P D Harvey

Summary

Publications

  1. ncbi request reprint Practice-related improvement in information processing with novel antipsychotic treatment
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 46:139-48. 2000
  2. ncbi request reprint Ziprasidone and cognition: the evolving story
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York University, New York 10029, USA
    J Clin Psychiatry 64:33-9. 2003
  3. ncbi request reprint Changes in cognitive functioning with risperidone and olanzapine treatment: a large-scale, double-blind, randomized study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Psychopharmacology (Berl) 169:404-11. 2003
  4. ncbi request reprint Cognition in schizophrenia: from basic science to clinical treatment
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, NY 10029, New York, USA
    Psychopharmacology (Berl) 169:213-4. 2003
  5. ncbi request reprint Cognitive impairment in elderly patients with schizophrenia: age related changes
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 16:S78-85. 2001
  6. ncbi request reprint Cognition in schizophrenia
    P D Harvey
    Department of Psychiatry, Box 1229, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Psychiatry Rep 3:423-8. 2001
  7. ncbi request reprint Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment
    P D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 158:176-84. 2001
  8. ncbi request reprint Clinical, cognitive and functional characteristics of long-stay patients with schizophrenia: a comparison of VA and state hospital patients
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, 10029, New York, NY, USA
    Schizophr Res 43:3-9. 2000
  9. ncbi request reprint Convergence of cognitive and adaptive decline in late-life schizophrenia
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 35:77-84. 1999
  10. ncbi request reprint Cognitive impairment in geriatric chronic schizophrenic patients: a cross-national study in New York and London
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 12:1001-7. 1997

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Practice-related improvement in information processing with novel antipsychotic treatment
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 46:139-48. 2000
    ..Novel antipsychotic treatment has been reported to improve certain cognitive skills in schizophrenic patients, but no information is yet available about the effect of newer medications on skill learning...
  2. ncbi request reprint Ziprasidone and cognition: the evolving story
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York University, New York 10029, USA
    J Clin Psychiatry 64:33-9. 2003
    ..Improvement in cognitive function observed with ziprasidone may have implications for long-term patient outcomes...
  3. ncbi request reprint Changes in cognitive functioning with risperidone and olanzapine treatment: a large-scale, double-blind, randomized study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Psychopharmacology (Berl) 169:404-11. 2003
    ..The effects of risperidone and olanzapine on cognitive functioning in patients with schizophrenia were compared in a randomized, double-blind trial...
  4. ncbi request reprint Cognition in schizophrenia: from basic science to clinical treatment
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, NY 10029, New York, USA
    Psychopharmacology (Berl) 169:213-4. 2003
  5. ncbi request reprint Cognitive impairment in elderly patients with schizophrenia: age related changes
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 16:S78-85. 2001
    ....
  6. ncbi request reprint Cognition in schizophrenia
    P D Harvey
    Department of Psychiatry, Box 1229, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Psychiatry Rep 3:423-8. 2001
    ....
  7. ncbi request reprint Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment
    P D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 158:176-84. 2001
    ..The ability to discriminate between high- and low-quality studies will be required to understand the true implications of these studies and their relevance to clinical practice...
  8. ncbi request reprint Clinical, cognitive and functional characteristics of long-stay patients with schizophrenia: a comparison of VA and state hospital patients
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, 10029, New York, NY, USA
    Schizophr Res 43:3-9. 2000
    ..These data indicate that VA patients may have reduced severity of functional and cognitive impairments relative to state hospital patients, but that the relationship between the different illness variables was similar in the two groups...
  9. ncbi request reprint Convergence of cognitive and adaptive decline in late-life schizophrenia
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 35:77-84. 1999
    ..These data indicate that cognitive decline may predict deterioration in overall functional status and imply that treatment of cognitive impairment might have a beneficial effect on global functional status...
  10. ncbi request reprint Cognitive impairment in geriatric chronic schizophrenic patients: a cross-national study in New York and London
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 12:1001-7. 1997
    ..These data add to previous results suggesting that cognitive impairment is a common feature in poor outcome geriatric patients with schizophrenia...
