Beate Heissig

Summary

Publications

  1. ncbi Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases
    Beate Heissig
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York, USA
    Curr Opin Hematol 10:136-41. 2003
  2. ncbi Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  3. ncbi Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment
    Shahin Rafii
    Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 996:49-60. 2003
  4. ncbi Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
    David K Jin
    Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 12:557-67. 2006
  5. ncbi Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion
    Petri Salven
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 16:1471-3. 2002
  6. ncbi Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology-Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
  7. ncbi Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
  8. ncbi The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1
    Koichi Hattori
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, Room D601 New York, NY 10021, USA
    Leuk Lymphoma 44:575-82. 2003
  9. ncbi Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
  10. ncbi Contribution of marrow-derived progenitors to vascular and cardiac regeneration
    Shahin Rafii
    Cornell University Medical College, New York, USA
    Semin Cell Dev Biol 13:61-7. 2002

Collaborators

Detail Information

Publications19

  1. ncbi Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases
    Beate Heissig
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York, USA
    Curr Opin Hematol 10:136-41. 2003
    ....
  2. ncbi Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  3. ncbi Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment
    Shahin Rafii
    Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 996:49-60. 2003
    ..PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative microenvironment within the BM, favoring differentiation, mobilization, and reconstitution of hematopoiesis...
  4. ncbi Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
    David K Jin
    Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 12:557-67. 2006
    ..Delivery of SDF-1 may be effective in restoring angiogenesis in individuals with vasculopathies...
  5. ncbi Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion
    Petri Salven
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 16:1471-3. 2002
    ..This novel mechanism of IL-1alpha-action may enhance the shift to angiogenic phenotype in various conditions designated by excessive angiogenesis...
  6. ncbi Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology-Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
    ..Progenitor-active chemokines offer a new strategy to restore hematopoiesis in a clinical setting...
  7. ncbi Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  8. ncbi The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1
    Koichi Hattori
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, Room D601 New York, NY 10021, USA
    Leuk Lymphoma 44:575-82. 2003
    ..These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting...
  9. ncbi Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
    ..Thus, PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative BM microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis...
  10. ncbi Contribution of marrow-derived progenitors to vascular and cardiac regeneration
    Shahin Rafii
    Cornell University Medical College, New York, USA
    Semin Cell Dev Biol 13:61-7. 2002
    ....
  11. ncbi Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Exp Neurol 205:74-81. 2007
    ..This study provides new mechanism and suggests that MMP inhibitors may offer a new therapeutic strategy for ALS...
  12. ncbi Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils
    Yuichi Ohki
    Department of Cardiology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    FASEB J 19:2005-7. 2005
    ..Our results indicated that administration of G-CSF into ischemic tissue provides a novel and safe therapeutic strategy to improve neovascularization...
  13. ncbi Role of c-kit/Kit ligand signaling in regulating vasculogenesis
    Beate Heissig
    Department of Transfusion Medicine/Stem Cell Biology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
    Thromb Haemost 90:570-6. 2003
    ....
  14. ncbi Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization
    Sina Y Rabbany
    Bioengineering Program, Hofstra University, Hempstead, NY 11549, USA
    Trends Mol Med 9:109-17. 2003
    ....
  15. ncbi Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization
    Beate Heissig
    Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    J Exp Med 202:739-50. 2005
    ..These data show a novel mechanism of neovascularization and suggest that low-dose irradiation may be used for therapeutic angiogenesis to augment vasculogenesis in ischemic tissues...
  16. ncbi A role for niches in hematopoietic cell development
    Beate Heissig
    Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
    Hematology 10:247-53. 2005
    ..This review summarizes the recent developments in our understanding of the stem cell niche with particular focus on the HSC niche...
  17. ncbi The plasminogen fibrinolytic pathway is required for hematopoietic regeneration
    Beate Heissig
    Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Cell Stem Cell 1:658-70. 2007
    ..Thus, activation of the fibrinolytic cascade is a critical step in regulating the hematopoietic stress response...
  18. ncbi [Bone marrow-derived cells contribute to niche formation in cancer progression]
    Koichi Hattori
    University of Tokyo, Institute of Medical Science, Laboratory of Stem Cell Regulation
    Clin Calcium 18:480-7. 2008
    ..Focus on the early cellular and molecular events in cancer infiltration, metastasis and proliferation will likely lead to new approaches to detect and prevent metastasis at its earliest inception...
  19. ncbi Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas
    Robert S Kerbel
    Proc Natl Acad Sci U S A 105:E54; author reply E55. 2008