Gregory M T Hare

Summary

Publications

  1. doi request reprint Anaemia: can we define haemoglobin thresholds for impaired oxygen homeostasis and suggest new strategies for treatment?
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Best Pract Res Clin Anaesthesiol 27:85-98. 2013
  2. doi request reprint Review article: risks of anemia and related management strategies: can perioperative blood management improve patient safety?
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 60:168-75. 2013
  3. doi request reprint Plasma methemoglobin as a potential biomarker of anemic stress in humans
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 59:348-56. 2012
  4. doi request reprint Assessment and treatment of preoperative anemia: Continuing Professional Development
    Gregory M T Hare
    Department of Anesthesia and Physiology, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 58:569-81. 2011
  5. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
  6. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
  7. pmc Metoprolol impairs resistance artery function in mice
    Mostafa H El Beheiry
    Department of Anesthesia, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, University of Toronto, Canada
    J Appl Physiol (1985) 111:1125-33. 2011
  8. doi request reprint Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle
    Albert K Y Tsui
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, ON, Canada
    Can J Anaesth 57:779-91. 2010
  9. ncbi request reprint A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution
    Anya T McLaren
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 56:502-9. 2009
  10. doi request reprint Cerebral cortical gene expression in acutely anemic rats: a microarray analysis
    Francoise Briet
    Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:921-34. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Anaemia: can we define haemoglobin thresholds for impaired oxygen homeostasis and suggest new strategies for treatment?
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Best Pract Res Clin Anaesthesiol 27:85-98. 2013
    ..The overall goal of these approaches is to improve patient outcomes, including event-free perioperative survival...
  2. doi request reprint Review article: risks of anemia and related management strategies: can perioperative blood management improve patient safety?
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 60:168-75. 2013
    ..We propose to review new strategies to avoid both anemia and transfusion with the goal of improving patient outcomes and safety...
  3. doi request reprint Plasma methemoglobin as a potential biomarker of anemic stress in humans
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 59:348-56. 2012
    ..Therefore, we tested the hypothesis that MetHb is a biomarker of hypoxic-anemic stress during acute hemodilution associated with cardiopulmonary bypass...
  4. doi request reprint Assessment and treatment of preoperative anemia: Continuing Professional Development
    Gregory M T Hare
    Department of Anesthesia and Physiology, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 58:569-81. 2011
    ..The purpose of this continuing professional development (CPD) module is to review the risk of anemia and transfusion in perioperative patients and to propose an approach for the diagnosis and treatment of preoperative anemia...
  5. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
    ..To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101)...
  6. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
    ..These data suggest that transfusion with hemoglobin raffimer may help to maintain cerebral oxygenation during severe anemia...
  7. pmc Metoprolol impairs resistance artery function in mice
    Mostafa H El Beheiry
    Department of Anesthesia, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, University of Toronto, Canada
    J Appl Physiol (1985) 111:1125-33. 2011
    ..This mechanism may contribute to the observed increase in mortality associated with acute administration of metoprolol in perioperative patients...
  8. doi request reprint Reassessing the risk of hemodilutional anemia: Some new pieces to an old puzzle
    Albert K Y Tsui
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, ON, Canada
    Can J Anaesth 57:779-91. 2010
    ....
  9. ncbi request reprint A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution
    Anya T McLaren
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 56:502-9. 2009
    ..This study assessed the effects of acute hemodilution on inducible NOS (iNOS) and systemic inflammatory cytokines...
  10. doi request reprint Cerebral cortical gene expression in acutely anemic rats: a microarray analysis
    Francoise Briet
    Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:921-34. 2009
    ..This study assesses whether hemodilutional anemia up-regulated inflammatory cerebral gene expression (microarray) to help define the mechanism...
  11. ncbi request reprint Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat
    C David Mazer
    Department of Anesthesia, University of Toronto, St Michael s Hospital, Seneca College, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:13-20. 2007
    ..This study tested the hypothesis that cardiopulmonary bypass and anemia stimulate an increase in cerebral and renal endothelial nitric oxide synthase gene expression in an experimental model of cardiopulmonary bypass...
