[Gene therapy for myocardial regeneration]Shin-ichiro Hayashi
Department of Geriatric Medicine, Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine
Nippon Rinsho 61:867-70. 2003
..Here, we presented recent progress, especially, in gene therapy for myocardial regeneration under ischemic heart disease and heart failure...
Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularizationShin Ichiro Hayashi
Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
Circulation 111:2210-8. 2005
..In this study, we focused on the function of ephrin-B2 in postnatal neovascularization...
Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagyShin Ichiro Hayashi
Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu, Japan
Arterioscler Thromb Vasc Biol 29:1909-15. 2009
..Although the majority of cases of Alzheimer disease (AD) are known to be attributable to the sporadic (nongenetic) form of the disease, the mechanism underlying its cause and progression still remains unclear...
The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagyShin Ichiro Hayashi
Department of Cell Signaling, Gifu University Graduate School of Medicine, Japan
Am J Pathol 175:2226-34. 2009
..These results suggest that phenotypic alteration in the endothelium by sirolimus or paclitaxel might affect the rates of late stent thrombosis, myocardial infarction, and mortality...
Immediate early gene IEX-1 induces astrocytic differentiation of U87-MG human glioma cellsFukka You
Department of Cell Signaling, Division of Cell and Molecular Biology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
J Cell Biochem 100:256-65. 2007
..These results indicate that IEX-1 plays an important role in astrocytic differentiation of human glioma cells and that IEX-1 functions at downstream of PKA...
Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapyYuka Ikegame
Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
Cytotherapy 13:675-85. 2011
..The present study compared the therapeutic potential of adipose-derived stem cells (ASC) with that of BM-derived stem cells (BMSC) in a murine stroke model...
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edemaYuka Ikegame
Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
Hypertens Res 33:703-7. 2010
..These results suggest that neutrophil elastase inhibition could protect blood-brain barrier function in acute cerebral ischemia by augmentation of angiopoietin-1 expression and survival of endothelial cells...
Human gastric cancer organizes neighboring lymphatic vessels via recruitment of bone marrow-derived lymphatic endothelial progenitor cellsMasahiro Tawada
Departments of Surgical Oncology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
J Gastroenterol 47:1057-60. 2012
..Studies suggest that lymphatic metastasis has been linked to lymphangiogenesis, the growth of lymphatic vessels, while the mechanisms of tumor lymphangiogenesis remain poorly characterized...
Overexpression of immediate early gene X-1 (IEX-1) enhances gamma-radiation-induced apoptosis of human glioma cell line, U87-MGKentaro Yamashita
Departments of Neurosurgery, Gifu University Graduate School of Medicine, Yanagido, Japan
Neuropathology 29:20-4. 2009
..Our findings suggest that IEX-1 may represent a new factor for the enhancement of radiation-induced apoptosis of human glioma cells...
Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regenerationHideki Iwaguro
Division of Cardiovascular Research and Medicine, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
Circulation 105:732-8. 2002
..In vivo, gene-modified EPCs facilitate the strategy of cell transplantation to augment naturally impaired neovascularization in an animal model of experimentally induced limb ischemia...
Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicineHironori Nakagami
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Japan
Hypertension 48:112-9. 2006
..In the future, a human ES-based tissue model would be an optional tool for the screening of pharmaceutical drugs for vascular disease...