H C Harsha

Summary

Publications

  1. pmc Quantitative proteomics for identifying biomarkers for Rabies
    Abhilash K Venugopal
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N, Broadway, BRB 527, Baltimore, MD, 21205, USA
    Clin Proteomics 10:3. 2013
  2. pmc Phosphoproteomics in cancer
    H C Harsha
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Mol Oncol 4:482-95. 2010
  3. pmc SILAC-based quantitative proteomic analysis of gastric cancer secretome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Proteomics Clin Appl 7:355-66. 2013
  4. doi request reprint Proteogenomic analysis of Candida glabrata using high resolution mass spectrometry
    T S Keshava Prasad
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India
    J Proteome Res 11:247-60. 2012
  5. pmc Plasma Proteome Database as a resource for proteomics research: 2014 update
    Vishalakshi Nanjappa
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, Karnataka, India, Amrita School of Biotechnology, Amrita University, Kollam 690 525, Kerala, India, Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605 014, India, Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605014, India, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560 022, Karnataka, India, Department of Biotechnology, Kuvempu University, Shankaraghatta 577 451, Karnataka, India, Government Medical College, Bhavnagar 364 001, Gujarat, India, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442 012, Maharashtra, India, The Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, Department of Internal Medicine, Armed Forces Medical College, Pune 411 040, Maharashtra, Japan
    Nucleic Acids Res 42:D959-65. 2014
  6. pmc Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery
    Harsh Pawar
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Cancer Biol Ther 12:510-22. 2011
  7. doi request reprint Proteomic analysis of an unsequenced plant--Mangifera indica
    Santosh Renuse
    Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560066, India
    J Proteomics 75:5793-6. 2012
  8. pmc Human protein reference database--2006 update
    Gopa R Mishra
    Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India
    Nucleic Acids Res 34:D411-4. 2006
  9. doi request reprint A proteogenomic approach to map the proteome of an unsequenced pathogen - Leishmania donovani
    Harsh Pawar
    Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India
    Proteomics 12:832-44. 2012
  10. doi request reprint Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Biochim Biophys Acta 1834:2308-16. 2013