  12. doi request reprint Anemia and cerebral outcomes: many questions, fewer answers
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Anesth Analg 107:1356-70. 2008
    ..A clearer understanding of these mechanisms may help us target therapies that will minimize anemia-induced cerebral injury in perioperative patients...
  13. ncbi request reprint Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats
    Tina Hu
    Department of Anesthesia, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond St, Toronto, ON M5B 1W8, Canada
    Anesth Analg 116:649-62. 2013
    ..We expanded on these findings by testing the hypothesis that acute β-blockade with a highly β(1)-specific antagonist (nebivolol) causes dose-dependent cerebral hypoxia during hemodilution...
  14. doi request reprint Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats
    Tenille E Ragoonanan
    Department of Anesthesia, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 111:988-1000. 2009
    ..This study investigated the effect of beta-blockade on cerebral tissue oxygen delivery in an experimental model of blood loss and fluid resuscitation (hemodilution)...
  15. ncbi request reprint Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    J Appl Physiol (1985) 103:1021-9. 2007
    ..05 for both). Hemodilutional anemia reduced cerebral Pbr(O(2)) and oxygen extraction and increased cell death following TBI. These results support our hypothesis that acute anemia accentuated hypoxic cerebral injury after neurotrauma...
  16. ncbi request reprint Selective β1-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients
    Catherine Ashes
    Cardiac Anesthesia Fellow, Department of Anesthesia, University Health Network, Toronto, Ontario, Canada Cardiac Anesthesia Fellow, Department of Anesthesia, St Michaels Hospital and the University of Toronto, Toronto, Ontario, Canada Assistant Professor, Department of Anesthesia, University Health Network Li Ka Shing Knowledge Institute of St Michael s Hospital Institute of Health Policy Management and Evaluation and University of Toronto Assistant Professor, Department of Anesthesia, University Health Network, and University of Toronto Professor, Department of Anesthesia, St Michaels Hospital and the University of Toronto, and Li Ka Shing Knowledge Institute of St Michael s Hospital Associate Professor, Department of Anesthesia, St Michaels Hospital and the University of Toronto, and Li Ka Shing Knowledge Institute of St Michael s Hospital Professor, Department of Anesthesia, University Health Network The Peter Munk Cardiac Centre within Toronto General Hospital, Toronto, Ontario, Canada and University of Toronto
    Anesthesiology 119:777-87. 2013
    ..The authors therefore conducted a cohort to study whether the highly β(1)-specific β-blocker (bisoprolol) was associated with a reduced risk of postoperative stroke compared with less selective β-blockers (metoprolol or atenolol)...
  17. doi request reprint Non-natriuretic doses of furosemide: potential use for decreasing the workload of the renal outer medulla with minimal magnesium wasting in the rat
    Namhee Kim
    Department of Anesthesia, Division of Nephrology, University of Toronto, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute, Toronto, Ont, Canada
    Nephron Physiol 122:7-12. 2012
    ..Mg(2+) is important because the ATP needed to perform work must have bound Mg(2+) to it...
  18. ncbi request reprint Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:1061-8. 2003
    ..To test the hypotheses that deliberate elevation of PaCO(2) increases cerebral tissue oxygen tension (PBrO(2)) by augmenting PaO(2) and regional cerebral blood flow (rCBF)...
  19. doi request reprint Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study
    W Scott Beattie
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 112:25-33. 2010
    ....
  20. ncbi request reprint Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats
    Gregory M T Hare
    Department of Anesthesia, St Michael s Hospital, Canada
    Can J Anaesth 53:1030-8. 2006
    ....
  21. ncbi request reprint Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats
    Anya T McLaren
    Department of Anesthesia, Cara Phelan Trauma Research Centre, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R403-14. 2007
    ..nNOS and VEGF protein levels were also increased within the cerebral cortex of anemic rats at clinically relevant hemoglobin concentrations...
  22. pmc Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia
    Albert K Y Tsui
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Keenan Research Centre in the Li Ka Shing Knowledge Institute, Toronto, ON, Canada M5B 1W8
    Proc Natl Acad Sci U S A 108:17544-9. 2011
    ..These findings identify nNOS effects on the HIF/pVHL signaling pathway as critically important in the physiological responses to anemia in vivo and provide essential mechanistic insight into the differences between anemia and hypoxia...
