Catherine C Hedrick
Zhu Y, Padgett L, Dinh H, Marcovecchio P, Blatchley A, Wu R, et al
. Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow. Cell Rep. 2018;24:2329-2341.e8 pubmed publisher
..Understanding the biology of hNeP should allow the development of new therapeutic targets for neutrophil-related diseases, including cancer. ..
Haynes L, Verma S, McDonald B, Wu R, Tacke R, Nowyhed H, et al
. Cardif (MAVS) Regulates the Maturation of NK Cells. J Immunol. 2015;195:2157-67 pubmed publisher
Gaddis D, Padgett L, Wu R, McSkimming C, Romines V, Taylor A, et al
. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018;9:1095 pubmed publisher
..Together our results suggest that ApoAI, the main protein in high-density lipoprotein particles, modulates the cellular fate of Treg cells and thus influences the immune response during atherosclerosis. ..
Nowyhed H, Huynh T, Thomas G, Blatchley A, Hedrick C. Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4. J Immunol. 2015;195:3515-9 pubmed publisher
..Our data support a novel and critical role for Nr4a1 in the regulation of CD8(+) T cell expansion and effector function through transcriptional repression of Irf4. ..
Zhu Y, Thomas G, Hedrick C. 2014 Jeffrey M. Hoeg Award Lecture: Transcriptional Control of Monocyte Development. Arterioscler Thromb Vasc Biol. 2016;36:1722-33 pubmed publisher
..This review highlights what is currently known about the transcription factors that are critical for monocyte development. ..
Thomas G, Hanna R, Vasudevan N, Hamers A, Romanoski C, McArdle S, et al
. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity. 2016;45:975-987 pubmed publisher
..Because Nr4a1 regulates inflammatory gene expression and differentiation of Ly6Clow monocytes, decoupling these processes allows Ly6Clow monocytes to be studied independently. ..
Marcovecchio P, Thomas G, Mikulski Z, Ehinger E, Mueller K, Blatchley A, et al
. Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis. Arterioscler Thromb Vasc Biol. 2017;37:2043-2052 pubmed publisher
..These data suggest that NCM function in an atheroprotective manner through sensing and responding to oxidized lipoprotein moieties via scavenger receptor engagement during early atherogenesis. ..