Anne Helmrich

Summary

Affiliation: IGBMC
Location: Strasbourg, France
Summary:
2006 - 2012 Postdoc at the IGBMC, France
2005 PhD obtained at the Technical University Dresden, Germany

Publications

  1. ncbi Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Oncogene 24:4174-82. 2005
  2. ncbi An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
    Michael Niedermaier
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Clin Invest 115:900-9. 2005
  3. ncbi Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Genome Res 16:1222-30. 2006
  4. ncbi Spectral karyotyping of human, mouse, rat and ape chromosomes--applications for genetic diagnostics and research
    E Schrock
    Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Cytogenet Genome Res 114:199-221. 2006
  5. ncbi Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Int J Cancer 120:48-54. 2007
  6. ncbi Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage
    Céline Ziegler-Birling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM U, Universite de Strasbourg, France
    Int J Dev Biol 53:1003-11. 2009
  7. ncbi Conference Scene: chromatin, replication and chromosomal stability
    Anne Helmrich
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, France
    Epigenomics 3:543-6. 2011
  8. ncbi Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
    Anne Helmrich
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, France
    Mol Cell 44:966-77. 2011

Collaborators

Detail Information

Publications8

  1. ncbi Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Oncogene 24:4174-82. 2005
    ..These data illustrate how cytogenetic information from cancer specimens might complement established prognostic markers and may improve anticancer treatment strategies...
  2. ncbi An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
    Michael Niedermaier
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Clin Invest 115:900-9. 2005
    ..This results in shortening of the digits through an arrest of chondrocyte differentiation and the disruption of joint development...
  3. ncbi Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Genome Res 16:1222-30. 2006
    ..Our findings suggest that the mechanisms that provoke instability at CFSs are evolutionarily conserved. The role that large transcriptionally active genes may play in CFS expression is discussed...
  4. ncbi Spectral karyotyping of human, mouse, rat and ape chromosomes--applications for genetic diagnostics and research
    E Schrock
    Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Cytogenet Genome Res 114:199-221. 2006
    ..Besides the hybridization of human chromosomes, mouse karyotyping has also contributed to the comprehensive characterization of mouse models of human disease and for gene therapy studies...
  5. ncbi Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints
    Anne Helmrich
    Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    Int J Cancer 120:48-54. 2007
    ..In addition, in contrast to all currently reported data, CFSs in chromosome band 7q31 do not show increased DNA helix flexibility in comparison with control regions without CFS expression...
  6. ncbi Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage
    Céline Ziegler-Birling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM U, Universite de Strasbourg, France
    Int J Dev Biol 53:1003-11. 2009
    ..We discuss the possible consequences of these findings on the genome-wide chromatin remodelling that ocurs in the preimplantation mammalian embryo...
  7. ncbi Conference Scene: chromatin, replication and chromosomal stability
    Anne Helmrich
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, France
    Epigenomics 3:543-6. 2011
    ..The tight control of all these mechanisms defines the final cellular character...
  8. ncbi Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes
    Anne Helmrich
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, France
    Mol Cell 44:966-77. 2011
    ..Functional replication machinery needs to be involved in the resolution of conflicts between transcription and replication machineries to ensure genomic stability...