William S Harris

Summary

Publications

  1. doi Multiple differences between patients who initiate fish oil supplementation post-myocardial infarction and those who do not: the TRIUMPH Study
    William S Harris
    Sanford School of Medicine, University of South Dakota and OmegaQuant Analytics, LLC 5009 W 12th St, Ste 8, Sioux Falls, SD, USA Electronic address
    Nutr Res 36:65-71. 2016
  2. doi Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans
    William S Harris
    Sanford School of Medicine, University of South Dakota and OmegaQuant Analytics, LLC, Sioux Falls, SD, USA Health Diagnostic Laboratory, Inc, Richmond, VA 23219, USA Electronic address
    Prostaglandins Leukot Essent Fatty Acids 90:55-9. 2014
  3. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
  4. doi Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:600S-604S. 2012
  5. pmc Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans
    William S Harris
    Sanford Research, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:1297-303. 2012
  6. pmc Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
    James V Pottala
    From the Department of Internal Medicine J V P, W S H, Sanford School of Medicine, University of South Dakota, Sioux Falls Health Diagnostic Laboratory Inc J V P, W S H, Richmond, VA Department of Psychiatry K Y, University of California Medical Center, San Francisco Departments of Epidemiology and Internal Medicine J R, R W, University of Iowa College of Public Health, Iowa City Department of Biostatistical Services M A E, Wake Forest School of Medicine, Winston Salem, NC and OmegaQuant Analytics W S H, Sioux Falls, SD
    Neurology 82:435-42. 2014
  7. doi Lipoprotein(a) mass: a massively misunderstood metric
    Joseph P McConnell
    Health Diagnostic Laboratory, Inc, Richmond, VA
    J Clin Lipidol 8:550-3. 2014
  8. doi Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients
    William S Harris
    Health Diagnostic Laboratory, Inc, Richmond, VA, United States
    Prostaglandins Leukot Essent Fatty Acids 88:257-63. 2013
  9. doi Omega-3 fatty acids and cardiovascular disease: new developments and applications
    William S Harris
    Professor of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD President, OmegaQuant Analytics, LLC, Sioux Falls, SD Senior Research Scientist, Health Diagnostic Laboratory, Inc, Richmond, VA
    Postgrad Med 125:100-13. 2013
  10. ncbi Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    Mark K Larson
    Sanford Research USD, 1100 E 21st Street, Sioux Falls, SD 57105, USA
    Thromb Haemost 100:634-41. 2008

