Xianlin Han

Summary

Publications

  1. doi request reprint Applications of mass spectrometry for cellular lipid analysis
    Chunyan Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, Florida 32827, USA
    Mol Biosyst 11:698-713. 2015
  2. pmc Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mass Spectrom Rev 31:134-78. 2012
  3. pmc Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, United States
    Anal Chem 85:9312-20. 2013
  4. pmc Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis
    Rowland H Han
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    J Lipid Res 54:1023-32. 2013
  5. pmc Mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA
    Oxid Med Cell Longev 2014:654198. 2014
  6. pmc Alterations in mouse brain lipidome after disruption of CST gene: a lipidomics study
    Chunyan Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL, 32827, USA
    Mol Neurobiol 50:88-96. 2014
  7. pmc A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis
    Ling Lai
    From the Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827
    J Biol Chem 289:2250-9. 2014
  8. pmc Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Int J Biochem Cell Biol 45:2749-55. 2013
  9. pmc Characterization and quantification of diacylglycerol species in biological extracts after one-step derivatization: a shotgun lipidomics approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827
    Anal Chem 86:2146-55. 2014
  10. doi request reprint Muscle-Specific Deletion of Comparative Gene Identification-58 (CGI-58) Causes Muscle Steatosis but Improves Insulin Sensitivity in Male Mice
    Ping Xie
    Departments of Biochemistry P X, Y M, F G, L Y and Anesthesiology L G, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 Department of Animal and Avian Sciences A K G G, Y M, L Y, University of Maryland, College Park, Maryland 20742 Diabetes and Obesity Research Center X H, M W, Sanford Burnham Medical Research Institute, Orlando, Florida 32827 Department of Biology B X, H S, Georgia State University, Atlanta, Georgia 30303 and The Key Laboratory of Remodeling Related Cardiovascular Diseases H L, Capital Medical University, Ministry of Education, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated the Capital Medical University, Beijing 100029, People s Republic of China
    Endocrinology 156:1648-58. 2015

Collaborators

  • Quan He
  • Ping Xie
  • Miao Wang
  • Chunyan Wang
  • Rowland H Han
  • Ling Lai
  • Hua Cheng
  • Yingying Huang
  • Jun Hayakawa
  • Jeffrey L Dupree
  • Daniel P Kelly
  • Kui Yang
  • Teresa C Leone
  • Ola J Martin
  • Rick B Vega
  • Yunhua Zhou
  • Xiaoling Fang
  • Nigel J Cairns
  • Jian Liang Li
  • Huafeng Fang

Detail Information

Publications16

  1. doi request reprint Applications of mass spectrometry for cellular lipid analysis
    Chunyan Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, Florida 32827, USA
    Mol Biosyst 11:698-713. 2015
    ..The applications of these methodologies to lipidomic research are also summarized. ..
  2. pmc Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mass Spectrom Rev 31:134-78. 2012
    ....
  3. pmc Fatty acidomics: global analysis of lipid species containing a carboxyl group with a charge-remote fragmentation-assisted approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, United States
    Anal Chem 85:9312-20. 2013
    ..We believe that this approach could greatly facilitate identification of the biochemical mechanisms underlying numerous pathological conditions. ..
  4. pmc Simulation of triacylglycerol ion profiles: bioinformatics for interpretation of triacylglycerol biosynthesis
    Rowland H Han
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    J Lipid Res 54:1023-32. 2013
    ..Collectively, this new development should greatly facilitate our understanding of the biochemical mechanisms underpinning TAG accumulation at the states of obesity and lipotoxicity...
  5. pmc Mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL 32827, USA
    Oxid Med Cell Longev 2014:654198. 2014
    ....
  6. pmc Alterations in mouse brain lipidome after disruption of CST gene: a lipidomics study
    Chunyan Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL, 32827, USA
    Mol Neurobiol 50:88-96. 2014
    ..These results might provide new insights into the role of CST in myelin function. ..
  7. pmc A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis
    Ling Lai
    From the Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827
    J Biol Chem 289:2250-9. 2014
    ..We conclude that the PGC-1/estrogen-related receptor axis coordinately regulates metabolic and membrane structural programs relevant to the maintenance of high capacity mitochondrial function in heart. ..
  8. pmc Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Int J Biochem Cell Biol 45:2749-55. 2013
    ..These studies suggested that increased mitochondrial stresses might be an underlying mechanism responsible for TAG accumulation manifest in obesity. ..
  9. pmc Characterization and quantification of diacylglycerol species in biological extracts after one-step derivatization: a shotgun lipidomics approach
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827
    Anal Chem 86:2146-55. 2014
    ..These results demonstrated the importance and power of the method for studying biochemical mechanisms underpinning disease states. ..
  10. doi request reprint Muscle-Specific Deletion of Comparative Gene Identification-58 (CGI-58) Causes Muscle Steatosis but Improves Insulin Sensitivity in Male Mice
    Ping Xie
    Departments of Biochemistry P X, Y M, F G, L Y and Anesthesiology L G, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 Department of Animal and Avian Sciences A K G G, Y M, L Y, University of Maryland, College Park, Maryland 20742 Diabetes and Obesity Research Center X H, M W, Sanford Burnham Medical Research Institute, Orlando, Florida 32827 Department of Biology B X, H S, Georgia State University, Atlanta, Georgia 30303 and The Key Laboratory of Remodeling Related Cardiovascular Diseases H L, Capital Medical University, Ministry of Education, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated the Capital Medical University, Beijing 100029, People s Republic of China
    Endocrinology 156:1648-58. 2015
    ..In conclusion, muscle CGI-58 deficiency causes cardiac dysfunction and fat deposition in oxidative muscles but induces a series of favorable metabolic changes in mice fed a high-fat diet. ..
  11. pmc Accurate mass searching of individual lipid species candidates from high-resolution mass spectra for shotgun lipidomics
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL, 32827, USA
    Rapid Commun Mass Spectrom 28:2201-10. 2014
    ..This partial overlap alone could cause a mass shift of the species L to the lower mass end up to 12 ppm around m/z 750 as well as significant peak broadening...
  12. pmc Multidimensional mass spectrometry-based shotgun lipidomics
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, 6400 Sanger Road, Orlando, FL, 32827, USA
    Methods Mol Biol 1198:203-20. 2014
    ....
  13. pmc Shotgun lipidomics analysis of 4-hydroxyalkenal species directly from lipid extracts after one-step in situ derivatization
    Miao Wang
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, United States
    Anal Chem 84:4580-6. 2012
    ..We believe that development of this novel methodology should provide a powerful tool for us to better understand the role of 4-hydroxyalkenal species in biological processes...
  14. doi request reprint Cardiolipin remodeling in diabetic heart
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Chem Phys Lipids 179:75-81. 2014
    ..The efficiency of cardiolipin remodeling and functional improvement is still under investigation. ..
  15. doi request reprint Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
    Quan He
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida and
    Am J Physiol Heart Circ Physiol 305:H1332-43. 2013
    ..We concluded that tafazzin knockdown interrupts the NVF cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome...
  16. pmc Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis
    Hua Cheng
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida, USA
    J Neurochem 127:733-8. 2013
    ....