Shao Heng He

Summary

Publications

  1. ncbi request reprint Self-amplification mechanisms of mast cell activation: a new look in allergy
    S He
    Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Curr Mol Med 12:1329-39. 2012
  2. doi request reprint An update on anti-allergic patents granted in China: 2009 - 2011
    Shu Zhang
    The First Affiliated Hospital of Nanjing Medical University, Clinical Research Center, Nanjing, China
    Expert Opin Ther Pat 22:715-34. 2012
  3. pmc Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups
    Chi Yu Zhang
    Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu 212001, China
    BMC Microbiol 6:88. 2006
  4. pmc Rhinosinusitis derived Staphylococcal enterotoxin B plays a possible role in pathogenesis of food allergy
    Tao Liu
    Institute of Allergy and Department of Otolaryngology, First Hospital, Shanxi Medical University, Taiyuan, China
    BMC Gastroenterol 6:24. 2006
  5. pmc The key role for local base order in the generation of multiple forms of China HIV-1 B'/C intersubtype recombinants
    Chi Yu Zhang
    Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu 212001, China
    BMC Evol Biol 5:53. 2005
  6. pmc Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF
    Haiwei Yang
    Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    BMC Cell Biol 10:37. 2009
  7. pmc Downregulation of protease activated receptor expression and cytokine production in P815 cells by RNA interference
    Liya Qiao
    Allergy and Inflammation Research Institute, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, PR China
    BMC Cell Biol 10:62. 2009
  8. pmc Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases
    Haiyan Wang
    Allergy and Inflammation Research Institute, The Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515031, China
    BMC Cell Biol 7:22. 2006
  9. pmc Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release
    Li Wang
    The First Affiliated Hospital, Shantou University Medical College, Shantou, China
    BMC Cell Biol 8:14. 2007
  10. ncbi request reprint Inhibition of tryptase release from human colon mast cells by histamine receptor antagonists
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Asian Pac J Allergy Immunol 23:35-9. 2005

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Self-amplification mechanisms of mast cell activation: a new look in allergy
    S He
    Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Curr Mol Med 12:1329-39. 2012
    ....
  2. doi request reprint An update on anti-allergic patents granted in China: 2009 - 2011
    Shu Zhang
    The First Affiliated Hospital of Nanjing Medical University, Clinical Research Center, Nanjing, China
    Expert Opin Ther Pat 22:715-34. 2012
    ..The prevalence of allergic diseases has increased dramatically in recent decades. Therefore, there is a pressing need for the development of effective anti-allergic services worldwide...
  3. pmc Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups
    Chi Yu Zhang
    Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu 212001, China
    BMC Microbiol 6:88. 2006
    ..However, the process of adaptive evolution of S protein and the exact positively selected sites associated with this process remain unknown...
  4. pmc Rhinosinusitis derived Staphylococcal enterotoxin B plays a possible role in pathogenesis of food allergy
    Tao Liu
    Institute of Allergy and Department of Otolaryngology, First Hospital, Shanxi Medical University, Taiyuan, China
    BMC Gastroenterol 6:24. 2006
    ..The objective of this study is to determine a possible association between rhinosinusitis derived SEB and pathogenesis of food allergy (FA)...
  5. pmc The key role for local base order in the generation of multiple forms of China HIV-1 B'/C intersubtype recombinants
    Chi Yu Zhang
    Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu 212001, China
    BMC Evol Biol 5:53. 2005
    ....
  6. pmc Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF
    Haiwei Yang
    Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China
    BMC Cell Biol 10:37. 2009
    ..However, whether GM-CSF modulates the expression of TLR and cytokine production in mast cells is not clear...
  7. pmc Downregulation of protease activated receptor expression and cytokine production in P815 cells by RNA interference
    Liya Qiao
    Allergy and Inflammation Research Institute, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, PR China
    BMC Cell Biol 10:62. 2009
    ..In order to further investigate the issues, RNA interference (RNAi) technique was employed and small interfering RNAs (siRNA) of PARs were transfected in P815 cells...
  8. pmc Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases
    Haiyan Wang
    Allergy and Inflammation Research Institute, The Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515031, China
    BMC Cell Biol 7:22. 2006
    ....
  9. pmc Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release
    Li Wang
    The First Affiliated Hospital, Shantou University Medical College, Shantou, China
    BMC Cell Biol 8:14. 2007
    ..In the present study, the influence of thrombin on proMMP-2 and proMMP-9 activity release from primary cultured HDFs, and its potential signaling pathways were investigated...
