William S Harris

Summary

Publications

  1. ncbi Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    Mark K Larson
    Sanford Research USD, 1100 E 21st Street, Sioux Falls, SD 57105, USA
    Thromb Haemost 100:634-41. 2008
  2. doi Omega-6 and omega-3 fatty acids: partners in prevention
    William Harris
    Sanford School of Medicine, University of South Dakota and Sanford Research USD, Sioux Falls, South Dakota 57105, USA
    Curr Opin Clin Nutr Metab Care 13:125-9. 2010
  3. doi Biological variability of blood omega-3 biomarkers
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Clin Biochem 43:338-40. 2010
  4. doi Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Lipids 43:805-11. 2008
  5. doi Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine at University of South Dakota, Sioux Falls, SD 57105, USA
    J Nutr 139:804S-19S. 2009
  6. doi Linoleic acid and coronary heart disease
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 79:169-71. 2008
  7. ncbi Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research University of South Dakota, 1100 E 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 10:503-9. 2008
  8. ncbi The omega-3 index: from biomarker to risk marker to risk factor
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, University of South Dakota, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 11:411-7. 2009
  9. pmc Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans
    William S Harris
    Sanford Research, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:1297-303. 2012
  10. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012

Research Grants

Collaborators

Detail Information

Publications69

  1. ncbi Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects
    Mark K Larson
    Sanford Research USD, 1100 E 21st Street, Sioux Falls, SD 57105, USA
    Thromb Haemost 100:634-41. 2008
    ..Since previous studies have not reported a clinically significant risk for bleeding in subjects on combined therapy, P-OM3 may safely enhance the anti-platelet effect of aspirin...
  2. doi Omega-6 and omega-3 fatty acids: partners in prevention
    William Harris
    Sanford School of Medicine, University of South Dakota and Sanford Research USD, Sioux Falls, South Dakota 57105, USA
    Curr Opin Clin Nutr Metab Care 13:125-9. 2010
    ..Although most clinicians understand that the omega-3 FAs are beneficial, there have been calls in the popular press to reduce the intake of the omega-6 FAs because of presumed proinflammatory and prothrombotic effects...
  3. doi Biological variability of blood omega-3 biomarkers
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Clin Biochem 43:338-40. 2010
    ..We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of 3 blood FA pools...
  4. doi Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Lipids 43:805-11. 2008
    ..Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs...
  5. doi Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine at University of South Dakota, Sioux Falls, SD 57105, USA
    J Nutr 139:804S-19S. 2009
    ....
  6. doi Linoleic acid and coronary heart disease
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 79:169-71. 2008
    ..Thus, current recommendations to consume 5-10% of energy from LA are evidence-based, and should not be reduced...
  7. ncbi Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research University of South Dakota, 1100 E 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 10:503-9. 2008
    ..We conclude, therefore, that an intake of 400 to 500 mg/d of EPA + DHA is achievable by diet alone and would be expected to significantly reduce risk for death from CHD in healthy adults...
  8. ncbi The omega-3 index: from biomarker to risk marker to risk factor
    William S Harris
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, University of South Dakota, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 11:411-7. 2009
    ..The omega-3 index appears to fulfill many of the requirements for a risk marker and, more importantly, for a risk factor...
  9. pmc Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans
    William S Harris
    Sanford Research, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:1297-303. 2012
    ..7 y, the proportion of trans fatty acids in RBC decreased. Those of EPA+DHA increased in people taking fish oil supplements. These changes could potentially translate into a lower risk for cardiovascular disease...
  10. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
    ..The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index...
  11. pmc Red blood cell fatty acid patterns and acute coronary syndrome
    Gregory C Shearer
    Sanford Research USD, Cardiovascular Health Research Center, Sioux Falls, SD, USA
    PLoS ONE 4:e5444. 2009
    ....
  12. doi Omega-3 fatty acids and cardiovascular disease: new developments and applications
    William S Harris
    Professor of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD President, OmegaQuant Analytics, LLC, Sioux Falls, SD Senior Research Scientist, Health Diagnostic Laboratory, Inc, Richmond, VA
    Postgrad Med 125:100-13. 2013
    ..Given the favorable risk-to-benefit ratio for these essentially nutritional agents, use is expected to continue to expand. ..
  13. doi ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA
    Eric M Ammann