  11. ncbi request reprint Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia: a comparison across treatment sites
    P D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine and Franklin Delano Roosevelt Veterans Administration Medical Center, Montrose, NY 10029, USA
    Am J Psychiatry 155:1080-6. 1998
    ....
  12. ncbi request reprint Severity of symptoms in chronically institutionalized geriatric schizophrenic patients
    M Davidson
    Department of Psychiatry, Mount Sinai School of Medicine, New York
    Am J Psychiatry 152:197-207. 1995
    ....
  13. ncbi request reprint Six-year follow-up study of cognitive and functional status across the lifespan in schizophrenia: a comparison with Alzheimer's disease and normal aging
    J I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 158:1441-8. 2001
    ..The rate of decline was compared to changes associated with Alzheimer's disease...
  14. ncbi request reprint The association between adaptive and cognitive deficits in geriatric chronic schizophrenic patients
    P D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 27:211-8. 1997
    ..These results suggest that interventions should be individually targeted to cognitive-adaptive impairments and undercontrolled behavior...
  15. ncbi request reprint Aggression in elderly schizophrenia patients: a comparison of nursing home and state hospital residents
    C R Bowie
    Department of Psychology, Hofstra University, Hempsted, New York, USA
    J Neuropsychiatry Clin Neurosci 13:357-66. 2001
    ....
  16. ncbi request reprint Guanfacine treatment of cognitive impairment in schizophrenia
    J I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 25:402-9. 2001
    ....
  17. ncbi request reprint The convergence of neuropsychological testing and clinical ratings of cognitive impairment in patients with schizophrenia
    P D Harvey
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Compr Psychiatry 42:306-13. 2001
    ..These results may also be specific to the clinical rating scale used, the Positive and Negative Syndrome Scale (PANSS)...
  18. ncbi request reprint A comprehensive analysis of verbal fluency deficit in geriatric schizophrenia
    C R Bowie
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Arch Clin Neuropsychol 19:289-303. 2004
    ..Verbal fluency impairment remains common and functionally relevant in schizophrenia patients in late life...
  19. ncbi request reprint Age-related shift in brain region activity during successful memory performance
    E A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neurobiol Aging 19:437-45. 1998
    ..Age-related functional change may reflect dynamic re-allocation in a network of brain areas, not merely anatomically fixed neuronal loss or diminished capacity to perform...
  20. ncbi request reprint Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia
    R S Keefe
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Arch Gen Psychiatry 54:169-76. 1997
    ..We investigated whether these hypothesized components of a schizophrenia-related phenotype are associated with one another or are independent in nonpsychotic relatives of patients with schizophrenia...
  21. ncbi request reprint Cognitive and functional impairments in elderly patients with schizophrenia: a review of the recent literature
    P D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Harv Rev Psychiatry 9:59-68. 2001
    ..The predictors and course of these declines, as well as their potential underlying causes, are described in detail. Evidence regarding schizophrenia as a lifelong, dynamic brain disease is also reviewed...
  22. ncbi request reprint Hypofrontality in unmedicated schizophrenia patients studied with PET during performance of a serial verbal learning task
    E A Hazlett
    Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, 1 Gustave L Levy Place, 10029 6574, New York, NY, USA
    Schizophr Res 43:33-46. 2000
    ..Patients also exhibited hypofrontality (lower ratio of frontal to occipital rGMR) compared with normal subjects. Among the patients, more severe hypofrontality was associated with increased perseveration errors...
  23. ncbi request reprint Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. A multisite, multimodel evaluation of the factorial structure of the Positive and Negative Syndrome Scale. The PANSS Study Group
    L White
    Department of Psychiatry, Mt Sinai School of Medicine New York, N Y, USA
    Psychopathology 30:263-74. 1997
    ..The results of this study also implicated some problems in the validity of the PANSS as currently configured when used to assess symptoms of schizophrenia...
  24. ncbi request reprint Effects of rivastigmine on cognitive function in patients with traumatic brain injury
    J M Silver
    New York University School of Medicine, New York, NY, USA
    Neurology 67:748-55. 2006
    ..To compare the efficacy and safety of rivastigmine (3 to 6 mg/day) vs placebo over 12 weeks in patients with traumatic brain injury and persistent cognitive impairment...
