New ways of insulin deliveryL Heinemann
Dusseldorf, Germany
Int J Clin Pract Suppl . 2011
..The selected studies were critically reviewed for novelty and appropriate study design etc. In some cases also reviews about a given topic were selected if they provide relevant novel insights...
Intramuscular versus subcutaneous injection of soluble and lispro insulin: comparison of metabolic effects in healthy subjectsK Rave
Department of Metabolic Diseases and Nutrition, WHO Collaborating Centre for Diabetes, Heinrich Heine University, Dusseldorf, Germany
Diabet Med 15:747-51. 1998
..c. administration. In contrast, the metabolic effect of insulin lispro was similar with either route. The time-action profile of i.m. injected soluble insulin lies between that of s.c. applied soluble insulin and insulin lispro...
- Insulin resistance and the effect of insulin on blood pressure in essential hypertension
T Heise
Department of Metabolic Diseases and Nutrition, Heinrich Heine University, Dusseldorf, Germany
Hypertension 32:243-8. 1998
..Administration of insulin exerts a small blood pressure-lowering effect in these patients. These data strongly argue against the postulated pressor action of insulin in essential hypertension...
- Hypoglycemia and insulin analogues: is there a reduction in the incidence?
L Heinemann
Department of Metabolic Diseases and Nutrition, WHO Collaborating Center for Diabetes, Heinrich Heine University, Dusseldorf, Germany
J Diabetes Complications 13:105-14. 1999
..Thus, rapid-acting insulin analogues do not appear to have revolutionized insulin therapy, but appropriate use should result in benefits such as improved metabolic control for diabetic patients...
- Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo
L Heinemann
Department of Metabolic Diseases and Nutrition, the World Health Organization Collaborating Centre for Diabetes, Heinrich Heine University, Dusseldorf, Germany
Diabetes Care 23:644-9. 2000
..To study the pharmacodynamic properties of the subcutaneously injected long-acting insulin analog HOE901 (30 microg/ml zinc) in comparison with those of NPH insulin and placebo...
- Insulin sensitivity in patients with essential hypertension: no influence of the ACE inhibitor enalapril
T Heise
Department of Metabolic Diseases and Nutrition, WHO Collaborating Center for Diabetes, Heinrich Heine University, Dusseldorf, Germany
Horm Metab Res 31:418-23. 1999
..8+/-3.0 [basal SI 5.1+/-2.4) mi/min x m2/microU/ml). In conclusion, no significant differences between ENA and NIT on insulin sensitivity were observed. The reduction of blood pressure had no apparent effect on insulin sensitivity...
- Variability of the metabolic effect of soluble insulin and the rapid-acting insulin analog insulin aspart
L Heinemann
Department of Metabolic Diseases and Nutrition, WHO Collaborating Centre for Diabetes, Heinrich Heine University, Dusseldorf, Germany
Diabetes Care 21:1910-4. 1998
..To study the intra- and interindividual variability of the metabolic activity of soluble insulin and of the rapid-acting insulin analog insulin aspart after subcutaneous injection...
- A cross-over evaluation of different methods and devices to measure blood pressure in type 1 diabetic patients with nephropathy
T Heise
Department of Metabolic Diseases and Nutrition, Heinrich Heine University, Dusseldorf, Germany
Blood Press Monit 5:175-80. 2000
..Additionally, for blood pressure self-monitoring, three different devices (the sphygmomanometer, upper-arm oscillometer and wrist oscillometer) were compared...
- Sensors for glucose monitoring: technical and clinical aspects
T Koschinsky
German Diabetes Research Institute, Dusseldorf, Germany
Diabetes Metab Res Rev 17:113-23. 2001
..Nevertheless, more minimal-invasive glucose sensors systems will become available for practical use in the near future, whereas it is still uncertain if this can be said for any non-invasive glucose sensor...
- Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study
S Martin
German Diabetes Clinic, German Diabetes Centre at the Heinrich Heine University, Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
Diabetologia 49:271-8. 2006
..The aim of this study was to obtain epidemiological data on self-monitoring of blood glucose (SMBG) in type 2 diabetes and to investigate the relationship of SMBG with disease-related morbidity and mortality...