  10. ncbi request reprint Inhibition of tryptase release from human colon mast cells by histamine receptor antagonists
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Asian Pac J Allergy Immunol 23:35-9. 2005
    ....
  11. ncbi request reprint Modulation of tryptase release from human tonsil mast cells by protease inhibitors
    Shaoheng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Pharmacol Rep 57:523-30. 2005
    ..To examine the influence of protease inhibitors on tryptase release, and as a comparison the influence of the inhibitors on histamine secretion was assessed...
  12. ncbi request reprint Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 26:568-74. 2005
    ..To investigate the effects of the agonists of proteinase activated receptor (PAR)-2, and histamine on degranulation of human mast cells...
  13. ncbi request reprint Induction of mucin secretion from human bronchial tissue and epithelial cells by rhinovirus and lipopolysaccharide
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 25:1176-81. 2004
    ..To examine the effects of rhinovirus and lipopolysaccharide (LPS) on mucin secretion from bronchial tissue and epithelial cells in vitro...
  14. doi request reprint CD14+ cell-derived IL-29 modulates proinflammatory cytokine production in patients with allergic airway inflammation
    S He
    Clinical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Allergy 66:238-46. 2011
    ..Whether it plays a role in immune disorders is unclear. This study aims to examine the role of IL-29 in the modulation of immune response under allergic environment...
  15. doi request reprint Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29
    Shaoheng He
    Clinical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Allergy 65:1234-41. 2010
    ..However, little is known about its role in the pathogenesis of allergy. Because mast cells are recognized as primary effector cells of allergy, we investigated the potential relationship between IL-29 and mast cells in this study...
  16. doi request reprint Analysis of properties and proinflammatory functions of cockroach allergens Per a 1.01s
    S He
    Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Scand J Immunol 74:288-95. 2011
    ..rPer a 1.0101 and rPer a 1.0104 have the capacity to upregulate the expression of PARs and to enhance Th2 cytokine production in mast cells...
  17. ncbi request reprint Stimulation of mucin secretion from human bronchial epithelial cells by mast cell chymase
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 25:827-32. 2004
    ..To investigate the effect of chymase on the mucin secretion from human bronchial epithelial cells...
  18. ncbi request reprint Key role of mast cells and their major secretory products in inflammatory bowel disease
    Shao Heng He
    Allergy and Inflammation Research Institute, Medical College, Shantou University, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:309-18. 2004
    ..Therefore, close attentions should be paid to the role of mast cells in IBD...
  19. ncbi request reprint Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:319-22. 2004
    ..To investigate the tryptase and histamine release ability of human colon mast cells upon IgE dependent or independent activation and the potential mechanisms...
  20. ncbi request reprint Modulation of tryptase secretion from human colon mast cells by histamine
    Shao Heng He
    Allergy and Inflammation Research Institute, Medical College, Shantou University, Shantou 515031, China
    World J Gastroenterol 10:323-6. 2004
    ..To investigate the ability of histamine to modulate tryptase release from human colon mast cells and the potential mechanisms...
  21. ncbi request reprint Activation of human colon mast cells through proteinase activated receptor-2
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:327-31. 2004
    ..To investigate the ability of agonists of PAR-2 to stimulate release of tryptase and histamine from human colon mast cells and the potential mechanisms...
  22. ncbi request reprint Inhibition of tryptase release from human colon mast cells by protease inhibitors
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:332-6. 2004
    ..To investigate the ability of protease inhibitors to modulate tryptase release from human colon mast cells...
  23. ncbi request reprint Modulation of histamine release from human colon mast cells by protease inhibitors
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:337-41. 2004
    ..To investigate the ability of protease inhibitors to modulate histamine release from human colon mast cells...
  24. doi request reprint Interferon-λ mediates oral tolerance and inhibits antigen-specific, T-helper 2 cell-mediated inflammation in mouse intestine
    Shao Heng He
    Clinical Experimental Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    Gastroenterology 141:249-58, 258.e1-2. 2011
    ..We investigated the role and the mechanism of IFN-λ in the development of oral tolerance and its effect on antigen-induced, T-helper (Th)-2 cell-mediated inflammation in the intestine...
  25. ncbi request reprint Inhibition of histamine release from human mast cells by natural chymase inhibitors
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 25:822-6. 2004
    ..To investigate the ability of natural chymase inhibitors to modulate histamine release from human mast cells...