  25. ncbi request reprint Diagnosis of manic episodes in adolescent inpatients: structured diagnostic procedures compared to clinical chart diagnoses
    D L Pogge
    Four Winds Hospital, Katonah, NY, USA
    Psychiatry Res 101:47-54. 2001
    ..The depression in these patients may not be adequately treated, and there are potential clinical implications of over-diagnosis of manic episodes in adolescents...
  26. ncbi request reprint Cognitive and functional effects of atypical antipsychotic medications
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 67:e13. 2006
    ..Depression and negative symptoms, for example, also affect an individual with schizophrenia and his or her functioning in the real world as opposed to within clinical studies...
  27. ncbi request reprint Risperidone and cognitive function in children with disruptive behavior disorders
    Gahan J Pandina
    Medical Affairs, Janssen Pharmaceutica, Inc, Titusville, New Jersey 08560, USA
    Biol Psychiatry 62:226-34. 2007
    ..Effects of risperidone on cognitive function in children with disruptive behavior disorders (DBDs) and subaverage intelligence quotient (IQ) were assessed...
  28. pmc Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophrenia
    Brent T Mausbach
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Psychiatr Res 42:320-7. 2008
    ..43, p=.015). The UPSA is a brief measure of functional capacity that predicts the ability of patients with schizophrenia to reside independently in the community...
  29. ncbi request reprint Enhanced effects of cortisol administration on episodic and working memory in aging veterans with PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 32:2581-91. 2007
    ..The findings suggest that there may be opportunities for developing therapeutic strategies using glucocorticoids in the treatment of aging combat veterans...
  30. ncbi request reprint The relationship between symptomatic remission and neuropsychological improvement in schizophrenia patients switched to treatment with ziprasidone
    Peter F Buckley
    Medical College of Georgia, United States
    Schizophr Res 94:99-106. 2007
    ....
  31. pmc Performance-based measures of functional skills: usefulness in clinical treatment studies
    Philip D Harvey
    Schizophr Bull 33:1138-48. 2007
    ....
  32. ncbi request reprint Improvement in social competence with short-term atypical antipsychotic treatment: a randomized, double-blind comparison of quetiapine versus risperidone for social competence, social cognition, and neuropsychological functioning
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 163:1918-25. 2006
    ....
  33. ncbi request reprint Longitudinal assessment of cognitive performance in Holocaust survivors with and without PTSD
    Rachel Yehuda
    The Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York 10468, USA
    Biol Psychiatry 60:714-21. 2006
    ..It is therefore unclear whether relationships between memory and symptoms differ over time among older persons with and without PTSD...
  34. ncbi request reprint Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: evidence for specificity of relationships?
    Margaret M McClure
    Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center MIRECC, 130 West Kingsbridge Road Bronx, NY 10468, USA
    Schizophr Res 89:330-8. 2007
    ..This study examined the specificity of the relationships between different NP abilities and performance-based measures of social and living skills...
  35. ncbi request reprint Defining and achieving recovery from bipolar disorder
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 67:14-8; discussion 36-42. 2006
    ....
  36. ncbi request reprint The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    ..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
  37. pmc Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop
    Alan S Bellack
    University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
    Schizophr Bull 33:805-22. 2007
    ..This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
  38. ncbi request reprint Treatment of cognitive deficits in schizophrenia
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Opin Investig Drugs 7:608-13. 2006
    ..This paper reviews the current status of cognitive deficit treatment in schizophrenia and offers suggestions for future work...
  39. ncbi request reprint Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  40. pmc Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 63:505-11. 2008
    ..This study examined the different predictive relationships between NP domains, functional competence, social competence, symptoms, and real-world behavior in domains of work skills, interpersonal relationships, and community activities...
  41. doi request reprint Six-year outcomes in first admission adolescent inpatients: clinical and cognitive characteristics at admission as predictors
    David L Pogge
    Department of Psychological Assessment, Four Winds Hospital, Katonah, NY, USA
    Psychiatry Res 160:47-54. 2008
    ..In contrast to psychosis, depression at follow-up was predicted by admission symptomatology, but not by cognitive deficits...
