Molecular origin of female meiotic aneuploidiesAlan H Handyside
London Bridge Fertility, Gynaecology and Genetics Centre, London, UK Institute of Integrative and Comparative Biology, University of Leeds, Leeds, UK Electronic address
Biochim Biophys Acta 1822:1913-20. 2012
..This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure...
Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisationAlan H Handyside
London Bridge Fertility, Gynaecology and Genetics Centre, London, UK
Eur J Hum Genet 20:742-7. 2012
..Furthermore, most abnormal zygotes had multiple aneuploidies. These differences in the aetiology of aneuploidy in IVF compared with natural conception may indicate a role for ovarian stimulation in perturbing meiosis in ageing oocytes...
- Preimplantation genetic diagnosis after 20 years
Alan H Handyside
London Bridge Fertility, Gynaecology and Genetics Centre, London, UK
Reprod Biomed Online 21:280-2. 2010
..With the increasing emphasis in medicine on early diagnosis and prevention of disease together with the availability of new molecular genetic diagnostic tools, a national IVF-PGD programme seems to be the next step in modern health care...
- Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes
Alan H Handyside
London Bridge Fertility, Gynaecology and Genetics Centre, One St Thomas Street, London SE1 9RY, UK
J Med Genet 47:651-8. 2010
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- PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: seeing the wood and the trees
Alan H Handyside
London Bridge Fertility, Gynaecology and Genetics Centre, 1 St Thomas Street, London SE1 9RY, UK
Reprod Biomed Online 23:686-91. 2011
..A consensus on how to validate aneuploidy testing and all other clinically relevant information resulting from genome-wide analysis is needed urgently...
The centrosome and early embryogenesis: clinical insightsKaterina Chatzimeletiou
The London Bridge Fertility, Gynaecology and Genetics Centre, 1 St Thomas Street, London, SE1 9RY
Reprod Biomed Online 16:485-91. 2008
..This paper is a brief review of the role of the centrosome and the implications of its dysfunction in early embryogenesis, with particular reference to the human embryo...
- Comparison of effects of zona drilling by non-contact infrared laser or acid Tyrode's on the development of human biopsied embryos as revealed by blastomere viability, cytoskeletal analysis and molecular cytogenetics
Katerina Chatzimeletiou
The London Bridge Fertility, Gynaecology and Genetics Centre, London SE1 9RY, UK
Reprod Biomed Online 11:697-710. 2005
..Acid Tyrode's drilling can also cause damage, and tended to retard blastocyst development...
- Scoring of sperm chromosomal abnormalities by manual and automated approaches: qualitative and quantitative comparisons
Helen G Tempest
Gynaecology and Genetics Centre, London, UK
Asian J Androl 12:257-62. 2010
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- Paternal inheritance of a 16qh-polymorphism in a patient with repeated IVF failure
Katerina Chatzimeletiou
The London Bridge Fertility, Gynaecology and Genetics Centre, 1 St Thomas Street, London SE1 9RY, UK
Reprod Biomed Online 13:864-7. 2006
..Furthermore, complete analysis of all embryonic nuclei from carrier embryos and others rejected for transfer because of aneuploidy revealed no abnormalities in the segregation pattern of chromosome 16...
- Spindle abnormalities in normally developing and arrested human preimplantation embryos in vitro identified by confocal laser scanning microscopy
Katerina Chatzimeletiou
The London Bridge Fertility, Gynaecology and Genetics Centre, One St Thomas Street, London SE1 9RY, UK
Hum Reprod 20:672-82. 2005
..The underlying mechanisms are largely unknown, but similarities with chromosome instability in human cancers led to the proposal that cell cycle checkpoints may not operate at these early stages...
- Isothermal whole genome amplification from single and small numbers of cells: a new era for preimplantation genetic diagnosis of inherited disease
Alan H Handyside
Leeds PGD Centre, Assisted Conception Unit, Clarendon Wing, Leeds General Infirmary, Leeds, UK
Mol Hum Reprod 10:767-72. 2004
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- Expression of Sox8, Sf1, Gata4, Wt1, Dax1, and Fog2 in the mouse ovarian follicle: implications for the regulation of Amh expression
Nicholas A Salmon
School of Biology, University of Leeds, Leeds, LS2 9JT, UK
Mol Reprod Dev 70:271-7. 2005
..These findings reveal Sox8 expression in the ovarian follicle and show that oocyte regulation of Amh expression is not due to oocyte regulation of Sf1, Gata4, Wt1, Dax1, or Fog2 expression in granulosa cells...