  26. ncbi request reprint [Effect of adenosine and anti-IgE antibody on histamine release from mast cells in BALF of asthma patients]
    Hua Xie
    Department of Respiratory Diseases, Northern China Hospital, Shenyang 110016, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 19:503-5. 2003
    ..To investigate the functional properties of mast cells in bronchoalveolar lavage fluid (BALF) of asthma patients...
  27. ncbi request reprint Purification, characterization and cytokine release function of a novel Arg-49 phospholipase A(2) from the venom of Protobothrops mucrosquamatus
    Ji Fu Wei
    Allergy and Inflammation Research Institute, The Shantou University Medical College, Xinling Road 11, 515031 Shantou, Guangdong, China
    Biochimie 88:1331-42. 2006
    ....
  28. doi request reprint Induction of inflammatory cell accumulation by TM-N49 and promutoxin, two novel phospholipase A(2)
    Ji Fu Wei
    Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, PR China
    Toxicon 56:580-8. 2010
    ..In conclusion, induction of inflammatory cell accumulation by TM-N49 and promutoxin confirms that group II PLA(2)s is pivotal stimulus for cell infiltration, through which they participate in the formation of snakebite inflammation...
  29. ncbi request reprint Cloning, expression, and characterization of pollen allergens from Humulus scandens (Lour) Merr and Ambrosia artemisiifolia L
    Ai lin Tao
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 26:1225-32. 2005
    ..To clone the pollen allergen genes in Humulus scandens (Lour) Merr (LvCao in Chinese) and short ragweed (Ambrosia artemisiifolia L) for recombinant allergen production and immunotherapy...
  30. ncbi request reprint Potent histamine-releasing activity of atrahagin, a novel snake venom metalloproteinase
    Ji Fu Wei
    Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong Province 515041, China
    Int J Biochem Cell Biol 38:510-20. 2006
    ..In conclusion, activation of human mast cells by atrahagin indicated that the enzyme might contribute to the pathogenesis of snakebite wound...
  31. ncbi request reprint N49 phospholipase A2, a unique subgroup of snake venom group II phospholipase A2
    Ji Fu Wei
    Allergy and Inflammation Research Institute, The Shantou University Medical College, Shantou, Guangdong, 515031, China
    Biochim Biophys Acta 1760:462-71. 2006
    ..Structural and functional analysis indicated that these phospholipase A2s are distinct from the other subgroups (D49 PLA2, S49 PLA2 and K49 PLA2) and represent a unique subgroup of snake venom group II PLA2, named N49 PLA2 subgroup...
  32. ncbi request reprint Modulation of expression and function of Toll-like receptor 3 in A549 and H292 cells by histamine
    Yi feng Hou
    Allergy and Inflammation Research Institute, The Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515041, China
    Mol Immunol 43:1982-92. 2006
    ..Histamine also enhanced poly (I:C) induced IL-8 secretion and phosphorylation of NF-kappaB. These observations suggest that histamine might play an important role in enhancing the innate immune responses of airway to viral infection...
  33. ncbi request reprint Inhibition of tryptase and chymase induced nucleated cell infiltration by proteinase inhibitors
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 25:1677-84. 2004
    ..To investigate the ability of proteinase inhibitors to modulate nucleated cell infiltration into the peritoneum of mice induced by tryptase and chymase...
  34. ncbi request reprint [Effect of tryptase inhibitors on histamine release from human colon mast cells]
    Hua Xie
    Allergy and Inflammation Research Institute, Medical College of Shantou University, Shantou 515031, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:678-81. 2004
    ..To investigate the effect of tryptase inhibitors (TPIs) on histamine release from human colon mast cells...
  35. ncbi request reprint [Modulatory effect of bisbenzamidine, a specific inhibitor of tryptase on mast cell secretion]
    Hua Xie
    Allergy and Inflammation Research Institute, Medical College of Shantou University, Shantou 515031, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 19:100-2. 2003
    ..To study the ability of bisbenzamidine, a specific inhibitor of tryptase, to stabilize mast cells...
  36. ncbi request reprint Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2
    Qing Xia Niu
    Allergy and Inflammation Research Institute, Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, Guangdong, China
    Clin Exp Pharmacol Physiol 35:89-96. 2008
    ..4. These data indicate the action of trypsin on HUVEC is most likely through activation of PAR-2, suggesting that PAR-2-related mechanisms are involved in the inflammatory process in humans...
