Lutz Heinemann

Summary

Publications

  1. pmc Accuracy in blood glucose measurement: what will a tightening of requirements yield?
    Lutz Heinemann
    Science and Co, Dusseldorf, Germany
    J Diabetes Sci Technol 6:435-43. 2012
  2. pmc AP@home: a novel European approach to bring the artificial pancreas home
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 5:1363-72. 2011
  3. pmc Continuous glucose monitoring during exercise in patients with type 1 diabetes on continuous subcutaneous insulin infusion
    Christoph Kapitza
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    J Diabetes Sci Technol 4:123-31. 2010
  4. pmc Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
  5. ncbi request reprint Enhancement of blood glucose lowering effect of a sulfonylurea when coadministered with an ACE inhibitor: results of a glucose-clamp study
    Klaus Rave
    Profil Institute for Metabolic Research, Neuss, Germany
    Diabetes Metab Res Rev 21:459-64. 2005
  6. ncbi request reprint Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro
    Klaus M Rave
    Profil Institut für Stoffwechselforschung, Hellersbergstr 9, D 41460 Neuss, Germany
    Diabetes Care 28:2400-5. 2005
  7. ncbi request reprint Measurement of insulin absorption and insulin action
    Lutz Heinemann
    Profil Institute for Metabolic Research, Neuss, Germany
    Diabetes Technol Ther 6:698-718. 2004
  8. pmc Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy
    Tim Heise
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    Diabetes Care 32:1431-3. 2009
  9. pmc Insulin pump therapy: what is the evidence for using different types of boluses for coverage of prandial insulin requirements?
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, GmbH, Neuss, Germany
    J Diabetes Sci Technol 3:1490-500. 2009
  10. pmc Changes in basal insulin infusion rates with subcutaneous insulin infusion: time until a change in metabolic effect is induced in patients with type 1 diabetes
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    Diabetes Care 32:1437-9. 2009