Collaborators

Detail Information

Publications32

  1. pmc Quantitative proteomics for identifying biomarkers for Rabies
    Abhilash K Venugopal
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N, Broadway, BRB 527, Baltimore, MD, 21205, USA
    Clin Proteomics 10:3. 2013
    ..Early diagnosis of this disease is particularly important as rabies is invariably fatal if adequate post exposure prophylaxis is not administered immediately following the bite...
  2. pmc Phosphoproteomics in cancer
    H C Harsha
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Mol Oncol 4:482-95. 2010
    ..This review summarizes various approaches used for analysis of the phosphoproteome in general, and protein kinases in particular, highlighting key cancer phosphoproteomic studies...
  3. pmc SILAC-based quantitative proteomic analysis of gastric cancer secretome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Proteomics Clin Appl 7:355-66. 2013
    ..However, there is no reliable blood-based screening test for this cancer. Identifying proteins secreted from tumor cells could lead to the discovery of clinically useful biomarkers for early detection of gastric cancer...
  4. doi request reprint Proteogenomic analysis of Candida glabrata using high resolution mass spectrometry
    T S Keshava Prasad
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India
    J Proteome Res 11:247-60. 2012
    ..Our study illustrates how proteogenomic analysis enabled by high resolution mass spectrometry can enrich genome annotation and should be an integral part of ongoing genome sequencing and annotation efforts...
  5. pmc Plasma Proteome Database as a resource for proteomics research: 2014 update
    Vishalakshi Nanjappa
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, Karnataka, India, Amrita School of Biotechnology, Amrita University, Kollam 690 525, Kerala, India, Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605 014, India, Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605014, India, Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560 022, Karnataka, India, Department of Biotechnology, Kuvempu University, Shankaraghatta 577 451, Karnataka, India, Government Medical College, Bhavnagar 364 001, Gujarat, India, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442 012, Maharashtra, India, The Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, Department of Internal Medicine, Armed Forces Medical College, Pune 411 040, Maharashtra, Japan
    Nucleic Acids Res 42:D959-65. 2014
    ..We believe that PPD will facilitate both clinical and basic research by serving as a comprehensive reference of plasma proteins in humans and accelerate biomarker discovery and translation efforts...
  6. pmc Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery
    Harsh Pawar
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Cancer Biol Ther 12:510-22. 2011
    ..The success of our study shows that this mass spectrometric strategy can be applied to cancers in general to develop a panel of candidate biomarkers, which can then be validated by other techniques...
  7. doi request reprint Proteomic analysis of an unsequenced plant--Mangifera indica
    Santosh Renuse
    Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560066, India
    J Proteomics 75:5793-6. 2012
    ..To our knowledge, this study is the first high-throughput analysis of mango leaf proteome and could pave the way for further genomic, transcriptomic and proteomic studies...
  8. pmc Human protein reference database--2006 update
    Gopa R Mishra
    Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India
    Nucleic Acids Res 34:D411-4. 2006
    ....
  9. doi request reprint A proteogenomic approach to map the proteome of an unsequenced pathogen - Leishmania donovani
    Harsh Pawar
    Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India
    Proteomics 12:832-44. 2012
    ..Here, we report results from proteomic profiling of L. donovani, an organism with an unsequenced genome...
  10. doi request reprint Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Biochim Biophys Acta 1834:2308-16. 2013
    ..Our study illustrates quantitative proteomics of secretome as a robust approach for identification of potential HNSCC biomarkers. This article is part of a Special Issue entitled: An Updated Secretome. ..
  11. doi request reprint Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma
    Manoj Kumar Kashyap
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Cancer Biomark 12:1-9. 2012
    ..Overall, our findings open up new avenues for development of novel therapeutics and/or diagnostic approaches in ESCC...
  12. doi request reprint Proteomic strategies to characterize signaling pathways
    H C Harsha
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Methods Mol Biol 1007:359-77. 2013
    ..Here, we discuss various proteomic strategies to characterize signaling pathways and provide protocols for phosphoproteomic analysis...
  13. pmc Quantitative proteomics for identifying biomarkers for tuberculous meningitis
    Ghantasala S Sameer Kumar
    Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India
    Clin Proteomics 9:12. 2012
    ..abstract:..
  14. pmc Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry
    Dhanashree S Kelkar
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Mol Cell Proteomics 10:M111.011627. 2011
    ..This proteogenomic approach should be generally applicable to other organisms whose genomes have already been sequenced for obtaining a more accurate catalogue of protein-coding genes...
  15. doi request reprint Comprehensive proteomic analysis of human bile
    Mustafa A Barbhuiya
    Centre for Genomics, Molecular and Human Genetics, Jiwaji University, Gwalior, India
    Proteomics 11:4443-53. 2011
    ..This catalog should serve as a baseline for the future studies aimed at discovering biomarkers from bile in gallbladder, hepatic, and biliary cancers...
  16. doi request reprint Moving from unsequenced to sequenced genome: reanalysis of the proteome of Leishmania donovani