  42. pmc Implementation considerations for multisite clinical trials with cognitive neuroscience tasks
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3270, Durham, NC 27710, USA
    Schizophr Bull 34:656-63. 2008
    ..Suggestions for overcoming these implementation challenges are offered...
  43. doi request reprint Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)
    Richard S E Keefe
    Department of Psychiatry, Box 3207, Duke University Medical Center, Durham, North Carolina 27710, USA
    Schizophr Res 102:108-15. 2008
    ..An education-correction factor was calculated and recommended only for non-schizophrenia patients. Eight different verbal memory tests were found to have equivalent levels of difficulty...
  44. doi request reprint Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
    J Abnorm Psychol 117:342-54. 2008
    ..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
  45. doi request reprint Communication abnormalities predict functional outcomes in chronic schizophrenia: differential associations with social and adaptive functions
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Ave, 4th Floor, Box 1230, New York, NY 10029, USA
    Schizophr Res 103:240-7. 2008
    ..In this chronically institutionalized sample, communication disorder was a stronger predictor of social, but not adaptive, outcomes than neurocognition or clinical symptoms...
  46. pmc Functional implications of neuropsychological normality and symptom remission in older outpatients diagnosed with schizophrenia: A cross-sectional study
    Winnie W Leung
    Department of Veterans Affairs, VISN 3 Mental Illness, Research, Education and Clinical Center MIRECC, Bronx, New York, USA
    J Int Neuropsychol Soc 14:479-88. 2008
    ..The disability seen in NP normal cases indicates that factors other than cognitive impairments may determine aspects of everyday outcomes in schizophrenia...
  47. doi request reprint Pharmacological treatment of cognition in schizophrenia: an idea whose method has come
    Philip D Harvey
    Am J Psychiatry 165:163-5. 2008
  48. doi request reprint The broad importance of cognitive impairments in aging-related disorders
    Philip D Harvey
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
    Am J Geriatr Psychiatry 16:99-101. 2008
  49. doi request reprint A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia
    Joseph I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychopharmacol 28:59-63. 2008
    ....
  50. ncbi request reprint Cognitive functioning and acute sedative effects of risperidone and quetiapine in patients with stable bipolar I disorder: a randomized, double-blind, crossover study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 68:1186-94. 2007
    ..The primary objective of this double-blind study was to compare the effects of treatment initiation with risperidone and quetiapine on cognitive function in subjects with stable bipolar disorder...
  51. ncbi request reprint Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings
    Abraham Reichenberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychol Bull 133:833-58. 2007
    ....
  52. ncbi request reprint Schizophrenia: measurements of psychopathology
    J P Lindenmayer
    Department of Psychiatry, New York University, and Manhattan Psychiatric Center, New York, NY, USA
    Psychiatr Clin North Am 30:339-63. 2007
    ..The instruments discussed cover the broad range of psychopathology found in patients who have schizophrenia...
  53. ncbi request reprint Cognition and aging in psychopathology: focus on schizophrenia and depression
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Clin Psychol 2:389-409. 2006
    ..We see cognitive changes as a possible commonality across persistent psychiatric disorders as well as healthy aging in late life...
  54. doi request reprint Neuropsychological and symptom predictors of aggression on the psychiatric inpatient service
    Mark Serper
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    J Clin Exp Neuropsychol 30:700-9. 2008
    ....
  55. ncbi request reprint Premorbid functioning and treatment response in recent-onset schizophrenia
    Jonathan Rabinowitz
    Bar Ilan University, Ramat Gan, Israel
    Br J Psychiatry 189:31-5. 2006
    ..Investigating the relationship between premorbid functioning and treatment response in schizophrenia is relevant to understanding the illness and predicting treatment outcomes...
  56. ncbi request reprint Stability of cognitive performance in older patients with schizophrenia: an 8-week test-retest study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 162:110-7. 2005
    ..There are several factors that could lead to spurious improvements in cognitive test scores, including practice effects and random test-retest errors...