Collaborators

Detail Information

Publications40

  1. doi Multiple differences between patients who initiate fish oil supplementation post-myocardial infarction and those who do not: the TRIUMPH Study
    William S Harris
    Sanford School of Medicine, University of South Dakota and OmegaQuant Analytics, LLC 5009 W 12th St, Ste 8, Sioux Falls, SD, USA Electronic address
    Nutr Res 36:65-71. 2016
    ..These differences are strongly associated with a better post-MI prognosis and may illuminate several sources of unmeasured confounding in observational studies. ..
  2. doi Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans
    William S Harris
    Sanford School of Medicine, University of South Dakota and OmegaQuant Analytics, LLC, Sioux Falls, SD, USA Health Diagnostic Laboratory, Inc, Richmond, VA 23219, USA Electronic address
    Prostaglandins Leukot Essent Fatty Acids 90:55-9. 2014
    ..In the U.S., the average Omega-3 Index is about 4-6% of RBC fatty acids, whereas in Japan it is 9-10%. The range of physiologically-possible levels for the Omega-3 Index in other mammals is unknown...
  3. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
    ..The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index...
  4. doi Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:600S-604S. 2012
    ..Thus, the consumption of foods containing SDA-enhanced soybean oil may be both a practical and sustainable approach to enriching tissues with beneficial (n-3) fatty acids...
  5. pmc Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans
    William S Harris
    Sanford Research, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:1297-303. 2012
    ..7 y, the proportion of trans fatty acids in RBC decreased. Those of EPA+DHA increased in people taking fish oil supplements. These changes could potentially translate into a lower risk for cardiovascular disease...
  6. pmc Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
    James V Pottala
    From the Department of Internal Medicine J V P, W S H, Sanford School of Medicine, University of South Dakota, Sioux Falls Health Diagnostic Laboratory Inc J V P, W S H, Richmond, VA Department of Psychiatry K Y, University of California Medical Center, San Francisco Departments of Epidemiology and Internal Medicine J R, R W, University of Iowa College of Public Health, Iowa City Department of Biostatistical Services M A E, Wake Forest School of Medicine, Winston Salem, NC and OmegaQuant Analytics W S H, Sioux Falls, SD
    Neurology 82:435-42. 2014
    ..To test whether red blood cell (RBC) levels of marine omega-3 fatty acids measured in the Women's Health Initiative Memory Study were related to MRI brain volumes measured 8 years later...
  7. doi Lipoprotein(a) mass: a massively misunderstood metric
    Joseph P McConnell
    Health Diagnostic Laboratory, Inc, Richmond, VA
    J Clin Lipidol 8:550-3. 2014
    ....
  8. doi Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients
    William S Harris
    Health Diagnostic Laboratory, Inc, Richmond, VA, United States
    Prostaglandins Leukot Essent Fatty Acids 88:257-63. 2013
    ..Higher linoleic acid (n-6) and lower trans FA levels have also been associated with improved CHD outcomes. Accordingly, the RBC FA panel has recently been introduced in routine clinical laboratory testing...
  9. doi Omega-3 fatty acids and cardiovascular disease: new developments and applications
    William S Harris
    Professor of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD President, OmegaQuant Analytics, LLC, Sioux Falls, SD Senior Research Scientist, Health Diagnostic Laboratory, Inc, Richmond, VA
    Postgrad Med 125:100-13. 2013
    ..Given the favorable risk-to-benefit ratio for these essentially nutritional agents, use is expected to continue to expand. ..
  10. ncbi Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    Mark K Larson
    Sanford Research USD, 1100 E 21st Street, Sioux Falls, SD 57105, USA
    Thromb Haemost 100:634-41. 2008
    ..Since previous studies have not reported a clinically significant risk for bleeding in subjects on combined therapy, P-OM3 may safely enhance the anti-platelet effect of aspirin...
  11. doi Comparison of cardiometabolic risk biomarkers from a national clinical laboratory with the US adult population
    Elliott Wolin
    Department of Research and Development, Health Diagnostic Laboratory, Inc, Richmond, VA, USA
    J Clin Lipidol 9:817-23. 2015
    ..However, the lack of associated clinical and/or demographic information and questionable generalizability to nonpatient populations often limit utility of these data...
  12. pmc ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA
    Eric M Ammann
    From the Department of Epidemiology E M A, R W, R M C, J G R, College of Public Health, and Departments of Internal Medicine R W, J G R and Neurology N L D, College of Medicine, University of Iowa, Iowa City OmegaQuant Analytics J V P, W S H, Sioux Falls Department of Medicine W S H, Sanford School of Medicine, University of South Dakota, Vermillion and Department of Biostatistical Sciences M A E, Wake Forest School of Medicine, Winston Salem, NC
    Neurology 81:1484-91. 2013
    ..To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older...
  13. doi Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Lipids 43:805-11. 2008
    ..Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs...
  14. pmc Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial
    Gregory C Shearer
    Sanford Research USD, University of South Dakota, Sioux Falls, SD, USA
    J Lipid Res 53:2429-35. 2012
    ..ERN and P-OM3 alone improved characteristics of metabolic syndrome; however, whereas subjects on combination therapy did not have improved vascular stiffness, TG and HDL levels improved as did certain lipoprotein subfractions...
  15. doi The omega-3 index: clinical utility for therapeutic intervention
    William S Harris
    Cardiovascular Health Research Center Sanford Research USD, 2301 East 60th Street North, Sioux Falls, SD 57104 0589, USA
    Curr Cardiol Rep 12:503-8. 2010
    ..Using the Omega-3 Index in the design of clinical studies might allow for a more efficient use of research resources...
  16. doi Validation of a lipoprotein(a) particle concentration assay by quantitative lipoprotein immunofixation electrophoresis
    Philip A Guadagno
    Health Diagnostic Laboratory, Inc, 737 N 5th Street, Richmond, VA 23219, United States
    Clin Chim Acta 439:219-24. 2015
    ..We have developed a method of determining Lp(a)-P suitable for routine clinical use...
  17. pmc Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?
    William S Harris
    Health Diagnostic Laboratory, Inc, 737 N 5th St, Suite 103, Richmond, VA, 23219, USA
    J Cardiovasc Transl Res 7:526-32. 2014
    ..In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype. ..
  18. pmc Red blood cell fatty acid levels improve GRACE score prediction of 2-yr mortality in patients with myocardial infarction
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Int J Cardiol 168:53-9. 2013
    ....
  19. doi n-3 Fatty acids affect haemostasis but do not increase the risk of bleeding: clinical observations and mechanistic insights