Detail Information

Publications34

  1. pmc Accuracy in blood glucose measurement: what will a tightening of requirements yield?
    Lutz Heinemann
    Science and Co, Dusseldorf, Germany
    J Diabetes Sci Technol 6:435-43. 2012
    ..Only under such circumstances will patients make appropriate therapeutic interventions to optimize and maintain metabolic control...
  2. pmc AP@home: a novel European approach to bring the artificial pancreas home
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 5:1363-72. 2011
    ....
  3. pmc Continuous glucose monitoring during exercise in patients with type 1 diabetes on continuous subcutaneous insulin infusion
    Christoph Kapitza
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    J Diabetes Sci Technol 4:123-31. 2010
    ..The aim of this study was to assess glucose changes during and after physical exercise in patients with type 1 diabetes managed by continuous subcutaneous insulin infusion before and after a 14-day moderate or intense exercise program...
  4. pmc Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
    ..Aim of this secondary analysis was to identify patient subgroups which differ in the decline of beta cell function during treatment with atorvastatin...
  5. ncbi request reprint Enhancement of blood glucose lowering effect of a sulfonylurea when coadministered with an ACE inhibitor: results of a glucose-clamp study
    Klaus Rave
    Profil Institute for Metabolic Research, Neuss, Germany
    Diabetes Metab Res Rev 21:459-64. 2005
    ..To investigate if coadministration of enalapril alters the metabolic effect of glibenclamide by employing an euglycemic glucose-clamp technique in healthy volunteers...
  6. ncbi request reprint Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro
    Klaus M Rave
    Profil Institut für Stoffwechselforschung, Hellersbergstr 9, D 41460 Neuss, Germany
    Diabetes Care 28:2400-5. 2005
    ..To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro...
  7. ncbi request reprint Measurement of insulin absorption and insulin action
    Lutz Heinemann
    Profil Institute for Metabolic Research, Neuss, Germany
    Diabetes Technol Ther 6:698-718. 2004
    ..The proposed glucose clamp technique makes possible the quantitative study of the pharmacokinetic and pharmacodynamic properties of insulin preparations under comparative and reproducible conditions...
  8. pmc Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy
    Tim Heise
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    Diabetes Care 32:1431-3. 2009
    ..GIR 24-h area under the curve for BIAsp t.i.d. was higher than for basal-bolus therapy: 2,585.2 vs. 2,289.2 mg/kg. CONCLUSIONS BIAsp had pharmacological advantages over BHI. BIAsp t.i.d. had a similar PD profile to basal-bolus therapy...
  9. pmc Insulin pump therapy: what is the evidence for using different types of boluses for coverage of prandial insulin requirements?
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, GmbH, Neuss, Germany
    J Diabetes Sci Technol 3:1490-500. 2009
    ..Therefore, the recommendation made in most of these studies (i.e., use of dual-wave bolus) has to be accepted with care, until we have better evidence...
  10. pmc Changes in basal insulin infusion rates with subcutaneous insulin infusion: time until a change in metabolic effect is induced in patients with type 1 diabetes
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    Diabetes Care 32:1437-9. 2009
    ..CONCLUSIONS Several hours are required until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion...
  11. pmc Oral insulin: a comparison with subcutaneous regular human insulin in patients with type 2 diabetes
    Christoph Kapitza
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    Diabetes Care 33:1288-90. 2010
    ..To determine the pharmacokinetic and pharmacodynamic properties of an oral insulin (OI) formulation compared with subcutaneously injected regular human insulin (RHI)...
  12. pmc The Systemic Immune Network in Recent Onset Type 1 Diabetes: Central Role of Interleukin-1 Receptor Antagonist (DIATOR Trial)
    Hubert Kolb
    West German Centre of Diabetes and Health, Verbund Katholischer Kliniken Düsseldorf, Dusseldorf, Germany
    PLoS ONE 8:e72440. 2013
    ..The hypothesis was tested that the systemic immune milieu in recent-onset type 1 diabetes is associated with residual beta cell function and other metabolic patient characteristics...
  13. ncbi request reprint Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes
    Tim Heise
    Profil Institut für Stoffwechselforschung, Hellersbergstr 9, D 41460 Neuss, Germany
    Diabetes 53:1614-20. 2004
    ..24 vs. 34%; INS-AUC((0- infinity )) 14 vs. 28 vs. 33%. The results suggest that insulin detemir has a significantly more predictable glucose-lowering effect than both NPH insulin and insulin glargine...
  14. pmc Insulin infusion set: the Achilles heel of continuous subcutaneous insulin infusion
    Lutz Heinemann
    Science and Co, Dusseldorf, Germany
    J Diabetes Sci Technol 6:954-64. 2012
    ..The aim of this review is to summarize the current knowledge and recommendations about IISs and to highlight potential directions of IIS development in order to make insulin absorption safer and more efficient...
  15. pmc Ultrafast-acting insulins: state of the art
    Lutz Heinemann
    Science and Co, Dusseldorf, Germany
    J Diabetes Sci Technol 6:728-42. 2012
    ..In time, daily practice will show if the introduction of UFIs will fulfill their clinical promise. In this review, the basic idea for UFIs will be presented and the different approaches will be briefly characterized...
  16. doi request reprint Biosimilar insulins
    Lutz Heinemann
    Science and Co, Kehler Str 24, 40468 Düsseldorf, Germany
    Expert Opin Biol Ther 12:1009-16. 2012
    ..Nevertheless, it is very likely that in the next years, BIs will come to the market also in highly regulated markets...
  17. doi request reprint Myocardial infarction and stroke in early years after diagnosis of type 2 diabetes: risk factors and relation to self-monitoring of blood glucose