    From the Department of Epidemiology E M A, R W, R M C, J G R, College of Public Health, and Departments of Internal Medicine R W, J G R and Neurology N L D, College of Medicine, University of Iowa, Iowa City OmegaQuant Analytics J V P, W S H, Sioux Falls Department of Medicine W S H, Sanford School of Medicine, University of South Dakota, Vermillion and Department of Biostatistical Sciences M A E, Wake Forest School of Medicine, Winston Salem, NC
    Neurology 81:1484-91. 2013
    ..To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older...
  14. pmc Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial
    Gregory C Shearer
    Sanford Research USD, University of South Dakota, Sioux Falls, SD, USA
    J Lipid Res 53:2429-35. 2012
    ..ERN and P-OM3 alone improved characteristics of metabolic syndrome; however, whereas subjects on combination therapy did not have improved vascular stiffness, TG and HDL levels improved as did certain lipoprotein subfractions...
  15. doi The omega-3 index: clinical utility for therapeutic intervention
    William S Harris
    Cardiovascular Health Research Center Sanford Research USD, 2301 East 60th Street North, Sioux Falls, SD 57104 0589, USA
    Curr Cardiol Rep 12:503-8. 2010
    ..Using the Omega-3 Index in the design of clinical studies might allow for a more efficient use of research resources...
  16. ncbi The omega-3 index as a risk factor for coronary heart disease
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, USA
    Am J Clin Nutr 87:1997S-2002S. 2008
    ..Before assessment of n-3 FA biostatus can be used in routine clinical evaluation of patients, standardized laboratory methods and quality control materials must become available...
  17. doi Stearidonic acid as a 'pro-eicosapentaenoic acid'
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Lipidol 23:30-4. 2012
    ..Ocean-based supplies are limited, and so land-based sources are being sought. Stearidonic acid-fortified soybean oil may help to meet this demand...
  18. doi Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
    J Nutr 142:600S-604S. 2012
    ..Thus, the consumption of foods containing SDA-enhanced soybean oil may be both a practical and sustainable approach to enriching tissues with beneficial (n-3) fatty acids...
  19. ncbi Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
    William S Harris
    Nutrition and Metabolic Disease Research, Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Atherosclerosis 197:12-24. 2008
    ..Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk...
  20. ncbi New evidence for the cardiovascular benefits of long chain omega-3 fatty acids
    Susan N Hansen
    Nutrition and Metabolic Disease Research Institute, Sanford Research University of South Dakota, 1400 West 22nd Street, L 07, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 9:434-40. 2007
    ..Finally, a supplementation study in cardiac surgery patients has demonstrated both the time course and extent of incorporation of LC n-3 FAs into the human heart...
  21. pmc Myocardial infarction does not affect fatty-acid profiles in rats
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, 1100 E 21st St, Sioux Falls, SD 57105, USA
    Prostaglandins Leukot Essent Fatty Acids 81:411-6. 2009
    ..This finding suggests that differences between cases and controls have prognostic implications...
  22. pmc Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study
    James V Pottala
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Circ Cardiovasc Qual Outcomes 3:406-12. 2010
    ..The purpose of this study was to determine the extent to which baseline blood n-3 FA levels are associated with reduced risk for all-cause mortality in patients with stable coronary heart disease...
  23. pmc Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor
    William S Harris
    Nutrition and Metabolic Disease Research Institute, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Pharmacol Res 55:217-23. 2007
    ..For these and a number of other reasons, the omega-3 index compares very favourably with other risk factors for sudden cardiac death...
  24. doi Are n-3 fatty acids still cardioprotective?
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Curr Opin Clin Nutr Metab Care 16:141-9. 2013
    ..Several recent randomized trials and subsequent meta-analyses have questioned the value of n-3 fatty acid supplementation in cardiovascular disease risk reduction...
  25. doi Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative
    James V Pottala
    OmegaQuant LLC, Sioux Falls, SD, USA
    Lipids 47:835-46. 2012
    ..The FA compositions of the degraded RBC samples from WHIMS were rehabilitated by application of regression calibration equations and multiple imputations, and these imputed datasets should be used in all future WHIMS studies...
  26. ncbi Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients
    William S Harris
    Sanford Research and School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Am J Cardiol 99:154-8. 2007
    ..In conclusion, low blood EPA + DHA content is an independent predictor of increased risk for ACS, but higher blood trans FA content is not. Blood EPA + DHA may serve as a new, modifiable risk factor for ACS...
  27. ncbi Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Atherosclerosis 193:1-10. 2007
    ..The purpose of this paper is to evaluate the published associations between risk for CHD events and tissue n-3 and n-6 FA composition...
  28. pmc Fish oil -- how does it reduce plasma triglycerides?
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, SD, USA
    Biochim Biophys Acta 1821:843-51. 2012
    ..This article is part of a Special Issue entitled Triglyceride Metabolism and Disease...