  57. ncbi request reprint Cognitive functioning predicts outpatient service utilization in schizophrenia
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ment Health Serv Res 6:185-8. 2004
    ..More case management services may be required to compensate for impairments in executive functioning in patients with schizophrenia...
  58. ncbi request reprint Working memory performance in poor outcome schizophrenia: relationship to age and executive functioning
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Exp Neuropsychol 26:153-60. 2004
    ..These findings indicate that LNS may be an index of executive functioning, particularly in patients who cannot perform the WCST...
  59. ncbi request reprint The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
    Schizophr Res 68:283-97. 2004
    ..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
  60. ncbi request reprint Cognitive functioning in schizophrenia: a consensus statement on its role in the definition and evaluation of effective treatments for the illness
    Philip D Harvey
    Mt Sinai School of Medicine, 1425 Madison Avenue, New York, N Y 10029, USA
    J Clin Psychiatry 65:361-72. 2004
    ..Thus, a much wider range of improvements, not widely produced by previous treatments, is required to take treatment for schizophrenia to a new level of effectiveness...
  61. ncbi request reprint Improvement in cognitive function following a switch to ziprasidone from conventional antipsychotics, olanzapine, or risperidone in outpatients with schizophrenia
    Philip D Harvey
    Mt Sinai School of Medicine, New York University, 1425 Madison Avenue, Fourth Floor, New York, NY 10029, USA
    Schizophr Res 66:101-13. 2004
    ....
  62. ncbi request reprint The relationship of neuropsychological test performance with the PANSS in antipsychotic naïve, first-episode psychosis patients
    Kimberley P Good
    Department of Psychiatry, Dalhousie University, Suite 9216 AJLB, 5909 Veterans Memorial Lane, Halifax, NS, Canada B3H 2E2
    Schizophr Res 68:11-9. 2004
    ..However, the relationship between the clinically rated cognitive factor and performance-based cognitive test scores has not been thoroughly examined, particularly in patients who are early in the course of illness...
  63. ncbi request reprint Randomized, controlled, double-blind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Psychopharmacology (Berl) 172:324-32. 2004
    ..Newer antipsychotic medications have been reported to enhance cognitive functioning in schizophrenia. Head to head studies with double-blind methods are still relatively few in number...
  64. ncbi request reprint Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder
    Philip D Harvey
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Geriatr Psychiatry 18:820-9. 2003
    ..To examine the effects of risperidone and olanzapine on cognitive functioning in elderly patients with schizophrenia or schizoaffective disorder...
  65. ncbi request reprint Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationale
    Richard S E Keefe
    Neurocognitive Assessment Unit, Duke University Medical Center, Durham, NC 27710, USA
    Schizophr Bull 29:45-55. 2003
    ....
  66. ncbi request reprint Cross-national cognitive assessment in schizophrenia clinical trials: a feasibility study
    Philip D Harvey
    Mt Sinai School of Medicine, New York, NY, USA
    Schizophr Res 59:243-51. 2003
    ..In general, these data support the validity of cross-national neuropsychological assessments...
  67. ncbi request reprint Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidity
    Joseph I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 159:1388-94. 2002
    ..While cognitive impairment has proven to be a major predictor of overall functional deficit in schizophrenia, other potential factors, such as medical comorbidity, need to be considered...
  68. ncbi request reprint Cortical and subcortical cognitive deficits in schizophrenia: convergence of classifications based on language and memory skill areas
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Exp Neuropsychol 24:55-66. 2002
    ..These data suggest that cortical versus subcortical profiles of cognitive performance in schizophrenia are inconsistent across ability areas, and are not likely to be the result of stable structural or functional brain deficits...
  69. ncbi request reprint Ziprasidone: efficacy, tolerability, and emerging data on wide-ranging effectiveness
    Philip D Harvey
    Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Expert Opin Pharmacother 6:337-46. 2005
    ..Several issues remain to be addressed, including the efficacy of once-daily dosing, the need to take the medication with food, and the correct dosing strategy...