  23. doi request reprint Response of the renal inner medulla to hypoxia: possible defense mechanisms
    Namhee Kim
    Department of Anesthesia, Keenan Research Centre of Li Ka Shing Knowledge Institute, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Nephron Physiol 121:p1-7. 2012
    ..Owing to the precarious blood supply to the renal medulla and the high metabolic requirement of the medullary thick ascending limb of Henle's loop, this nephron segment should be especially vulnerable when its supply of O(2) declines...
  24. ncbi request reprint Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia
    Albert K Y Tsui
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Ontario, Canada Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 307:R13-25. 2014
    ..This knowledge may help define the mechanism(s) by which the brain and kidney maintain oxygen homeostasis during anemia. ..
  25. doi request reprint Recombinant factor VIIa affects anastomotic patency of vascular grafts in a rabbit model
    C David Mazer
    Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:418-23. 2011
    ..We hypothesized that recombinant factor VIIa would cause a dose-dependent reduction in vascular graft patency in rabbits...
  26. doi request reprint Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A
    Ishita Siddiq
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 29:2647-59. 2012
    ..Collectively, the results provide supportive evidence for the concept of acute and delayed treatment following TBI using VEGF-ZFP to induce angiogenesis, reduce cell death, and enhance functional recovery...
  27. ncbi request reprint Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression
    Gregory M T Hare
    Department of Anaesthesia, University of Toronto, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Appl Physiol (1985) 94:2058-67. 2003
    ..Hemodilutional anemia caused an acute reduction in Pbr(O(2)) and an increase in cerebral cortical nNOS mRNA, supporting a role for nNOS in the physiological response to acute anemia...
  28. doi request reprint A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery
    Nadine Shehata
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Transfusion 52:91-9. 2012
    ..Because a definitive trial will require thousands of patients, and because there is variability in transfusion practices, a pilot study was undertaken to determine adherence to proposed strategies...
  29. ncbi request reprint Case report: profound hypotension associated with labetalol therapy in a patient with cerebral aneurysms and subarachnoid hemorrhage
    Sana Jivraj
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Ontario, Canada
    Can J Anaesth 53:678-83. 2006
    ..We present a case of profound hypotension, refractory to inotropic and vasopressor therapy following an iv infusion of labetalol...
  30. ncbi request reprint The effects of an automatic, low pressure and constant flow ventilation device versus manual ventilation during cardiovascular resuscitation in a porcine model of cardiac arrest
    Xudong Hu
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Resuscitation 84:1150-5. 2013
    ..We hypothesized that ventilation with a pneumatically powered, automatic ventilator (Oxylator(®)) can provide adequate ventilation in a model of cardiac arrest and improve the consistency of ventilations during CPR...
  31. ncbi request reprint Hypocapnia attenuates mesenteric ischemia-reperfusion injury in a rat model
    Michelle Duggan
    Lung Biology Program, The Research Institute and The Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Can J Anaesth 52:262-8. 2005
    ..We hypothesized that hypocapnia would potentiate the effects of mesenteric ischemia-reperfusion on bowel, liver and lung injury...
  32. ncbi request reprint Anesthetic approach to high-risk patients and prolonged awake craniotomy using dexmedetomidine and scalp block
    Marco M Garavaglia
    Department of Anesthesia Division of Neurosurgery, St Michael s Hospital, University of Toronto Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    J Neurosurg Anesthesiol 26:226-33. 2014
    ..The anesthetic management of neurosurgical patients who possess these contraindications but would be optimally treated by an awake procedure remains unclear...
  33. ncbi request reprint Successful treatment using recombinant factor VIIa for severe bleeding post cardiopulmonary bypass
    Viren N Naik
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:599-602. 2003
    ..To describe a case of persistent and excessive bleeding following an aortic valve and ascending aorta replacement that was successfully managed with recombinant factor VIIa (rFVIIa). The postulated mechanisms for rFVIIa are discussed...