  29. ncbi n-3 Fatty acid fortification: opportunities and obstacles
    William S Harris
    Sanford Research USD, Nutrition and Metabolic Disease Research Institute, Internal Medicine Department, Sanford School of Medicine of The University of South Dakota and Sioux Valley Hospitals and Health Systems, Sioux Falls, USA
    Br J Nutr 97:593-5. 2007
  30. pmc Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts
    Jinghai Chen
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD 57104, USA
    Circulation 123:584-93. 2011
    ..The present study assessed the effects of ω-3 polyunsaturated fatty acids on cardiac fibrosis...
  31. pmc Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, SD, USA
    J Lipid Res 51:2074-81. 2010
    ..The extent to which the beneficial cardiovascular effects of n-3 FAs are mediated by increased n-3 and/or reduced n-6 oxylipin levels remains to be explored...
  32. ncbi International recommendations for consumption of long-chain omega-3 fatty acids
    William S Harris
    Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota 57105, USA
    J Cardiovasc Med (Hagerstown) 8:S50-2. 2007
    ..Fortification is perhaps the best long-term solution to the chronically-low intake of omega-3 fatty acids that plagues western cultures...
  33. ncbi The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses
    William S Harris
    University of South Dakota, Nutrition and Metabolic Diseases Research Institute, South Dakota Health Research Foundation, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 8:453-9. 2006
    ..Metrics that include the n-3 FAs alone, especially eicosapentaenoic and docosahexaenoic acids, appear to hold the greatest promise...
  34. doi Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility
    William S Harris
    Health Diagnostic Laboratory, Inc, 737 N 5th Street, Suite 103, Richmond, VA 23219, USA OmegaQuant Analytics, LLC, Sioux Falls, SD, USA Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA Electronic address
    J Clin Lipidol 7:433-40. 2013
    ..The matrix that exhibits the lower within-person variability and is less affected by an acute dose of n-3 FA is preferred in clinical practice...
  35. pmc Red blood cell fatty acid levels improve GRACE score prediction of 2-yr mortality in patients with myocardial infarction
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Int J Cardiol 168:53-9. 2013
    ....
  36. ncbi Expert opinion: omega-3 fatty acids and bleeding-cause for concern?
    William S Harris
    Sanford School of Medicine of University of South Dakota, Sioux Falls, South Dakota 57105, USA
    Am J Cardiol 99:44C-46C. 2007
    ..As such, the benefits of triglyceride lowering with omega-3 fatty acids more than outweigh any theoretical risks for increased bleeding...
  37. ncbi Cardiovascular benefits of omega-3 fatty acids
    Clemens von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstrasse 1, D 80336 Munich, Germany
    Cardiovasc Res 73:310-5. 2007
    ..As is the case now for LDL, in the future, the cardiac societies might very well recommend treatment with EPA and DHA to become goal oriented (e.g. an omega-3 index>8%)...
  38. ncbi n-3 Fatty acids and cardiovascular disease
    Dennis W T Nilsen
    Am J Clin Nutr 79:166. 2004
  39. ncbi The Omega-3 Index: a new risk factor for death from coronary heart disease?
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, University of Missouri KC School of Medicine, Kansas City, MO 64111, USA
    Prev Med 39:212-20. 2004
    ..Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD...
  40. ncbi Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids
    Yongsoon Park
    Lipid and Diabetes Research Center, Saint Luke s Hospital, and The University of Missouri Kansas City School of Medicine, 64111, USA
    Am J Clin Nutr 80:45-50. 2004
    ..Margination occurs when blood borne particles attach to the vessel wall. Triacylglycerol-rich lipoprotein (TRL) particles marginate when they bind to endothelial lipoprotein lipase (LpL)...
  41. ncbi Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Circulation 110:1645-9. 2004
    ..The extent of incorporation has not been determined in humans...
  42. ncbi Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?
    William S Harris
    St Luke s Mid America Heart Institute and Department of Medicine, University of Missouri Kansas City School of Medicine, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 6:447-52. 2004
    ..The strength of the n-3 story has now led to a proposal that blood levels of EPA plus DHA be considered a new, modifiable, and clinically relevant risk factor for death from CHD...
  43. ncbi Preventive use of N-3 fatty acids
    William S Harris
    Circulation 108:e139; author reply e139. 2003
  44. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  45. ncbi n-3 Long-chain polyunsaturated fatty acids reduce risk of coronary heart disease death: extending the evidence to the elderly
    William S Harris
    Am J Clin Nutr 77:279-80. 2003
  46. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:e20-30. 2003
  47. ncbi Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:151-2. 2003
  48. ncbi Fish oil supplementation: evidence for health benefits
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, Kansas City, MO, USA
    Cleve Clin J Med 71:208-10, 212, 215-8 passim. 2004
    ..This article answers a series of questions that health care professionals often ask regarding fish oil, such as what are proper dosages, and are there risks of ingesting pollutants by eating more fish or using supplements?..
