Influenza virus-like particle vaccinesJoel R Haynes
LigoCyte Pharmaceuticals, Inc, 2155 Analysis Drive, Bozeman, MT 59718, USA
Expert Rev Vaccines 8:435-45. 2009
..This new influenza vaccine paradigm offers potential advantages over the conventional egg-based, split-vaccine platform in terms of enhanced immunogenicity and better breadth of protection...
- Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge
Joel R Haynes
LigoCyte Pharmaceuticals, Inc 2155 Analysis Dr, Bozeman, MT 59718, USA
Vaccine 27:530-41. 2009
..These data demonstrate robust vaccine protection of Gag-based, influenza-pseudotyped VLPs carrying a variety of influenza antigens and suggest applicability toward a number of additional respiratory viruses...
Potent protective cellular immune responses generated by a DNA vaccine encoding HSV-2 ICP27 and the E. coli heat labile enterotoxinJoel R Haynes
PowderJect Vaccines Inc, Middleton, WI, USA
Vaccine 24:5016-26. 2006
..These data demonstrate that augmented cellular immune responses resulting from LT vector plus antigen vector administration to the skin are biologically significant, leading to enhanced protection against mucosal pathogenic challenge...
Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccinesJoshua Arrington
PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
J Virol 76:4536-46. 2002
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- Epidermal DNA vaccine for influenza is immunogenic in humans
Robert J Drape
PowderJect Vaccines, Inc, 8551 Research Way, Middleton, WI 53562, USA
Vaccine 24:4475-81. 2006
..Treatment-related reactions were mild to moderate, and included skin reactions at the vaccine site. These results provide a preliminary indication of the safety and immunogenicity of a prototype epidermal DNA vaccine for influenza...
- Particle-mediated DNA vaccine delivery to the skin
Joel R Haynes
PowderJect Vaccines, Inc, 8551 Research Way, Middleton, WI 53562, USA
Expert Opin Biol Ther 4:889-900. 2004
..Particle-mediated DNA vaccines represent a promising tool for developing candidate vaccines against some of the more difficult infectious, parasitic and oncologic disease targets...
- DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued
Deborah Heydenburg Fuller
PowderJect Vaccines, Inc, Middleton, WI 53562, USA
Virology 348:200-15. 2006
..Immunizing before infection or with multi-epitopes enhanced these effects. These results demonstrate that DNA immunization during antiretroviral therapy may be an effective strategy to treat HIV infection...
- Needle-free epidermal powder immunization
Dexiang Chen
PowderJect Vaccines Inc, Madison, WI 53711, USA
Expert Rev Vaccines 1:265-76. 2002
..Emphasis will be placed on epidermal powder immunization and particle-mediated ('gene gun') DNA immunization, which use similar mechanical devices to deliver protein and DNA vaccines, respectively, into the viable epidermis...
- Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine
Deborah Heydenburg Fuller
PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
J Virol 76:3309-17. 2002
..These results support further development of a DNA vaccine for protection against HIV...
- Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma
Lendon G Payne
Address PowderJect Vaccines Inc, Madison, WI 53711, USA
Curr Opin Mol Ther 4:459-66. 2002
..This review highlights the current body of data showing that particle-mediated DNA immunization is highly effective in the induction Th1-type responses and is an efficient method for inducing immune responses in humans...
