Takahiro Hata

Summary

Publications

  1. doi request reprint JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner
    Takahiro Hata
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, Takatsuki, Osaka 569 1125, Japan
    J Pharmacol Exp Ther 336:850-6. 2011
  2. doi request reprint JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats
    T Hata
    Biological Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan
    Diabetes Obes Metab 13:629-38. 2011
  3. doi request reprint A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats
    Yukihito Ishii
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan
    Nutr Res 30:483-91. 2010
  4. doi request reprint Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein
    Yasuko Mera
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    J Pharmacol Exp Ther 336:321-7. 2011
  5. ncbi request reprint Pathophysiological analysis of female Spontaneously Diabetic Torii fatty rats
    Yukihito Ishii
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka, Japan
    Exp Anim 59:73-84. 2010

Collaborators

Detail Information

Publications5

  1. doi request reprint JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner
    Takahiro Hata
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, Takatsuki, Osaka 569 1125, Japan
    J Pharmacol Exp Ther 336:850-6. 2011
    ..The present findings indicate that JTT-130 causes satiety responses, decreased food intake, and gastric emptying in a dietary fat-dependent manner, with enhanced production of gut peptides such as PYY and GLP-1 from the intestine...
  2. doi request reprint JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats
    T Hata
    Biological Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan
    Diabetes Obes Metab 13:629-38. 2011
    ..We investigated the effects of JTT-130, a novel intestine-specific MTP inhibitor, on impaired glucose and lipid metabolism in Zucker diabetic fatty (ZDF) rats...
  3. doi request reprint A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats
    Yukihito Ishii
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan
    Nutr Res 30:483-91. 2010
    ..The hyperfunction of pancreatic beta cells induced by a high-fat diet before the onset of hyperglycemia appears to suppress development of hyperglycemia/hypoinsulinemia...
  4. doi request reprint Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein
    Yasuko Mera
    Japan Tobacco Inc, Central Pharmaceutical Research Institute, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    J Pharmacol Exp Ther 336:321-7. 2011
    ..These results indicated that JTT-130 is a potent inhibitor specific to intestinal MTP and suggested that JTT-130 would be a useful compound for the treatment of dyslipidemia without inducing hepatotoxicity...
  5. ncbi request reprint Pathophysiological analysis of female Spontaneously Diabetic Torii fatty rats
    Yukihito Ishii
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka, Japan
    Exp Anim 59:73-84. 2010
    ..In conclusion, the female SDT-fa/fa rat has the potential to become an important animal model of type 2 diabetes mellitus with obesity, especially for women, for which few models currently exist...