B C Hansen

Summary

Publications

  1. ncbi request reprint Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality
    B C Hansen
    Obesity and Diabetes Research Center, University of Maryland, Baltimore 21201, USA
    Toxicol Sci 52:56-60. 1999
  2. doi request reprint Longitudinal dynamics of body weight change in the development of type 2 diabetes
    Barbara C Hansen
    Obesity, Diabetes and Aging Research Center, College of Medicine, University of South Florida, Tampa, Florida, USA
    Obesity (Silver Spring) 21:1643-9. 2013
  3. doi request reprint Investigation and treatment of type 2 diabetes in nonhuman primates
    Barbara C Hansen
    Departments of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA
    Methods Mol Biol 933:177-85. 2012
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
  5. pmc Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome
    Barbara C Hansen
    Department of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA
    Cardiovasc Diabetol 10:7. 2011
  6. doi request reprint Emerging strategies for weight management. Summary
    B C Hansen
    Department of Physiology, University of Maryland Hospital Obesity and Diabetes Research Center, 10 S Pine Street, Baltimore, MD 21201, USA
    Postgrad Med 109:40-4. 2001
  7. doi request reprint Emerging strategies for weight management
    B C Hansen
    Department of Physiology, University of Maryland Hospital, Obesity and Diabetes Research Center, 10 S Pine Street, Baltimore, MD 21201, USA
    Postgrad Med 109:3-9. 2001
  8. pmc A thiazolidinedione improves in vivo insulin action on skeletal muscle glycogen synthase in insulin-resistant monkeys
    H K Ortmeyer
    Obesity and Diabetes Research Center, Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Int J Exp Diabetes Res 1:195-202. 2000
  9. ncbi request reprint Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys
    K Hotta
    Obesity and Diabetes Research Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore 21201, USA
    Int J Obes Relat Metab Disord 22:1000-10. 1998
  10. ncbi request reprint Paradoxical phosphorylation of skeletal muscle glycogen synthase by in vivo insulin in very lean young adult rhesus monkeys
    H K Ortmeyer
    Department of Physiology, School of Medicine, University of Maryland, Baltimore 21201, USA
    Ann N Y Acad Sci 892:247-60. 1999