    Stephan Martin
    German Diabetes Center, Institute for Clinical Diabetes Research, Dusseldorf, Germany
    Diabetes Technol Ther 11:234-41. 2009
    ..The natural course of macrovascular events in patients with type 2 diabetes was analyzed: what are the risk factors, and what is the relationship to the use of self-monitoring of blood glucose (SMBG)?..
  18. pmc Biosimilar insulins: how similar is similar?
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    J Diabetes Sci Technol 5:741-54. 2011
    ....
  19. ncbi request reprint Correlation between anthropometric parameters and abdominal fat volumes assessed by a magnetic resonance imaging method in patients with diabetes
    LudgerWilhelm Poll
    Institute of Diagnostic Radiology, University Hospital Dusseldorf, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Technol Ther 6:844-9. 2004
    ..The aim of this study was to evaluate the relationship between selected anthropometric parameters and MRI-estimated abdominal fat volumes in patients with diabetes...
  20. ncbi request reprint Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects
    Tim Heise
    Profil Institute for Metabolic Research, Neuss, Germany
    Metabolism 53:1227-32. 2004
    ..These results showed that pramlintide did not impair the symptom, catecholamine, and glucagon responses to insulin-induced hypoglycemia in healthy subjects...
  21. ncbi request reprint Impact of particle size and aerosolization time on the metabolic effect of an inhaled insulin aerosol
    Christoph Kapitza
    Profil Institute for Metabolic Research, Neuss, Germany
    Diabetes Technol Ther 6:119-27. 2004
    ..Based on the observed biopotency and the rapid onset of action, inhalation of a liquid insulin aerosol generated by the Aerodose Insulin Inhaler shows promise for covering prandial insulin requirements...
  22. pmc Insulin absorption from lipodystrophic areas: a (neglected) source of trouble for insulin therapy?
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 4:750-3. 2010
    ..Nevertheless, it is impressive to see how often metabolic control improves considerably once the patients apply the insulin into other skin areas...
  23. ncbi request reprint Future directions in insulin therapy and treatment of diabetes mellitus: a critical comment
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    Clin Cornerstone 8:66-74. 2007
    ..It requires an open discussion involving all relevant parties, including patients, about the types of clinical studies that are required...
  24. pmc Oral insulin and buccal insulin: a critical reappraisal
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 3:568-84. 2009
    ..In summary, after the failure of inhaled insulin, oral insulin and buccal insulin are hot candidates to come to the market as the next alternative routes of insulin administration...
  25. pmc Lancing: quo vadis?
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    J Diabetes Sci Technol 5:966-81. 2011
    ..This may have a greater impact on metabolic control than many of the new and expensive antidiabetic drugs...
  26. pmc Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: the Randomized DIATOR Trial
    Stephan Martin
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 6:e17554. 2011
    ..The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes...
  27. ncbi request reprint Future directions for insulin therapy and diabetes treatment
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany
    Endocrinol Metab Clin North Am 36:69-79. 2007
  28. pmc Considerations for an institution for evaluation of diabetes technology devices to improve their quality in the European Union
    Lutz Heinemann
    Science and Co, Kehler Str 24, Düsseldorf 40468, Germany
    J Diabetes Sci Technol 7:542-7. 2013
    ..Positive evaluation results should be a prerequisite prior to any reimbursement for such devices...
  29. ncbi request reprint Glucose sensors and the alternate site testing-like phenomenon: relationship between rapid blood glucose changes and glucose sensor signals
    Theodor Koschinsky
    German Diabetes Research Institute, Dusseldorf, Germany
    Diabetes Technol Ther 5:829-42. 2003
    ..Depending on the measurement technology used for the individual type of glucose monitoring system probably this phenomenon has a variable impact on the results obtained...
  30. ncbi request reprint Variability of insulin absorption and insulin action
    Lutz Heinemann
    Profil Institute for Metabolic Research GmbH, Neuss, Germany
    Diabetes Technol Ther 4:673-82. 2002
    ..To date no means have been found that could lead to a clinically relevant reduction in the variable metabolic effect...
  31. doi request reprint Quality of glucose measurement with blood glucose meters at the point-of-care: relevance of interfering factors
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung GmbH, Hellersbergstrasse 9, Neuss, Germany
    Diabetes Technol Ther 12:847-57. 2010
    ..This depends on the application in which meters designed for self-monitoring of BG (SMBG) are used...
  32. pmc Reduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 5:681-6. 2011
    ..Evaluation of postprandial glycemic excursions in patients with type 1 diabetes with three prandial insulins: VIAject™ (Linjeta™), an ultra-fast insulin (UFI); insulin lispro (LIS); and regular human insulin (RHI)...
  33. pmc Reimbursement for continuous glucose monitoring: a European view
    Lutz Heinemann
    Science and Co, Düorf, Germany
    J Diabetes Sci Technol 6:1498-502. 2012
    ..Imminent technological and manufacturing developments are expected to reduce the day-to-day costs of CGM...
  34. pmc Continuous glucose monitoring and clinical trials
    Lutz Heinemann
    Profil Institut für Stoffwechselforschung, Neuss, Germany
    J Diabetes Sci Technol 3:981-5. 2009
    ..g., comparing medications that are designed to control glycemia). Therefore, the use of CGM in clinical trials requires much more careful consideration than was initially thought...