    John K Wachira
    Department of Internal Medicine, Sanford School of Medicine, Health Science Center, The University of South Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Br J Nutr 111:1652-62. 2014
    ..On the contrary, the use of these fatty acids in several settings improved clinical outcomes. ..
  20. doi Stearidonic acid as a 'pro-eicosapentaenoic acid'
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Lipidol 23:30-4. 2012
    ..Ocean-based supplies are limited, and so land-based sources are being sought. Stearidonic acid-fortified soybean oil may help to meet this demand...
  21. pmc Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study
    James V Pottala
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Circ Cardiovasc Qual Outcomes 3:406-12. 2010
    ..The purpose of this study was to determine the extent to which baseline blood n-3 FA levels are associated with reduced risk for all-cause mortality in patients with stable coronary heart disease...
  22. pmc Myocardial infarction does not affect fatty-acid profiles in rats
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, 1100 E 21st St, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 81:411-6. 2009
    ..This finding suggests that differences between cases and controls have prognostic implications...
  23. ncbi Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research University of South Dakota, 1100 E 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 10:503-9. 2008
    ..We conclude, therefore, that an intake of 400 to 500 mg/d of EPA + DHA is achievable by diet alone and would be expected to significantly reduce risk for death from CHD in healthy adults...
  24. doi Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study
    William S Harris
    Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, and OmegaQuant Analytics, LLC, Sioux Falls, South Dakota, United States of America
    PLoS ONE 11:e0147894. 2016
    ....
  25. doi Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol
    Olga V Savinova
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD, USA Electronic address
    Atherosclerosis 240:520-5. 2015
    ..The purpose of this study was to describe the effects of mono- and combination (Combo) therapy of these agents in patients with the metabolic syndrome...
  26. pmc Structural equation modeling for analyzing erythrocyte fatty acids in Framingham
    James V Pottala
    Health Diagnostic Laboratory Inc, Richmond, VA 23219, USA Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Comput Math Methods Med 2014:160520. 2014
    ..Whether the PUFA factor score can improve the performance of risk prediction in cardiovascular diseases remains to be tested. ..
  27. doi Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility
    William S Harris
    Health Diagnostic Laboratory, Inc, 737 N 5th Street, Suite 103, Richmond, VA 23219, USA OmegaQuant Analytics, LLC, Sioux Falls, SD, USA Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA Electronic address
    J Clin Lipidol 7:433-40. 2013
    ..The matrix that exhibits the lower within-person variability and is less affected by an acute dose of n-3 FA is preferred in clinical practice...
  28. doi Are n-3 fatty acids still cardioprotective?
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Clin Nutr Metab Care 16:141-9. 2013
    ..Several recent randomized trials and subsequent meta-analyses have questioned the value of n-3 fatty acid supplementation in cardiovascular disease risk reduction...
  29. ncbi New evidence for the cardiovascular benefits of long chain omega-3 fatty acids
    Susan N Hansen
    Nutrition and Metabolic Disease Research Institute, Sanford Research University of South Dakota, 1400 West 22nd Street, L 07, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 9:434-40. 2007
    ..Finally, a supplementation study in cardiac surgery patients has demonstrated both the time course and extent of incorporation of LC n-3 FAs into the human heart...
  30. ncbi The omega-3 index as a risk factor for coronary heart disease
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, USA
    Am J Clin Nutr 87:1997S-2002S. 2008
    ..Before assessment of n-3 FA biostatus can be used in routine clinical evaluation of patients, standardized laboratory methods and quality control materials must become available...
  31. doi Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative
    James V Pottala
    OmegaQuant LLC, Sioux Falls, SD, USA
    Lipids 47:835-46. 2012
    ..The FA compositions of the degraded RBC samples from WHIMS were rehabilitated by application of regression calibration equations and multiple imputations, and these imputed datasets should be used in all future WHIMS studies...
  32. pmc Red blood cell fatty acid patterns and acute coronary syndrome
    Gregory C Shearer
    Sanford Research USD, Cardiovascular Health Research Center, Sioux Falls, SD, USA
    PLoS ONE 4:e5444. 2009
    ....
  33. doi Biological variability of blood omega-3 biomarkers
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Clin Biochem 43:338-40. 2010
    ..We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of 3 blood FA pools...
  34. pmc Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts
    Jinghai Chen
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD 57104, USA
    Circulation 123:584-93. 2011
    ..The present study assessed the effects of ω-3 polyunsaturated fatty acids on cardiac fibrosis...
  35. pmc Reduced apolipoprotein glycosylation in patients with the metabolic syndrome
    Olga V Savinova
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, South Dakota, United States of America
    PLoS ONE 9:e104833. 2014
    ..The purpose of this study was to compare the apolipoprotein composition of the three major lipoprotein classes in patients with metabolic syndrome to healthy controls...
  36. ncbi The omega-3 index: from biomarker to risk marker to risk factor
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, University of South Dakota, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 11:411-7. 2009
    ..The omega-3 index appears to fulfill many of the requirements for a risk marker and, more importantly, for a risk factor...
  37. doi Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine at University of South Dakota, Sioux Falls, SD 57105, USA
    J Nutr 139:804S-19S. 2009
    ....
  38. pmc Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD, USA
    J Lipid Res 51:2074-81. 2010
    ..The extent to which the beneficial cardiovascular effects of n-3 FAs are mediated by increased n-3 and/or reduced n-6 oxylipin levels remains to be explored...
  39. doi Linoleic acid and coronary heart disease
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 79:169-71. 2008
    ..Thus, current recommendations to consume 5-10% of energy from LA are evidence-based, and should not be reduced...
  40. pmc Fish oil -- how does it reduce plasma triglycerides?
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, SD, USA
    Biochim Biophys Acta 1821:843-51. 2012
    ..This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...