    Raja Sekhar Nirujogi
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India Bioinformatics Centre, School of Life Sciences, Pondicherry University, Puducherry 605014, India
    J Proteomics 97:48-61. 2014
    ..donovani genome, which led to 255 genome search-specific peptides (GSSPs) resulting in identification of 20 novel genes and correction of 40 existing gene models in L. donovani...
  17. doi request reprint Phosphoproteome of Cryptococcus neoformans
    Lakshmi Dhevi N Selvan
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India Amrita School of Biotechnology, Amrita University, Kollam 690 525, India
    J Proteomics 97:287-95. 2014
    ..These studies provide a framework for understanding virulence mechanisms in the context of signalling pathways in pathogenic yeast. This article is part of a Special Issue entitled: Trends in Microbial Proteomics...
  18. pmc SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome
    Manoj Kumar Kashyap
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Cancer Biol Ther 10:796-810. 2010
    ..Hence, we conclude that these potential biomarkers are excellent candidates for further evaluation to test their role and efficacy in the early detection of ESCC...
  19. pmc Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis
    Renu Goel
    Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India
    Mol Biosyst 8:453-63. 2012
    ..This review aims to provide a composite view of phosphoproteomic data pertaining to human proteins in HPRD and Human Proteinpedia...
  20. doi request reprint Activated epidermal growth factor receptor as a novel target in pancreatic cancer therapy
    H C Harsha
    Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India
    J Proteome Res 7:4651-8. 2008
    ..Further, we propose immunohistochemical labeling of activated EGFR (pEGFR (1068)) as an efficient screening tool to select patients who are more likely to respond to EGFR inhibitors...
  21. ncbi request reprint Neglected Tropical Diseases and Omics Science: Proteogenomics Analysis of the Promastigote Stage of Leishmania major Parasite
    Harsh Pawar
    1 Institute of Bioinformatics, International Technology Park, Bangalore, India
    OMICS 18:499-512. 2014
    ..major, one of the largest acetylated peptide datasets thus far in Leishmania. This dataset should be a valuable resource to researchers focusing on neglected tropical diseases. ..
  22. pmc NetSlim: high-confidence curated signaling maps
    Rajesh Raju
    Institute of Bioinformatics, International Tech Park, Bangalore, India
    Database (Oxford) 2011:bar032. 2011
    ..NetSlim is a new resource that contains this 'core' subset of reactions for each pathway for easy visualization and manipulation. The pathways in NetSlim are freely available at http://www.netpath.org/netslim...
  23. doi request reprint IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase
    Lavanya Balakrishnan
    Institute of Bioinformatics, Bangalore, India
    Cell Commun Adhes 20:81-6. 2013
    ..We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders. ..
  24. pmc A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway
    Mitali Bhattacharjee
    Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
    J Signal Transduct 2012:376470. 2012
    ..This in turn may lead to the identification of potential therapeutic targets in TWEAK-associated disorders...
  25. doi request reprint A comprehensive map of the human urinary proteome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India
    J Proteome Res 10:2734-43. 2011
    ..This data set should serve as a comprehensive reference list for future studies aimed at identification and characterization of urinary biomarkers for various diseases...
  26. pmc A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway
    Rajesh Raju
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Database (Oxford) 2011:bar021. 2011
    ..We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions...
  27. doi request reprint Quantitative proteomics using stable isotope labeling with amino acids in cell culture
    H C Harsha
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, Karnataka, India
    Nat Protoc 3:505-16. 2008
    ..Although the overall time is largely dependent on the rate of cell growth and various sample processing steps employed, a typical SILAC experiment from start to finish, including data analysis, should take anywhere between 20 and 25 d...
  28. ncbi request reprint Bioinformatics and proteomics approaches for aging research
    Chaerkady Raghothama
    Institute of Bioinformatics, International Tech Park Ltd, 560066, Bangalore, India
    Biogerontology 6:227-32. 2005
    ..Here, we discuss various genomic, transcriptomic and proteomic approaches that have the potential to provide a comprehensive mechanistic insight into the aging process...
  29. pmc A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma
    Raghothama Chaerkady
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    J Proteome Res 7:4289-98. 2008
    ..Our results demonstrate quantitative proteomics as a robust discovery tool for the identification of differentially regulated proteins in cancers...
  30. pmc A compendium of molecules involved in vector-pathogen interactions pertaining to malaria
    Sreelakshmi K Sreenivasamurthy
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Malar J 12:216. 2013
    ..This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission. ..
  31. ncbi request reprint Molecular alterations in exocrine neoplasms of the pancreas
    Prathibha Ranganathan
    Institute of Bioinformatics, International Technology Park, Bangalore, India
    Arch Pathol Lab Med 133:405-12. 2009
    ....
  32. ncbi request reprint Plasma Proteome Database as a resource for proteomics research
    Babylakshmi Muthusamy
    Institute of Bioinformatics, Bangalore, India
    Proteomics 5:3531-6. 2005
    ..This database is an attempt at comprehensive annotation of a complex subproteome and is available on the web at http://www.plasmaproteomedatabase.org...