Identification of Taxus microRNAs and their targets with high-throughput sequencing and degradome analysisDa Cheng Hao
Biotechnology Institute, School of Environment, Dalian Jiaotong University, Dalian, 116028, China
Physiol Plant 146:388-403. 2012
..This study represents the first transcriptome-based analysis of miRNAs and degradome in gymnosperms...
[Research progress and trend analysis of biology and chemistry of Taxus medicinal resources]Da Cheng Hao
Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China
Yao Xue Xue Bao 47:827-35. 2012
..Systems biology and various omics technologies will play an increasingly important role in the coming decades...
- De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum
DaCheng Hao
Biotechnology Institute, School of Environment, Dalian Jiaotong University, Dalian, China
Sci China Life Sci 55:452-66. 2012
..This information will be very useful for future functional, phylogenetic and evolutionary studies of these plants...
The first insight into the tissue specific taxus transcriptome via Illumina second generation sequencingDa Cheng Hao
Biotechnology Institute, Dalian Jiaotong University, Dalian, China
PLoS ONE 6:e21220. 2011
..The research of its tissue-specific transcriptome is absent. There is also no study concerning the association between the plant transcriptome and metabolome with respect to the plant tissue type...
- The first insight into the Taxus genome via fosmid library construction and end sequencing
DaCheng Hao
Biotechnology Institute, Dalian Jiaotong University, Dalian 116028, China
Mol Genet Genomics 285:197-205. 2011
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- Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution
DaCheng Hao
College of Environment, Dalian Jiaotong University, Dalian, 116028, China
Sci China Life Sci 53:1252-62. 2010
..Furthermore, the molecular evolutionary patterns of phase II enzymes were characterized with regards to the predicted deleterious nsSNPs...
- Physicochemical evolution and positive selection of the gymnosperm matK proteins
Da Cheng Hao
Biotechnology Institute, College of Environment, Dalian Jiaotong University, Dalian 116028, People s Republic of China
J Genet 89:81-9. 2010
..Despite the evolutionary constraint on the rapidly evolving matK, this protein evolves under positive selection in gymnosperm. Several regions of matK have experienced molecular adaptation which fine-tunes maturase performance...
- Molecular evolution and positive Darwinian selection of the chloroplast maturase matK
Da Cheng Hao
Biotechnology Institute, College of Environment, Dalian Jiaotong University, 116028 Dalian, China
J Plant Res 123:241-7. 2010
..Our results suggest that the rapidly evolving matK evolves under positive selection in some lineages of land plants. Several regions of matK have experienced molecular adaptation, which fine-tunes maturase performance...
- Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases
Da Cheng Hao
Laboratory of Biotechnology, Dalian Jiaotong University, 116028 Dalian, China
Genetica 137:173-87. 2009
..Finally, critical amino acid residues for FMO functional divergence (type I & II) after gene duplication were detected and characterized...
- Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species
Da Cheng Hao
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Dalian, 116023, China
Genetica 135:123-35. 2009
..These findings demonstrate that the pattern of adaptive paclitaxel biosynthetic enzyme evolution can be documented between closely related Taxus species, where species-specific taxane metabolism has evolved recently...
- Phylogenetic relationships of the genus Taxus inferred from chloroplast intergenic spacer and nuclear coding DNA
Da Cheng Hao
Laboratory of Pharmaceutical Resource Discovery, Biotechnology Division, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Biol Pharm Bull 31:260-5. 2008
..Using trnS-trnQ spacer sequences, we were able to distinguish T. mairei from all other species of Taxus...
- Evolution of the chloroplast trnL-trnF region in the gymnosperm lineages Taxaceae and Cephalotaxaceae
Da Cheng Hao
Laboratory of Biotechnology, Dalian Jiaotong University, Dalian, People s Republic of China
Biochem Genet 47:351-69. 2009
..Stem-loop regions P6, P8, and P9 of the trnL intron and the trnL-F spacer (except the promoter elements) might undergo neutral evolution with respect to their escape from functional constraints...
- Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations
DaCheng Hao
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Cell Biochem Funct 25:443-53. 2007
..The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes...
- Non-neutral nonsynonymous single nucleotide polymorphisms in human ABC transporters: the first comparison of six prediction methods
Da Cheng Hao
Laboratory of Biotechnology, College of Environment, Dalian Jiaotong University, Dalian 116028, China
Pharmacol Rep 63:924-34. 2011
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- Bacterial diversity of Taxus rhizosphere: culture-independent and culture-dependent approaches
Da Cheng Hao
Laboratory of Biotechnology, Dalian Jiaotong University, Dalian, China
FEMS Microbiol Lett 284:204-12. 2008
..Taken together, the present studies provide, for the first time, the knowledge of the biodiversity of microorganisms populating Taxus rhizospheres...
- Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus
Da Cheng Hao
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Biochem Genet 44:391-407. 2006
..The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes...