  49. ncbi Cardiovascular disease and long-chain omega-3 fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Hospital, University of Missouri Kansas City School of Medicine, 64111, USA
    Curr Opin Lipidol 14:9-14. 2003
    ..Of all known dietary factors, long-chain omega-3 fatty acids may be the most protective against death from coronary heart disease. New evidence has confirmed and refined the cardioprotective role of these fatty acids...
  50. ncbi Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
    Yongsoon Park
    Department of Medicine, University of Missouri, Kansas City, MO 64108, USA
    J Lipid Res 44:455-63. 2003
    ..The results suggest that omega-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective...
  51. ncbi The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes
    Scott A Sands
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
    Lipids 40:343-7. 2005
    ..Given the importance of n-3 FA in influencing risk for death from CHD, further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content...
  52. ncbi Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Lipids 42:325-33. 2007
    ..Compared to dietary EPA, SDA was 20-23% as efficient in raising tissue EPA levels. In conclusion, SDA supplementation increased the EPA content of RBC and heart and may have utility as a plant-based source of omega-3 FA...
  53. ncbi Cardiovascular risk and the omega-3 index
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Cardiovasc Med (Hagerstown) 8:S46-9. 2007
    ..Cardiac societies recommend EPA + DHA for prevention of SCD. The omega-3 index can assess risk for SCD and monitor therapy with EPA + DHA. Moreover, it compares very favourably with other risk factors for SCD...
  54. ncbi Effects of moderate variations in the macronutrient content of the diet on cardiovascular disease risk factors in obese patients with the metabolic syndrome
    Fulvio Muzio
    Clinical Nutrition Unit, G Salvini Hospital, Garbagnate Milanese, Milan, Italy
    Am J Clin Nutr 86:946-51. 2007
    ..Even if there is full agreement that lifestyle changes to induce weight loss are the first-line approach, the ideal diet for the treatment of the metabolic syndrome remains uncertain...
  55. pmc UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
    John C Stanley
    Trinity College and St Hugh s College, Oxford, UK
    Br J Nutr 98:1305-10. 2007
    ..Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful...
  56. ncbi Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease
    William S Harris
    Department of Medicine, Mid America Heart Institute of Saint Luke s Health System, Kansas City, Missouri, USA
    Am J Cardiol 98:19i-26i. 2006
    ..Tissue EPA + DHA appears to be the best fatty acid metric for evaluating for CAD risk...
  57. doi Omega-3 fatty acids for cardioprotection
    John H Lee
    Mid America Heart Institute and University of Missouri Kansas City, 4330 Wornall Road, Kansas City, MO 64111, USA
    Mayo Clin Proc 83:324-32. 2008
    ..Blood DHA and EPA levels could one day be used to identify patients with deficient levels and to individualize therapeutic recommendations...
  58. ncbi n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    Sarah K Gebauer
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 83:1526S-1535S. 2006
    ..Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d...
  59. pmc Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Nutr 138:1135-40. 2008
    ..Our results raise the possibility that (n-3) fatty acids may be an important mediating factor in the association between low SES and CVD...
  60. ncbi Why do omega-3 fatty acids lower serum triglycerides?
    William S Harris
    Mid America Heart Institute, Saint Luke s Health System, USA
    Curr Opin Lipidol 17:387-93. 2006
    ....
  61. ncbi Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...
  62. doi You are what you eat applies to fish, too
    William S Harris
    J Am Diet Assoc 108:1131-3. 2008
  63. ncbi Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify?
    William S Harris
    Circulation 118:323-4. 2008
  64. ncbi n-3 Fatty acids and health: DaVinci's code
    William S Harris
    Am J Clin Nutr 88:595-6. 2008
  65. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  66. ncbi Hypertriglyceridemia: management of atherogenic dyslipidemia
    Thomas Bersot
    Gladstone Institute of Cardiovascular Disease, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Fam Pract 55:S1-8. 2006
    ..Fibrates, niacin, and omega-3 acid ethyl esters are highly effective at reducing triglycerides, while statins are considered moderately efficacious (SOR: A)...
  67. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  68. ncbi Extending the cardiovascular benefits of omega-3 Fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute, Saint Luke s Health System, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 7:375-80. 2005
    ..If intakes of the latter are adequate (perhaps over 250 mg/d), then there appears to be little need to consume more ALA or less LA...
  69. ncbi Risks and benefits of fish intake
    Michel Lucas
    JAMA 297:585; author reply 586. 2007

Research Grants9

  1. Red Blood Cell Fatty Acid Biomarkers and Cardiovascular Disease Risk
    William S Harris; Fiscal Year: 2010
    ....
  2. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  3. Red Blood Cell Fatty Acid Biomarkers and Cardiovascular Disease Risk
    William Harris; Fiscal Year: 2009
    ....
  4. Mechanisms of cardiovascular remodeling
    William S Harris; Fiscal Year: 2010
    ....