diagnosis, how to properly utilize NATs (sample preparation, nucleic amplification techniques, amplification targets and primer design); and interprets the results obtained in recent studies...
  26. pmc Survey for bat lyssaviruses, Thailand
    Boonlert Lumlertdacha
    Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama 4 Rd, Bangkok 10330, Thailand
    Emerg Infect Dis 11:232-6. 2005
    ..lylei (n = 15) and E. spelaea (n = 1). These results are consistent with the presence of naturally occurring viruses related to new putative lyssavirus genotypes...
  27. ncbi request reprint Ethical issues in research grant applications
    Sukhit Phaosavasdi
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 85:638-40. 2002
  28. ncbi request reprint Postexposure treatment of rabies infection: can it be done without immunoglobulin?
    Henry Wilde
    Queen Saovabha Memorial Institute Thai Red Cross Society and Department of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Infect Dis 34:477-80. 2002
    ..Early, aggressive wound cleansing and more intensive efforts at canine control and are ever more important. Countries that have the resources to manufacture their own rabies immunoglobulins must be encouraged to do so...
  29. ncbi request reprint Clinical manifestations of acetylcholine receptor antibody positive and negative myasthenia gravis
    Nath Pasutharnchat
    Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 95:313-9. 2012
    ..Acquired myasthenia gravis (MG) is the most common neuromuscular junction disorder. Acetylcholine receptor (AChR) antibody is found in the majority of MG...