J M Harris

Summary

Publications

  1. ncbi Pegylation: a novel process for modifying pharmacokinetics
    J M Harris
    Shearwater Corporation, Huntsville, Alabama 35801, USA
    Clin Pharmacokinet 40:539-51. 2001
  2. ncbi Reductive amination using poly(ethylene glycol) acetaldehyde hydrate generated in situ: applications to chitosan and lysozyme
    M D Bentley
    Shearwater Polymers, Inc, 2307 Spring Branch Road, Huntsville, Alabama 35801, USA
    J Pharm Sci 87:1446-9. 1998
  3. ncbi Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy
    M J Roberts
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    J Pharm Sci 87:1440-5. 1998

Detail Information

Publications3

  1. ncbi Pegylation: a novel process for modifying pharmacokinetics
    J M Harris
    Shearwater Corporation, Huntsville, Alabama 35801, USA
    Clin Pharmacokinet 40:539-51. 2001
    ..Because the size, geometry and attachment site of the PEG moiety play a crucial role in determining these properties, therapeutically optimised agents must be designed on a protein-by-protein basis...
  2. ncbi Reductive amination using poly(ethylene glycol) acetaldehyde hydrate generated in situ: applications to chitosan and lysozyme
    M D Bentley
    Shearwater Polymers, Inc, 2307 Spring Branch Road, Huntsville, Alabama 35801, USA
    J Pharm Sci 87:1446-9. 1998
    ..We demonstrate application of these methods in PEGylation of lysozyme and chitosan to form water-soluble methoxy poly(ethylene glycol) (mPEG) derivatives and PEG-chitosan hydrogels...
  3. ncbi Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy
    M J Roberts
    Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    J Pharm Sci 87:1440-5. 1998
    ..Capillary electrophoresis has advantages of high efficiency separations, rapid analysis, and ease of use...