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality
    B C Hansen
    Obesity and Diabetes Research Center, University of Maryland, Baltimore 21201, USA
    Toxicol Sci 52:56-60. 1999
    ..This calorie restriction-induced prevention of morbidity does not require excessive leanness, but is clearly present when body fat is within the normal range of 10 to 22%, and this is likely to be true in humans as well...
  2. doi request reprint Longitudinal dynamics of body weight change in the development of type 2 diabetes
    Barbara C Hansen
    Obesity, Diabetes and Aging Research Center, College of Medicine, University of South Florida, Tampa, Florida, USA
    Obesity (Silver Spring) 21:1643-9. 2013
    ..The aim of this study was to test the obesity-type 2 diabetes mellitus (T2DM) link in the context of longitudinal changes in body weight during the progression to diabetes in mature adult nonhuman primates (NHP)...
  3. doi request reprint Investigation and treatment of type 2 diabetes in nonhuman primates
    Barbara C Hansen
    Departments of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA
    Methods Mol Biol 933:177-85. 2012
    ..This chapter provides guidance for the development and management of a colony of monkeys with naturally occurring type 2 diabetes mellitus...
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
    ..We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome...
  5. pmc Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome
    Barbara C Hansen
    Department of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA
    Cardiovasc Diabetol 10:7. 2011
    ....
  6. doi request reprint Emerging strategies for weight management. Summary
    B C Hansen
    Department of Physiology, University of Maryland Hospital Obesity and Diabetes Research Center, 10 S Pine Street, Baltimore, MD 21201, USA
    Postgrad Med 109:40-4. 2001
    ..Weight loss improves obesity-related health complications and may decrease their incidence as well...
  7. doi request reprint Emerging strategies for weight management
    B C Hansen
    Department of Physiology, University of Maryland Hospital, Obesity and Diabetes Research Center, 10 S Pine Street, Baltimore, MD 21201, USA
    Postgrad Med 109:3-9. 2001
    ..Also included is a review of the costs of obesity to the healthcare system in terms of productivity losses and other expenses...
  8. pmc A thiazolidinedione improves in vivo insulin action on skeletal muscle glycogen synthase in insulin-resistant monkeys
    H K Ortmeyer
    Obesity and Diabetes Research Center, Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Int J Exp Diabetes Res 1:195-202. 2000
    ..This improvement in insulin sensitivity may be a key factor in the anti-diabetic effect of the thiazolidinedione class of agents...
  9. ncbi request reprint Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys
    K Hotta
    Obesity and Diabetes Research Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore 21201, USA
    Int J Obes Relat Metab Disord 22:1000-10. 1998
    ....
  10. ncbi request reprint Paradoxical phosphorylation of skeletal muscle glycogen synthase by in vivo insulin in very lean young adult rhesus monkeys
    H K Ortmeyer
    Department of Physiology, School of Medicine, University of Maryland, Baltimore 21201, USA
    Ann N Y Acad Sci 892:247-60. 1999
    ....
  11. ncbi request reprint Is microvascular flow rate related to ghrelin, leptin and adiponectin levels?
    Xenia T Tigno
    Department of Physiology, College of Medicine, University of the Philippines, Ermita, Manila, Philippines
    Clin Hemorheol Microcirc 29:409-16. 2003
    ..Trends show that flow was also negatively correlated to circulating triglyceride levels (p=0.08). The data indicate that the three hormones appear to possess microvascular actions that may impact on their other physiologic functions...
  12. ncbi request reprint Insulin unexpectedly increases the glucose 6-phosphate Ka of skeletal muscle glycogen synthase in calorie-restricted monkeys
    H K Ortmeyer
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Basic Clin Physiol Pharmacol 9:309-23. 1998
    ..These alterations are likely to be involved in the anti-diabetogenic effects of calorie restriction...
  13. ncbi request reprint Monkey leptin receptor mRNA: sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys
    K Hotta
    Obesity and Diabetes Research Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Obes Res 6:353-60. 1998
    ..We have cloned the rhesus monkey leptin receptor and examined its mRNA expression levels in the adipose tissue of monkeys to investigate the regulation of gene expression of the leptin receptor...
  14. ncbi request reprint The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys
    N L Bodkin
    Obesity and Diabetes Research Center, School of Medicine, Dept of Physiology, University of Maryland, Baltimore, MD 21201, USA
    Horm Metab Res 35:617-24. 2003
    ..These results indicate the necessity of future study of K-111 for metabolic syndrome in humans, and suggest potential in reducing the risks of diabetes and cardiovascular disease...
  15. ncbi request reprint Hyperleptinemia: relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey
    N L Bodkin
    Obesity and Diabetes Research Center, School of Medicine, University of Maryland, Baltimore 21201, USA
    Horm Metab Res 28:674-8. 1996
    ..However, the potential role of leptin in the development of peripheral insulin resistance, hyperglycemia and type 2 diabetes will require further study...
  16. ncbi request reprint Prostaglandylinositol cyclic phosphate synthase activity in the liver of insulin-resistant rhesus monkeys before and after a euglycemic hyperinsulinemic clamp
    P N Shashkin
    Obesity and Diabetes Research Center, Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Basic Clin Physiol Pharmacol 12:1-18. 2001
    ..94, p<0.005. The findings suggest that in the liver of insulin-resistant rhesus monkeys, cPIP synthase activity, which leads to the synthesis of the low-molecular weight mediator cPIP, may oppose cAMP synthesis and PKA activity...
  17. ncbi request reprint Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus
    K Hotta
    Obesity and Diabetes Research Center, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 271:25327-31. 1996
    ..Circulating levels of the ob gene product leptin were also significantly correlated with body weight. These results show that ob gene expression is related to body weight and is not acutely regulated by insulin...
  18. ncbi request reprint The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64
    J Walston
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University Bayview Medical Center, Baltimore, MD 21224, USA
    Gene 188:207-13. 1997
    ....
  19. ncbi request reprint Heat shock cognate-70 gene expression declines during normal aging of the primate retina
    S L Bernstein
    Departments of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201, USA
    Invest Ophthalmol Vis Sci 41:2857-62. 2000
    ..This study was undertaken to definitively characterize gene expression in the primate retina during aging...
  20. ncbi request reprint Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger of insulin action. Comparative analysis of two kinds of "insulin mediators"
    P N Shashkin
    Obesity and Diabetes Research Center, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes Metab Res Rev 17:273-84. 2001
    ..Further studies on cPIP and other types of insulin mediators are necessary to aid our understanding of insulin action...
  21. ncbi request reprint Ocular structure and function in an aged monkey with spontaneous diabetes mellitus
    M A Johnson
    Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Eye Res 80:37-42. 2005
    ..Choroidal vascular dysfunction in both large and small vessels was associated with age-related macular degeneration-like changes in Bruch's membrane and photoreceptor degeneration...