  37. ncbi request reprint Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors
    Shao Heng He
    Allergy and Inflammation Research Institute, Medical College of Shantou University, Shantou 515031, China
    Acta Pharmacol Sin 24:923-9. 2003
    ..To investigate the actions of protease inhibitors on the enzymatic activities of tryptase and chymase in similar experimental systems...
  38. doi request reprint [Induction of monocyte-derived dendritic cell differentiation by asthmatic serum in a transendothelial trafficking model]
    Lin Fu Zhou
    Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, China
    Zhonghua Jie He He Hu Xi Za Zhi 34:169-73. 2011
    ..To explore the effect of asthmatic and healthy serum on differentiation and function of monocyte-derived dendritic cells (MDDC) in a transendothelial trafficking model...
  39. ncbi request reprint Purification, characterization and potent lung lesion activity of an L-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom
    Xiao Long Wei
    Allergy and Inflammation Research Institute, The Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041, China
    Toxicon 50:1126-39. 2007
    ..In conclusion, ABU-LAO potently induces lesions in lungs and livers. The ability of ABU-LAO will contribute to the understanding of the pathogenesis of snakebite wound...
  40. ncbi request reprint Bridging PCR and partially overlapping primers for novel allergen gene cloning and expression insert decoration
    Ai lin Tao
    Allergy and Inflammation Research Institute, Medical College, Shantou University, 22 Xin Ling Road, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:2103-8. 2004
    ..To obtain the entire gene open reading frame (ORF) and to construct the expression vectors for recombinant allergen production...
  41. ncbi request reprint [Human lung epithelial cells produce interleukin-8 through protease-activated receptor 1]
    Hai Yan Wang
    Allergy and Inflammation Research Institute, Medical College of Shantou University, Shantou 515031, China
    Di Yi Jun Yi Da Xue Xue Bao 25:963-6. 2005
    ..To investigate the actions of protease-activated receptor 1 (PAR1) agonists and thrombin on the secretion of interleukin-8 (IL-8) from human lung epithelial cells...
  42. doi request reprint Eosinophil-derived interferon-lambda contributes to initiation of allergen-related inflammation in the intestine
    Shao Heng He
    Clinical Experimental Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Cytokine 58:186-92. 2012
    ..The present study aimed to elucidate the mechanism by which the eosinophil-derived interferon (IFN)-lambda induced the gut epithelial barrier dysfunction...
  43. pmc Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2
    Ji Fu Wei
    Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China
    BMC Immunol 10:21. 2009
    ..Since the purification procedure developed is able to supply us with relatively large quantity of highly purified TM-N49, we investigated the ability of TM-N49 in induction of inflammation...
  44. doi request reprint Targeted NF-kappaB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking model
    Xiao Yan Gu
    Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Cell Immunol 260:14-20. 2009
    ..These results suggest that AdIkappaBalphaM-transferred MDDC are at a more immature stage which is beneficial to augment the immune tolerance in asthma...
  45. ncbi request reprint Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells
    Ming Cai Li
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515041, China
    Acta Pharmacol Sin 27:453-9. 2006
    ....
  46. ncbi request reprint Plant allergic proteins and their biological functions
    Dong Dong Li
    Institute of Allergy and Inflammation, Medical Collage of Shantou University, Shantou 515031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:789-92. 2003
    ..Currently, research on the plant allergens and their related allergic diseases is setting up a novel and cross-subjects field involving plant molecular biology, immunology and allergy...
  47. ncbi request reprint [Cloning full-length homologous cDNAs of pollen allergens in Humulus Scandens(Lour.) Merr by degenerate primer]
    Ai lin Tao
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:99-103. 2004
    ..To establish a stable and reliable method for fast cloning homologous genes of pollen allergens in allergen-containing plants...
  48. doi request reprint Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2
    Ji Fu Wei
    Clinical Experiment Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China
    Toxicon 55:888-96. 2010
    ....
  49. ncbi request reprint [Analysis of total proteins in the seed of almond (Prunus dulcis) by two-dimensional electrophoresis]
    Dong Dong Li
    Allergy and Inflammation Research Institute, Medical College, Shantou University, Shantou 515031, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:473-7. 2004
    ..To analyse the total proteins in the seeds of almond (Prunus dulcis), one of the popular ingestent allergens in China, by two-dimensional electrophoresis...