  70. ncbi request reprint The longitudinal course of thought disorder in geriatric patients with chronic schizophrenia
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Ave, 4th Floor, Box 1230, New York, NY 10029, USA
    Am J Psychiatry 162:793-5. 2005
    ..This study longitudinally assessed previously validated dimensions of thought disorder--verbal underproductivity and disconnection--in geriatric schizophrenia and replicated previous cross-sectional differences in communication disorders...
  71. ncbi request reprint The dimensions of clinical and cognitive change in schizophrenia: evidence for independence of improvements
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Psychopharmacology (Berl) 187:356-63. 2006
    ..Thus, this study used a database from an existing clinical trial and examined the relationships between changes in clinical symptoms and cognitive deficits with several different strategies...
  72. ncbi request reprint Convergence of clinical staff ratings and research ratings to assess patients with schizophrenia in nursing homes
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Psychiatr Serv 57:838-43. 2006
    ....
  73. ncbi request reprint Baseline neurocognitive deficits in the CATIE schizophrenia trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:2033-46. 2006
    ..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity...
  74. ncbi request reprint Neuropsychological normalization with long-term atypical antipsychotic treatment: results of a six-month randomized, double-blind comparison of ziprasidone vs. olanzapine
    Philip D Harvey
    Department of Psychiatry, Box 1229 Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neuropsychiatry Clin Neurosci 18:54-63. 2006
    ....
  75. ncbi request reprint The Schizophrenia Cognition Rating Scale: an interview-based assessment and its relationship to cognition, real-world functioning, and functional capacity
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 163:426-32. 2006
    ..This study describes the reliability and validity of a new interview-based assessment of cognition, the Schizophrenia Cognition Rating Scale (SCoRS), that involves interviews with patients and informants...
  76. ncbi request reprint Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 163:418-25. 2006
    ..Assessment of the ability to perform life skills under optimal conditions (i.e., assessment of functional capacity) has been proposed as a means to clarify these relationships...
  77. ncbi request reprint The relationship of the Brief Assessment of Cognition in Schizophrenia (BACS) to functional capacity and real-world functional outcome
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Exp Neuropsychol 28:260-9. 2006
    ..They also suggest that the measures being considered as potential co-primary indicators of cognitive function for registration trials are significantly correlated with cognition as assessed by brief cognitive assessments...
  78. ncbi request reprint From clinical research to clinical practice: a 4-year review of ziprasidone
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    CNS Spectr 10:1-20. 2005
    ..This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania...
  79. pmc Negative symptoms and cognitive deficits: what is the nature of their relationship?
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, USA
    Schizophr Bull 32:250-8. 2006
    ....
  80. ncbi request reprint Treatment of cognitive impairment in early psychosis: a comparison of risperidone and haloperidol in a large long-term trial
    Philip D Harvey
    Bar Ilan University, Ramat Gan, Israel
    Am J Psychiatry 162:1888-95. 2005
    ..The study was conducted in a large group of patients experiencing their first episode of schizophrenia...
  81. ncbi request reprint Cognition in schizophrenia: impairments, determinants, and functional importance
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatr Clin North Am 28:613-33, 626. 2005
    ..General psychopathology symptoms, such as depression and anxiety, may become important treatment targets as strategies are developed for translating cognitive enhancement to real-world functional performance...
  82. ncbi request reprint The effect of citalopram adjunctive treatment added to atypical antipsychotic medications for cognitive performance in patients with schizophrenia
    Joseph I Friedman
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychopharmacol 25:237-42. 2005
    ..Further research on alternative serotonergic approaches to cognitive enhancement in schizophrenia is warranted...
  83. ncbi request reprint Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial
    Nina Schooler
    Hurwich Professor, Bar Ilan University, Ramat Gan, Israel
    Am J Psychiatry 162:947-53. 2005
    ..Thus, initial treatment of active symptoms and subsequent relapse prevention are central goals of pharmacotherapy. This study compared long-term effectiveness of risperidone versus haloperidol in first-episode psychosis patients...
  84. ncbi request reprint A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia
    Joseph I Friedman
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 51:349-57. 2002
    ..Subtle changes in cholinergic function in schizophrenic patients provide the rationale to test the effectiveness of cholinesterase inhibitors in treating cognitive impairment in schizophrenia...