Xianlin Han

Summary

Publications

  1. pmc Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mass Spectrom Rev 31:134-78. 2012
  2. pmc A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis
    Ling Lai
    From the Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827
    J Biol Chem 289:2250-9. 2014
  3. pmc Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Int J Biochem Cell Biol 45:2749-55. 2013
  4. pmc Characterization and quantification of diacylglycerol species in biological extracts after one-step derivatization: a shotgun lipidomics approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827
    Anal Chem 86:2146-55. 2014
  5. pmc Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis
    Hua Cheng
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida, USA
    J Neurochem 127:733-8. 2013
  6. pmc Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, United States
    Anal Chem 85:9312-20. 2013
  7. doi request reprint Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida and
    Am J Physiol Heart Circ Physiol 305:H1332-43. 2013
  8. doi request reprint Cardiolipin remodeling in diabetic heart
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Chem Phys Lipids 179:75-81. 2014

Collaborators

  • Quan He
  • Miao Wang
  • Ling Lai
  • Hua Cheng
  • Ola J Martin
  • Teresa C Leone
  • Rick B Vega
  • Jun Hayakawa
  • Daniel P Kelly
  • Kui Yang
  • Nigel J Cairns
  • Jian Liang Li
  • Rowland H Han

Detail Information

Publications8

  1. pmc Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mass Spectrom Rev 31:134-78. 2012
    ....
  2. pmc A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis
    Ling Lai
    From the Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827
    J Biol Chem 289:2250-9. 2014
    ..We conclude that the PGC-1/estrogen-related receptor axis coordinately regulates metabolic and membrane structural programs relevant to the maintenance of high capacity mitochondrial function in heart. ..
  3. pmc Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Int J Biochem Cell Biol 45:2749-55. 2013
    ..These studies suggested that increased mitochondrial stresses might be an underlying mechanism responsible for TAG accumulation manifest in obesity. ..
  4. pmc Characterization and quantification of diacylglycerol species in biological extracts after one-step derivatization: a shotgun lipidomics approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827
    Anal Chem 86:2146-55. 2014
    ..These results demonstrated the importance and power of the method for studying biochemical mechanisms underpinning disease states. ..
  5. pmc Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis
    Hua Cheng
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida, USA
    J Neurochem 127:733-8. 2013
    ....
  6. pmc Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, United States
    Anal Chem 85:9312-20. 2013
    ..We believe that this approach could greatly facilitate identification of the biochemical mechanisms underlying numerous pathological conditions. ..
  7. doi request reprint Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida and
    Am J Physiol Heart Circ Physiol 305:H1332-43. 2013
    ..We concluded that tafazzin knockdown interrupts the NVF cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome...
  8. doi request reprint Cardiolipin remodeling in diabetic heart
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Chem Phys Lipids 179:75-81. 2014
    ..The efficiency of cardiolipin remodeling and functional improvement is still under investigation. ..

Research Grants4

  1. Shotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's Diseases
    Xianlin Han; Fiscal Year: 2007
    ..The obtained results will reveal the biochemical mechanisms underlying sulfatide loss in AD, identify novel lipid biomarkers for the early diagnosis of AD, and provide insight into AD pathogenesis. ..
  2. Shotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's Diseases
    Xianlin Han; Fiscal Year: 2009
    ..The obtained results will reveal the biochemical mechanisms underlying sulfatide loss in AD, identify novel lipid biomarkers for the early diagnosis of AD, and provide insight into AD pathogenesis. ..
  3. Shotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's Diseases
    Xianlin Han; Fiscal Year: 2010
    ..The obtained results will reveal the biochemical mechanisms underlying sulfatide loss in AD, identify novel lipid biomarkers for the early diagnosis of AD, and provide insight into AD pathogenesis. ..