  50. ncbi request reprint Roles of histamine and its receptors in allergic and inflammatory bowel diseases
    Hua Xie
    Allergy and Inflammation Research Institute, Shantou University Medical College, 22 Xin Ling Road, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 11:2851-7. 2005
    ..In a word, histamine is an important mediator in allergic diseases and IBD, its antagonists may be developed as a group of mast cell stabilizers to treat these diseases...
  51. ncbi request reprint [Effect of a proteinase-activated receptor-2 (PAR-2) agonist on tryptase release from human mast cells]
    Shao Heng He
    Allergy and Inflammation Research Institute, the Medical College of Shantou University, Shantou 515031
    Sheng Li Xue Bao 54:531-4. 2002
    ..The above-mentioned results indicate that tc-LIGRLO is a potent stimulus of tryptase release from human mast cells, which strongly suggests that PAR-2s are expressed in human mast cells...
  52. doi request reprint Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venom
    Ji Fu Wei
    Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Toxicon 54:262-71. 2009
    ..In conclusion, the cytotoxic and proinflammatory activities of BF-LAAO could be the main cause of the local inflammation, which helps us to understand the pathogenesis of snakebite...
  53. ncbi request reprint IL-10 and its related cytokines for treatment of inflammatory bowel disease
    Ming Cai Li
    Allergy and Inflammation Research Institute, Shantou University Medical College, 22 Xin Ling Road, Shantou 515041, Guangdong Province, China
    World J Gastroenterol 10:620-5. 2004
    ..The use of IL-10 and IL-10-related cytokines will provide new insights into cell-based and gene-based treatment against IBD in near future...
  54. doi request reprint Unusual life-threatening Rosai-Dorfman disease of the trachea: role of NF-κB
    Lin Fu Zhou
    Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Thorax 65:927-9. 2010
    ..The patient remains well with no evidence of progression without treatment. Histological confirmation should be sought in all cases as the clinical manifestation of RDD is similar to asthma or lung carcinoma...
  55. ncbi request reprint Cloning and expression of human colon mast cell carboxypeptidase
    Zhang Quan Chen
    Allergy and Inflammation Research Institute, Medical College, Shantou University, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 10:342-7. 2004
    ..To clone and express the human colon mast cell carboxypeptidase (MC-CP) gene...
  56. doi request reprint Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis
    Shao Heng He
    1 Allergy and Clinical Immunology Research Centre, Liaoning Medical University, Jinzhou 121001, China 2 Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 34:1270-83. 2013
    ..Based on currently available laboratory allergy tests, we here propose a laboratory examination procedure for allergy...
  57. ncbi request reprint [Preparation and characterization of monoclonal antibodies against human secretory leukocyte protease inhibitor]
    Yu Zhen Chen
    Research Institute of Allergy and Inflammation, Shantou University Medical College, Shantou 515031, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:54-7. 2006
    ..To prepare and identify monoclonal antibodies(mAbs) against human secretory leukocyte protease inhibitor (hSLPI)...
  58. doi request reprint Analysis of patents on anti-allergic therapies issued in China from 1988 to 2008
    Shu Zhang
    The First Affiliated Hospital of Nanjing Medical University, Clinical Research Center, Nanjing, Jiangsu 210029, China
    Expert Opin Ther Pat 20:727-37. 2010
    ..However, little is known what anti-allergic products have been patented in China and what the potential drug candidates for patents are in China...
  59. pmc Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea
    Bai Sui Feng
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 171:537-47. 2007
    ..Blockade of TLR2 or NOD1 or treating mice with a mast cell stabilizer can efficiently inhibit PGN-induced-diarrhea, providing potential therapeutic significance...
  60. ncbi request reprint Evaluation of FORS-D analysis: a comparison with the statistically significant stem-loop potential
    Chi Yu Zhang
    Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, Zhenjiang, Jiangsu, P R China
    Biochem Genet 46:29-40. 2008
    ..The results also suggest that for some purposes the online program SigStb developed by Le and Maizel may be used as an alternative tool for FORS-D analysis...
  61. ncbi request reprint Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function
    Ping Chang Yang
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    J Gastroenterol Hepatol 22:1823-31. 2007
    ..However, the mechanism remains unclear. The aim of this study was to characterize a novel signal transduction pathway via which heat stress compromises intestinal epithelial barrier function...
  62. ncbi request reprint Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2
    Linda Wu
    Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Immunol Cell Biol 85:538-45. 2007
    ..T84 monolayer transported PGN activates HMC-1 cells to release chemical mediators to induce T84 monolayer dysfunction that are mediated by TLR2 and NOD2...